ES2191628T3 - Procedimiento para extraccion y purificacion de paclitaxel a partir de fuentes naturales. - Google Patents

Procedimiento para extraccion y purificacion de paclitaxel a partir de fuentes naturales.

Info

Publication number
ES2191628T3
ES2191628T3 ES00938356T ES00938356T ES2191628T3 ES 2191628 T3 ES2191628 T3 ES 2191628T3 ES 00938356 T ES00938356 T ES 00938356T ES 00938356 T ES00938356 T ES 00938356T ES 2191628 T3 ES2191628 T3 ES 2191628T3
Authority
ES
Spain
Prior art keywords
biomass
paclitaxel
crystals
drying
purification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00938356T
Other languages
English (en)
Inventor
Trung Bui-Khac
Nicolas Dupuis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chaichem Pharmaceuticals International Inc
Original Assignee
Chaichem Pharmaceuticals International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2275980 external-priority patent/CA2275980A1/fr
Application filed by Chaichem Pharmaceuticals International Inc filed Critical Chaichem Pharmaceuticals International Inc
Application granted granted Critical
Publication of ES2191628T3 publication Critical patent/ES2191628T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/55—Liquid-liquid separation; Phase separation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimiento para la extracción y purificación de Paclitaxel a partir de una fuente natural de taxanos que contienen dicho Paclitaxel que ha de ser extraído, comprendiendo dicho procedimiento las siguientes etapas: a) extraer con un solvente orgánico, una materia prima que contiene Paclitaxel a partir de dicha fuente natural de taxanos; b) tratar dicha materia prima en un medio básico o un medio acídico con el fin de obtener una biomasa por precipitación, aislando dicha biomasa y secándola; c) percolorar la biomasa así aislada mediante extracción de la resina y de los pigmentos naturales contenidos en la misma, disolviendo dicha biomasa en acetona y añadiendo a continuación a la misma al menos un solvente no polar hasta que se obtenga una fase aceitosa enriquecida con Paclitaxel; d) tratar la biomasa contenida en la fase aceitosa enriquecida con Paclitaxel recuperada en la etapa anterior, con un medio acídico cuando el tratamiento de la etapa (b) ha sido llevado a cabo con un medio básico,o con un medio básico cuando del el tratamiento de la etapa (b) ha sido llevado a cabo con un medio acídico, con el fin de obtener otra biomasa por precipitación, aislando dicha otra biomasa y secándola; e) purificar cromatográficamente, al menos una vez, una solución de la otra biomasa aislada obtenida en la etapa anterior en un solvente volátil, y cristalizar, al menos una vez, la solución purificada obtenida por cromatografía.
ES00938356T 1999-06-22 2000-05-25 Procedimiento para extraccion y purificacion de paclitaxel a partir de fuentes naturales. Expired - Lifetime ES2191628T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA 2275980 CA2275980A1 (fr) 1999-06-22 1999-06-22 Procede de recuperation de pacitaxeline a partir de sources naturelles
CA2299149A CA2299149C (fr) 1999-06-22 2000-02-22 Procede d'isolation et de purification du paclitaxel a partir de sources naturelles

Publications (1)

Publication Number Publication Date
ES2191628T3 true ES2191628T3 (es) 2003-09-16

Family

ID=25681018

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00938356T Expired - Lifetime ES2191628T3 (es) 1999-06-22 2000-05-25 Procedimiento para extraccion y purificacion de paclitaxel a partir de fuentes naturales.

Country Status (12)

Country Link
EP (1) EP1194423B1 (es)
JP (1) JP4563632B2 (es)
KR (1) KR100706983B1 (es)
CN (1) CN1148364C (es)
AT (1) ATE230736T1 (es)
AU (1) AU5377100A (es)
CA (1) CA2299149C (es)
DE (1) DE60001173T2 (es)
DK (1) DK1194423T3 (es)
ES (1) ES2191628T3 (es)
HK (1) HK1047285A1 (es)
WO (1) WO2000078741A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100459708B1 (ko) 2002-03-29 2004-12-04 삼성전자주식회사 자동 레이저 출력 제어 기능을 가지는 레이저 다이오드 드라이버
US6759539B1 (en) * 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
US7259268B2 (en) 2003-12-31 2007-08-21 Samyang Genex Corporation Method for purification of paclitaxel from paclitaxel-containing materials
DK1616868T3 (da) * 2004-07-13 2008-01-21 Indena Spa Fremgangsmåder til at opnå paclitaxel fra Taxus-planter
WO2007112570A1 (en) 2006-04-03 2007-10-11 Pharmatherm Chemicals Inc. Thermal extraction method and product
CN101747403B (zh) * 2009-12-31 2012-06-20 江南大学 从油茶籽粕中提取茶皂素的方法
US20110284359A1 (en) 2010-05-20 2011-11-24 Uop Llc Processes for controlling afterburn in a reheater and for controlling loss of entrained solid particles in combustion product flue gas
US8499702B2 (en) 2010-07-15 2013-08-06 Ensyn Renewables, Inc. Char-handling processes in a pyrolysis system
US9441887B2 (en) 2011-02-22 2016-09-13 Ensyn Renewables, Inc. Heat removal and recovery in biomass pyrolysis
ES2522932T3 (es) * 2011-07-09 2014-11-19 Clariant International Ltd. Nueva gama viable de colorantes de azufre para teñir materiales textiles y papel
US9347005B2 (en) 2011-09-13 2016-05-24 Ensyn Renewables, Inc. Methods and apparatuses for rapid thermal processing of carbonaceous material
US9044727B2 (en) 2011-09-22 2015-06-02 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US10041667B2 (en) 2011-09-22 2018-08-07 Ensyn Renewables, Inc. Apparatuses for controlling heat for rapid thermal processing of carbonaceous material and methods for the same
US10400175B2 (en) 2011-09-22 2019-09-03 Ensyn Renewables, Inc. Apparatuses and methods for controlling heat for rapid thermal processing of carbonaceous material
US9109177B2 (en) 2011-12-12 2015-08-18 Ensyn Renewables, Inc. Systems and methods for renewable fuel
US9670413B2 (en) 2012-06-28 2017-06-06 Ensyn Renewables, Inc. Methods and apparatuses for thermally converting biomass
WO2014210150A1 (en) 2013-06-26 2014-12-31 Ensyn Renewables, Inc. Systems and methods for renewable fuel
KR101666438B1 (ko) * 2014-01-07 2016-10-14 공주대학교 산학협력단 파클리탁셀 추출용 바이오매스 조성물 및 이를 이용한 파클리탁셀 추출방법
CN104140689B (zh) * 2014-07-14 2016-02-17 红豆集团无锡南国企业有限公司 从红豆杉制药残渣中提取天然色素的方法
US10337726B2 (en) 2015-08-21 2019-07-02 Ensyn Renewables, Inc. Liquid biomass heating system
CN106243066A (zh) * 2016-08-05 2016-12-21 上海贝美医药科技有限公司 紫杉醇的结晶纯化方法
BR112019013387B1 (pt) 2016-12-29 2023-03-28 Ensyn Renewables, Inc Desmetalização de biomassa
CN110882213B (zh) * 2019-11-21 2021-05-04 海南紫杉园制药有限公司 一种紫杉醇注射液及其制备方法
CN110845451A (zh) * 2019-11-28 2020-02-28 云南皓瑞逸生物科技有限公司 一种从红豆杉中提取紫杉醇的方法
CN112521349B (zh) * 2020-11-11 2023-04-07 福建齐衡科技有限公司 一种紫杉醇的纯化方法
CN113376271A (zh) * 2021-05-26 2021-09-10 华东理工大学 一种基于lc-ms的生物样品中壳寡糖的高灵敏度检测分析方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627010A4 (en) * 1992-12-07 1995-05-03 Univ Michigan PROCESS FOR ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM -i (TAXUS) spp.
US5279949A (en) * 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
US5440055A (en) * 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
JPH0940567A (ja) * 1995-07-27 1997-02-10 Taisho Pharmaceut Co Ltd タキソールおよびタキサンテルペノイド類の製造方法
JPH0940657A (ja) * 1995-07-27 1997-02-10 Taisho Pharmaceut Co Ltd タキソールおよびタキサンテルペノイド類の製造方法

Also Published As

Publication number Publication date
CA2299149A1 (fr) 2000-12-22
CA2299149C (fr) 2010-09-21
JP2003502414A (ja) 2003-01-21
WO2000078741A3 (en) 2001-05-17
EP1194423A2 (en) 2002-04-10
CN1356992A (zh) 2002-07-03
DE60001173D1 (de) 2003-02-13
DK1194423T3 (da) 2003-04-22
DE60001173T2 (de) 2003-11-20
ATE230736T1 (de) 2003-01-15
CN1148364C (zh) 2004-05-05
JP4563632B2 (ja) 2010-10-13
WO2000078741A2 (en) 2000-12-28
KR100706983B1 (ko) 2007-04-11
AU5377100A (en) 2001-01-09
KR20020031345A (ko) 2002-05-01
EP1194423B1 (en) 2003-01-08
HK1047285A1 (en) 2003-02-14

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