DE60009407D1 - Verfahren zur Herstellung von N-carbamat-geschütztem beta-Aminoepoxid und beta-Aminoalkohol - Google Patents

Verfahren zur Herstellung von N-carbamat-geschütztem beta-Aminoepoxid und beta-Aminoalkohol

Info

Publication number
DE60009407D1
DE60009407D1 DE60009407T DE60009407T DE60009407D1 DE 60009407 D1 DE60009407 D1 DE 60009407D1 DE 60009407 T DE60009407 T DE 60009407T DE 60009407 T DE60009407 T DE 60009407T DE 60009407 D1 DE60009407 D1 DE 60009407D1
Authority
DE
Germany
Prior art keywords
carbamate
protected beta
beta
aminoepoxide
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60009407T
Other languages
English (en)
Other versions
DE60009407T2 (de
Inventor
Tomoyuki Onishi
Naoko Hirose
Yasuyuki Otake
Takashi Nakano
Yutaka Honda
Masakazu Nakazawa
Kunisuke Izawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE60009407D1 publication Critical patent/DE60009407D1/de
Publication of DE60009407T2 publication Critical patent/DE60009407T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60009407T 1999-08-31 2000-08-31 Verfahren zur Herstellung von N-carbamat-geschütztem beta-Aminoepoxid und beta-Aminoalkohol Expired - Lifetime DE60009407T2 (de)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP24564599 1999-08-31
JP24564599 1999-08-31
JP2000035074 2000-02-14
JP2000035074 2000-02-14
JP2000082895 2000-03-23
JP2000082895 2000-03-23
JP2000199234 2000-06-30
JP2000199234 2000-06-30

Publications (2)

Publication Number Publication Date
DE60009407D1 true DE60009407D1 (de) 2004-05-06
DE60009407T2 DE60009407T2 (de) 2005-03-03

Family

ID=27478006

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009407T Expired - Lifetime DE60009407T2 (de) 1999-08-31 2000-08-31 Verfahren zur Herstellung von N-carbamat-geschütztem beta-Aminoepoxid und beta-Aminoalkohol

Country Status (7)

Country Link
US (1) US6765100B2 (de)
EP (2) EP1081133B1 (de)
KR (2) KR100708221B1 (de)
AT (1) ATE263145T1 (de)
CA (1) CA2317198A1 (de)
DE (1) DE60009407T2 (de)
ES (1) ES2216828T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020046948A (ko) * 2000-12-12 2002-06-21 에가시라 구니오 에폭사이드 결정의 제조방법
JP2002371044A (ja) 2001-04-11 2002-12-26 Ajinomoto Co Inc β−アミノ−α−ヒドロキシカルボン酸の製造方法
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
JP2007112723A (ja) * 2005-10-18 2007-05-10 Ajinomoto Co Inc アミノクロロヒドリン硫酸塩の製造方法
CN102432621B (zh) 2006-11-09 2016-02-17 爱尔兰詹森科学公司 六氢呋喃并[2,3-b]呋喃-3-醇的制备方法
MX2009011574A (es) 2007-04-27 2009-11-09 Tibotec Pharm Ltd Metodos para la preparacion de derivados de n-isobutil-n-(2-hidrox i-3-amino-4-fenilbutil)-p-nitrobencensulfonilamida.
KR20100033378A (ko) * 2007-06-22 2010-03-29 브리스톨-마이어스 스큅 컴퍼니 아타자나비르를 함유하는 정제 조성물
ES2449074T3 (es) * 2007-06-22 2014-03-18 Bristol-Myers Squibb Holdings Ireland Composiciones en forma de comprimidos que contienen atazanavir
MX2009013499A (es) * 2007-06-22 2010-01-18 Bristol Myers Squibb Co Composiciones comprimidas que contienen atazanavir.
ATE503467T1 (de) * 2007-06-22 2011-04-15 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
US20110178305A1 (en) * 2008-05-08 2011-07-21 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2528923B1 (de) 2010-01-28 2014-07-30 Mapi Pharma Limited Verfahren zur herstellung von darunavir und darunavir-zwischenprodukten
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
CN102766074B (zh) * 2012-08-07 2014-05-07 江西东邦药业有限公司 抗艾滋病药物中间体的制备方法
CN103044361B (zh) * 2012-12-30 2014-08-06 江苏八巨药业有限公司 一种（2r,3s）-环氧化氨基苯丁烷的制备方法
CN105461662A (zh) * 2014-08-31 2016-04-06 复旦大学 一种抗hiv药物中间体的手性环氧化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0735019T3 (da) * 1990-11-19 2000-10-23 Monsanto Co Retrovirale proteaseinhibitorer
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
CA2186483A1 (en) * 1995-02-03 1996-08-08 Akira Nishiyama Processes for producing .alpha.-halo ketones, .alpha.-halohydrins and epoxides
CA2190570C (en) * 1995-11-17 2005-05-03 Yutaka Honda Process for producing 3-amino-2-oxo-1-halogenopropane derivatives
HUP0101263A3 (en) 1998-01-28 2002-04-29 Nippon Kayaku Kk Process for producing optically active threo-3-amino-1,2-epoxy compounds
AU3075400A (en) 1999-01-21 2000-08-07 Kaneka Corporation Method for purifying and isolating (2s,3s)- or (2r,3s)-halohydrin derivatives
EP1661893A3 (de) 1999-01-29 2006-06-07 Kaneka Corporation Verfahren zur Herstellung von threo-1,2-epoxy-3-amino-4-phenylbutan-Derivaten
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres

Also Published As

Publication number Publication date
DE60009407T2 (de) 2005-03-03
KR100706567B1 (ko) 2007-04-13
KR20010067130A (ko) 2001-07-12
EP1428818A3 (de) 2004-11-03
KR100708221B1 (ko) 2007-04-17
KR20060116182A (ko) 2006-11-14
ES2216828T3 (es) 2004-11-01
CA2317198A1 (en) 2001-02-28
EP1081133A1 (de) 2001-03-07
US20020072621A1 (en) 2002-06-13
EP1428818A2 (de) 2004-06-16
US6765100B2 (en) 2004-07-20
EP1081133B1 (de) 2004-03-31
ATE263145T1 (de) 2004-04-15

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