ATE250425T1 - Analoga des parathyroid-hormons - Google Patents

Analoga des parathyroid-hormons

Info

Publication number
ATE250425T1
ATE250425T1 AT96924355T AT96924355T ATE250425T1 AT E250425 T1 ATE250425 T1 AT E250425T1 AT 96924355 T AT96924355 T AT 96924355T AT 96924355 T AT96924355 T AT 96924355T AT E250425 T1 ATE250425 T1 AT E250425T1
Authority
AT
Austria
Prior art keywords
amino acid
parathyroid hormone
analogues
acid residue
alpha
Prior art date
Application number
AT96924355T
Other languages
English (en)
Inventor
Zheng Xin Dong
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of ATE250425T1 publication Critical patent/ATE250425T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AT96924355T 1995-07-13 1996-07-03 Analoga des parathyroid-hormons ATE250425T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US110595P 1995-07-13 1995-07-13
US330595P 1995-09-06 1995-09-06
US08/626,186 US5723577A (en) 1995-07-13 1996-03-29 Analogs of parathyroid hormone
PCT/US1996/011292 WO1997002834A1 (en) 1995-07-13 1996-07-03 Analogs of parathyroid hormone

Publications (1)

Publication Number Publication Date
ATE250425T1 true ATE250425T1 (de) 2003-10-15

Family

ID=27356825

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96924355T ATE250425T1 (de) 1995-07-13 1996-07-03 Analoga des parathyroid-hormons
AT03077383T ATE442159T1 (de) 1995-07-13 1996-07-03 Parathyroidhormon analoge

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03077383T ATE442159T1 (de) 1995-07-13 1996-07-03 Parathyroidhormon analoge

Country Status (20)

Country Link
US (1) US5723577A (de)
EP (2) EP0847278B1 (de)
JP (3) JPH11509201A (de)
KR (5) KR100500853B1 (de)
CN (3) CN1247260C (de)
AT (2) ATE250425T1 (de)
AU (1) AU707094B2 (de)
DE (2) DE69638025D1 (de)
DK (2) DK1405861T3 (de)
ES (2) ES2329233T3 (de)
HK (2) HK1014876A1 (de)
HU (1) HU226935B1 (de)
IL (1) IL122837A (de)
MX (1) MX9800418A (de)
NZ (1) NZ312899A (de)
PL (1) PL186710B1 (de)
PT (2) PT847278E (de)
SK (1) SK3198A3 (de)
TW (1) TW482766B (de)
WO (1) WO1997002834A1 (de)

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US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US5955425A (en) * 1996-08-02 1999-09-21 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US6544949B1 (en) * 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
HUP0003349A3 (en) * 1997-05-14 2001-12-28 Aventis Pharmaceuticals Inc Co Peptide parathyroid hormone analogs, pharmaceutical compositions comprising thereof and their use
AU752925B2 (en) * 1997-09-09 2002-10-03 F. Hoffmann-La Roche Ag Fracture healing using PTHrP analogs
EP1075491B1 (de) * 1998-05-05 2008-04-16 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Pth2 rezeptor selektive verbindungen
EP1098906B1 (de) * 1998-07-20 2009-11-25 Ipsen Pharma Pacap-peptidanaloga
AU1447600A (en) * 1998-10-22 2000-05-08 Thomas J. Gardella Bioactive peptides and peptide derivatives of parathyroid hormone (pth) and parathyroid hormone-related peptide (pthrp)
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
US6689566B1 (en) 1999-01-14 2004-02-10 Scantibodies Laboratory, Inc. Methods, kits, and antibodies for detecting parathyroid hormone
US7820393B2 (en) * 1999-01-14 2010-10-26 Scantibodies Laboratory, Inc. Methods, kits and antibodies for detecting parathyroid hormone
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
US7893021B2 (en) * 1999-06-02 2011-02-22 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
DE60040678D1 (en) 1999-09-29 2008-12-11 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
WO2001023521A2 (en) * 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20040186050A1 (en) 2001-06-01 2004-09-23 Ault Joseph M Method for orally administering parathyroid hormone (pth)
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
US7572765B2 (en) * 2001-07-23 2009-08-11 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US20040067526A1 (en) * 2002-10-03 2004-04-08 Cantor Thomas L. Methods for diagnosing and guiding treatment of bone turnover disease
EP1610813A4 (de) * 2003-03-19 2009-07-01 Gen Hospital Corp KONFORMATIONSEINGESCHRÄNKTE PARATHORMONE MIT a-HELIX-STABILISATOREN
KR100540659B1 (ko) * 2003-07-02 2006-01-10 삼성전자주식회사 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
EP1653985A4 (de) 2003-07-17 2009-08-05 Gen Hospital Corp Zwangsform-parathormon (pth)-analoga
MXPA06001428A (es) * 2003-08-06 2006-05-15 Rhodia Metodo para promover el crecimiento del hueso.
US7465703B1 (en) 2003-10-01 2008-12-16 Scantibodies Laboratory, Inc. Methods and kits useful for guiding osteoporosis related therapy
US7541140B2 (en) * 2004-06-03 2009-06-02 Scantibodies Laboratory, Inc. Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
EP1945245A2 (de) * 2005-11-10 2008-07-23 The Board of Control of Michigan Technological University Schwarzbär-parathyroid-hormon und verfahren zur verwendung des schwarzbär-parathyroid-hormons
EP2054077A4 (de) * 2006-08-04 2010-10-13 Gen Hospital Corp Polypeptidderivate des parathyroidhormons (pth)
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US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
SI2084183T1 (sl) 2006-10-13 2010-09-30 Lilly Co Eli Pegilirani pth kot modulatorji pth receptorja in njihove uporabe
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
KR101661730B1 (ko) 2007-08-01 2016-10-04 더 제너럴 하스피탈 코포레이션 Ｇ―단백질 결합 수용체를 이용한 스크리닝 방법 및 관련 조성물
EP2411038B1 (de) 2009-03-27 2016-12-28 Van Andel Research Institute Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür
US8987201B2 (en) 2009-12-07 2015-03-24 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
HUE030072T2 (en) 2010-05-12 2017-04-28 Radius Health Inc Therapeutic prescriptions
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Also Published As

Publication number Publication date
KR100500853B1 (ko) 2005-10-24
EP1405861A2 (de) 2004-04-07
AU6483496A (en) 1997-02-10
DE69638025D1 (de) 2009-10-22
IL122837A (en) 2002-11-10
CN100412091C (zh) 2008-08-20
HK1096976A1 (en) 2007-06-15
JP2003238595A (ja) 2003-08-27
SK3198A3 (en) 1998-07-08
ES2207680T3 (es) 2004-06-01
EP1405861A3 (de) 2004-07-21
DE69630133D1 (de) 2003-10-30
KR20040041709A (ko) 2004-05-17
KR20040053215A (ko) 2004-06-23
IL122837A0 (en) 1998-08-16
PT1405861E (pt) 2009-09-30
CN101851288A (zh) 2010-10-06
CN1199340A (zh) 1998-11-18
KR100563601B1 (ko) 2006-03-22
KR100563602B1 (ko) 2006-03-22
PL325905A1 (en) 1998-08-17
EP0847278B1 (de) 2003-09-24
HUP9901718A3 (en) 2000-10-30
ES2329233T3 (es) 2009-11-24
WO1997002834A1 (en) 1997-01-30
DK0847278T3 (da) 2003-12-22
PT847278E (pt) 2004-02-27
TW482766B (en) 2002-04-11
HK1014876A1 (en) 1999-10-08
PL186710B1 (pl) 2004-02-27
KR19990028947A (ko) 1999-04-15
EP0847278A1 (de) 1998-06-17
JP2007302682A (ja) 2007-11-22
JP4008825B2 (ja) 2007-11-14
EP0847278A4 (de) 1999-01-13
EP1405861B1 (de) 2009-09-09
CN1247260C (zh) 2006-03-29
NZ312899A (en) 1999-10-28
DK1405861T3 (da) 2009-12-07
MX9800418A (es) 1998-09-30
ATE442159T1 (de) 2009-09-15
KR20040053216A (ko) 2004-06-23
HU226935B1 (en) 2010-03-29
CN1521189A (zh) 2004-08-18
AU707094B2 (en) 1999-07-01
KR100563600B1 (ko) 2006-03-22
KR100563112B1 (ko) 2006-03-27
JPH11509201A (ja) 1999-08-17
DE69630133T2 (de) 2004-06-09
US5723577A (en) 1998-03-03
HUP9901718A2 (hu) 1999-09-28
KR20040042907A (ko) 2004-05-20

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