ES2058290T3 - Analogos de somatostatina terapeuticos. - Google Patents

Analogos de somatostatina terapeuticos.

Info

Publication number
ES2058290T3
ES2058290T3 ES88306188T ES88306188T ES2058290T3 ES 2058290 T3 ES2058290 T3 ES 2058290T3 ES 88306188 T ES88306188 T ES 88306188T ES 88306188 T ES88306188 T ES 88306188T ES 2058290 T3 ES2058290 T3 ES 2058290T3
Authority
ES
Spain
Prior art keywords
somatostatina
analogs
therapeutic
image
octapeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88306188T
Other languages
English (en)
Inventor
David H Coy
William A Murphy
Mark L Heiman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Application granted granted Critical
Publication of ES2058290T3 publication Critical patent/ES2058290T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

SE DESCRIBEN PEPTIDOS QUE TIENEN LA SECUENCIA -CYS - X - D - TRP - LYS VAL - CYS-, DONDE X REPRESENTA CUALQUIER RESTO AMINOACIDO, EN PARICULAR OCTAPEPTIDOS DE FORMULAS D - (BETA) - NAL - CYS - TYR - D - TRP - LYS - VAL CYS - (BETA) - NAL - NH2; D - PHE - CYS - TYR - D - TRP - LYS - VAL - CYS - (BETA) NAL - NH2; Y D - PHE - CYS - (BETA) - NAL - D - TRP - LYS - VAL - CYS - THR NH2, QUE SON ANALOGOS A SOMATOSTATINA (UN FACTOR DE LIBERACION DE LA HORMONA DEL CRECIMIENTO.
ES88306188T 1987-07-07 1988-07-07 Analogos de somatostatina terapeuticos. Expired - Lifetime ES2058290T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7040087A 1987-07-07 1987-07-07

Publications (1)

Publication Number Publication Date
ES2058290T3 true ES2058290T3 (es) 1994-11-01

Family

ID=22095075

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88306188T Expired - Lifetime ES2058290T3 (es) 1987-07-07 1988-07-07 Analogos de somatostatina terapeuticos.

Country Status (6)

Country Link
EP (1) EP0298732B1 (es)
JP (1) JP2809403B2 (es)
AT (1) ATE93866T1 (es)
CA (1) CA1338302C (es)
DE (1) DE3883649T2 (es)
ES (1) ES2058290T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0173119B1 (ko) * 1989-04-26 1999-02-01 닐 에이. 밴스로우 선형 소마토스타틴 유사체
DK0457888T3 (da) * 1989-12-08 1996-08-12 Univ Tulane Octapeptidanaloger af somatostatin med threonin i 6-stillingen
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US5462926A (en) * 1992-07-27 1995-10-31 Biomeasure, Inc. Neuromedin B receptor antagonists which demonstrate selectivity
ATE206307T1 (de) * 1992-07-27 2001-10-15 Univ Tulane Antagonisten des neuromedin b rezeptors
US5569741A (en) * 1992-07-27 1996-10-29 Biomeasure, Inc. Cyclic octapeptide neuromedin B receptor antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4328135A (en) * 1980-06-13 1982-05-04 American Home Products Corporation Octapeptides lowering growth hormone
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
EP0222578A3 (en) * 1985-11-06 1990-04-04 Merck & Co. Inc. Use of cyclic somatostatin analogues in the treatment of immediate hypersensitivity diseases

Also Published As

Publication number Publication date
DE3883649D1 (de) 1993-10-07
EP0298732B1 (en) 1993-09-01
EP0298732A3 (en) 1990-06-06
DE3883649T2 (de) 1993-12-16
EP0298732A2 (en) 1989-01-11
ATE93866T1 (de) 1993-09-15
JPS6470500A (en) 1989-03-15
JP2809403B2 (ja) 1998-10-08
CA1338302C (en) 1996-04-30

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