DK1405861T3 - Analoger af parathyroidhormon - Google Patents
Analoger af parathyroidhormonInfo
- Publication number
- DK1405861T3 DK1405861T3 DK03077383T DK03077383T DK1405861T3 DK 1405861 T3 DK1405861 T3 DK 1405861T3 DK 03077383 T DK03077383 T DK 03077383T DK 03077383 T DK03077383 T DK 03077383T DK 1405861 T3 DK1405861 T3 DK 1405861T3
- Authority
- DK
- Denmark
- Prior art keywords
- amino acid
- parathyroid hormone
- analogues
- acid residue
- alpha
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US110595P | 1995-07-13 | 1995-07-13 | |
US330595P | 1995-09-06 | 1995-09-06 | |
US08/626,186 US5723577A (en) | 1995-07-13 | 1996-03-29 | Analogs of parathyroid hormone |
PCT/US1996/011292 WO1997002834A1 (en) | 1995-07-13 | 1996-07-03 | Analogs of parathyroid hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1405861T3 true DK1405861T3 (da) | 2009-12-07 |
Family
ID=27356825
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03077383T DK1405861T3 (da) | 1995-07-13 | 1996-07-03 | Analoger af parathyroidhormon |
DK96924355T DK0847278T3 (da) | 1995-07-13 | 1996-07-03 | Parathyroideahormon-analoger |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96924355T DK0847278T3 (da) | 1995-07-13 | 1996-07-03 | Parathyroideahormon-analoger |
Country Status (20)
Country | Link |
---|---|
US (1) | US5723577A (da) |
EP (2) | EP1405861B1 (da) |
JP (3) | JPH11509201A (da) |
KR (5) | KR100563112B1 (da) |
CN (3) | CN101851288A (da) |
AT (2) | ATE442159T1 (da) |
AU (1) | AU707094B2 (da) |
DE (2) | DE69630133T2 (da) |
DK (2) | DK1405861T3 (da) |
ES (2) | ES2207680T3 (da) |
HK (2) | HK1014876A1 (da) |
HU (1) | HU226935B1 (da) |
IL (1) | IL122837A (da) |
MX (1) | MX9800418A (da) |
NZ (1) | NZ312899A (da) |
PL (1) | PL186710B1 (da) |
PT (2) | PT847278E (da) |
SK (1) | SK3198A3 (da) |
TW (1) | TW482766B (da) |
WO (1) | WO1997002834A1 (da) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5955425A (en) * | 1996-08-02 | 1999-09-21 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
US6110892A (en) | 1994-06-20 | 2000-08-29 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
US5969095A (en) * | 1995-07-13 | 1999-10-19 | Biomeasure, Inc. | Analogs of parathyroid hormone |
US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
US6544949B1 (en) | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
US7410948B2 (en) * | 1995-07-13 | 2008-08-12 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Analogs of parathyroid hormone |
HUP0003349A3 (en) * | 1997-05-14 | 2001-12-28 | Aventis Pharmaceuticals Inc Co | Peptide parathyroid hormone analogs, pharmaceutical compositions comprising thereof and their use |
RS49707B (sr) * | 1997-09-09 | 2007-12-31 | F.Hoffmann-La Roche Ag., | Primena polipeptidnog analoga peptida srodnog paratireoidnom hormonu i njegovih soli za proizvodnju medikamenata za lečenje preloma kostiju |
WO1999057139A2 (en) * | 1998-05-05 | 1999-11-11 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Pth2 receptor selective compounds |
ATE449789T1 (de) * | 1998-07-20 | 2009-12-15 | Ipsen Pharma | Pacap-peptidanaloga |
JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン(PTH)および副甲状腺ホルモン関連ペプチド(PTHrP)の生物活性ペプチドおよびペプチド誘導体 |
WO2000040698A1 (en) | 1998-12-31 | 2000-07-13 | The General Hospital Corporation | Pth receptor and screening assay utilizing the same |
US6689566B1 (en) * | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
US7820393B2 (en) * | 1999-01-14 | 2010-10-26 | Scantibodies Laboratory, Inc. | Methods, kits and antibodies for detecting parathyroid hormone |
US7893021B2 (en) * | 1999-06-02 | 2011-02-22 | Scantibodies Laboratory, Inc. | Parathyroid hormone antagonists and uses thereof |
US20080108086A1 (en) * | 1999-06-02 | 2008-05-08 | Cantor Thomas L | Parathyroid hormone antagonists and uses thereof |
JP4723144B2 (ja) | 1999-09-29 | 2011-07-13 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン(pth)のポリペプチド誘導体 |
US7022815B1 (en) | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
AU7734800A (en) * | 1999-09-29 | 2001-04-30 | General Hospital Corporation, The | Polypeptide derivatives of parathyroid hormone (pth) |
US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
NZ529439A (en) | 2001-06-01 | 2005-11-25 | Novartis Ag | Method for orally administering parathyroid hormone (PTH) |
KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
WO2003009804A2 (en) * | 2001-07-23 | 2003-02-06 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
US20040067526A1 (en) * | 2002-10-03 | 2004-04-08 | Cantor Thomas L. | Methods for diagnosing and guiding treatment of bone turnover disease |
JP4334480B2 (ja) * | 2003-03-19 | 2009-09-30 | ザ ジェネラル ホスピタル コーポレイション | α−ヘリックス安定化剤を用いる高次構造的に制約された副甲状腺ホルモン |
KR100540659B1 (ko) * | 2003-07-02 | 2006-01-10 | 삼성전자주식회사 | 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체 |
WO2005009358A2 (en) | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
US20050037089A1 (en) * | 2003-08-06 | 2005-02-17 | Jobbins Jill Marie | Method for promoting bone growth |
US7465703B1 (en) | 2003-10-01 | 2008-12-16 | Scantibodies Laboratory, Inc. | Methods and kits useful for guiding osteoporosis related therapy |
US7541140B2 (en) * | 2004-06-03 | 2009-06-02 | Scantibodies Laboratory, Inc. | Assessing risk for kidney stones using parathyroid hormone agonist and antagonist |
CA2628945A1 (en) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
US8143374B2 (en) * | 2006-08-04 | 2012-03-27 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
KR20150020289A (ko) * | 2006-10-03 | 2015-02-25 | 라디우스 헬쓰, 인코포레이티드 | 골 아나볼릭 단백질을 위한 약물 전달 방법 |
USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
DK2084183T3 (da) | 2006-10-13 | 2010-08-16 | Lilly Co Eli | Pegyleret PTH som PTH-receptormodulatorer og anvendelser deraf |
EP1961765A1 (en) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Truncated PTH peptides with a cyclic conformation |
MX353986B (es) * | 2007-08-01 | 2017-11-06 | Massachusetts Gen Hospital | Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas. |
EP2411038B1 (en) | 2009-03-27 | 2016-12-28 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
WO2011071480A1 (en) | 2009-12-07 | 2011-06-16 | Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
PT2568806T (pt) | 2010-05-12 | 2016-08-05 | Radius Health Inc | Regimes terapêuticos |
EP2569003B1 (en) | 2010-05-13 | 2017-10-25 | The General Hospital Corporation | Parathyroid hormone analogs and uses thereof |
JP5965909B2 (ja) | 2010-09-28 | 2016-08-10 | ラジウス ヘルス,インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
WO2012111852A1 (ja) * | 2011-02-17 | 2012-08-23 | 帝人ファーマ株式会社 | 椎体骨折治療剤及びその評価方法 |
IL255148B2 (en) | 2015-04-29 | 2023-04-01 | Radius Pharmaceuticals Inc | 1901 rad for use in a method to inhibit a cancerous growth or induce tumor regression in a patient who is resistant to the drug and/or has cancer positive for an estrogen receptor alpha mutation |
ES2913470T3 (es) | 2016-06-22 | 2022-06-02 | Ellipses Pharma Ltd | Métodos de tratamiento de cáncer de mama AR+ |
KR102322802B1 (ko) | 2017-01-05 | 2021-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
EP3765488A1 (en) | 2018-03-12 | 2021-01-20 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of pthrp analogue |
AU2019297421A1 (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals, Inc. | Polymorphic forms of RAD 1901-2HCL |
WO2023223296A1 (en) * | 2022-05-20 | 2023-11-23 | Radius Health, Inc. | Process of making abaloparatide |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
EP0293158A3 (en) * | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroid hormone antagonists |
JPH03504201A (ja) * | 1989-02-23 | 1991-09-19 | ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング (ゲー・ベー・エフ) | Pth変種をコードするdna配列、pth変種、発現ベクター、細菌宿主、利用と治療用組成物 |
CA2040264A1 (en) * | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
WO1993006846A1 (en) * | 1991-10-10 | 1993-04-15 | Pang Peter K T | Parathyroid hormone analogues and use in osteoporosis treatment |
US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
CA2098639A1 (en) * | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
CN1070500C (zh) * | 1993-07-13 | 2001-09-05 | 森德克斯(美国)股份有限公司 | 甲状旁腺激素类似物和甲状旁腺激素相关肽:合成和治疗骨质疏松症的用途 |
-
1996
- 1996-03-29 US US08/626,186 patent/US5723577A/en not_active Expired - Lifetime
- 1996-07-03 DK DK03077383T patent/DK1405861T3/da active
- 1996-07-03 IL IL12283796A patent/IL122837A/en not_active IP Right Cessation
- 1996-07-03 AT AT03077383T patent/ATE442159T1/de active
- 1996-07-03 JP JP9505897A patent/JPH11509201A/ja active Pending
- 1996-07-03 EP EP03077383A patent/EP1405861B1/en not_active Expired - Lifetime
- 1996-07-03 HU HU9901718A patent/HU226935B1/hu unknown
- 1996-07-03 NZ NZ312899A patent/NZ312899A/en not_active IP Right Cessation
- 1996-07-03 PL PL96325905A patent/PL186710B1/pl unknown
- 1996-07-03 KR KR1020047006341A patent/KR100563112B1/ko not_active IP Right Cessation
- 1996-07-03 DE DE69630133T patent/DE69630133T2/de not_active Expired - Lifetime
- 1996-07-03 CN CN201010150544A patent/CN101851288A/zh active Pending
- 1996-07-03 AT AT96924355T patent/ATE250425T1/de active
- 1996-07-03 PT PT96924355T patent/PT847278E/pt unknown
- 1996-07-03 DK DK96924355T patent/DK0847278T3/da active
- 1996-07-03 ES ES96924355T patent/ES2207680T3/es not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006340A patent/KR100563602B1/ko not_active IP Right Cessation
- 1996-07-03 ES ES03077383T patent/ES2329233T3/es not_active Expired - Lifetime
- 1996-07-03 SK SK31-98A patent/SK3198A3/sk unknown
- 1996-07-03 WO PCT/US1996/011292 patent/WO1997002834A1/en active IP Right Grant
- 1996-07-03 DE DE69638025T patent/DE69638025D1/de not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006338A patent/KR100563600B1/ko not_active IP Right Cessation
- 1996-07-03 KR KR10-1998-0700249A patent/KR100500853B1/ko not_active IP Right Cessation
- 1996-07-03 KR KR1020047006339A patent/KR100563601B1/ko not_active IP Right Cessation
- 1996-07-03 PT PT03077383T patent/PT1405861E/pt unknown
- 1996-07-03 CN CNB2004100054277A patent/CN100412091C/zh not_active Expired - Fee Related
- 1996-07-03 CN CNB961969261A patent/CN1247260C/zh not_active Expired - Fee Related
- 1996-07-03 AU AU64834/96A patent/AU707094B2/en not_active Expired
- 1996-07-03 EP EP96924355A patent/EP0847278B1/en not_active Expired - Lifetime
- 1996-07-11 TW TW085108390A patent/TW482766B/zh not_active IP Right Cessation
-
1998
- 1998-01-13 MX MX9800418A patent/MX9800418A/es active IP Right Grant
-
1999
- 1999-01-13 HK HK99100132A patent/HK1014876A1/xx not_active IP Right Cessation
-
2003
- 2003-01-16 JP JP2003008027A patent/JP4008825B2/ja not_active Expired - Fee Related
-
2007
- 2007-04-16 HK HK07103960.3A patent/HK1096976A1/xx not_active IP Right Cessation
- 2007-07-02 JP JP2007174291A patent/JP2007302682A/ja active Pending
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