HK1014876A1 - Analogs of parathyroid hormone - Google Patents
Analogs of parathyroid hormoneInfo
- Publication number
- HK1014876A1 HK1014876A1 HK99100132A HK99100132A HK1014876A1 HK 1014876 A1 HK1014876 A1 HK 1014876A1 HK 99100132 A HK99100132 A HK 99100132A HK 99100132 A HK99100132 A HK 99100132A HK 1014876 A1 HK1014876 A1 HK 1014876A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- amino acid
- parathyroid hormone
- analogs
- acid residue
- alpha
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US110595P | 1995-07-13 | 1995-07-13 | |
US330595P | 1995-09-06 | 1995-09-06 | |
US08/626,186 US5723577A (en) | 1995-07-13 | 1996-03-29 | Analogs of parathyroid hormone |
PCT/US1996/011292 WO1997002834A1 (en) | 1995-07-13 | 1996-07-03 | Analogs of parathyroid hormone |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1014876A1 true HK1014876A1 (en) | 1999-10-08 |
Family
ID=27356825
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK99100132A HK1014876A1 (en) | 1995-07-13 | 1999-01-13 | Analogs of parathyroid hormone |
HK07103960.3A HK1096976A1 (en) | 1995-07-13 | 2007-04-16 | Analogs of parathyroid hormone |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07103960.3A HK1096976A1 (en) | 1995-07-13 | 2007-04-16 | Analogs of parathyroid hormone |
Country Status (20)
Country | Link |
---|---|
US (1) | US5723577A (de) |
EP (2) | EP1405861B1 (de) |
JP (3) | JPH11509201A (de) |
KR (5) | KR100563602B1 (de) |
CN (3) | CN101851288A (de) |
AT (2) | ATE250425T1 (de) |
AU (1) | AU707094B2 (de) |
DE (2) | DE69638025D1 (de) |
DK (2) | DK0847278T3 (de) |
ES (2) | ES2329233T3 (de) |
HK (2) | HK1014876A1 (de) |
HU (1) | HU226935B1 (de) |
IL (1) | IL122837A (de) |
MX (1) | MX9800418A (de) |
NZ (1) | NZ312899A (de) |
PL (1) | PL186710B1 (de) |
PT (2) | PT1405861E (de) |
SK (1) | SK3198A3 (de) |
TW (1) | TW482766B (de) |
WO (1) | WO1997002834A1 (de) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5955425A (en) * | 1996-08-02 | 1999-09-21 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
US6110892A (en) * | 1994-06-20 | 2000-08-29 | National Research Council Of Canada | Parathyroid hormone analogues for the treatment of osteoporosis |
US6544949B1 (en) * | 1995-07-13 | 2003-04-08 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Analogs of parathyroid hormone |
US5969095A (en) * | 1995-07-13 | 1999-10-19 | Biomeasure, Inc. | Analogs of parathyroid hormone |
US5955574A (en) * | 1995-07-13 | 1999-09-21 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. | Analogs of parathyroid hormone |
US7410948B2 (en) * | 1995-07-13 | 2008-08-12 | Societe De Conseils De Recherches Et D'applications Scientifiques, Sas | Analogs of parathyroid hormone |
UA62967C2 (en) * | 1997-05-14 | 2004-01-15 | Aventis Pharm Prod Inc | Peptide analogs of parathyroid hormons |
EP1005359B1 (de) * | 1997-09-09 | 2005-06-15 | F. Hoffmann-La Roche Ag | HEILUNG VON BRUCHVERLETZUNGEN UNTER VERWENDUNG VON PTHrP ANALOGEN |
CA2327509A1 (en) * | 1998-05-05 | 1999-11-11 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Pth2 receptor selective compounds |
WO2000005260A1 (en) * | 1998-07-20 | 2000-02-03 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Peptide analogues of pacap |
JP4486256B2 (ja) * | 1998-10-22 | 2010-06-23 | ザ・ジェネラル・ホスピタル・コーポレイション | 副甲状腺ホルモン(PTH)および副甲状腺ホルモン関連ペプチド(PTHrP)の生物活性ペプチドおよびペプチド誘導体 |
ES2251793T3 (es) | 1998-12-31 | 2006-05-01 | The General Hospital Corporation | Receptor pth y ensayo de seleccion utilizando el mismo. |
US6689566B1 (en) | 1999-01-14 | 2004-02-10 | Scantibodies Laboratory, Inc. | Methods, kits, and antibodies for detecting parathyroid hormone |
US7820393B2 (en) * | 1999-01-14 | 2010-10-26 | Scantibodies Laboratory, Inc. | Methods, kits and antibodies for detecting parathyroid hormone |
WO2004028444A2 (en) * | 1999-06-02 | 2004-04-08 | Scantibodies Laboratory, Inc. | Parathyroid hormone antagonists and uses thereof |
US20080108086A1 (en) * | 1999-06-02 | 2008-05-08 | Cantor Thomas L | Parathyroid hormone antagonists and uses thereof |
ES2316354T3 (es) * | 1999-09-29 | 2009-04-16 | The General Hospital Corporation | Derivados polipeptidos de la hormona paratiroidea (pth). |
AU7734800A (en) * | 1999-09-29 | 2001-04-30 | General Hospital Corporation, The | Polypeptide derivatives of parathyroid hormone (pth) |
US7022815B1 (en) | 1999-09-29 | 2006-04-04 | The General Hospital Corporation | Polypeptide derivatives of parathyroid hormone (PTH) |
US20050124537A1 (en) * | 2000-04-27 | 2005-06-09 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
US6756480B2 (en) * | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
SK287697B6 (sk) | 2001-06-01 | 2011-06-06 | Novartis Ag | Orálne podanie paratyroidného hormónu a kalcitonínu |
KR100491737B1 (ko) * | 2001-07-20 | 2005-05-27 | 주식회사 한국아이템개발 | 공기 정화 기능의 모기 퇴치기 |
CA2454275C (en) * | 2001-07-23 | 2012-10-23 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
US20040067526A1 (en) * | 2002-10-03 | 2004-04-08 | Cantor Thomas L. | Methods for diagnosing and guiding treatment of bone turnover disease |
US7795220B2 (en) * | 2003-03-19 | 2010-09-14 | The General Hospital Corporation | Conformationally constrained parathyroid hormones with alpha-helix stabilizers |
KR100540659B1 (ko) * | 2003-07-02 | 2006-01-10 | 삼성전자주식회사 | 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체 |
WO2005009358A2 (en) | 2003-07-17 | 2005-02-03 | The General Hospital Corporation | Conformationally constrained parathyroid hormone (pth) analogs |
EP1651246A4 (de) * | 2003-08-06 | 2009-06-24 | Innophos Inc | Verfahren zur förderung des knochenwachstums |
US7465703B1 (en) | 2003-10-01 | 2008-12-16 | Scantibodies Laboratory, Inc. | Methods and kits useful for guiding osteoporosis related therapy |
US7541140B2 (en) * | 2004-06-03 | 2009-06-02 | Scantibodies Laboratory, Inc. | Assessing risk for kidney stones using parathyroid hormone agonist and antagonist |
CA2628945A1 (en) * | 2005-11-10 | 2007-05-24 | Board Of Control Of Michigan Technological University | Black bear parathyroid hormone and methods of using black bear parathyroid hormone |
JP2009545320A (ja) * | 2006-08-04 | 2009-12-24 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン(pth)のポリペプチド誘導体 |
USRE49444E1 (en) | 2006-10-03 | 2023-03-07 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
US7803770B2 (en) * | 2006-10-03 | 2010-09-28 | Radius Health, Inc. | Method of treating osteoporosis comprising administration of PTHrP analog |
CA2664734C (en) * | 2006-10-03 | 2023-08-01 | Radius Health, Inc. | Method of drug delivery for bone anabolic protein |
AU2007313001B2 (en) | 2006-10-13 | 2012-03-22 | Eli Lilly And Company | Pegylated PTH as PTH receptor modulators and uses thereof |
EP1961765A1 (de) * | 2006-12-08 | 2008-08-27 | Zealand Pharma A/S | Verkürzte PTH-Peptide mit zyklischer Konformation |
JP5711966B2 (ja) | 2007-08-01 | 2015-05-07 | ザ ジェネラル ホスピタル コーポレイション | Gタンパク質共役受容体および関連組成物を使用するスクリーニング方法 |
EP2411038B1 (de) | 2009-03-27 | 2016-12-28 | Van Andel Research Institute | Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür |
EP2509996A1 (de) | 2009-12-07 | 2012-10-17 | Michigan Technological University | Schwarzbär-parathyroid-hormon und verfahren zur verwendung des schwarzbär-parathyroid-hormons |
ME02474B (de) | 2010-05-12 | 2017-02-20 | Radius Health Inc | Therapiepläne |
JP5941040B2 (ja) | 2010-05-13 | 2016-06-29 | ザ ジェネラル ホスピタル コーポレイション | 副甲状腺ホルモン類似体およびその使用 |
BR112013007685B1 (pt) | 2010-09-28 | 2021-11-09 | Radius Pharmaceuticals, Inc | Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto |
WO2012111852A1 (ja) * | 2011-02-17 | 2012-08-23 | 帝人ファーマ株式会社 | 椎体骨折治療剤及びその評価方法 |
CN113750091A (zh) | 2015-04-29 | 2021-12-07 | 雷迪厄斯制药公司 | 用于治疗癌症的方法 |
PT3474841T (pt) | 2016-06-22 | 2022-06-20 | Radius Health Inc | Métodos de tratamento do cancro de mama ar+ |
KR20230109795A (ko) | 2017-01-05 | 2023-07-20 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
WO2019175173A1 (en) | 2018-03-12 | 2019-09-19 | Fresenius Kabi Ipsum S.R.L. | Process for the manufacture of pthrp analogue |
KR20210030393A (ko) | 2018-07-04 | 2021-03-17 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
WO2023223296A1 (en) * | 2022-05-20 | 2023-11-23 | Radius Health, Inc. | Process of making abaloparatide |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2550204B1 (fr) * | 1983-08-05 | 1987-11-13 | Toyo Jozo Kk | Derives peptidiques de (nle8,nle1b, tyr34)-h-pth |
EP0293158A3 (de) * | 1987-05-26 | 1990-05-09 | Merck & Co. Inc. | Parathyroide Hormon-Antagonisten |
JPH03504201A (ja) * | 1989-02-23 | 1991-09-19 | ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング (ゲー・ベー・エフ) | Pth変種をコードするdna配列、pth変種、発現ベクター、細菌宿主、利用と治療用組成物 |
CA2040264A1 (en) * | 1990-04-12 | 1991-10-13 | Tatsuhiko Kanmera | Parathyroid hormone antagonists |
WO1993006846A1 (en) * | 1991-10-10 | 1993-04-15 | Pang Peter K T | Parathyroid hormone analogues and use in osteoporosis treatment |
US5434246A (en) * | 1992-03-19 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Parathyroid hormone derivatives |
CA2098639A1 (en) * | 1992-06-19 | 1993-12-20 | K. Anne Kronis | Bone stimulating, non-vasoactive parathyroid hormone variants |
US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
AU672790B2 (en) * | 1992-07-15 | 1996-10-17 | Novartis Ag | Variants of parathyroid hormone and its fragments |
WO1995002610A1 (en) * | 1993-07-13 | 1995-01-26 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
-
1996
- 1996-03-29 US US08/626,186 patent/US5723577A/en not_active Expired - Lifetime
- 1996-07-03 PT PT03077383T patent/PT1405861E/pt unknown
- 1996-07-03 DE DE69638025T patent/DE69638025D1/de not_active Expired - Lifetime
- 1996-07-03 CN CN201010150544A patent/CN101851288A/zh active Pending
- 1996-07-03 KR KR1020047006340A patent/KR100563602B1/ko not_active IP Right Cessation
- 1996-07-03 AT AT96924355T patent/ATE250425T1/de active
- 1996-07-03 JP JP9505897A patent/JPH11509201A/ja active Pending
- 1996-07-03 PL PL96325905A patent/PL186710B1/pl unknown
- 1996-07-03 ES ES03077383T patent/ES2329233T3/es not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006339A patent/KR100563601B1/ko not_active IP Right Cessation
- 1996-07-03 AT AT03077383T patent/ATE442159T1/de active
- 1996-07-03 CN CNB961969261A patent/CN1247260C/zh not_active Expired - Fee Related
- 1996-07-03 DK DK96924355T patent/DK0847278T3/da active
- 1996-07-03 EP EP03077383A patent/EP1405861B1/de not_active Expired - Lifetime
- 1996-07-03 NZ NZ312899A patent/NZ312899A/en not_active IP Right Cessation
- 1996-07-03 CN CNB2004100054277A patent/CN100412091C/zh not_active Expired - Fee Related
- 1996-07-03 AU AU64834/96A patent/AU707094B2/en not_active Expired
- 1996-07-03 KR KR10-1998-0700249A patent/KR100500853B1/ko not_active IP Right Cessation
- 1996-07-03 EP EP96924355A patent/EP0847278B1/de not_active Expired - Lifetime
- 1996-07-03 IL IL12283796A patent/IL122837A/en not_active IP Right Cessation
- 1996-07-03 ES ES96924355T patent/ES2207680T3/es not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006341A patent/KR100563112B1/ko not_active IP Right Cessation
- 1996-07-03 DE DE69630133T patent/DE69630133T2/de not_active Expired - Lifetime
- 1996-07-03 KR KR1020047006338A patent/KR100563600B1/ko not_active IP Right Cessation
- 1996-07-03 SK SK31-98A patent/SK3198A3/sk unknown
- 1996-07-03 HU HU9901718A patent/HU226935B1/hu unknown
- 1996-07-03 PT PT96924355T patent/PT847278E/pt unknown
- 1996-07-03 DK DK03077383T patent/DK1405861T3/da active
- 1996-07-03 WO PCT/US1996/011292 patent/WO1997002834A1/en active IP Right Grant
- 1996-07-11 TW TW085108390A patent/TW482766B/zh not_active IP Right Cessation
-
1998
- 1998-01-13 MX MX9800418A patent/MX9800418A/es active IP Right Grant
-
1999
- 1999-01-13 HK HK99100132A patent/HK1014876A1/xx not_active IP Right Cessation
-
2003
- 2003-01-16 JP JP2003008027A patent/JP4008825B2/ja not_active Expired - Fee Related
-
2007
- 2007-04-16 HK HK07103960.3A patent/HK1096976A1/xx not_active IP Right Cessation
- 2007-07-02 JP JP2007174291A patent/JP2007302682A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130703 |