HK1014876A1 - Analogs of parathyroid hormone - Google Patents

Analogs of parathyroid hormone

Info

Publication number
HK1014876A1
HK1014876A1 HK99100132A HK99100132A HK1014876A1 HK 1014876 A1 HK1014876 A1 HK 1014876A1 HK 99100132 A HK99100132 A HK 99100132A HK 99100132 A HK99100132 A HK 99100132A HK 1014876 A1 HK1014876 A1 HK 1014876A1
Authority
HK
Hong Kong
Prior art keywords
amino acid
parathyroid hormone
analogs
acid residue
alpha
Prior art date
Application number
HK99100132A
Other languages
English (en)
Inventor
Zheng Xin Dong
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of HK1014876A1 publication Critical patent/HK1014876A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
HK99100132A 1995-07-13 1999-01-13 Analogs of parathyroid hormone HK1014876A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US110595P 1995-07-13 1995-07-13
US330595P 1995-09-06 1995-09-06
US08/626,186 US5723577A (en) 1995-07-13 1996-03-29 Analogs of parathyroid hormone
PCT/US1996/011292 WO1997002834A1 (en) 1995-07-13 1996-07-03 Analogs of parathyroid hormone

Publications (1)

Publication Number Publication Date
HK1014876A1 true HK1014876A1 (en) 1999-10-08

Family

ID=27356825

Family Applications (2)

Application Number Title Priority Date Filing Date
HK99100132A HK1014876A1 (en) 1995-07-13 1999-01-13 Analogs of parathyroid hormone
HK07103960.3A HK1096976A1 (en) 1995-07-13 2007-04-16 Analogs of parathyroid hormone

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK07103960.3A HK1096976A1 (en) 1995-07-13 2007-04-16 Analogs of parathyroid hormone

Country Status (20)

Country Link
US (1) US5723577A (de)
EP (2) EP1405861B1 (de)
JP (3) JPH11509201A (de)
KR (5) KR100563602B1 (de)
CN (3) CN101851288A (de)
AT (2) ATE250425T1 (de)
AU (1) AU707094B2 (de)
DE (2) DE69638025D1 (de)
DK (2) DK0847278T3 (de)
ES (2) ES2329233T3 (de)
HK (2) HK1014876A1 (de)
HU (1) HU226935B1 (de)
IL (1) IL122837A (de)
MX (1) MX9800418A (de)
NZ (1) NZ312899A (de)
PL (1) PL186710B1 (de)
PT (2) PT1405861E (de)
SK (1) SK3198A3 (de)
TW (1) TW482766B (de)
WO (1) WO1997002834A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955425A (en) * 1996-08-02 1999-09-21 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6110892A (en) * 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6544949B1 (en) * 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
UA62967C2 (en) * 1997-05-14 2004-01-15 Aventis Pharm Prod Inc Peptide analogs of parathyroid hormons
EP1005359B1 (de) * 1997-09-09 2005-06-15 F. Hoffmann-La Roche Ag HEILUNG VON BRUCHVERLETZUNGEN UNTER VERWENDUNG VON PTHrP ANALOGEN
CA2327509A1 (en) * 1998-05-05 1999-11-11 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Pth2 receptor selective compounds
WO2000005260A1 (en) * 1998-07-20 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Peptide analogues of pacap
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン(PTH)および副甲状腺ホルモン関連ペプチド(PTHrP)の生物活性ペプチドおよびペプチド誘導体
ES2251793T3 (es) 1998-12-31 2006-05-01 The General Hospital Corporation Receptor pth y ensayo de seleccion utilizando el mismo.
US6689566B1 (en) 1999-01-14 2004-02-10 Scantibodies Laboratory, Inc. Methods, kits, and antibodies for detecting parathyroid hormone
US7820393B2 (en) * 1999-01-14 2010-10-26 Scantibodies Laboratory, Inc. Methods, kits and antibodies for detecting parathyroid hormone
WO2004028444A2 (en) * 1999-06-02 2004-04-08 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
ES2316354T3 (es) * 1999-09-29 2009-04-16 The General Hospital Corporation Derivados polipeptidos de la hormona paratiroidea (pth).
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
SK287697B6 (sk) 2001-06-01 2011-06-06 Novartis Ag Orálne podanie paratyroidného hormónu a kalcitonínu
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
CA2454275C (en) * 2001-07-23 2012-10-23 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US20040067526A1 (en) * 2002-10-03 2004-04-08 Cantor Thomas L. Methods for diagnosing and guiding treatment of bone turnover disease
US7795220B2 (en) * 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
KR100540659B1 (ko) * 2003-07-02 2006-01-10 삼성전자주식회사 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
EP1651246A4 (de) * 2003-08-06 2009-06-24 Innophos Inc Verfahren zur förderung des knochenwachstums
US7465703B1 (en) 2003-10-01 2008-12-16 Scantibodies Laboratory, Inc. Methods and kits useful for guiding osteoporosis related therapy
US7541140B2 (en) * 2004-06-03 2009-06-02 Scantibodies Laboratory, Inc. Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
CA2628945A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
JP2009545320A (ja) * 2006-08-04 2009-12-24 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン(pth)のポリペプチド誘導体
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
CA2664734C (en) * 2006-10-03 2023-08-01 Radius Health, Inc. Method of drug delivery for bone anabolic protein
AU2007313001B2 (en) 2006-10-13 2012-03-22 Eli Lilly And Company Pegylated PTH as PTH receptor modulators and uses thereof
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
JP5711966B2 (ja) 2007-08-01 2015-05-07 ザ ジェネラル ホスピタル コーポレイション Gタンパク質共役受容体および関連組成物を使用するスクリーニング方法
EP2411038B1 (de) 2009-03-27 2016-12-28 Van Andel Research Institute Parathryoidhormonpeptide und parathyroidhormonbezogene proteinpeptide sowie anwendungsverfahren dafür
EP2509996A1 (de) 2009-12-07 2012-10-17 Michigan Technological University Schwarzbär-parathyroid-hormon und verfahren zur verwendung des schwarzbär-parathyroid-hormons
ME02474B (de) 2010-05-12 2017-02-20 Radius Health Inc Therapiepläne
JP5941040B2 (ja) 2010-05-13 2016-06-29 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン類似体およびその使用
BR112013007685B1 (pt) 2010-09-28 2021-11-09 Radius Pharmaceuticals, Inc Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto
WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
CN113750091A (zh) 2015-04-29 2021-12-07 雷迪厄斯制药公司 用于治疗癌症的方法
PT3474841T (pt) 2016-06-22 2022-06-20 Radius Health Inc Métodos de tratamento do cancro de mama ar+
KR20230109795A (ko) 2017-01-05 2023-07-20 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
WO2019175173A1 (en) 2018-03-12 2019-09-19 Fresenius Kabi Ipsum S.R.L. Process for the manufacture of pthrp analogue
KR20210030393A (ko) 2018-07-04 2021-03-17 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
WO2023223296A1 (en) * 2022-05-20 2023-11-23 Radius Health, Inc. Process of making abaloparatide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (de) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroide Hormon-Antagonisten
JPH03504201A (ja) * 1989-02-23 1991-09-19 ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング (ゲー・ベー・エフ) Pth変種をコードするdna配列、pth変種、発現ベクター、細菌宿主、利用と治療用組成物
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
WO1993006846A1 (en) * 1991-10-10 1993-04-15 Pang Peter K T Parathyroid hormone analogues and use in osteoporosis treatment
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
CA2098639A1 (en) * 1992-06-19 1993-12-20 K. Anne Kronis Bone stimulating, non-vasoactive parathyroid hormone variants
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis

Also Published As

Publication number Publication date
KR20040041709A (ko) 2004-05-17
PT847278E (pt) 2004-02-27
KR100563112B1 (ko) 2006-03-27
DK1405861T3 (da) 2009-12-07
CN101851288A (zh) 2010-10-06
EP1405861A2 (de) 2004-04-07
ATE442159T1 (de) 2009-09-15
IL122837A (en) 2002-11-10
PL325905A1 (en) 1998-08-17
DE69630133D1 (de) 2003-10-30
TW482766B (en) 2002-04-11
AU6483496A (en) 1997-02-10
WO1997002834A1 (en) 1997-01-30
EP1405861A3 (de) 2004-07-21
KR100500853B1 (ko) 2005-10-24
EP1405861B1 (de) 2009-09-09
EP0847278A4 (de) 1999-01-13
KR100563601B1 (ko) 2006-03-22
HK1096976A1 (en) 2007-06-15
JP2007302682A (ja) 2007-11-22
KR100563600B1 (ko) 2006-03-22
NZ312899A (en) 1999-10-28
JP2003238595A (ja) 2003-08-27
SK3198A3 (en) 1998-07-08
AU707094B2 (en) 1999-07-01
KR100563602B1 (ko) 2006-03-22
EP0847278B1 (de) 2003-09-24
CN1247260C (zh) 2006-03-29
HU226935B1 (en) 2010-03-29
IL122837A0 (en) 1998-08-16
ES2329233T3 (es) 2009-11-24
KR20040042907A (ko) 2004-05-20
EP0847278A1 (de) 1998-06-17
PL186710B1 (pl) 2004-02-27
KR20040053215A (ko) 2004-06-23
ATE250425T1 (de) 2003-10-15
MX9800418A (es) 1998-09-30
CN1521189A (zh) 2004-08-18
CN100412091C (zh) 2008-08-20
CN1199340A (zh) 1998-11-18
KR19990028947A (ko) 1999-04-15
HUP9901718A2 (hu) 1999-09-28
JPH11509201A (ja) 1999-08-17
KR20040053216A (ko) 2004-06-23
ES2207680T3 (es) 2004-06-01
DE69638025D1 (de) 2009-10-22
DK0847278T3 (da) 2003-12-22
US5723577A (en) 1998-03-03
HUP9901718A3 (en) 2000-10-30
JP4008825B2 (ja) 2007-11-14
DE69630133T2 (de) 2004-06-09
PT1405861E (pt) 2009-09-30

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Effective date: 20130703