DK1405861T3 - Analoger af parathyroidhormon - Google Patents

Analoger af parathyroidhormon

Info

Publication number
DK1405861T3
DK1405861T3 DK03077383T DK03077383T DK1405861T3 DK 1405861 T3 DK1405861 T3 DK 1405861T3 DK 03077383 T DK03077383 T DK 03077383T DK 03077383 T DK03077383 T DK 03077383T DK 1405861 T3 DK1405861 T3 DK 1405861T3
Authority
DK
Denmark
Prior art keywords
amino acid
parathyroid hormone
analogues
acid residue
alpha
Prior art date
Application number
DK03077383T
Other languages
Danish (da)
English (en)
Inventor
Zheng Xin Dong
Original Assignee
Ipsen Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas
Application granted granted Critical
Publication of DK1405861T3 publication Critical patent/DK1405861T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/29Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK03077383T 1995-07-13 1996-07-03 Analoger af parathyroidhormon DK1405861T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US110595P 1995-07-13 1995-07-13
US330595P 1995-09-06 1995-09-06
US08/626,186 US5723577A (en) 1995-07-13 1996-03-29 Analogs of parathyroid hormone
PCT/US1996/011292 WO1997002834A1 (en) 1995-07-13 1996-07-03 Analogs of parathyroid hormone

Publications (1)

Publication Number Publication Date
DK1405861T3 true DK1405861T3 (da) 2009-12-07

Family

ID=27356825

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03077383T DK1405861T3 (da) 1995-07-13 1996-07-03 Analoger af parathyroidhormon
DK96924355T DK0847278T3 (da) 1995-07-13 1996-07-03 Parathyroideahormon-analoger

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK96924355T DK0847278T3 (da) 1995-07-13 1996-07-03 Parathyroideahormon-analoger

Country Status (20)

Country Link
US (1) US5723577A (de)
EP (2) EP0847278B1 (de)
JP (3) JPH11509201A (de)
KR (5) KR100500853B1 (de)
CN (3) CN100412091C (de)
AT (2) ATE442159T1 (de)
AU (1) AU707094B2 (de)
DE (2) DE69638025D1 (de)
DK (2) DK1405861T3 (de)
ES (2) ES2207680T3 (de)
HK (2) HK1014876A1 (de)
HU (1) HU226935B1 (de)
IL (1) IL122837A (de)
MX (1) MX9800418A (de)
NZ (1) NZ312899A (de)
PL (1) PL186710B1 (de)
PT (2) PT847278E (de)
SK (1) SK3198A3 (de)
TW (1) TW482766B (de)
WO (1) WO1997002834A1 (de)

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US5955425A (en) * 1996-08-02 1999-09-21 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US6110892A (en) 1994-06-20 2000-08-29 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US5969095A (en) * 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
IL132901A0 (en) * 1997-05-14 2001-03-19 Aventis Pharm Prod Inc Peptide parathyroid hormone analogs
ZA988030B (en) 1997-09-09 1999-03-09 Hoffmann La Roche Fracture healing using pthrp analogs
PL344645A1 (en) * 1998-05-05 2001-11-19 Sod Conseils Rech Applic Pth2 receptor selective compounds
CA2335341A1 (en) * 1998-07-20 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Peptide analogues of pacap
WO2000023594A1 (en) * 1998-10-22 2000-04-27 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
DK1141237T3 (da) 1998-12-31 2006-02-13 Gen Hospital Corp PTH-receptor og screeningsassay der anvender denne
US7820393B2 (en) * 1999-01-14 2010-10-26 Scantibodies Laboratory, Inc. Methods, kits and antibodies for detecting parathyroid hormone
US6689566B1 (en) 1999-01-14 2004-02-10 Scantibodies Laboratory, Inc. Methods, kits, and antibodies for detecting parathyroid hormone
US7893021B2 (en) * 1999-06-02 2011-02-22 Scantibodies Laboratory, Inc. Parathyroid hormone antagonists and uses thereof
US20080108086A1 (en) * 1999-06-02 2008-05-08 Cantor Thomas L Parathyroid hormone antagonists and uses thereof
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
KR20040007617A (ko) 2001-06-01 2004-01-24 노파르티스 아게 부갑상선 호르몬 및 칼시토닌의 경구 투여
KR100491737B1 (ko) * 2001-07-20 2005-05-27 주식회사 한국아이템개발 공기 정화 기능의 모기 퇴치기
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US20040067526A1 (en) * 2002-10-03 2004-04-08 Cantor Thomas L. Methods for diagnosing and guiding treatment of bone turnover disease
JP4334480B2 (ja) * 2003-03-19 2009-09-30 ザ ジェネラル ホスピタル コーポレイション α−ヘリックス安定化剤を用いる高次構造的に制約された副甲状腺ホルモン
KR100540659B1 (ko) * 2003-07-02 2006-01-10 삼성전자주식회사 이미지 확대 인쇄 방법과 장치 및 컴퓨터 프로그램을저장하는 컴퓨터로 읽을 수 있는 기록 매체
WO2005009358A2 (en) 2003-07-17 2005-02-03 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
US20050037089A1 (en) * 2003-08-06 2005-02-17 Jobbins Jill Marie Method for promoting bone growth
US7465703B1 (en) 2003-10-01 2008-12-16 Scantibodies Laboratory, Inc. Methods and kits useful for guiding osteoporosis related therapy
US7541140B2 (en) * 2004-06-03 2009-06-02 Scantibodies Laboratory, Inc. Assessing risk for kidney stones using parathyroid hormone agonist and antagonist
AU2006315132A1 (en) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US8143374B2 (en) * 2006-08-04 2012-03-27 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
KR20180117738A (ko) * 2006-10-03 2018-10-29 라디우스 헬쓰, 인코포레이티드 골 아나볼릭 단백질을 위한 약물 전달 방법
ATE469173T1 (de) 2006-10-13 2010-06-15 Lilly Co Eli Pegyliertes pth als pth-rezeptormodulatoren und ihre verwendung
EP1961765A1 (de) * 2006-12-08 2008-08-27 Zealand Pharma A/S Verkürzte PTH-Peptide mit zyklischer Konformation
EP2187902B1 (de) * 2007-08-01 2013-04-17 The General Hospital Corporation Screeningverfahren mit g-protein-gekoppelten rezeptoren und entsprechende zusammensetzungen
WO2010111617A2 (en) 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US8987201B2 (en) 2009-12-07 2015-03-24 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
PL2568806T3 (pl) 2010-05-12 2017-03-31 Radius Health, Inc. Schematy lecznicze
WO2011143406A2 (en) 2010-05-13 2011-11-17 The General Hospital Corporation Parathyroid hormone analogs and uses thereof
WO2012047617A1 (en) 2010-09-28 2012-04-12 Radius Health, Inc. Selective androgen receptor modulators
WO2012111852A1 (ja) * 2011-02-17 2012-08-23 帝人ファーマ株式会社 椎体骨折治療剤及びその評価方法
WO2016176665A1 (en) 2015-04-29 2016-11-03 Radius Health, Inc. Methods of treating cancer
PL3474841T3 (pl) 2016-06-22 2022-07-11 Ellipses Pharma Ltd Sposoby leczenia nowotworu złośliwego piersi ar+
AU2018205285C9 (en) 2017-01-05 2024-05-23 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3765488A1 (de) 2018-03-12 2021-01-20 Fresenius Kabi iPSUM S.r.l. Verfahren zur herstellung von pthrp-analog
CA3104395A1 (en) 2018-07-04 2020-01-09 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
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FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (de) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroide Hormon-Antagonisten
US5457047A (en) * 1989-02-23 1995-10-10 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) DNA Sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
AU2807892A (en) * 1991-10-10 1993-05-03 Peter K.T. Pang Parathyroid hormone analogues and use in osteoporosis treatment
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
CA2098639A1 (en) * 1992-06-19 1993-12-20 K. Anne Kronis Bone stimulating, non-vasoactive parathyroid hormone variants
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
WO1995002610A1 (en) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis

Also Published As

Publication number Publication date
EP0847278A1 (de) 1998-06-17
JP4008825B2 (ja) 2007-11-14
KR20040041709A (ko) 2004-05-17
PT1405861E (pt) 2009-09-30
DE69630133D1 (de) 2003-10-30
KR100500853B1 (ko) 2005-10-24
KR100563601B1 (ko) 2006-03-22
PL325905A1 (en) 1998-08-17
CN101851288A (zh) 2010-10-06
EP0847278A4 (de) 1999-01-13
IL122837A (en) 2002-11-10
KR100563112B1 (ko) 2006-03-27
US5723577A (en) 1998-03-03
CN1521189A (zh) 2004-08-18
HUP9901718A2 (hu) 1999-09-28
PT847278E (pt) 2004-02-27
DK0847278T3 (da) 2003-12-22
KR100563602B1 (ko) 2006-03-22
KR19990028947A (ko) 1999-04-15
EP1405861A2 (de) 2004-04-07
CN1199340A (zh) 1998-11-18
CN100412091C (zh) 2008-08-20
EP0847278B1 (de) 2003-09-24
HK1096976A1 (en) 2007-06-15
PL186710B1 (pl) 2004-02-27
KR20040053216A (ko) 2004-06-23
HUP9901718A3 (en) 2000-10-30
JPH11509201A (ja) 1999-08-17
KR100563600B1 (ko) 2006-03-22
KR20040053215A (ko) 2004-06-23
MX9800418A (es) 1998-09-30
DE69638025D1 (de) 2009-10-22
NZ312899A (en) 1999-10-28
IL122837A0 (en) 1998-08-16
ATE442159T1 (de) 2009-09-15
TW482766B (en) 2002-04-11
KR20040042907A (ko) 2004-05-20
JP2007302682A (ja) 2007-11-22
ATE250425T1 (de) 2003-10-15
HU226935B1 (en) 2010-03-29
WO1997002834A1 (en) 1997-01-30
ES2207680T3 (es) 2004-06-01
AU6483496A (en) 1997-02-10
AU707094B2 (en) 1999-07-01
ES2329233T3 (es) 2009-11-24
SK3198A3 (en) 1998-07-08
JP2003238595A (ja) 2003-08-27
HK1014876A1 (en) 1999-10-08
EP1405861A3 (de) 2004-07-21
DE69630133T2 (de) 2004-06-09
EP1405861B1 (de) 2009-09-09
CN1247260C (zh) 2006-03-29

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