ATE215384T1 - Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung - Google Patents

Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung

Info

Publication number
ATE215384T1
ATE215384T1 AT96922508T AT96922508T ATE215384T1 AT E215384 T1 ATE215384 T1 AT E215384T1 AT 96922508 T AT96922508 T AT 96922508T AT 96922508 T AT96922508 T AT 96922508T AT E215384 T1 ATE215384 T1 AT E215384T1
Authority
AT
Austria
Prior art keywords
aliquot
strain
mem
cells
plaques
Prior art date
Application number
AT96922508T
Other languages
English (en)
Inventor
Han Soo Joo
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of ATE215384T1 publication Critical patent/ATE215384T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT96922508T 1995-06-21 1996-06-19 Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung ATE215384T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/493,265 US5690940A (en) 1995-06-21 1995-06-21 Low pathogencity PRRS live virus vaccines and methods of preparation thereof
PCT/US1996/010595 WO1997000696A1 (en) 1995-06-21 1996-06-19 Low pathogenicity prrs live virus vaccines and methods of preparation thereof

Publications (1)

Publication Number Publication Date
ATE215384T1 true ATE215384T1 (de) 2002-04-15

Family

ID=23959539

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96922508T ATE215384T1 (de) 1995-06-21 1996-06-19 Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung

Country Status (21)

Country Link
US (1) US5690940A (de)
EP (1) EP0833661B1 (de)
JP (1) JP4709094B2 (de)
KR (1) KR100444809B1 (de)
CN (1) CN1126569C (de)
AT (1) ATE215384T1 (de)
AU (1) AU703084B2 (de)
BR (1) BR9608648A (de)
CA (1) CA2225388C (de)
CZ (1) CZ291611B6 (de)
DE (1) DE69620402T2 (de)
DK (1) DK0833661T3 (de)
ES (1) ES2173300T3 (de)
HK (1) HK1016870A1 (de)
HU (1) HU227754B1 (de)
PL (1) PL184231B1 (de)
PT (1) PT833661E (de)
RU (1) RU2192887C2 (de)
SK (1) SK281024B6 (de)
UA (1) UA47433C2 (de)
WO (1) WO1997000696A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2103460C (en) 1991-06-06 2000-09-26 Gert Wensvoort Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
JP3135069B2 (ja) * 1996-03-01 2001-02-13 シェーリング コーポレイション ブタ生殖および呼吸症候群ワクチン
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
EP0839912A1 (de) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Ansteckende Klone von RNA-Viren und darauf basierende Impfstoffe und diagnostisches Verfahren
DE69837992T2 (de) 1997-05-06 2008-03-20 Boehringer Ingelheim Vetmedica Gmbh Prrsv-antigene, die auf peptidsequenzen des prrs-virus basieren, für die verwendung als impfstoff und für diagnostische tests
EP1157121B1 (de) * 1999-03-08 2013-04-24 Boehringer Ingelheim Vetmedica GmbH Prrsv replikon
MXPA01010681A (es) * 1999-04-22 2003-08-20 Us Agriculture Vacuna de sindrome respiratorio y reproductiva porcina a base de ja-142 aislado.
SG83740A1 (en) * 1999-08-10 2001-10-16 Inst Of Molecular Agrobiology An attenuated porcine reproductive and respiratory syndrome virus strain and methods of use
AR049924A1 (es) * 2004-06-18 2006-09-13 Univ Minnesota Identificacion de organismos viralmente infectados y vacunados
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
CA2894069C (en) 2005-06-24 2019-02-26 Regents Of The University Of Minnesota Prrs viruses, infectious clones, mutants thereof, and methods of use
US7241582B2 (en) 2005-07-05 2007-07-10 Mj Biologics, Inc. Diagnostic test kits
JP2010531143A (ja) * 2007-06-25 2010-09-24 サウス ダコタ ステート ユニバーシティー 組換え北アメリカ１型ブタ生殖器呼吸器症候群ウイルス及び使用方法
WO2010025109A1 (en) * 2008-08-25 2010-03-04 Boehringer Ingelheim Vetmedia, Inc. Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs)
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050251B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8545857B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100111835A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8849441B2 (en) 2008-10-31 2014-09-30 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8551506B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8784384B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Frozen compositions and array devices thereof
US8545806B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
TWI627281B (zh) * 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物
US8492454B2 (en) * 2009-10-05 2013-07-23 Creative Nail Design, Inc. Removable color layer for artificial nail coatings and methods therefore
US8263677B2 (en) 2009-09-08 2012-09-11 Creative Nail Design, Inc. Removable color gel basecoat for artificial nail coatings and methods therefore
US8541482B2 (en) * 2009-10-05 2013-09-24 Creative Nail Design, Inc. Removable multilayer nail coating system and methods therefore
US9944902B2 (en) 2011-02-17 2018-04-17 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of PRRSV
PL2675475T3 (pl) 2011-02-17 2015-12-31 Boehringer Ingelheim Vetmedica Gmbh Nowy europejski szczep prrs
AU2011361736A1 (en) 2011-03-07 2013-05-02 Creative Nail Design, Inc. Compositions and methods for UV-curable cosmetic nail coatings
KR101281361B1 (ko) 2011-07-18 2013-07-02 서울대학교산학협력단 북미형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 및 이를 포함하는 혼합백신 조성물
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
US9315781B2 (en) 2011-07-29 2016-04-19 Boehringer Ingelheim Vetmedica Gmbh Infectious CDNA clone of european PRRS virus and uses thereof
CN105308178B (zh) 2012-12-07 2019-06-07 伊利诺伊大学评议会 猪繁殖与呼吸综合征病毒组合物及其用途
EP2968513A2 (de) 2013-03-15 2016-01-20 Boehringer Ingelheim Vetmedica, Inc. Prrs-virus, zusammensetzungen, impfstoff und verfahren zur verwendung
US10279031B2 (en) 2016-05-11 2019-05-07 Phibro Animal Health Corporation Composition comprising antigens and a mucosal adjuvant and a method for using

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0610250B2 (de) * 1991-10-14 2008-10-29 Intervet International BV Impstoff und diagnostik für das fortpflanzungs- und atmungssyndrom bei schweinen (prrs) und diagnose
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
CZ289743B6 (cs) * 1993-02-08 2002-03-13 Bayer Corporation Izolát viru vepřového reprodukčního a respiračního syndromu PRRSV, způsob kultivace PRRSV, tkáňová kultura, způsob přípravy vakcíny a vakcína obsahující PRRSV izolát

Also Published As

Publication number Publication date
AU703084B2 (en) 1999-03-18
EP0833661A1 (de) 1998-04-08
CZ412797A3 (cs) 1998-05-13
BR9608648A (pt) 1999-12-07
DK0833661T3 (da) 2002-05-06
SK281024B6 (sk) 2000-11-07
JPH11509087A (ja) 1999-08-17
HUP9903169A2 (hu) 2000-01-28
HU227754B1 (en) 2012-02-28
CN1126569C (zh) 2003-11-05
KR100444809B1 (ko) 2004-11-06
HUP9903169A3 (en) 2001-06-28
CZ291611B6 (cs) 2003-04-16
HK1016870A1 (en) 1999-11-12
PL184231B1 (pl) 2002-09-30
MX9710149A (es) 1998-07-31
CN1188417A (zh) 1998-07-22
DE69620402D1 (de) 2002-05-08
EP0833661A4 (de) 1998-10-21
JP3954101B2 (ja) 2007-08-08
EP0833661B1 (de) 2002-04-03
KR19990022848A (ko) 1999-03-25
AU6336196A (en) 1997-01-22
SK165797A3 (en) 1998-05-06
JP2006306894A (ja) 2006-11-09
CA2225388C (en) 2010-03-23
PL324204A1 (en) 1998-05-11
US5690940A (en) 1997-11-25
JP4709094B2 (ja) 2011-06-22
UA47433C2 (uk) 2002-07-15
WO1997000696A1 (en) 1997-01-09
RU2192887C2 (ru) 2002-11-20
ES2173300T3 (es) 2002-10-16
PT833661E (pt) 2002-08-30
DE69620402T2 (de) 2002-11-07
CA2225388A1 (en) 1997-01-09

Similar Documents

Publication Publication Date Title
ATE215384T1 (de) Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung
RU98101129A (ru) Низкопатогенные живые вакцины вируса prrs и способы их получения
JP2750557B2 (ja) 豚ミステリー病に関連するウイルス性因子
DE69626022D1 (de) Verfahren zur industriellen herstellung eines japanischen enkephalitis impfstoffes, und so erhaltener impfstoff
HU9502330D0 (en) Process for growing porcine reproductive and respiratory syndrome virus and its use in vaccines
KR930006160A (ko) L-트레오닌의 제조방법
US4965205A (en) Culture medium for bacteria of the bordetella genus containing etherified derivative of D-glucose and a cyclodextrin
Muse et al. Mycoplasma pneumoniae in hamster tracheal organ culture studied by scanning electron microscopy
Giron et al. Propagation of MM virus in L cells
MXPA02007198A (es) Atenuacion recombinante de prrsv.
KR900008047A (ko) L-트레오닌의 제조방법
KR930018034A (ko) 트레할로오스의 제조방법
Murtaugh The PRRS virus
RU2220202C1 (ru) Штамм "бд" вируса репродуктивно-респираторного синдрома свиней для изготовления диагностических и вакцинных препаратов
JPS5867182A (ja) 培養方法及び培地
KR0153543B1 (ko) 재조합 헤파타이티스 비 표면항원과 이에 대한 백신의 제조공정
JP2960322B2 (ja) 豚の生殖器・呼吸器症候群ウイルス産生性細胞およびその作出法
JPS54140793A (en) Preparation of dihydro-coenzyme q10
Taylor et al. A plaque assay system for rinderpest virus and its use in characterising virus adsorption
JPS5699795A (en) Preparation of polysaccharide
JPS6041481A (ja) プトレシンオキシダ−ゼの製造方法
JPS6232174B2 (de)
KR920002771A (ko) 돼지콜레라 바이러스의 외피 당단백질을 추출정제하는 방법
Sodhi et al. Adaptation and cytopathic effects of avian mycoplasma in chicken embryo cell cultures
KR960006940A (ko) 동물세포 배양법을 이용한 뉴캣슬병 백신의 생산방법

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification