ATE215384T1 - Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung - Google Patents

Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung

Info

Publication number
ATE215384T1
ATE215384T1 AT96922508T AT96922508T ATE215384T1 AT E215384 T1 ATE215384 T1 AT E215384T1 AT 96922508 T AT96922508 T AT 96922508T AT 96922508 T AT96922508 T AT 96922508T AT E215384 T1 ATE215384 T1 AT E215384T1
Authority
AT
Austria
Prior art keywords
aliquot
strain
mem
cells
plaques
Prior art date
Application number
AT96922508T
Other languages
English (en)
Inventor
Han Soo Joo
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of ATE215384T1 publication Critical patent/ATE215384T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT96922508T 1995-06-21 1996-06-19 Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung ATE215384T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/493,265 US5690940A (en) 1995-06-21 1995-06-21 Low pathogencity PRRS live virus vaccines and methods of preparation thereof
PCT/US1996/010595 WO1997000696A1 (en) 1995-06-21 1996-06-19 Low pathogenicity prrs live virus vaccines and methods of preparation thereof

Publications (1)

Publication Number Publication Date
ATE215384T1 true ATE215384T1 (de) 2002-04-15

Family

ID=23959539

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96922508T ATE215384T1 (de) 1995-06-21 1996-06-19 Prrs-virus-lebendimpfstoffe mit geringer pathogenitaet und verfahren zu deren herstellung

Country Status (21)

Country Link
US (1) US5690940A (de)
EP (1) EP0833661B1 (de)
JP (1) JP4709094B2 (de)
KR (1) KR100444809B1 (de)
CN (1) CN1126569C (de)
AT (1) ATE215384T1 (de)
AU (1) AU703084B2 (de)
BR (1) BR9608648A (de)
CA (1) CA2225388C (de)
CZ (1) CZ291611B6 (de)
DE (1) DE69620402T2 (de)
DK (1) DK0833661T3 (de)
ES (1) ES2173300T3 (de)
HK (1) HK1016870A1 (de)
HU (1) HU227754B1 (de)
PL (1) PL184231B1 (de)
PT (1) PT833661E (de)
RU (1) RU2192887C2 (de)
SK (1) SK281024B6 (de)
UA (1) UA47433C2 (de)
WO (1) WO1997000696A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0587780T4 (da) * 1991-06-06 2008-10-13 Boehringer Ingelheim Vetmed Smitstof, som forårsager Mystery Swine Disease,vaccinepræparater og diagnostiske sæt
US5866401A (en) * 1996-03-01 1999-02-02 Schering Corporation Porcine reproductive and respiratory syndrome vaccine
EP0894007A1 (de) * 1996-03-01 1999-02-03 Schering Corporation Impfstoff gegen das fortpflanzungs- und atmungssyndrom bei schweinen
EP0839912A1 (de) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Ansteckende Klone von RNA-Viren und darauf basierende Impfstoffe und diagnostisches Verfahren
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
ID23399A (id) 1997-05-06 2000-04-20 Stichting Dienst Landbouwkundi Situs antigenik prrsv untuk mengidentifikasi urutan peptida dari virus prrs yang digunakan untuk vaksin atau pengujian diagnostik
EP1157121B1 (de) * 1999-03-08 2013-04-24 Boehringer Ingelheim Vetmedica GmbH Prrsv replikon
DK2251419T3 (da) * 1999-04-22 2012-07-02 Us Agriculture Porcint reproduktions- og respirations-syndrom-vaccine baseret på isolat JA-142
SG83740A1 (en) * 1999-08-10 2001-10-16 Inst Of Molecular Agrobiology An attenuated porcine reproductive and respiratory syndrome virus strain and methods of use
BRPI0510928A (pt) * 2004-06-18 2007-11-13 Univ Minnesota identificação de organismos viralmente infectados e vacinados
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
MX2007015849A (es) 2005-06-24 2008-02-22 Univ Minnesota Virus del sindrome respiratorio y reproductivo porcino, clones infecciosos, mutantes de los mismos, y metodos de uso.
US7241582B2 (en) * 2005-07-05 2007-07-10 Mj Biologics, Inc. Diagnostic test kits
CA2691755A1 (en) * 2007-06-25 2008-12-31 South Dakota State University Recombinant north american type 1 porcine reproductive and respiratory syndrome virus and methods of use
BRPI0917887A2 (pt) * 2008-08-25 2019-09-03 Boehringer Ingelheim Vetmedica Inc vacina contra síndrome reprodutiva e respiratória suína altamente patogênica (hp pprs)
US20100111835A1 (en) * 2008-10-31 2010-05-06 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with frozen particles
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US8563012B2 (en) 2008-10-31 2013-10-22 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8414356B2 (en) 2008-10-31 2013-04-09 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8721583B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9050251B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8551505B2 (en) 2008-10-31 2013-10-08 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8603494B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8613937B2 (en) 2008-10-31 2013-12-24 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8409376B2 (en) 2008-10-31 2013-04-02 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8545855B2 (en) 2008-10-31 2013-10-01 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US8858912B2 (en) 2008-10-31 2014-10-14 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
AR078253A1 (es) * 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
US8541482B2 (en) * 2009-10-05 2013-09-24 Creative Nail Design, Inc. Removable multilayer nail coating system and methods therefore
US8263677B2 (en) 2009-09-08 2012-09-11 Creative Nail Design, Inc. Removable color gel basecoat for artificial nail coatings and methods therefore
US8492454B2 (en) 2009-10-05 2013-07-23 Creative Nail Design, Inc. Removable color layer for artificial nail coatings and methods therefore
CA2827337C (en) 2011-02-17 2019-07-09 Boehringer Ingelheim Vetmedica Gmbh Commercial scale process for production of prrsv
DK2959916T3 (en) 2011-02-17 2018-10-29 Boehringer Ingelheim Vetmedica Gmbh New European PRRSV strain.
CN103501755A (zh) 2011-03-07 2014-01-08 创意指甲设计公司 用于可uv固化的化妆品指甲涂层的组合物和方法
KR101281361B1 (ko) 2011-07-18 2013-07-02 서울대학교산학협력단 북미형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 및 이를 포함하는 혼합백신 조성물
EP2737059A1 (de) 2011-07-29 2014-06-04 Boehringer Ingelheim Vetmedica GmbH Neuartiges prrs-virus zur induktion von interferon des typs i in empfindlichen zellen
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
CN105308178B (zh) 2012-12-07 2019-06-07 伊利诺伊大学评议会 猪繁殖与呼吸综合征病毒组合物及其用途
US9579373B2 (en) 2013-03-15 2017-02-28 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
US10279031B2 (en) 2016-05-11 2019-05-07 Phibro Animal Health Corporation Composition comprising antigens and a mucosal adjuvant and a method for using

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69206631T2 (de) * 1991-10-14 1996-05-15 Akzo Nobel Nv Impfstoff gegen das Fortpflanzungs- und Atmungssyndrom bei Schweinen (PRRS) und Diagnose.
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
CN1080300C (zh) * 1993-02-08 2002-03-06 美国拜尔公司 培养猪生殖和呼吸综合症病毒的方法及其在疫苗中的应用

Also Published As

Publication number Publication date
KR19990022848A (ko) 1999-03-25
HUP9903169A2 (hu) 2000-01-28
RU2192887C2 (ru) 2002-11-20
JP3954101B2 (ja) 2007-08-08
DK0833661T3 (da) 2002-05-06
CN1188417A (zh) 1998-07-22
PT833661E (pt) 2002-08-30
KR100444809B1 (ko) 2004-11-06
CZ412797A3 (cs) 1998-05-13
EP0833661A4 (de) 1998-10-21
ES2173300T3 (es) 2002-10-16
WO1997000696A1 (en) 1997-01-09
PL324204A1 (en) 1998-05-11
PL184231B1 (pl) 2002-09-30
MX9710149A (es) 1998-07-31
JP4709094B2 (ja) 2011-06-22
HK1016870A1 (en) 1999-11-12
CN1126569C (zh) 2003-11-05
HUP9903169A3 (en) 2001-06-28
DE69620402D1 (de) 2002-05-08
US5690940A (en) 1997-11-25
SK281024B6 (sk) 2000-11-07
HU227754B1 (en) 2012-02-28
CZ291611B6 (cs) 2003-04-16
EP0833661B1 (de) 2002-04-03
EP0833661A1 (de) 1998-04-08
JP2006306894A (ja) 2006-11-09
DE69620402T2 (de) 2002-11-07
SK165797A3 (en) 1998-05-06
AU6336196A (en) 1997-01-22
CA2225388C (en) 2010-03-23
UA47433C2 (uk) 2002-07-15
JPH11509087A (ja) 1999-08-17
CA2225388A1 (en) 1997-01-09
AU703084B2 (en) 1999-03-18
BR9608648A (pt) 1999-12-07

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