ATE210624T1 - Synthese von alpha-chlor- oder alpha-fluorketonen - Google Patents

Synthese von alpha-chlor- oder alpha-fluorketonen

Info

Publication number
ATE210624T1
ATE210624T1 AT96930823T AT96930823T ATE210624T1 AT E210624 T1 ATE210624 T1 AT E210624T1 AT 96930823 T AT96930823 T AT 96930823T AT 96930823 T AT96930823 T AT 96930823T AT E210624 T1 ATE210624 T1 AT E210624T1
Authority
AT
Austria
Prior art keywords
alpha
fluorketones
synthesis
chlorine
alpha chlorine
Prior art date
Application number
AT96930823T
Other languages
English (en)
Inventor
Ulf H Dolling
Lisa F Frey
Richard D Tillyer
David M Tschaen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602925.1A external-priority patent/GB9602925D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE210624T1 publication Critical patent/ATE210624T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96930823T 1995-09-15 1996-09-11 Synthese von alpha-chlor- oder alpha-fluorketonen ATE210624T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US382395P 1995-09-15 1995-09-15
GBGB9602925.1A GB9602925D0 (en) 1996-02-13 1996-02-13 Synthesis of a-chloro or fluoro ketones
PCT/US1996/014565 WO1997010195A1 (en) 1995-09-15 1996-09-11 SYNTHESIS OF α-CHLORO OR FLUORO KETONES

Publications (1)

Publication Number Publication Date
ATE210624T1 true ATE210624T1 (de) 2001-12-15

Family

ID=26308680

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96930823T ATE210624T1 (de) 1995-09-15 1996-09-11 Synthese von alpha-chlor- oder alpha-fluorketonen

Country Status (18)

Country Link
EP (1) EP0851850B1 (de)
CN (1) CN1101374C (de)
AR (1) AR003509A1 (de)
AT (1) ATE210624T1 (de)
AU (1) AU6973896A (de)
BR (1) BR9610272A (de)
CZ (1) CZ290202B6 (de)
DE (1) DE69617969T2 (de)
DK (1) DK0851850T3 (de)
EA (1) EA001935B1 (de)
ES (1) ES2167600T3 (de)
HK (1) HK1010189A1 (de)
PT (1) PT851850E (de)
RO (1) RO120706B1 (de)
SK (1) SK282779B6 (de)
TW (1) TW338032B (de)
UA (1) UA57001C2 (de)
WO (1) WO1997010195A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60015036T2 (de) 1999-07-23 2006-03-02 Pfizer Products Inc., Groton Zwischenprodukte und ein Verfahren zur Herstellung von beta3-Adrenergischer Rezeptor-Agoniste
CN107746388B (zh) * 2017-11-23 2021-01-01 江苏恒盛药业有限公司 一种伏立康唑中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1596278A (en) * 1976-11-30 1981-08-26 Glaxo Operations Ltd 7-(-oxyimino-acetamino)cephalosporin derivatives

Also Published As

Publication number Publication date
HK1010189A1 (en) 1999-06-17
DE69617969D1 (de) 2002-01-24
UA57001C2 (uk) 2003-06-16
RO120706B1 (ro) 2006-06-30
EA001935B1 (ru) 2001-10-22
EA199800297A1 (ru) 1998-08-27
DK0851850T3 (da) 2002-03-25
ES2167600T3 (es) 2002-05-16
DE69617969T2 (de) 2002-06-27
SK32898A3 (en) 1998-11-04
SK282779B6 (sk) 2002-12-03
WO1997010195A1 (en) 1997-03-20
EP0851850B1 (de) 2001-12-12
CN1101374C (zh) 2003-02-12
AU6973896A (en) 1997-04-01
PT851850E (pt) 2002-05-31
TW338032B (en) 1998-08-11
CZ76998A3 (cs) 1998-07-15
BR9610272A (pt) 1999-07-06
AR003509A1 (es) 1998-08-05
EP0851850A1 (de) 1998-07-08
CZ290202B6 (cs) 2002-06-12
CN1195337A (zh) 1998-10-07

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee