EA199800297A1 - СИНТЕЗ α-ХЛОР- ИЛИ ФТОРКЕТОНОВ - Google Patents

СИНТЕЗ α-ХЛОР- ИЛИ ФТОРКЕТОНОВ

Info

Publication number
EA199800297A1
EA199800297A1 EA199800297A EA199800297A EA199800297A1 EA 199800297 A1 EA199800297 A1 EA 199800297A1 EA 199800297 A EA199800297 A EA 199800297A EA 199800297 A EA199800297 A EA 199800297A EA 199800297 A1 EA199800297 A1 EA 199800297A1
Authority
EA
Eurasian Patent Office
Prior art keywords
synthesis
fluoroketones
chlorine
methylchloroacetamide
chloroketones
Prior art date
Application number
EA199800297A
Other languages
English (en)
Other versions
EA001935B1 (ru
Inventor
Ульф Х. Доллинг
Лайза Ф. Фрей
Ричард Д. Тилльер
Дэвид М. Тшаен
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602925.1A external-priority patent/GB9602925D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199800297A1 publication Critical patent/EA199800297A1/ru
Publication of EA001935B1 publication Critical patent/EA001935B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Описан простой синтез α-хлоркетонов с высоким выходом, включающий ацилирование реактива Гриньяра и литийорганических реагентов N-метокси-N-метилхлорацетамидом. Эффективность способа дополнительно повышается путем рециклирования N,O-диметилгидроксиламина.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800297A 1995-09-15 1996-09-11 СИНТЕЗ α-ХЛОР- ИЛИ ФТОРКЕТОНОВ EA001935B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US382395P 1995-09-15 1995-09-15
GBGB9602925.1A GB9602925D0 (en) 1996-02-13 1996-02-13 Synthesis of a-chloro or fluoro ketones
PCT/US1996/014565 WO1997010195A1 (en) 1995-09-15 1996-09-11 SYNTHESIS OF α-CHLORO OR FLUORO KETONES

Publications (2)

Publication Number Publication Date
EA199800297A1 true EA199800297A1 (ru) 1998-08-27
EA001935B1 EA001935B1 (ru) 2001-10-22

Family

ID=26308680

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800297A EA001935B1 (ru) 1995-09-15 1996-09-11 СИНТЕЗ α-ХЛОР- ИЛИ ФТОРКЕТОНОВ

Country Status (18)

Country Link
EP (1) EP0851850B1 (ru)
CN (1) CN1101374C (ru)
AR (1) AR003509A1 (ru)
AT (1) ATE210624T1 (ru)
AU (1) AU6973896A (ru)
BR (1) BR9610272A (ru)
CZ (1) CZ290202B6 (ru)
DE (1) DE69617969T2 (ru)
DK (1) DK0851850T3 (ru)
EA (1) EA001935B1 (ru)
ES (1) ES2167600T3 (ru)
HK (1) HK1010189A1 (ru)
PT (1) PT851850E (ru)
RO (1) RO120706B1 (ru)
SK (1) SK282779B6 (ru)
TW (1) TW338032B (ru)
UA (1) UA57001C2 (ru)
WO (1) WO1997010195A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60015036T2 (de) 1999-07-23 2006-03-02 Pfizer Products Inc., Groton Zwischenprodukte und ein Verfahren zur Herstellung von beta3-Adrenergischer Rezeptor-Agoniste
CN107746388B (zh) * 2017-11-23 2021-01-01 江苏恒盛药业有限公司 一种伏立康唑中间体的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1596278A (en) * 1976-11-30 1981-08-26 Glaxo Operations Ltd 7-(-oxyimino-acetamino)cephalosporin derivatives

Also Published As

Publication number Publication date
HK1010189A1 (en) 1999-06-17
ATE210624T1 (de) 2001-12-15
DE69617969D1 (de) 2002-01-24
UA57001C2 (ru) 2003-06-16
RO120706B1 (ro) 2006-06-30
EA001935B1 (ru) 2001-10-22
DK0851850T3 (da) 2002-03-25
ES2167600T3 (es) 2002-05-16
DE69617969T2 (de) 2002-06-27
SK32898A3 (en) 1998-11-04
SK282779B6 (sk) 2002-12-03
WO1997010195A1 (en) 1997-03-20
EP0851850B1 (en) 2001-12-12
CN1101374C (zh) 2003-02-12
AU6973896A (en) 1997-04-01
PT851850E (pt) 2002-05-31
TW338032B (en) 1998-08-11
CZ76998A3 (cs) 1998-07-15
BR9610272A (pt) 1999-07-06
AR003509A1 (es) 1998-08-05
EP0851850A1 (en) 1998-07-08
CZ290202B6 (cs) 2002-06-12
CN1195337A (zh) 1998-10-07

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU