ATE1995T1 - Neue derivate der 2,4,6-trijod-isophthalsaeure, verfahren zu deren herstellung und diese enthaltende roentgenkontrastmittel. - Google Patents

Neue derivate der 2,4,6-trijod-isophthalsaeure, verfahren zu deren herstellung und diese enthaltende roentgenkontrastmittel.

Info

Publication number
ATE1995T1
ATE1995T1 AT80104243T AT80104243T ATE1995T1 AT E1995 T1 ATE1995 T1 AT E1995T1 AT 80104243 T AT80104243 T AT 80104243T AT 80104243 T AT80104243 T AT 80104243T AT E1995 T1 ATE1995 T1 AT E1995T1
Authority
AT
Austria
Prior art keywords
triiodo
preparation
media containing
contrast media
ray contrast
Prior art date
Application number
AT80104243T
Other languages
German (de)
English (en)
Inventor
Ernst Prof. Dr. Felder
Davide Prof. Dr. Pitre
Original Assignee
Bracco Industria Chimica Societa Per Azioni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Industria Chimica Societa Per Azioni filed Critical Bracco Industria Chimica Societa Per Azioni
Application granted granted Critical
Publication of ATE1995T1 publication Critical patent/ATE1995T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT80104243T 1979-08-09 1980-07-18 Neue derivate der 2,4,6-trijod-isophthalsaeure, verfahren zu deren herstellung und diese enthaltende roentgenkontrastmittel. ATE1995T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT25026/79A IT1193211B (it) 1979-08-09 1979-08-09 Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
EP80104243A EP0026281B1 (de) 1979-08-09 1980-07-18 Neue Derivate der 2,4,6-Trijod-isophthalsäure, Verfahren zu deren Herstellung und diese enthaltende Röntgenkontrastmittel

Publications (1)

Publication Number Publication Date
ATE1995T1 true ATE1995T1 (de) 1982-12-15

Family

ID=11215461

Family Applications (1)

Application Number Title Priority Date Filing Date
AT80104243T ATE1995T1 (de) 1979-08-09 1980-07-18 Neue derivate der 2,4,6-trijod-isophthalsaeure, verfahren zu deren herstellung und diese enthaltende roentgenkontrastmittel.

Country Status (19)

Country Link
US (1) US4352788A (nl)
EP (1) EP0026281B1 (nl)
JP (1) JPS5827264B2 (nl)
AR (2) AR225773A1 (nl)
AT (1) ATE1995T1 (nl)
AU (1) AU541428B2 (nl)
CA (1) CA1128065A (nl)
DE (1) DE3061347D1 (nl)
DK (1) DK158659C (nl)
ES (1) ES494076A0 (nl)
FI (1) FI71124C (nl)
IE (1) IE50149B1 (nl)
IT (1) IT1193211B (nl)
MX (1) MX9202639A (nl)
NL (1) NL940024I2 (nl)
NO (1) NO150154C (nl)
PL (2) PL123167B1 (nl)
PT (1) PT71682B (nl)
YU (1) YU42352B (nl)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56127373A (en) * 1980-01-31 1981-10-06 Univ California Novel amino-dioxepane intermediate for synthesizing novel nonionic contrast agent
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
DE3150917A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US4584401A (en) * 1983-10-20 1986-04-22 Biophysica Foundation Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media
JPS628984A (ja) * 1985-07-04 1987-01-16 三菱電機株式会社 エレベ−タ−の運転装置
WO1987000757A1 (en) * 1985-08-09 1987-02-12 Cook Imaging, Inc. Non-ionic polyol contrast media from ionic contrast media
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
US5869024A (en) * 1989-11-29 1999-02-09 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
IL96324A (en) * 1989-11-29 1995-01-24 Squibb & Sons Inc History of 5-amino-2,4,6-triadiodo-1,3-benzenecarboxylic acid, processes for their preparation, and methods used as contrast agents
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
US5356613A (en) * 1991-03-18 1994-10-18 Mallinckrodt Medical, Inc. X-ray contrast agents, compositions and methods
US5278311A (en) * 1992-06-05 1994-01-11 E. R. Squibb & Sons, Inc. Nonionic radiographic contrast agents
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
IT1271107B (it) * 1994-11-29 1997-05-26 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
DE19510864A1 (de) * 1995-03-16 1996-09-19 Schering Ag Röntgenkontrastmittel für die Computertomographie und Urographie
IT1275429B (it) * 1995-05-18 1997-08-07 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di composti organici
JP4012566B2 (ja) * 1995-05-23 2007-11-21 ブラッコ イメージング エッセ ピ ア ジカルボン酸二塩化物の製造方法
IT1288114B1 (it) * 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
IT1292127B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la dissalazione di sostanze instabili a ph acidi
US6723746B2 (en) * 1998-09-08 2004-04-20 Veritas Pharmaceuticals, Inc. Functional radiographic imaging methods and agents
US20010038682A1 (en) * 1998-09-08 2001-11-08 Jesse Salb Radiographic assessment of tissue response to compounds
US6226352B1 (en) * 1998-09-08 2001-05-01 Veritas Pharmaceuticals, Inc. System and method for radiographic imaging of tissue
US6751290B2 (en) 1998-09-08 2004-06-15 Veritas Pharmaceuticals, Inc. Radiographic assessment of tissue after exposure to a compound
US20040170561A1 (en) * 1998-09-08 2004-09-02 Jesse Salb Functional radiographic imaging methods and agents
US6803485B2 (en) * 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
IT1319671B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
DE602005010747D1 (de) 2005-01-13 2008-12-11 Cinv Ag Kohlenstoffnanopartikel enthaltende verbundwerkstoffe
CA2675121A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
US20080206862A1 (en) * 2007-02-28 2008-08-28 Cinvention Ag High surface cultivation system bag
US7955234B1 (en) 2007-02-28 2011-06-07 Pursley Michael G Exercise device and method
CN101646764A (zh) * 2007-02-28 2010-02-10 金文申有限公司 高表面积培养系统
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
US20110256068A1 (en) 2009-01-09 2011-10-20 Wistand Lars-Goeran Contrast media compositions
EP2243767A1 (en) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102363600B (zh) * 2011-10-24 2013-07-17 江苏省原子医学研究所 一种碘美普尔的制备方法
DE102012109481A1 (de) 2012-10-05 2014-04-10 Faro Technologies, Inc. Vorrichtung zum optischen Abtasten und Vermessen einer Umgebung
US10067231B2 (en) 2012-10-05 2018-09-04 Faro Technologies, Inc. Registration calculation of three-dimensional scanner data performed between scans based on measurements by two-dimensional scanner
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
CN106316878B (zh) * 2015-06-15 2018-01-19 重庆常捷医药有限公司 一种碘美普尔杂质的制备方法
CN110023279B (zh) 2016-12-05 2022-03-11 伯拉考成像股份公司 放射照相剂中间体的机械化学合成
CN107253918A (zh) * 2017-07-27 2017-10-17 成都丽璟科技有限公司 一种制备碘美普尔的新方法
KR102128423B1 (ko) 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
CN118414325A (zh) 2021-12-20 2024-07-30 伯拉考成像股份公司 制备2,4,6-三碘间苯二甲酸双酰胺的方法
CN116354842A (zh) * 2021-12-20 2023-06-30 重庆圣华曦药业股份有限公司 一种改进的碘美普尔制备方法及其在制剂中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (nl) * 1966-12-13 1972-04-04 Pharmacia Ab
SE315975B (nl) * 1967-12-28 1969-10-13 Pharmacia Ab
US3701771A (en) * 1969-06-27 1972-10-31 Nyegaard & Co As N-(2,4,6-triiodobenzoyl)-sugar amines
US3886859A (en) * 1974-04-26 1975-06-03 Gen Electric Compactor brake
CH616403A5 (en) * 1975-10-29 1980-03-31 Bracco Ind Chimica Spa Process for the preparation of 2,4,6-triodoisophthalamides which are readily soluble in water.
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
DE2909439A1 (de) * 1979-03-08 1980-09-18 Schering Ag Neue nichtionische roentgenkontrastmittel

Also Published As

Publication number Publication date
IE801684L (en) 1981-02-09
YU201180A (en) 1983-02-28
PL226143A1 (nl) 1981-05-08
EP0026281B1 (de) 1982-12-15
EP0026281A1 (de) 1981-04-08
AR225836A1 (es) 1982-04-30
PT71682A (en) 1980-09-01
NO150154C (no) 1984-08-29
NL940024I1 (nl) 1995-01-16
FI71124C (fi) 1986-11-24
JPS5629553A (en) 1981-03-24
US4352788A (en) 1982-10-05
PL123167B1 (en) 1982-09-30
YU42352B (en) 1988-08-31
NO150154B (no) 1984-05-21
NL940024I2 (nl) 1999-06-01
DK343980A (da) 1981-02-10
MX9202639A (es) 1992-06-30
ES8106696A1 (es) 1981-09-01
PT71682B (en) 1981-06-15
DK158659B (da) 1990-07-02
DE3061347D1 (en) 1983-01-20
PL126118B1 (en) 1983-07-30
IT7925026A0 (it) 1979-08-09
DK158659C (da) 1991-01-21
ES494076A0 (es) 1981-09-01
AU6061680A (en) 1981-02-12
IT1193211B (it) 1988-06-15
IE50149B1 (en) 1986-02-19
AU541428B2 (en) 1985-01-10
FI802373A (fi) 1981-02-10
CA1128065A (en) 1982-07-20
JPS5827264B2 (ja) 1983-06-08
AR225773A1 (es) 1982-04-30
NO802373L (no) 1981-02-10
FI71124B (fi) 1986-08-14

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