ATE185083T1 - Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation - Google Patents

Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation

Info

Publication number
ATE185083T1
ATE185083T1 AT96916550T AT96916550T ATE185083T1 AT E185083 T1 ATE185083 T1 AT E185083T1 AT 96916550 T AT96916550 T AT 96916550T AT 96916550 T AT96916550 T AT 96916550T AT E185083 T1 ATE185083 T1 AT E185083T1
Authority
AT
Austria
Prior art keywords
electroporation
medications
genes
administration
tumors
Prior art date
Application number
AT96916550T
Other languages
English (en)
Inventor
Gunter A Hofmann
Richard A Gilbert
Yosuhiko Hayakawa
Richard Heller
Mark J Jaroszeski
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/467,566 external-priority patent/US5702359A/en
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ATE185083T1 publication Critical patent/ATE185083T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Electromagnetism (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT96916550T 1995-06-06 1996-05-22 Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation ATE185083T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,566 US5702359A (en) 1995-06-06 1995-06-06 Needle electrodes for mediated delivery of drugs and genes
US08/537,265 US5993434A (en) 1993-04-01 1995-09-29 Method of treatment using electroporation mediated delivery of drugs and genes

Publications (1)

Publication Number Publication Date
ATE185083T1 true ATE185083T1 (de) 1999-10-15

Family

ID=27042102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916550T ATE185083T1 (de) 1995-06-06 1996-05-22 Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation

Country Status (12)

Country Link
US (6) US5993434A (de)
EP (1) EP0874663B1 (de)
JP (1) JPH11506630A (de)
KR (1) KR100260238B1 (de)
CN (1) CN1150950C (de)
AT (1) ATE185083T1 (de)
AU (1) AU702054B2 (de)
CA (1) CA2218255C (de)
DE (1) DE69604509T2 (de)
ES (1) ES2140096T3 (de)
GR (1) GR3031963T3 (de)
WO (1) WO1996039226A1 (de)

Families Citing this family (298)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
IL132103A0 (en) * 1997-04-03 2001-03-19 Eletrofect As Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
AU8444698A (en) 1997-06-30 1999-01-25 Centre National De La Recherche Scientifique Improved method for transferring nucleic acid into multicelled eukaryo tic organism cells and combination therefor
CN1261807A (zh) * 1997-06-30 2000-08-02 罗纳-布朗克罗莱尔股份有限公司 向横纹肌中转移核酸的改进方法和用于实施该方法的组合
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
SE9704076D0 (sv) * 1997-11-06 1997-11-06 Holdingbolaget Vid Goeteborgs Method for permeabilisation of cell structures and use thereof
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
FR2773326B3 (fr) * 1998-01-06 2000-05-12 Michel Siros Dispositif d'aide a un traitement de cellules vivantes dans un milieu donne
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
AU760619B2 (en) * 1998-06-26 2003-05-22 Genetronics, Inc. Synergism of photodynamic and electropermeation effects on cell vitality as a novel cytotoxic agent
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
JP2002520101A (ja) 1998-07-13 2002-07-09 ジェネトロニクス、インコーポレーテッド 電気的に補助される化粧用薬剤の局部送達法および装置
WO2000002621A1 (en) 1998-07-13 2000-01-20 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
GB9817078D0 (en) 1998-08-05 1998-10-07 Habib Nagy A Device for liver surgery
EP1109594B1 (de) 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
US6314316B1 (en) 1998-12-17 2001-11-06 University Of South Florida Nonpenetrating electroporation device and method
WO2000044438A1 (en) * 1999-01-28 2000-08-03 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
WO2000056395A1 (en) 1999-03-25 2000-09-28 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
EP1171195B1 (de) 1999-04-16 2005-03-16 Johnson & Johnson Consumer Companies, Inc. Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
CN1068525C (zh) * 1999-04-23 2001-07-18 孙才均 热针电化学肿瘤治疗装置
US6514762B1 (en) 1999-04-23 2003-02-04 New Mexico State University Technology Transfer Corporation Delivery of nucleotides by electrochemical release
AU4996300A (en) 1999-05-10 2000-11-21 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US7074747B1 (en) * 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
AU5764800A (en) 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
DE69922270T2 (de) * 1999-12-15 2005-11-10 University Of South Florida, Tampa Vorrichtung zur elektroporation
AU2495801A (en) * 1999-12-22 2001-07-09 Innovation And Development Corporation Method and apparatus for targeting localised electroporation
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
US7013179B2 (en) * 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US6584358B2 (en) 2000-01-07 2003-06-24 Biowave Corporation Electro therapy method and apparatus
US7927612B2 (en) * 2000-01-19 2011-04-19 Baofa Yu Combinations and methods for treating neoplasms
AU2001228841A1 (en) * 2000-01-27 2001-08-07 The Mollennium Laboratories Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
WO2002000278A2 (en) * 2000-06-26 2002-01-03 Microheart, Inc. Method and apparatus for treating ischemic tissue
US6846306B1 (en) * 2000-10-10 2005-01-25 Cold Spring Harbor Laboratory Single cell electroporation
SE0003841D0 (sv) * 2000-10-20 2000-10-20 Daniel Chiu A method and apparatus for penetration of lipid bilayer membranes
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
US6706016B2 (en) * 2000-11-24 2004-03-16 Ckm Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
US7101703B2 (en) * 2001-03-09 2006-09-05 Cornell Research Foundation, Inc. Electrofusion microelectrode
US20030170642A1 (en) * 2001-03-12 2003-09-11 Irm, Llc Identification of cellular targets for biologically active molecules
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
JP4209767B2 (ja) 2001-06-12 2009-01-14 ペリカン テクノロジーズ インコーポレイテッド 皮膚の性状の一時的変化に対する適応手段を備えた自動最適化形切開器具
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
JP4149911B2 (ja) 2001-06-12 2008-09-17 ペリカン テクノロジーズ インコーポレイテッド 電気式ランセットアクチュエータ
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8337419B2 (en) * 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
EP1448771B1 (de) 2001-11-27 2007-01-03 Cellectricon AB Verfahren zur kombinierten parallelen zuführung von agentien und elektroporation für zellstrukturen und verwendung davon
US20030170898A1 (en) * 2001-12-04 2003-09-11 Gundersen Martin A. Method for intracellular modifications within living cells using pulsed electric fields
CA2476452A1 (en) * 2002-02-15 2003-08-28 Zycos Inc. Electroporation methods for introducing bioactive agents into cells
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
DE10212008A1 (de) * 2002-03-18 2003-10-09 Aventis Behring Gmbh Nadelhalter
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
WO2003089046A1 (en) 2002-04-16 2003-10-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US20030198625A1 (en) * 2002-04-19 2003-10-23 Genteric, Inc. Electroporation-mediated transfection of the salivary gland
US7291117B2 (en) * 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
WO2004037341A2 (en) * 2002-05-07 2004-05-06 Schroeppel Edward A Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US10130415B2 (en) * 2002-06-10 2018-11-20 Wisconsin Alumni Research Foundation Circumferential electrode array for tissue ablation
US20070265582A1 (en) * 2002-06-12 2007-11-15 University Of Southern California Injection Devices for Unimpeded Target Location Testing
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
CA2502696A1 (en) 2002-10-21 2004-05-06 Mgi Pharma Biologics, Inc. Compositions and methods for treating human papillomavirus-mediated disease
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20040253304A1 (en) * 2003-01-29 2004-12-16 Yossi Gross Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
ES2490740T3 (es) 2003-06-06 2014-09-04 Sanofi-Aventis Deutschland Gmbh Aparato para toma de muestras de fluido sanguíneo y detección de analitos
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US7521224B2 (en) * 2003-09-30 2009-04-21 The United States Of America As Represented By The Secretary Of The Navy Microelectronic cell electroporation array
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
CA2559083C (en) 2004-03-08 2015-06-16 Ichor Medical Systems, Inc. Improved apparatus for electrically mediated delivery of therapeutic agents
JP2005278480A (ja) * 2004-03-29 2005-10-13 Fujitsu Ltd 物質導入装置及び物質導入用チップ
WO2005096979A1 (en) 2004-04-01 2005-10-20 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
JP4504082B2 (ja) * 2004-04-28 2010-07-14 富士通株式会社 液体注入装置
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
US7212865B2 (en) * 2004-05-25 2007-05-01 Philip Cory Nerve stimulator and method
EP1765194A4 (de) 2004-06-03 2010-09-29 Pelikan Technologies Inc Verfahren und gerät für eine flüssigkeitsentnahmenvorrichtung
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
US6897069B1 (en) 2004-06-08 2005-05-24 Ambion, Inc. System and method for electroporating a sample
WO2005123182A2 (en) * 2004-06-11 2005-12-29 University Of South Florida Nervous tissue electrode device
USRE50241E1 (en) 2004-06-12 2024-12-24 Life Technologies Holdings PTE Ltd. Electroporation apparatus having an elongated hollow member
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
EP1786514B1 (de) * 2004-06-24 2015-01-07 Sphergen Vorrichtung zum transfer von molekülen zu zellen unter verwendung von elektrischer energie
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
JP2006102255A (ja) * 2004-10-06 2006-04-20 Nippon Sherwood Medical Industries Ltd 輸液ラインの接続構造及びその接続構造を備えたコネクター
US20060165668A1 (en) * 2004-12-10 2006-07-27 Liu Linda N Genetically modified tumor cells as cancer vaccines
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
GB0502384D0 (en) * 2005-02-04 2005-03-16 Instrumedical Ltd Electro-surgical needle apparatus
WO2007012907A2 (en) * 2005-02-08 2007-02-01 Allen, John Electric therapy machine
EP1885437A2 (de) * 2005-05-19 2008-02-13 E-Pill Pharma Ltd. Einnehmbare vorrichtung zur erzeugung von stickoxid in gewebe
ES2696824T3 (es) 2005-05-31 2019-01-18 Univ Colorado Regents Métodos para suministrar genes
US7933648B2 (en) * 2005-07-21 2011-04-26 Naim Erturk Tanrisever High voltage transcutaneous electrical stimulation device and method
US7647122B2 (en) * 2005-07-26 2010-01-12 Medtronic, Inc. Surgical needle driver
DE102005062933A1 (de) * 2005-08-24 2007-03-22 Triton Gmbh Verfahren zur Behandlung von eine Zellstruktur aufweisenden Rohstoffen in der fleisch-, fleischnebenprodukte-, fisch- und seafoodverarbeitenden Nahrungsmittelindustrie
US20070083075A1 (en) * 2005-10-12 2007-04-12 Moshe Ein-Gal Method and apparatus for applying energy to tissues
US20070142885A1 (en) * 2005-11-29 2007-06-21 Reliant Technologies, Inc. Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue
WO2007120234A2 (en) * 2005-12-07 2007-10-25 Genetronics, Inc Variable volume electroporation chamber and methods therefore
US7915044B2 (en) * 2005-12-22 2011-03-29 Cornell Research Foundation, Inc. Electrofusion microelectrode and methods of using it to manipulate cells and/or cellular components
JP4614451B2 (ja) * 2005-12-26 2011-01-19 日本シャーウッド株式会社 医療用縫合具
AU2007212269B2 (en) * 2006-02-09 2013-03-28 Deka Products Limited Partnership Fluid delivery systems and methods
AU2007215263B2 (en) * 2006-02-11 2011-07-07 Genetronics, Inc. Device and method for single-needle in vivo electroporation
KR101444471B1 (ko) * 2006-03-03 2014-09-24 제네트로닉스, 인코포레이티드 외과적 절제술 이후에 조직내 남아 있는 미세 잔류 종양을 치료하는 장치
JPWO2007123142A1 (ja) * 2006-04-20 2009-09-03 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
US20080119797A1 (en) * 2006-11-20 2008-05-22 Stanley Kim System with a syringe device and a needle device
US20070276425A1 (en) * 2006-05-29 2007-11-29 Stanley Kim Painless Blood Sampling Lancet with Bundled Multiple Thin Needles
US20080139989A1 (en) * 2006-12-11 2008-06-12 Stanley Kim Hemodialysis needle device having multiple needles mounted on a needle hub
ATE518484T1 (de) * 2006-05-31 2011-08-15 Covidien Ag Medizinisches nahtinstrument mit greifvorrichtung
ES2336626T3 (es) * 2006-06-12 2010-04-14 Region Hovedstaden V/Herlev Hospital Dispositivo introductor de electrodos.
CN101138634A (zh) 2006-09-07 2008-03-12 于保法 用于治疗肿瘤的组合物
JP4536698B2 (ja) * 2006-10-05 2010-09-01 日本シャーウッド株式会社 医療用縫合具
US20080208179A1 (en) * 2006-10-26 2008-08-28 Reliant Technologies, Inc. Methods of increasing skin permeability by treatment with electromagnetic radiation
EP2548438B1 (de) 2006-11-08 2015-08-05 Veritas Bio, LLC In-vivo-Abgabe von Doppelstrang-RNA an eine Zielzelle
JP4565576B2 (ja) * 2007-02-20 2010-10-20 日本シャーウッド株式会社 穿刺針補助具
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
CA2696209C (en) 2007-08-14 2016-10-25 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
DE102008008614A1 (de) 2008-02-12 2009-08-13 Leibniz-Institut für Plasmaforschung und Technologie e.V. Plama-Gerät zur selektiven Behandlung elektroporierter Zellen
CA2720168C (en) 2008-04-04 2024-04-30 David B. Weiner Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
CN107083391A (zh) * 2008-04-04 2017-08-22 宾夕法尼亚大学托管会 屈曲病毒蛋白共有序列、编码该屈曲病毒蛋白共有序列的核酸分子和组合物及其使用方法
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
KR101084528B1 (ko) 2008-04-15 2011-11-18 인비트로겐 싱가포르 피티이. 엘티디. 전기천공 장치용 파이펫 팁
US8348938B2 (en) 2008-05-06 2013-01-08 Old Dominian University Research Foundation Apparatus, systems and methods for treating a human tissue condition
JP5185706B2 (ja) * 2008-06-24 2013-04-17 日本コヴィディエン株式会社 穿刺針補助具
US9597145B2 (en) 2008-08-20 2017-03-21 Prostacare Pty Ltd Non-thermal ablation system for treating tissue
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
WO2010129899A1 (en) * 2009-05-08 2010-11-11 Cellutions, Inc. Treatment system with a pulse forming network for achieving plasma in tissue
EP3488837B1 (de) 2009-07-15 2024-11-27 NewSouth Innovations Pty Limited Elektroporationsvorrichtung zur verabreichung von mitteln in die hörschnecke
DE102009028462A1 (de) 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas
KR20120093163A (ko) 2009-09-14 2012-08-22 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Ｉｌ-15 수용체 알파 및/또는 이를 인코딩하는 핵산 분자를 포함하는 백신 및 면역 치료제, 및 이를 이용하는 방법
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA2810514C (en) * 2010-09-09 2021-05-04 Old Dominion University Research Foundation Multi-electrode electrical pulse delivery system for treatment of biological tissues
WO2012041867A2 (en) 2010-09-27 2012-04-05 China Agricultural University Combined antigen and dna vaccine for preventing and treating autoimmune diseases
US9428565B2 (en) 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
CN102631243B (zh) * 2011-02-15 2014-09-17 成功大学 电磁热疗法的治疗器具
WO2012158132A1 (en) 2011-05-18 2012-11-22 Eteka Llc Apparatus for the enhancement of food properties by electroporation or pulsed electric fields
EP2720740A1 (de) 2011-06-15 2014-04-23 ChronTech Pharma AB Injektionsnadel und vorrichtung
CN102284135A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于单针形电极的高压脉冲电场治疗装置
CN102284132A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于多针形电极的高压脉冲电场治疗装置
AU2012321317B2 (en) 2011-07-12 2016-01-28 Inovio Pharmaceuticals, Inc Novel clostridium difficile DNA vaccine
EA201490636A1 (ru) 2011-09-16 2014-08-29 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Сконструированные с помощью рнк t-клетки для лечения злокачественных новообразований
WO2013044225A1 (en) 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
WO2013063530A2 (en) 2011-10-28 2013-05-02 Presage Biosciences, Inc. Methods for drug delivery
US9272002B2 (en) 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
CN104168912B (zh) 2011-11-10 2016-08-24 北京艾棣维欣生物技术有限公司 促进剂-dna组合疫苗
US20130197425A1 (en) * 2011-12-16 2013-08-01 The Regents Of The University Of California Current cage for reduction of a non-target tissue exposure to electric fields in electroporation based treatment
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
SG11201404284SA (en) 2012-02-22 2014-10-30 Univ Pennsylvania Use of the cd2 signaling domain in second-generation chimeric antigen receptors
CA2864688C (en) 2012-02-22 2023-09-05 The Trustees Of The University Of Pennsylvania Use of icos-based cars to enhance antitumor activity and car persistence
EP2852352B1 (de) 2012-05-04 2021-09-01 Roger Khouri Chirurgische instrumente
CN104583230A (zh) 2012-07-13 2015-04-29 宾夕法尼亚大学董事会 通过共同引入双特异性抗体增强car t细胞的活性
US9144459B2 (en) 2012-07-19 2015-09-29 Cook Medical Technologies Llc Endoscopic ultrasound ablation needle
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
AR092745A1 (es) 2012-10-01 2015-04-29 Univ Pennsylvania Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
MX364732B (es) 2012-12-13 2019-05-06 Univ Pennsylvania Vacuna contra el tumor de wilms 1.
EP2968606B1 (de) 2013-03-15 2020-10-07 Loma Linda University Behandlung von autoimmunerkrankungen
US10098585B2 (en) 2013-03-15 2018-10-16 Cadwell Laboratories, Inc. Neuromonitoring systems and methods
EP3848045A1 (de) 2013-05-21 2021-07-14 President and Fellows of Harvard College Manipulierte hämbindende zusammensetzungen und verwendungen davon
DK3028048T3 (en) 2013-07-31 2019-01-21 Bioventures Llc COMPOSITIONS FOR TREATMENT AND PREVENTION OF CANCER TARGETING AGAINST TUMOR-ASSOCIATED CARBOHYDRATE ANTIGEN
AU2014332352B9 (en) 2013-10-07 2017-05-11 Inovio Pharmaceuticals, Inc. Vaccines with Interleukin-33 as an adjuvant
EP3964231A1 (de) 2013-11-14 2022-03-09 Inovio Pharmaceuticals, Inc. Hiv-1-env-dna-impfstoff plus proteinboost
IL305392A (en) 2013-11-29 2023-10-01 Inovio Pharmaceuticals Inc Mers-cov vaccine
WO2015103602A1 (en) 2014-01-06 2015-07-09 The Trustees Of The University Of Pennsylvania Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
ES2963718T3 (es) 2014-01-21 2024-04-01 Novartis Ag Capacidad presentadora de antígenos de células CAR-T potenciada mediante introducción conjunta de moléculas co-estimuladoras
ES2939542T3 (es) 2014-01-31 2023-04-24 Factor Bioscience Inc Métodos y productos para la producción y la administración de ácido nucleico
JP6737778B2 (ja) 2014-10-01 2020-08-12 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗原およびアジュバントとしてのインターロイキン−２１を有するワクチン
CN107106670A (zh) 2014-10-31 2017-08-29 宾夕法尼亚大学董事会 用于修饰的t细胞的方法和组合物
KR102546296B1 (ko) 2014-10-31 2023-06-21 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 변형된 t 세포에서 유전자 발현의 변경 및 그의 용도
CA2966035A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding t cells
CN107106531A (zh) 2014-11-26 2017-08-29 于保法 微创精准个体化肿瘤内化学诱导免疫治疗方法半抗原增强的化学免疫治疗
DK3242947T3 (da) * 2015-01-09 2020-08-03 Oncosec Medical Inc Genterapi og elektroporese til behandling af maligniteter
CA2974956A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
CA2975147C (en) 2015-01-31 2025-06-10 The Trustees Of The University Of Pennsylvania COMPOSITIONS AND METHODS OF ADMINISTRATION OF THERAPEUTIC MOLECULES TO T CELLS
EP3256585A4 (de) 2015-02-13 2018-08-15 Factor Bioscience Inc. Nukleinsäureprodukte und verabreichungsverfahren dafür
WO2016168601A1 (en) 2015-04-17 2016-10-20 Khalid Shah Agents, systems and methods for treating cancer
EP4088732A1 (de) 2015-05-01 2022-11-16 The Regents of The University of California Glycan-abhängige immuntherapeutische moleküle
US11649435B2 (en) 2015-08-28 2023-05-16 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
JP6292705B2 (ja) 2016-02-22 2018-03-14 公益財団法人東京都医学総合研究所 エレクトロポレーション用電極
EP3432924A1 (de) 2016-03-23 2019-01-30 Novartis AG Zellsekretierte minikörper und verwendungen davon
EP4570825A3 (de) 2016-04-29 2025-09-03 Inovio Pharmaceuticals, Inc. In-vivo-verwendung von chondroitinase und/oder hyaluronidase zur verbesserung der abgabe eines wirkstoffs
CA3029260A1 (en) 2016-06-27 2018-01-04 Gala Therapeutics, Inc. Generator and a catheter with an electrode and a method for treating a lung passageway
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
CN116115629A (zh) 2016-08-17 2023-05-16 菲克特生物科学股份有限公司 核酸产品及其施用方法
US9935395B1 (en) 2017-01-23 2018-04-03 Cadwell Laboratories, Inc. Mass connection plate for electrical connectors
US11827705B2 (en) 2017-03-28 2023-11-28 The Trustees Of The University Of Pennsylvania Methods to protect transplanted tissue from rejection
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
SG11202006666XA (en) 2017-11-27 2020-08-28 Prostacare Pty Ltd An apparatus and a method for the treatment of a prostatic disease
EP4218641B1 (de) 2017-12-26 2025-05-07 Galvanize Therapeutics, Inc. Optimierung der energieabgabe für verschiedene anwendungen
JP7372920B2 (ja) 2017-12-29 2023-11-01 セレクティス Ｃａｒ ｔ細胞の作製を改良するための方法
AU2019222659B2 (en) 2018-02-13 2024-04-04 Nanovis, LLC Inactivating bacteria with electric pulses and antibiotics
US11224474B2 (en) 2018-02-28 2022-01-18 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for BPH
WO2019177987A1 (en) * 2018-03-13 2019-09-19 Pulse Biosciences, Inc. Moving electrodes for the application of electrical therapy within a tissue
US11992339B2 (en) 2018-05-04 2024-05-28 Cadwell Laboratories, Inc. Systems and methods for dynamic neurophysiological stimulation
US11253182B2 (en) 2018-05-04 2022-02-22 Cadwell Laboratories, Inc. Apparatus and method for polyphasic multi-output constant-current and constant-voltage neurophysiological stimulation
AU2019269601A1 (en) 2018-05-17 2020-11-26 Regents Of The University Of Minnesota Drug-resistant immune cells and methods of use thereof
US11443649B2 (en) 2018-06-29 2022-09-13 Cadwell Laboratories, Inc. Neurophysiological monitoring training simulator
US12497611B2 (en) 2018-08-17 2025-12-16 Yale University Compositions and methods for high-throughput activation screening to boost T cell effector function
US20220170097A1 (en) 2018-10-29 2022-06-02 The Broad Institute, Inc. Car t cell transcriptional atlas
US12226148B2 (en) 2018-11-05 2025-02-18 Region Hovedstaden V/Herlev Hospital Electrode assembly for improved electric field distribution
JP7260933B2 (ja) * 2019-02-04 2023-04-19 ラトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー 微小電極を使用する組織電気泳動転写用デバイス
US12534714B2 (en) 2019-03-18 2026-01-27 The Broad Institute, Inc. Type VII CRISPR proteins and systems
CN120944827A (zh) 2019-03-27 2025-11-14 宾夕法尼亚大学董事会 Tn-MUC1嵌合抗原受体(CAR)T细胞疗法
EP3997059A4 (de) 2019-07-03 2023-12-13 Factor Bioscience Inc. Kationische lipide und ihre verwendungen
CA3147592A1 (en) 2019-07-16 2021-01-21 Galary, Inc. Treatment of the reproductive tract with pulsed electric fields
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
WO2021074695A1 (en) 2019-10-16 2021-04-22 Avacta Life Sciences Limited PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
EP4048796B1 (de) 2019-10-23 2025-08-27 Yale University Zusammensetzungen und verfahren mit viralen vektorsystemen zur multiplexierten aktivierung endogener gene als immuntherapie und immun-gentherapie auf viraler basis
PE20230171A1 (es) 2020-02-25 2023-02-01 Inovio Pharmaceuticals Inc Vacunas contra el coronavirus y metodos de uso
EP4114860A1 (de) 2020-03-06 2023-01-11 Go Therapeutics, Inc. Anti-glyco-cd44-antikörper und deren verwendungen
CN111317558A (zh) * 2020-03-12 2020-06-23 北京三春晖医疗器械有限公司 一种运用超高压正负复合脉冲电场的肿瘤消融设备
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
US20210322471A1 (en) 2020-03-27 2021-10-21 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
PH12022553102A1 (en) 2020-05-14 2023-11-20 Inovio Pharmaceuticals Inc Vaccines for recurrent respiratory papillomatosis and methods of using the same
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
EP4165183A1 (de) 2020-06-12 2023-04-19 University of Rochester Codierung und expression von ace-trnas
AU2021302958A1 (en) 2020-06-30 2023-02-16 Mendus B.V. Use of leukemia-derived cells in ovarian cancer vaccines
EP4210832A1 (de) 2020-09-14 2023-07-19 Vor Biopharma, Inc. Chimäre antigenrezeptoren zur behandlung von krebs
CA3196677A1 (en) 2020-11-05 2022-05-12 Erik Hans MANTING Use of tumor-independent antigens in immunotherapies
US12397055B2 (en) 2021-01-22 2025-08-26 Mendus B.V. Methods of tumor vaccination
US20250326855A1 (en) 2021-03-05 2025-10-23 Go Therapeutics, Inc. Anti-glyco-cd44 antibodies and their uses
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
JP2024528086A (ja) 2021-07-29 2024-07-26 ブイオーアール バイオファーマ インコーポレーテッド がん治療用キメラ抗原受容体
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
CA3228178A1 (en) 2021-08-05 2023-02-09 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
EP4384642A4 (de) 2021-08-13 2025-10-22 Inovio Pharmaceuticals Inc Kombinationstherapie zur behandlung von hirnkrebs
US20250066498A1 (en) 2021-09-03 2025-02-27 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
WO2023034569A1 (en) 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-cmet antibodies and their uses
CA3243439A1 (en) 2022-02-07 2023-08-10 University Of Rochester SEQUENCES OPTIMIZED FOR ENHANCED DNA EXPRESSION AND/OR NONSENSE MUTATION DELETION
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
KR102789925B1 (ko) * 2022-06-09 2025-04-04 김경수 전파를 이용한 환자 치료 정보를 제공하는 방법
EP4634373A1 (de) 2022-12-16 2025-10-22 University of Rochester Reparatur von dysfunktion der barriere in der speiseröhre
EP4461803A1 (de) * 2023-05-11 2024-11-13 Cellectis S.A. Modulares elektroporationsverfahren und system
WO2024236547A1 (en) 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
WO2025046513A1 (en) 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function
WO2026047626A1 (en) 2024-08-30 2026-03-05 Inceptor Bio, Llc Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1099062A (en) * 1913-12-10 1914-06-02 Peter P Laposkey Electric scalp appliance.
DE863111C (de) * 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
US4116238A (en) * 1976-08-18 1978-09-26 Midgard Electronics Company, Inc. High voltage constant current source for iontophoresis
US4528265A (en) * 1982-05-11 1985-07-09 Becker Robert O Processes and products involving cell modification
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
ATE131081T1 (de) 1988-01-21 1995-12-15 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
US4955378A (en) 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
WO1989010690A1 (en) * 1988-05-02 1989-11-16 University Of South Florida Method for electrofusing biological particles to tissues
ES2012944A6 (es) * 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) * 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
IL132103A0 (en) * 1997-04-03 2001-03-19 Eletrofect As Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template

Also Published As

Publication number Publication date
US5993434A (en) 1999-11-30
EP0874663B1 (de) 1999-09-29
DE69604509T2 (de) 2000-01-13
AU5925996A (en) 1996-12-24
ES2140096T3 (es) 2000-02-16
DE69604509D1 (de) 1999-11-04
US20030009148A1 (en) 2003-01-09
CN1187145A (zh) 1998-07-08
US6567694B2 (en) 2003-05-20
US20020198485A1 (en) 2002-12-26
CA2218255C (en) 2001-11-20
US6763264B2 (en) 2004-07-13
US6418341B1 (en) 2002-07-09
US20030097089A1 (en) 2003-05-22
CN1150950C (zh) 2004-05-26
EP0874663A1 (de) 1998-11-04
AU702054B2 (en) 1999-02-11
KR19990021949A (ko) 1999-03-25
US6451002B1 (en) 2002-09-17
JPH11506630A (ja) 1999-06-15
KR100260238B1 (ko) 2000-07-01
WO1996039226A1 (en) 1996-12-12
US6569149B2 (en) 2003-05-27
CA2218255A1 (en) 1996-12-12
GR3031963T3 (en) 2000-03-31

Similar Documents

Publication Publication Date Title
ATE185083T1 (de) Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation
CA2288785C (en) Bio-active frequency generator and method having replaceable memories
DE69324680D1 (de) Elektrische stimulierung zur behandlung von inkontinenz und anderen neuromuskularerkrankungen
NZ504026A (en) Methods for treating hypercoagulable states or acquired protein C deficiency using human-activated protein C
ATE480294T1 (de) Gerät zur verabreichung von medikamenten und genen mittels elektroporation
ATE114118T1 (de) System zur verabreichung von medikamenten durch ein zweistufiges iontophoresenverfahren.
DE69114442D1 (de) Verfahren und Gerät zur Rhythmuskorrektur und Stimulation des Herzens in Abhängigkeit von Neurosignalen.
ATE427771T1 (de) Vorrichtung zur mehrstellenbehandlung von tachykardien
DE69504705D1 (de) Vorrichtung zur verabreichung von medikamenten durch elektrotransport
ES2012944A6 (es) Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
DE69732489D1 (de) Ausdehnbare vorrichtung zur behandlung von tumoren
ATE255128T1 (de) Peptid-immitierende substanzen in der krebstherapie
ATE490800T1 (de) System zur modifikation von neuralem gewebe
ATE52927T1 (de) Geraet zur elektrostimulation von nerven und muskeln.
NZ513404A (en) Iontophoresis, electroporation and combination patches for local drug delivery
DE69733954D1 (de) Diagnostizierverfahren und -geräte für therapeutische vorrichtungen
KR890003416A (ko) 저주파 치료기
ATE116140T1 (de) Vorrichtung zur elektrostimulation.
ATE442184T1 (de) Vorrichtung zur iontophoretischen, transdermalen verabreichung von fentanyl und sufentanil
ATE220923T1 (de) Rekombinante adenoviren und deren verwendung in der gentherapie zur behandlung von augenerkrankungen
ATE226094T1 (de) Verfahren zur arzneistoffabgabe mittels gentherapie
RU95118746A (ru) Способ лечения больных токсикоманиями
DE3789257D1 (de) Tragbares Elektrotherapiesystem.
DE69205307D1 (de) Vorrichtung zum Behandeln von Akupunkturpunkten mittels elektrischen Feldern und Medikamentenionen.
MX9708316A (es) Metodo de tratamiento utilizando administracion de farmacos genes por medio de electroporacion.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee