ATE185083T1 - Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation - Google Patents

Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation

Info

Publication number
ATE185083T1
ATE185083T1 AT96916550T AT96916550T ATE185083T1 AT E185083 T1 ATE185083 T1 AT E185083T1 AT 96916550 T AT96916550 T AT 96916550T AT 96916550 T AT96916550 T AT 96916550T AT E185083 T1 ATE185083 T1 AT E185083T1
Authority
AT
Austria
Prior art keywords
electroporation
medications
genes
administration
tumors
Prior art date
Application number
AT96916550T
Other languages
English (en)
Inventor
Gunter A Hofmann
Richard A Gilbert
Yosuhiko Hayakawa
Richard Heller
Mark J Jaroszeski
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/467,566 external-priority patent/US5702359A/en
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ATE185083T1 publication Critical patent/ATE185083T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Electromagnetism (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT96916550T 1995-06-06 1996-05-22 Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation ATE185083T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,566 US5702359A (en) 1995-06-06 1995-06-06 Needle electrodes for mediated delivery of drugs and genes
US08/537,265 US5993434A (en) 1993-04-01 1995-09-29 Method of treatment using electroporation mediated delivery of drugs and genes

Publications (1)

Publication Number Publication Date
ATE185083T1 true ATE185083T1 (de) 1999-10-15

Family

ID=27042102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916550T ATE185083T1 (de) 1995-06-06 1996-05-22 Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation

Country Status (12)

Country Link
US (6) US5993434A (de)
EP (1) EP0874663B1 (de)
JP (1) JPH11506630A (de)
KR (1) KR100260238B1 (de)
CN (1) CN1150950C (de)
AT (1) ATE185083T1 (de)
AU (1) AU702054B2 (de)
CA (1) CA2218255C (de)
DE (1) DE69604509T2 (de)
ES (1) ES2140096T3 (de)
GR (1) GR3031963T3 (de)
WO (1) WO1996039226A1 (de)

Families Citing this family (297)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
EA002087B1 (ru) * 1997-04-03 2001-12-24 Электрофект Ас Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
ATE290403T1 (de) 1997-06-30 2005-03-15 Roussy Inst Gustave Verbesserung der verabreichung der nukleinsäure in zellen der plurizellulären eukaryotischen organismen und kombination zur durchführung des verfahrens
JP2002507985A (ja) * 1997-06-30 2002-03-12 ローヌ−プーラン・ロレ・エス・アー 横紋筋に核酸を導入する改良法およびその組合せ
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
SE9704076D0 (sv) 1997-11-06 1997-11-06 Holdingbolaget Vid Goeteborgs Method for permeabilisation of cell structures and use thereof
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
FR2773326B3 (fr) * 1998-01-06 2000-05-12 Michel Siros Dispositif d'aide a un traitement de cellules vivantes dans un milieu donne
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
DK1100576T3 (da) * 1998-06-26 2007-12-03 Genetronics Inc Synergisme af fotodynamisk effekt og elektropermeringseffekt på cellevitalitet som nyt cytotoksisk middel
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
JP2002520101A (ja) 1998-07-13 2002-07-09 ジェネトロニクス、インコーポレーテッド 電気的に補助される化粧用薬剤の局部送達法および装置
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
JP2003505114A (ja) 1998-07-13 2003-02-12 ジェネトロニクス、インコーポレーテッド パルス電場による皮膚および筋肉を標的とした遺伝子治療
GB9817078D0 (en) 1998-08-05 1998-10-07 Habib Nagy A Device for liver surgery
EP1109594B1 (de) 1998-08-31 2004-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
US6314316B1 (en) * 1998-12-17 2001-11-06 University Of South Florida Nonpenetrating electroporation device and method
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
DE60007290T2 (de) 1999-01-28 2004-09-23 Cyto Pulse Sciences, Inc. Einbringen von makromolekülen in zellen
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
CA2368728A1 (en) 1999-03-25 2000-09-28 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
WO2000062857A1 (en) 1999-04-16 2000-10-26 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6514762B1 (en) 1999-04-23 2003-02-04 New Mexico State University Technology Transfer Corporation Delivery of nucleotides by electrochemical release
CN1068525C (zh) * 1999-04-23 2001-07-18 孙才均 热针电化学肿瘤治疗装置
WO2000067837A1 (en) 1999-05-10 2000-11-16 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
US7074747B1 (en) * 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
AU5764800A (en) 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
ATE283092T1 (de) * 1999-12-15 2004-12-15 Univ South Florida Vorrichtung zur elektroporation
WO2001048180A2 (en) * 1999-12-22 2001-07-05 Innovation And Development Corporation Method and apparatus for targeting localised electroporation
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
DE60112886T2 (de) 2000-01-07 2006-06-14 Biowave Corp Elektrotherapiegerät
US7927612B2 (en) * 2000-01-19 2011-04-19 Baofa Yu Combinations and methods for treating neoplasms
JP4740503B2 (ja) * 2000-01-27 2011-08-03 株式会社モレニアムラボラトリーズ 分子導入装置及び分子導入方法
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7588554B2 (en) * 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
US6846306B1 (en) * 2000-10-10 2005-01-25 Cold Spring Harbor Laboratory Single cell electroporation
SE0003841D0 (sv) * 2000-10-20 2000-10-20 Daniel Chiu A method and apparatus for penetration of lipid bilayer membranes
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002055127A2 (en) * 2000-11-24 2002-07-18 Ckm Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
US7101703B2 (en) * 2001-03-09 2006-09-05 Cornell Research Foundation, Inc. Electrofusion microelectrode
US20030170642A1 (en) * 2001-03-12 2003-09-11 Irm, Llc Identification of cellular targets for biologically active molecules
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US6936469B2 (en) * 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
DE60238119D1 (de) 2001-06-12 2010-12-09 Pelikan Technologies Inc Elektrisches betätigungselement für eine lanzette
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
JP4209767B2 (ja) 2001-06-12 2009-01-14 ペリカン テクノロジーズ インコーポレイテッド 皮膚の性状の一時的変化に対する適応手段を備えた自動最適化形切開器具
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
CA2468511A1 (en) 2001-11-27 2003-06-05 Kerstin Nolkrantz A method for combined sequential agent delivery and electroporation for cell structures and use thereof
US20030170898A1 (en) * 2001-12-04 2003-09-11 Gundersen Martin A. Method for intracellular modifications within living cells using pulsed electric fields
WO2003070905A2 (en) * 2002-02-15 2003-08-28 Zycos, Inc. Electroporation methods for introducing bioactive agents into cells
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
DE10212008A1 (de) * 2002-03-18 2003-10-09 Aventis Behring Gmbh Nadelhalter
US6912417B1 (en) 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
US20060089674A1 (en) 2002-04-16 2006-04-27 Walters Richard E Method of treating biological materials with translating electrical fields and electrode polarity reversal
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) * 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US20030198625A1 (en) * 2002-04-19 2003-10-23 Genteric, Inc. Electroporation-mediated transfection of the salivary gland
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) * 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
AU2003299471A1 (en) * 2002-05-07 2004-05-13 Kai Kroll Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US10130415B2 (en) * 2002-06-10 2018-11-20 Wisconsin Alumni Research Foundation Circumferential electrode array for tissue ablation
US20070265582A1 (en) * 2002-06-12 2007-11-15 University Of Southern California Injection Devices for Unimpeded Target Location Testing
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
DE60332377D1 (de) 2002-10-21 2010-06-10 Eisai Inc Zusammensetzungen und verfahren zurbehandlung von krankheiten, die durch das humane papillomavirus vermitteltwerden
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
RU2334506C2 (ru) * 2003-01-29 2008-09-27 И-Пилл Фарма Лтд. Активная доставка лекарственного средства в желудочно-кишечном тракте
WO2004107975A2 (en) 2003-05-30 2004-12-16 Pelikan Technologies, Inc. Method and apparatus for fluid injection
EP1633235B1 (de) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Gerät für die entnahme von körperflüssigkeiten und analyten-nachweis
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US7521224B2 (en) * 2003-09-30 2009-04-21 The United States Of America As Represented By The Secretary Of The Navy Microelectronic cell electroporation array
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
EP1729848B1 (de) 2004-03-08 2015-04-29 Ichor Medical Systems Inc. Verbessertes gerät für die elektrisch vermittelte abgabe von therapeutika
JP2005278480A (ja) * 2004-03-29 2005-10-13 Fujitsu Ltd 物質導入装置及び物質導入用チップ
EP2301471A1 (de) 2004-04-01 2011-03-30 The General Hospital Corporation Verfahren und Vorrichtung zur dermatologischen Behandlung und Gewebeneuformung
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
JP4504082B2 (ja) * 2004-04-28 2010-07-14 富士通株式会社 液体注入装置
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
US7212865B2 (en) * 2004-05-25 2007-05-01 Philip Cory Nerve stimulator and method
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
WO2005120365A1 (en) 2004-06-03 2005-12-22 Pelikan Technologies, Inc. Method and apparatus for a fluid sampling device
US6897069B1 (en) 2004-06-08 2005-05-24 Ambion, Inc. System and method for electroporating a sample
US20070167903A1 (en) * 2004-06-11 2007-07-19 University Of South Florida Nervous Tissue Electrode Device
MXPA06014461A (es) * 2004-06-12 2007-05-23 Digital Biotechnology Co Ltd Electroporador que tiene un miembro hueco alargado.
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
EP1786514B1 (de) * 2004-06-24 2015-01-07 Sphergen Vorrichtung zum transfer von molekülen zu zellen unter verwendung von elektrischer energie
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
JP2006102255A (ja) * 2004-10-06 2006-04-20 Nippon Sherwood Medical Industries Ltd 輸液ラインの接続構造及びその接続構造を備えたコネクター
WO2006063301A1 (en) * 2004-12-10 2006-06-15 Maxcyte, Inc. Genetically modified tumor cells as cancer vaccines
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
GB0502384D0 (en) * 2005-02-04 2005-03-16 Instrumedical Ltd Electro-surgical needle apparatus
WO2007012907A2 (en) * 2005-02-08 2007-02-01 Allen, John Electric therapy machine
KR20080015845A (ko) * 2005-05-19 2008-02-20 이-필 파마 리미티드 조직에서 산화질소를 생성하기 위한 섭취가능한 디바이스
LT2816118T (lt) 2005-05-31 2018-12-10 The Regents Of The University Of Colorado, A Body Corporate Genų pristatymo būdai
US7933648B2 (en) * 2005-07-21 2011-04-26 Naim Erturk Tanrisever High voltage transcutaneous electrical stimulation device and method
US7647122B2 (en) * 2005-07-26 2010-01-12 Medtronic, Inc. Surgical needle driver
DE102005062933A1 (de) * 2005-08-24 2007-03-22 Triton Gmbh Verfahren zur Behandlung von eine Zellstruktur aufweisenden Rohstoffen in der fleisch-, fleischnebenprodukte-, fisch- und seafoodverarbeitenden Nahrungsmittelindustrie
US20070083075A1 (en) * 2005-10-12 2007-04-12 Moshe Ein-Gal Method and apparatus for applying energy to tissues
US20070142885A1 (en) * 2005-11-29 2007-06-21 Reliant Technologies, Inc. Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue
WO2007120234A2 (en) * 2005-12-07 2007-10-25 Genetronics, Inc Variable volume electroporation chamber and methods therefore
US7915044B2 (en) * 2005-12-22 2011-03-29 Cornell Research Foundation, Inc. Electrofusion microelectrode and methods of using it to manipulate cells and/or cellular components
JP4614451B2 (ja) * 2005-12-26 2011-01-19 日本シャーウッド株式会社 医療用縫合具
CN103736165B (zh) * 2006-02-09 2017-05-10 德卡产品有限公司 流体分配器件、流体流的测量方法和系统及流体输送系统
CA3063263C (en) * 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation
DK1991303T3 (da) 2006-03-03 2021-06-07 Oncosec Medical Inc Fremgangsmåde og anordning til behandling af mikroskopiske resttumorer i væv, der er tilbage efter kirurgisk resektion
WO2007123142A1 (ja) * 2006-04-20 2007-11-01 Tti Ellebeau, Inc. イオントフォレーシス装置
US20080139989A1 (en) * 2006-12-11 2008-06-12 Stanley Kim Hemodialysis needle device having multiple needles mounted on a needle hub
US20070276425A1 (en) * 2006-05-29 2007-11-29 Stanley Kim Painless Blood Sampling Lancet with Bundled Multiple Thin Needles
US20080119797A1 (en) * 2006-11-20 2008-05-22 Stanley Kim System with a syringe device and a needle device
ATE518484T1 (de) * 2006-05-31 2011-08-15 Covidien Ag Medizinisches nahtinstrument mit greifvorrichtung
AU2007260354B2 (en) * 2006-06-12 2014-01-23 Region Hovedstaden V/Herlev Hospital Electrode introducer device
CN101138634A (zh) 2006-09-07 2008-03-12 于保法 用于治疗肿瘤的组合物
JP4536698B2 (ja) * 2006-10-05 2010-09-01 日本シャーウッド株式会社 医療用縫合具
WO2008052198A2 (en) * 2006-10-26 2008-05-02 Reliant Technologies, Inc. Methods of increasing skin permeability by treatment with electromagnetic radiation
DK2548438T3 (en) 2006-11-08 2015-10-19 Veritas Bio LLC IN VIVO SUBMITTING DOUBLE-STRENGTH RNA TO A CELL
JP4565576B2 (ja) * 2007-02-20 2010-10-20 日本シャーウッド株式会社 穿刺針補助具
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
CN103083794B (zh) 2007-08-14 2016-03-02 弗雷德哈钦森癌症研究中心 用于递送治疗药物的针阵列组件和方法
DE102008008614A1 (de) 2008-02-12 2009-08-13 Leibniz-Institut für Plasmaforschung und Technologie e.V. Plama-Gerät zur selektiven Behandlung elektroporierter Zellen
CA2720166A1 (en) * 2008-04-04 2009-10-08 David B. Weiner Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
CN105535961A (zh) 2008-04-04 2016-05-04 宾夕法尼亚大学托管会 使用il-28和组合物的疫苗和免疫治疗及其使用方法
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
KR101084528B1 (ko) 2008-04-15 2011-11-18 인비트로겐 싱가포르 피티이. 엘티디. 전기천공 장치용 파이펫 팁
WO2009137609A2 (en) 2008-05-06 2009-11-12 Cellutions, Inc. Apparatus and systems for treating a human tissue condition
JP5185706B2 (ja) * 2008-06-24 2013-04-17 日本コヴィディエン株式会社 穿刺針補助具
US10736689B2 (en) 2008-08-20 2020-08-11 Prostacare Pty Ltd Low-corrosion electrode for treating tissue
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
WO2010129899A1 (en) * 2009-05-08 2010-11-11 Cellutions, Inc. Treatment system with a pulse forming network for achieving plasma in tissue
EP3488837B1 (de) * 2009-07-15 2024-11-27 NewSouth Innovations Pty Limited Elektroporationsvorrichtung zur verabreichung von mitteln in die hörschnecke
DE102009028462A1 (de) 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas
CN102821790A (zh) 2009-09-14 2012-12-12 宾夕法尼亚大学托管会 包含IL-15受体α和/或编码IL-15受体α的核酸分子的疫苗和免疫治疗剂,以及其使用方法
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
CA2810514C (en) * 2010-09-09 2021-05-04 Old Dominion University Research Foundation Multi-electrode electrical pulse delivery system for treatment of biological tissues
CA2809360A1 (en) 2010-09-27 2012-04-05 China Agricultural University Combined antigen and dna vaccine for preventing and treating autoimmune diseases
EP2670426B1 (de) 2011-01-31 2017-05-10 The General Hospital Corporation Multimodale trail-moleküle und ihre verwendungen in zelltherapien
CN102631243B (zh) * 2011-02-15 2014-09-17 成功大学 电磁热疗法的治疗器具
WO2012158132A1 (en) 2011-05-18 2012-11-22 Eteka Llc Apparatus for the enhancement of food properties by electroporation or pulsed electric fields
KR20140068000A (ko) 2011-06-15 2014-06-05 크론테크 파마 아베 주사 바늘 및 장치
CN102284132A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于多针形电极的高压脉冲电场治疗装置
CN102284135A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于单针形电极的高压脉冲电场治疗装置
KR101955365B1 (ko) 2011-07-12 2019-03-07 필라델피아 헬스 앤드 에듀케이션 코포레이션 디/비/에이 드렉셀 유니버시티 컬리지 오브 메디슨 신규한 클로스트리듐 디피실(Clostridium Difficile) DNA 백신
BR112014006176A8 (pt) 2011-09-16 2017-09-12 Univ Pennsylvania Rna transcrito in vitro ou rna sintético, composição, método para gerar uma população de células t geneticamente modificadas por rna, e, uso de uma célula t geneticamente modificada
US9708384B2 (en) 2011-09-22 2017-07-18 The Trustees Of The University Of Pennsylvania Universal immune receptor expressed by T cells for the targeting of diverse and multiple antigens
SG11201401851UA (en) 2011-10-28 2014-05-29 Presage Biosciences Inc Methods for drug delivery
WO2013063419A2 (en) 2011-10-28 2013-05-02 The Trustees Of The University Of Pennsylvania A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
CN104168912B (zh) 2011-11-10 2016-08-24 北京艾棣维欣生物技术有限公司 促进剂-dna组合疫苗
US20130197425A1 (en) * 2011-12-16 2013-08-01 The Regents Of The University Of California Current cage for reduction of a non-target tissue exposure to electric fields in electroporation based treatment
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
EP2817331B1 (de) 2012-02-22 2023-08-30 The Trustees of the University of Pennsylvania Verwendung der cd2-signalisierungsdomäne bei chimären antigenrezeptoren der zweiten generation
EA201491574A1 (ru) 2012-02-22 2014-12-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Применение car, основанных на icos, для усиления противоопухолевой активности и длительного сохранения car
US11318009B2 (en) * 2012-05-04 2022-05-03 Lipocosm, Llc Surgical tools and methods for their use
MX2015000426A (es) 2012-07-13 2015-07-14 Univ Pennsylvania Incremento de actividad de celulas t car mediante cointroduccion de un anticuerpo biespecifico.
US9144459B2 (en) 2012-07-19 2015-09-29 Cook Medical Technologies Llc Endoscopic ultrasound ablation needle
US9605074B2 (en) 2012-08-30 2017-03-28 The General Hospital Corporation Multifunctional nanobodies for treating cancer
EP2904106A4 (de) 2012-10-01 2016-05-11 Univ Pennsylvania Zusammensetzungen und verfahren zum anzielung von stromazellen zur behandlung von krebs
US9598489B2 (en) 2012-10-05 2017-03-21 The Trustees Of The Univeristy Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
EP3782640A1 (de) 2012-12-13 2021-02-24 The Trustees Of The University Of Pennsylvania Wt1-impfstoff
EP2968606B1 (de) 2013-03-15 2020-10-07 Loma Linda University Behandlung von autoimmunerkrankungen
US10098585B2 (en) 2013-03-15 2018-10-16 Cadwell Laboratories, Inc. Neuromonitoring systems and methods
JP6649250B2 (ja) 2013-05-21 2020-02-19 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 操作されたヘム結合性構成物およびその使用
US10272144B2 (en) 2013-07-31 2019-04-30 Bioventures, Llc Compositions for and methods of treating and preventing targeting tumor associated carbohydrate antigens
CN111012905B (zh) 2013-10-07 2023-12-22 宾夕法尼亚大学理事会 具有作为佐剂的白介素-33的疫苗
US20160256539A1 (en) 2013-11-14 2016-09-08 The Trustees Of The University Of Pennsylvania HIV-1 ENV DNA Vaccine Plus Protein Boost Delivered by EP Expands B- and T-Cell Response and Neutralizing
CN105939730B (zh) 2013-11-29 2020-09-11 宾夕法尼亚大学理事会 MERS-CoV疫苗
KR20220062143A (ko) 2014-01-06 2022-05-13 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Pd1 및 pdl1 항체 및 백신 조합 및 면역요법을 위한 이들의 사용
EP3097117B1 (de) 2014-01-21 2023-10-04 Novartis Ag Verbessertes antigen mit car-t-zellfähigkeit durch co-einführung von co-stimulatorischen molekülen
ES2939542T3 (es) 2014-01-31 2023-04-24 Factor Bioscience Inc Métodos y productos para la producción y la administración de ácido nucleico
JP6737778B2 (ja) 2014-10-01 2020-08-12 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗原およびアジュバントとしてのインターロイキン−２１を有するワクチン
WO2016069993A1 (en) 2014-10-31 2016-05-06 The Trustees Of The University Of Pennsylvania Compositions and methods of stimulating and expanding t cells
EP3212225B1 (de) 2014-10-31 2025-11-19 The Trustees of the University of Pennsylvania Verfahren und zusammensetzungen für modifizierte t-zellen
CN107206024B (zh) 2014-10-31 2021-12-03 宾夕法尼亚大学董事会 改变cart细胞中的基因表达及其用途
SG11201704175WA (en) 2014-11-26 2017-06-29 Baofa Yu Hapten-enhanced chemoimmunotherapy by ultra-minimum incision personalized intratumoral chemoimmunotherapy
EP3799879B1 (de) * 2015-01-09 2025-06-04 Grand Decade Developments Limited Gentherapie mit co-stimulierende moleküle und cytokine zur behandlung von malignomen
ES2929532T3 (es) 2015-01-29 2022-11-30 Univ Pennsylvania Combinaciones de inhibidores de puntos de control y vacunas y su uso en inmunoterapia
WO2016122738A1 (en) 2015-01-31 2016-08-04 The Trustees Of The University Of Pennsylvania Compositions and methods for t cell delivery of therapeutic molecules
EP4406585A3 (de) 2015-02-13 2024-10-23 Factor Bioscience Inc. Nukleinsäureprodukte und verfahren zur verabreichung davon
WO2016168601A1 (en) 2015-04-17 2016-10-20 Khalid Shah Agents, systems and methods for treating cancer
RU2754661C2 (ru) 2015-05-01 2021-09-06 Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния Гликанзависимые иммунотерапевтические молекулы
US11649435B2 (en) 2015-08-28 2023-05-16 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
CN108778400B (zh) 2016-02-22 2022-02-25 公益财团法人东京都医学综合研究所 电穿孔用电极
WO2017165683A1 (en) 2016-03-23 2017-09-28 Novartis Ag Cell secreted minibodies and uses thereof
WO2017190147A1 (en) 2016-04-29 2017-11-02 Inovio Pharmaceuticals, Inc. The in vivo use of chondroitinase and/or hyaluronidase to enhance delivery of an agent
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
EP3474760B1 (de) 2016-06-27 2023-01-11 Galvanize Therapeutics, Inc. Generator und ein katheter mit einer elektrode zur behandlung eines lungengangs
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
CN109803977B (zh) 2016-08-17 2023-03-17 菲克特生物科学股份有限公司 核酸产品及其施用方法
US9935395B1 (en) 2017-01-23 2018-04-03 Cadwell Laboratories, Inc. Mass connection plate for electrical connectors
JP7618192B2 (ja) 2017-03-28 2025-01-21 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 移植された組織を拒絶反応から保護するための方法
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
SG11202006666XA (en) 2017-11-27 2020-08-28 Prostacare Pty Ltd An apparatus and a method for the treatment of a prostatic disease
JP2021508533A (ja) 2017-12-26 2021-03-11 ギャラリー，インコーポレイテッド 様々な用途のためのエネルギー送達の最適化
CA3086267A1 (en) 2017-12-29 2019-07-04 Cellectis Method for improving production of car t cells
WO2019160897A1 (en) 2018-02-13 2019-08-22 Purdue Research Foundation Inactivating bacteria with electric pulses and antibiotics
US11224474B2 (en) 2018-02-28 2022-01-18 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for BPH
WO2019177987A1 (en) * 2018-03-13 2019-09-19 Pulse Biosciences, Inc. Moving electrodes for the application of electrical therapy within a tissue
US11253182B2 (en) 2018-05-04 2022-02-22 Cadwell Laboratories, Inc. Apparatus and method for polyphasic multi-output constant-current and constant-voltage neurophysiological stimulation
US11992339B2 (en) 2018-05-04 2024-05-28 Cadwell Laboratories, Inc. Systems and methods for dynamic neurophysiological stimulation
SG11202011146TA (en) 2018-05-17 2020-12-30 Univ Minnesota Drug-resistant immune cells and methods of use thereof
US11443649B2 (en) 2018-06-29 2022-09-13 Cadwell Laboratories, Inc. Neurophysiological monitoring training simulator
WO2020037142A1 (en) 2018-08-17 2020-02-20 Yale University Compositions and methods for high-throughput activation screening to boost t cell effector function
US20220170097A1 (en) 2018-10-29 2022-06-02 The Broad Institute, Inc. Car t cell transcriptional atlas
EP3877039B1 (de) * 2018-11-05 2023-04-05 Region Hovedstaden v/Herlev Hospital Elektrodenanordnung zur verbesserten verteilung eines elektrischen feldes
US12508423B2 (en) 2019-02-04 2025-12-30 Rutgers, The State University Of New Jersey Device for tissue electrotransfer using a microelectrode
US12534714B2 (en) 2019-03-18 2026-01-27 The Broad Institute, Inc. Type VII CRISPR proteins and systems
CN120944827A (zh) 2019-03-27 2025-11-14 宾夕法尼亚大学董事会 Tn-MUC1嵌合抗原受体(CAR)T细胞疗法
AU2020301036A1 (en) 2019-07-03 2022-02-17 Factor Bioscience Inc. Cationic lipids and uses thereof
JP7586890B2 (ja) 2019-07-16 2024-11-19 ガルヴァナイズ セラピューティクス，インコーポレイテッド パルス電界による生殖器の治療
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
TW202128775A (zh) 2019-10-16 2021-08-01 英商阿法克塔生命科學有限公司 PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
US20220387626A1 (en) 2019-10-23 2022-12-08 Yale University Compositions and methods comprising viral vector systems for multiplexed activation of endogenous genes as immunotherapy and viral-based immune-gene therapy
CU24743B1 (es) 2020-02-25 2025-03-10 Inovio Pharmaceuticals Inc Composiciones inmunogénicas contra el coronavirus
EP4114860A1 (de) 2020-03-06 2023-01-11 Go Therapeutics, Inc. Anti-glyco-cd44-antikörper und deren verwendungen
CN111317558A (zh) * 2020-03-12 2020-06-23 北京三春晖医疗器械有限公司 一种运用超高压正负复合脉冲电场的肿瘤消融设备
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
EP4125943A1 (de) 2020-03-27 2023-02-08 Mendus B.V. In-vivo-verwendung von modifizierten zellen leukämischen ursprungs zur verbesserung der wirksamkeit einer adoptiven zelltherapie
US11744885B2 (en) 2020-05-14 2023-09-05 Inovio Pharmaceuticals, Inc. Vaccines for recurrent respiratory papillomatosis and methods of using the same
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
IL298874A (en) 2020-06-12 2023-02-01 Univ Rochester ENCODING AND EXPRESSION OF ACE-tRNAs
JP2023531537A (ja) 2020-06-30 2023-07-24 メンドゥス・ベスローテン・フェンノートシャップ 卵巣癌ワクチンでの白血病由来細胞の使用
WO2022056490A1 (en) 2020-09-14 2022-03-17 Vor Biopharma, Inc. Chimeric antigen receptors for treatment of cancer
WO2022097068A1 (en) 2020-11-05 2022-05-12 Dcprime B.V. Use of tumor-independent antigens in immunotherapies
CA3203705A1 (en) 2021-01-22 2022-07-28 Erik Hans MANTING Methods of tumor vaccination
EP4301782A1 (de) 2021-03-05 2024-01-10 Go Therapeutics, Inc. Anti-glyco-cd44-antikörper und deren verwendungen
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
US20250082755A1 (en) 2021-07-29 2025-03-13 Vor Biopharma Inc. Chimeric antigen receptors for treatment of cancer
EP4380604A1 (de) 2021-08-05 2024-06-12 Go Therapeutics, Inc. Anti-glyco-muc4-antikörper und ihre verwendungen
MX2024001948A (es) 2021-08-13 2024-05-17 Inovio Pharmaceuticals Inc Terapia combinada para tratar el cáncer cerebral.
CN118354789A (zh) 2021-09-03 2024-07-16 Go医疗股份有限公司 抗糖-cMET抗体及其用途
US20250066498A1 (en) 2021-09-03 2025-02-27 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
IL314679A (en) 2022-02-07 2024-10-01 Univ Rochester Effective sequences for enhanced tRNA expression and/or enhanced stop mutation suppression
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
KR102789925B1 (ko) * 2022-06-09 2025-04-04 김경수 전파를 이용한 환자 치료 정보를 제공하는 방법
EP4634373A1 (de) 2022-12-16 2025-10-22 University of Rochester Reparatur von dysfunktion der barriere in der speiseröhre
EP4461803A1 (de) * 2023-05-11 2024-11-13 Cellectis S.A. Modulares elektroporationsverfahren und system
WO2024236547A1 (en) 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
WO2025046513A1 (en) 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas
WO2026030209A1 (en) 2024-07-29 2026-02-05 University Of Rochester Use of decoding trnas to boost protein expression or function

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1099062A (en) * 1913-12-10 1914-06-02 Peter P Laposkey Electric scalp appliance.
DE863111C (de) * 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
US4116238A (en) * 1976-08-18 1978-09-26 Midgard Electronics Company, Inc. High voltage constant current source for iontophoresis
US4528265A (en) * 1982-05-11 1985-07-09 Becker Robert O Processes and products involving cell modification
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
DE68925030T2 (de) 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US4955378A (en) 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
WO1989010690A1 (en) * 1988-05-02 1989-11-16 University Of South Florida Method for electrofusing biological particles to tissues
ES2012944A6 (es) * 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) * 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
EA002087B1 (ru) * 1997-04-03 2001-12-24 Электрофект Ас Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template

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AU702054B2 (en) 1999-02-11
EP0874663A1 (de) 1998-11-04
DE69604509D1 (de) 1999-11-04
US20030009148A1 (en) 2003-01-09
US5993434A (en) 1999-11-30
US20030097089A1 (en) 2003-05-22
US6763264B2 (en) 2004-07-13
KR19990021949A (ko) 1999-03-25
US6569149B2 (en) 2003-05-27
JPH11506630A (ja) 1999-06-15
WO1996039226A1 (en) 1996-12-12
US20020198485A1 (en) 2002-12-26
CN1187145A (zh) 1998-07-08
CA2218255A1 (en) 1996-12-12
DE69604509T2 (de) 2000-01-13
AU5925996A (en) 1996-12-24
US6567694B2 (en) 2003-05-20
CN1150950C (zh) 2004-05-26
US6418341B1 (en) 2002-07-09
US6451002B1 (en) 2002-09-17
GR3031963T3 (en) 2000-03-31
ES2140096T3 (es) 2000-02-16
CA2218255C (en) 2001-11-20
KR100260238B1 (ko) 2000-07-01
EP0874663B1 (de) 1999-09-29

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