ATE185083T1 - Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation - Google Patents

Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation

Info

Publication number
ATE185083T1
ATE185083T1 AT96916550T AT96916550T ATE185083T1 AT E185083 T1 ATE185083 T1 AT E185083T1 AT 96916550 T AT96916550 T AT 96916550T AT 96916550 T AT96916550 T AT 96916550T AT E185083 T1 ATE185083 T1 AT E185083T1
Authority
AT
Austria
Prior art keywords
electroporation
medications
genes
administration
tumors
Prior art date
Application number
AT96916550T
Other languages
English (en)
Inventor
Gunter A Hofmann
Richard A Gilbert
Yosuhiko Hayakawa
Richard Heller
Mark J Jaroszeski
Original Assignee
Genetronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/467,566 external-priority patent/US5702359A/en
Application filed by Genetronics Inc filed Critical Genetronics Inc
Application granted granted Critical
Publication of ATE185083T1 publication Critical patent/ATE185083T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Electromagnetism (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT96916550T 1995-06-06 1996-05-22 Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation ATE185083T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/467,566 US5702359A (en) 1995-06-06 1995-06-06 Needle electrodes for mediated delivery of drugs and genes
US08/537,265 US5993434A (en) 1993-04-01 1995-09-29 Method of treatment using electroporation mediated delivery of drugs and genes

Publications (1)

Publication Number Publication Date
ATE185083T1 true ATE185083T1 (de) 1999-10-15

Family

ID=27042102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916550T ATE185083T1 (de) 1995-06-06 1996-05-22 Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation

Country Status (12)

Country Link
US (6) US5993434A (de)
EP (1) EP0874663B1 (de)
JP (1) JPH11506630A (de)
KR (1) KR100260238B1 (de)
CN (1) CN1150950C (de)
AT (1) ATE185083T1 (de)
AU (1) AU702054B2 (de)
CA (1) CA2218255C (de)
DE (1) DE69604509T2 (de)
ES (1) ES2140096T3 (de)
GR (1) GR3031963T3 (de)
WO (1) WO1996039226A1 (de)

Families Citing this family (296)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
EA002087B1 (ru) * 1997-04-03 2001-12-24 Электрофект Ас Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
IL133708A0 (en) 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into multicelled eukaryotic organism cells and combination thereof
IL133710A0 (en) * 1997-06-30 2001-04-30 Rhone Poulence Rorer S A Improved method for transferring nucleic acid into the striped muscle and combination thereof
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
SE9704076D0 (sv) * 1997-11-06 1997-11-06 Holdingbolaget Vid Goeteborgs Method for permeabilisation of cell structures and use thereof
WO2003046171A1 (en) 2001-11-27 2003-06-05 Cellectricon Ab A method for combined sequential agent delivery and electroporation for cell structures and use thereof
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
FR2773326B3 (fr) * 1998-01-06 2000-05-12 Michel Siros Dispositif d'aide a un traitement de cellules vivantes dans un milieu donne
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
CA2335888A1 (en) * 1998-06-26 2000-01-06 Genetronics, Inc. Synergism of photodynamic and electropermeation effects on cell vitality as a novel cytotoxic agent
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
EP2428250A1 (de) 1998-07-13 2012-03-14 Genetronics, Inc. Haut- und muskelgerichtete Gentherapie mit hilfe eines gepulsten elektrischen Felds
EP1102608A4 (de) 1998-07-13 2008-09-17 Genetronics Inc Methode und gerät zur elektrisch unterstützten oberflächlichen auftragung von kosmetikmitteln
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
GB9817078D0 (en) 1998-08-05 1998-10-07 Habib Nagy A Device for liver surgery
WO2000012173A1 (en) 1998-08-31 2000-03-09 Johnson & Johnson Consumer Companies, Inc. Electrotransport device comprising blades
US6314316B1 (en) * 1998-12-17 2001-11-06 University Of South Florida Nonpenetrating electroporation device and method
US6937890B2 (en) 1998-12-17 2005-08-30 University Of South Florida Nonpenetrating electroporation device
US6713291B2 (en) * 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
ATE256484T1 (de) * 1999-01-28 2004-01-15 Cyto Pulse Sciences Inc Einbringen von makromolekülen in zellen
WO2000056395A1 (en) 1999-03-25 2000-09-28 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US6678558B1 (en) * 1999-03-25 2004-01-13 Genetronics, Inc. Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
US7412285B2 (en) * 1999-04-09 2008-08-12 Oncostim, Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US6678554B1 (en) 1999-04-16 2004-01-13 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US6514762B1 (en) 1999-04-23 2003-02-04 New Mexico State University Technology Transfer Corporation Delivery of nucleotides by electrochemical release
CN1068525C (zh) * 1999-04-23 2001-07-18 孙才均 热针电化学肿瘤治疗装置
AU4996300A (en) 1999-05-10 2000-11-21 Gentronics, Inc. Method of electroporation-enhanced delivery of active agents
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
AU5764800A (en) 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
US7074747B1 (en) 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
US6326177B1 (en) 1999-08-04 2001-12-04 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Method and apparatus for intracellular electro-manipulation
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
WO2001043817A1 (en) * 1999-12-15 2001-06-21 University Of South Florida Electroporation device and method
CA2395492A1 (en) * 1999-12-22 2001-07-05 Diana Wang Method and apparatus for targeting localised electroporation
US7013179B2 (en) 2000-01-07 2006-03-14 Biowave Corporation Percutaneous electrode array
ATE302634T1 (de) 2000-01-07 2005-09-15 Biowave Corp Vorrichtung zur elektrotherapie
US20080033492A1 (en) * 2000-01-07 2008-02-07 Biowave Corporation Electro-therapy method
US7927612B2 (en) * 2000-01-19 2011-04-19 Baofa Yu Combinations and methods for treating neoplasms
AU2001228841A1 (en) * 2000-01-27 2001-08-07 The Mollennium Laboratories Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US7588554B2 (en) * 2000-06-26 2009-09-15 Boston Scientific Scimed, Inc. Method and apparatus for treating ischemic tissue
US6846306B1 (en) * 2000-10-10 2005-01-25 Cold Spring Harbor Laboratory Single cell electroporation
SE0003841D0 (sv) * 2000-10-20 2000-10-20 Daniel Chiu A method and apparatus for penetration of lipid bilayer membranes
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002055127A2 (en) * 2000-11-24 2002-07-18 Ckm Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
US7101703B2 (en) * 2001-03-09 2006-09-05 Cornell Research Foundation, Inc. Electrofusion microelectrode
AU2002254212A1 (en) * 2001-03-12 2002-09-24 Irm, Llc Identification of cellular targets for biologically active molecules
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US7294511B2 (en) 2001-03-22 2007-11-13 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) * 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
EP1404235A4 (de) * 2001-06-12 2008-08-20 Pelikan Technologies Inc Verfahren und gerät für eine auf einer blutentnahmekartusche integrierte lanzettenvorrichtung
WO2002100251A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US20040204669A1 (en) * 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
AU2002360540A1 (en) * 2001-12-04 2003-06-17 University Of Southern California Method for intracellular modifications within living cells using pulsed electric fields
JP2005530695A (ja) * 2002-02-15 2005-10-13 ザイコス インク． 生理活性物質を細胞内に導入するエレクトロポレーション法
US7245963B2 (en) * 2002-03-07 2007-07-17 Advisys, Inc. Electrode assembly for constant-current electroporation and use
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
DE10212008A1 (de) * 2002-03-18 2003-10-09 Aventis Behring Gmbh Nadelhalter
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
WO2003089046A1 (en) 2002-04-16 2003-10-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7291117B2 (en) * 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7648468B2 (en) * 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US20030198625A1 (en) * 2002-04-19 2003-10-23 Genteric, Inc. Electroporation-mediated transfection of the salivary gland
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US10130415B2 (en) * 2002-06-10 2018-11-20 Wisconsin Alumni Research Foundation Circumferential electrode array for tissue ablation
US20070265582A1 (en) * 2002-06-12 2007-11-15 University Of Southern California Injection Devices for Unimpeded Target Location Testing
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
ATE465753T1 (de) 2002-10-21 2010-05-15 Eisai Inc Zusammensetzungen und verfahren zurbehandlung von krankheiten, die durch das humane papillomavirus vermitteltwerden
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
WO2004066903A2 (en) * 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
DE602004028463D1 (de) 2003-05-30 2010-09-16 Pelikan Technologies Inc Verfahren und vorrichtung zur injektion von flüssigkeit
EP1633235B1 (de) 2003-06-06 2014-05-21 Sanofi-Aventis Deutschland GmbH Gerät für die entnahme von körperflüssigkeiten und analyten-nachweis
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
US7261882B2 (en) 2003-06-23 2007-08-28 Reagents Of The University Of Colorado Methods for treating neuropathic pain by administering IL-10 polypeptides
US7330851B2 (en) * 2003-08-18 2008-02-12 Eaglehawk, Limited Data security through dissembly of data elements or connections between elements
US8282576B2 (en) 2003-09-29 2012-10-09 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
US7521224B2 (en) * 2003-09-30 2009-04-21 The United States Of America As Represented By The Secretary Of The Navy Microelectronic cell electroporation array
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
JP5221127B2 (ja) 2004-03-08 2013-06-26 アイコアー メディカル システムズ、インク． 電気を利用した治療剤移送のための改良された装置
JP2005278480A (ja) * 2004-03-29 2005-10-13 Fujitsu Ltd 物質導入装置及び物質導入用チップ
EP2343021A1 (de) 2004-04-01 2011-07-13 The General Hospital Corporation Verfahren und Vorrichtung zur dermatologischen Behandlung und Gewebeneuformung
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
JP4504082B2 (ja) * 2004-04-28 2010-07-14 富士通株式会社 液体注入装置
EP1751546A2 (de) 2004-05-20 2007-02-14 Albatros Technologies GmbH & Co. KG Bedruckbares wassergel für biosensoren
US7212865B2 (en) * 2004-05-25 2007-05-01 Philip Cory Nerve stimulator and method
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (de) 2004-06-03 2010-09-29 Pelikan Technologies Inc Verfahren und gerät für eine flüssigkeitsentnahmenvorrichtung
US6897069B1 (en) 2004-06-08 2005-05-24 Ambion, Inc. System and method for electroporating a sample
WO2005123182A2 (en) * 2004-06-11 2005-12-29 University Of South Florida Nervous tissue electrode device
AU2005257583A1 (en) * 2004-06-12 2006-01-05 Digital Bio Technology Co., Ltd. Electroporator having an elongated hollow member
TW200613554A (en) 2004-06-17 2006-05-01 Wyeth Corp Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV
WO2006010837A2 (fr) * 2004-06-24 2006-02-02 Sphergen Dispositif our le transfert de molecules aux cellules utilisant une force electrique
FR2880808A1 (fr) 2005-01-20 2006-07-21 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus a l'aide d'electrodes de surface non invasives
FR2872056B1 (fr) 2004-06-24 2007-08-10 Yves Scherman Dispositif pour l'administration de principe actif aux cellules et tissus utilisant une ou deux forces physiques
JP2006102255A (ja) * 2004-10-06 2006-04-20 Nippon Sherwood Medical Industries Ltd 輸液ラインの接続構造及びその接続構造を備えたコネクター
WO2006063301A1 (en) * 2004-12-10 2006-06-15 Maxcyte, Inc. Genetically modified tumor cells as cancer vaccines
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
GB0502384D0 (en) * 2005-02-04 2005-03-16 Instrumedical Ltd Electro-surgical needle apparatus
WO2007012907A2 (en) * 2005-02-08 2007-02-01 Allen, John Electric therapy machine
US20060276844A1 (en) * 2005-05-19 2006-12-07 Ruth Alon Ingestible device for nitric oxide production in tissue
EP1885863B1 (de) 2005-05-31 2014-11-19 The Regents of the University of Colorado, a body corporate Verfahren zur genverabreichung
US7933648B2 (en) * 2005-07-21 2011-04-26 Naim Erturk Tanrisever High voltage transcutaneous electrical stimulation device and method
US7647122B2 (en) * 2005-07-26 2010-01-12 Medtronic, Inc. Surgical needle driver
DE102005062933A1 (de) * 2005-08-24 2007-03-22 Triton Gmbh Verfahren zur Behandlung von eine Zellstruktur aufweisenden Rohstoffen in der fleisch-, fleischnebenprodukte-, fisch- und seafoodverarbeitenden Nahrungsmittelindustrie
US20070083075A1 (en) * 2005-10-12 2007-04-12 Moshe Ein-Gal Method and apparatus for applying energy to tissues
US20070142885A1 (en) * 2005-11-29 2007-06-21 Reliant Technologies, Inc. Method and Apparatus for Micro-Needle Array Electrode Treatment of Tissue
AU2006342101A1 (en) * 2005-12-07 2007-10-25 Genetronics, Inc Variable volume electroporation chamber and methods therefore
US7915044B2 (en) * 2005-12-22 2011-03-29 Cornell Research Foundation, Inc. Electrofusion microelectrode and methods of using it to manipulate cells and/or cellular components
JP4614451B2 (ja) * 2005-12-26 2011-01-19 日本シャーウッド株式会社 医療用縫合具
AU2007212269B2 (en) * 2006-02-09 2013-03-28 Deka Products Limited Partnership Fluid delivery systems and methods
CA2635437C (en) * 2006-02-11 2020-01-28 Genetronics, Inc. Device and method for single-needle in vivo electroporation
WO2007103070A2 (en) 2006-03-03 2007-09-13 Genetronics, Inc. Method and device for treating microscopic residual tumors remaining in tissues following surgical resection
WO2007123142A1 (ja) * 2006-04-20 2007-11-01 Tti Ellebeau, Inc. イオントフォレーシス装置
US20070276425A1 (en) * 2006-05-29 2007-11-29 Stanley Kim Painless Blood Sampling Lancet with Bundled Multiple Thin Needles
US20080139989A1 (en) * 2006-12-11 2008-06-12 Stanley Kim Hemodialysis needle device having multiple needles mounted on a needle hub
US20080119797A1 (en) * 2006-11-20 2008-05-22 Stanley Kim System with a syringe device and a needle device
ATE518484T1 (de) * 2006-05-31 2011-08-15 Covidien Ag Medizinisches nahtinstrument mit greifvorrichtung
ES2336626T3 (es) * 2006-06-12 2010-04-14 Region Hovedstaden V/Herlev Hospital Dispositivo introductor de electrodos.
CN101138634A (zh) 2006-09-07 2008-03-12 于保法 用于治疗肿瘤的组合物
JP4536698B2 (ja) * 2006-10-05 2010-09-01 日本シャーウッド株式会社 医療用縫合具
US20080208179A1 (en) * 2006-10-26 2008-08-28 Reliant Technologies, Inc. Methods of increasing skin permeability by treatment with electromagnetic radiation
WO2008118212A2 (en) * 2006-11-08 2008-10-02 Veritas, Llc In vivo delivery of double stranded rna to a target cell
JP4565576B2 (ja) * 2007-02-20 2010-10-20 日本シャーウッド株式会社 穿刺針補助具
US20080312648A1 (en) * 2007-06-12 2008-12-18 Darion Peterson Fat removal and sculpting device
CA2696209C (en) 2007-08-14 2016-10-25 Fred Hutchinson Cancer Research Center Needle array assembly and method for delivering therapeutic agents
DE102008008614A1 (de) 2008-02-12 2009-08-13 Leibniz-Institut für Plasmaforschung und Technologie e.V. Plama-Gerät zur selektiven Behandlung elektroporierter Zellen
US8852609B2 (en) * 2008-04-04 2014-10-07 The Trustees Of The University Of Pennsylvania Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
CA2720168C (en) 2008-04-04 2024-04-30 David B. Weiner Vaccines and immunotherapeutics using il-28 and compositions and methods of using the same
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
KR101084528B1 (ko) 2008-04-15 2011-11-18 인비트로겐 싱가포르 피티이. 엘티디. 전기천공 장치용 파이펫 팁
WO2009137609A2 (en) 2008-05-06 2009-11-12 Cellutions, Inc. Apparatus and systems for treating a human tissue condition
JP5185706B2 (ja) * 2008-06-24 2013-04-17 日本コヴィディエン株式会社 穿刺針補助具
US10842555B2 (en) 2008-08-20 2020-11-24 Prostacare Pty Ltd Catheter for treating tissue with non-thermal ablation
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US20100298825A1 (en) * 2009-05-08 2010-11-25 Cellutions, Inc. Treatment System With A Pulse Forming Network For Achieving Plasma In Tissue
WO2011006204A1 (en) 2009-07-15 2011-01-20 Newsouth Innovations Pty Limited Method of providing agents to the cochlea
DE102009028462A1 (de) 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas
JP2013504600A (ja) 2009-09-14 2013-02-07 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア ＩＬ−１５受容体αおよび／またはそれをコードする核酸分子を含むワクチンおよび免疫治療薬、ならびにそれを用いる方法
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
WO2012033984A1 (en) * 2010-09-09 2012-03-15 Old Dominion University Research Foundation Multi-electrode electrical pulse delivery system for treatment of biological tissues
EP2621522A2 (de) 2010-09-27 2013-08-07 China Agricultural University Kombinierter antigen- und dna-impfstoff zur vorbeugung und behandlung von autoimmunkrankheiten
US9428565B2 (en) 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
CN102631243B (zh) * 2011-02-15 2014-09-17 成功大学 电磁热疗法的治疗器具
WO2012158132A1 (en) 2011-05-18 2012-11-22 Eteka Llc Apparatus for the enhancement of food properties by electroporation or pulsed electric fields
CN103717249B (zh) 2011-06-15 2017-03-22 克洛恩泰克制药股份公司 注射针和装置
CN102284135A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于单针形电极的高压脉冲电场治疗装置
CN102284132A (zh) * 2011-06-30 2011-12-21 杭州电子科技大学 基于多针形电极的高压脉冲电场治疗装置
US9446112B2 (en) 2011-07-12 2016-09-20 Philadelphia Health & Education Corporation Clostridium difficile DNA vaccine
EA201490636A1 (ru) 2011-09-16 2014-08-29 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Сконструированные с помощью рнк t-клетки для лечения злокачественных новообразований
WO2013044225A1 (en) 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
US9272002B2 (en) 2011-10-28 2016-03-01 The Trustees Of The University Of Pennsylvania Fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
AU2012328457A1 (en) 2011-10-28 2014-04-24 Presage Biosciences, Inc. Methods for drug delivery
WO2013067652A1 (en) 2011-11-10 2013-05-16 Beijing Advaccine Biotechnology Co., Ltd. Facilitator-dna combination vaccine
US20130197425A1 (en) * 2011-12-16 2013-08-01 The Regents Of The University Of California Current cage for reduction of a non-target tissue exposure to electric fields in electroporation based treatment
CN103239734B (zh) 2012-02-10 2016-02-24 北京艾棣维欣生物技术有限公司 用于预防和/或治疗呼吸道合胞病毒感染的疫苗
EP4230647A1 (de) 2012-02-22 2023-08-23 The Trustees of the University of Pennsylvania Verwendung von cars auf icos-basis zur verbesserung der antitumoraktivität und der car-persistenz
ES2959443T3 (es) 2012-02-22 2024-02-26 Univ Pennsylvania Uso del dominio de señalización de CD2 en receptores de antígenos quiméricos de segunda generación
EP2852352B1 (de) 2012-05-04 2021-09-01 Roger Khouri Chirurgische instrumente
WO2014011988A2 (en) 2012-07-13 2014-01-16 The Trustees Of The University Of Pennsylvania Enhancing activity of car t cells by co-introducing a bispecific antibody
US9144459B2 (en) 2012-07-19 2015-09-29 Cook Medical Technologies Llc Endoscopic ultrasound ablation needle
EP2890720B1 (de) 2012-08-30 2019-07-17 The General Hospital Corporation Zusammensetzungen und verfahren zur behandlung von krebs
AR092745A1 (es) 2012-10-01 2015-04-29 Univ Pennsylvania Composiciones que comprenden un dominio de union anti-fap y metodos para hacer blanco en celulas estromales para el tratamiento del cancer
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
WO2014055771A1 (en) 2012-10-05 2014-04-10 The Trustees Of The University Of Pennsylvania Human alpha-folate receptor chimeric antigen receptor
AU2013358947B2 (en) 2012-12-13 2016-10-20 Inovio Pharmaceuticals, Inc. WT1 vaccine
US10098585B2 (en) 2013-03-15 2018-10-16 Cadwell Laboratories, Inc. Neuromonitoring systems and methods
ES2825078T3 (es) 2013-03-15 2021-05-14 Univ Loma Linda Tratamiento de enfermedades autoinmunitarias
US9988617B2 (en) 2013-05-21 2018-06-05 President And Fellows Of Harvard College Engineered heme-binding compositions and uses thereof
US10272144B2 (en) 2013-07-31 2019-04-30 Bioventures, Llc Compositions for and methods of treating and preventing targeting tumor associated carbohydrate antigens
EP3054972B1 (de) 2013-10-07 2019-02-27 The Trustees Of The University Of Pennsylvania Impfstoffe mit interleukin-33 als adjuvans
CA2930695C (en) 2013-11-14 2024-05-14 Inovio Pharmaceuticals, Inc. Hiv-1 env dna vaccine plus protein boost
KR20160091350A (ko) 2013-11-29 2016-08-02 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 중동 호흡기 증후군 코로나바이러스(MERS-CoV) 백신
EP3092004A4 (de) 2014-01-06 2017-02-22 The Trustees Of The University Of Pennsylvania Pd1- und pdl1-antikörper und impfstoffkombinationen und verwendung davon zur immuntherapie
EP4303229A3 (de) 2014-01-21 2024-04-17 Novartis AG Verbessertes antigen mit car-t-zellfähigkeit durch co-einführung von co-stimulatorischen molekülen
KR102726294B1 (ko) 2014-01-31 2024-11-06 팩터 바이오사이언스 인크. 핵산 제조 및 송달을 위한 방법 및 산물
US10166288B2 (en) 2014-10-01 2019-01-01 The Trustees Of The University Of Pennsylvania Vaccines having an antigen and interleukin-21 as an adjuvant
ES2983094T3 (es) 2014-10-31 2024-10-21 Univ Pennsylvania Alteración de la expresión génica en células CAR-T y usos de los mismos
JP6884697B2 (ja) 2014-10-31 2021-06-09 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｔ細胞を刺激および拡大する組成物および方法
US20170258835A1 (en) 2014-10-31 2017-09-14 The Trustees Of The University Of Pennsylvania Methods and compositions for modified t cells
EA201791126A1 (ru) 2014-11-26 2017-11-30 Баофа Ю Химиоиммунотерапия, усиленная гаптенами, в виде персонализированной внутриопухолевой химиоиммунотерапии со сверхминимальным разрезом
EP3799879B1 (de) * 2015-01-09 2025-06-04 Grand Decade Developments Limited Gentherapie mit co-stimulierende moleküle und cytokine zur behandlung von malignomen
CA2974956A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
CA3248123A1 (en) 2015-01-31 2025-11-29 The Trustees Of The University Of Pennsylvania Compositions and methods for t cell delivery of therapeutic molecules
EP3543339A1 (de) 2015-02-13 2019-09-25 Factor Bioscience Inc. Nukleinsäureprodukte und verabreichungsverfahren dafür
EP3283529B1 (de) 2015-04-17 2023-06-07 The General Hospital Corporation Wirkstoffe, systeme und verfahren zur behandlung von krebs
WO2016178996A1 (en) 2015-05-01 2016-11-10 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
WO2017040195A1 (en) 2015-08-28 2017-03-09 The Trustees Of The University Of Pennsylvania Methods and compositions for cells expressing a chimeric intracellular signaling molecule
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
EP3421078B1 (de) 2016-02-22 2023-04-05 Tokyo Metropolitan Institute of Medical Science Elektroden für elektroporation
US11549099B2 (en) 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
KR20240011868A (ko) 2016-04-29 2024-01-26 이노비오 파마수티컬즈, 인크. 제제의 전달을 향상시키기 위한 콘드로이티나제 및/또는 히알루로니다제의 생체내 용도
EP3474760B1 (de) 2016-06-27 2023-01-11 Galvanize Therapeutics, Inc. Generator und ein katheter mit einer elektrode zur behandlung eines lungengangs
US12403305B2 (en) 2016-06-27 2025-09-02 Galvanize Therapeutics, Inc. Immunostimulation in the treatment of viral infection
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation
JP2018035137A (ja) 2016-07-13 2018-03-08 マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用
JP2019528284A (ja) 2016-08-17 2019-10-10 ファクター バイオサイエンス インコーポレイテッド 核酸産物およびその投与方法
US9935395B1 (en) 2017-01-23 2018-04-03 Cadwell Laboratories, Inc. Mass connection plate for electrical connectors
CN110678190A (zh) 2017-03-28 2020-01-10 宾夕法尼亚大学董事会 保护移植的组织免受排斥的方法
GB201710973D0 (en) 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
AU2018373389B2 (en) 2017-11-27 2024-07-18 Thayne LARSON An apparatus and a method for the treatment of a prostatic disease
AU2018397478B2 (en) 2017-12-26 2024-11-07 Galvanize Therapeutics, Inc. Optimization of energy delivery for various applications
JP7372920B2 (ja) 2017-12-29 2023-11-01 セレクティス Ｃａｒ ｔ細胞の作製を改良するための方法
WO2019160897A1 (en) 2018-02-13 2019-08-22 Purdue Research Foundation Inactivating bacteria with electric pulses and antibiotics
US11224474B2 (en) 2018-02-28 2022-01-18 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for BPH
US11577071B2 (en) 2018-03-13 2023-02-14 Pulse Biosciences, Inc. Moving electrodes for the application of electrical therapy within a tissue
US11253182B2 (en) 2018-05-04 2022-02-22 Cadwell Laboratories, Inc. Apparatus and method for polyphasic multi-output constant-current and constant-voltage neurophysiological stimulation
US11992339B2 (en) 2018-05-04 2024-05-28 Cadwell Laboratories, Inc. Systems and methods for dynamic neurophysiological stimulation
WO2019222513A1 (en) 2018-05-17 2019-11-21 Regents Of The University Of Minnesota Drug-resistant immune cells and methods of use thereof
US11443649B2 (en) 2018-06-29 2022-09-13 Cadwell Laboratories, Inc. Neurophysiological monitoring training simulator
US12497611B2 (en) 2018-08-17 2025-12-16 Yale University Compositions and methods for high-throughput activation screening to boost T cell effector function
US20220170097A1 (en) 2018-10-29 2022-06-02 The Broad Institute, Inc. Car t cell transcriptional atlas
ES2949058T3 (es) 2018-11-05 2023-09-25 Region Hovedstaden V/Herlev Hospital Un conjunto de electrodos para mejorar la distribución del campo eléctrico
US12508423B2 (en) 2019-02-04 2025-12-30 Rutgers, The State University Of New Jersey Device for tissue electrotransfer using a microelectrode
WO2020191102A1 (en) 2019-03-18 2020-09-24 The Broad Institute, Inc. Type vii crispr proteins and systems
WO2020198413A1 (en) 2019-03-27 2020-10-01 The Trustees Of The University Of Pennsylvania Tn-muc1 chimeric antigen receptor (car) t cell therapy
CN114450265B (zh) 2019-07-03 2024-12-24 菲克特生物科学股份有限公司 阳离子脂质及其用途
WO2021011733A1 (en) 2019-07-16 2021-01-21 Galary, Inc. Treatment of the reproductive tract with pulsed electric fields
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
TW202128775A (zh) 2019-10-16 2021-08-01 英商阿法克塔生命科學有限公司 PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分
EP4048796B1 (de) 2019-10-23 2025-08-27 Yale University Zusammensetzungen und verfahren mit viralen vektorsystemen zur multiplexierten aktivierung endogener gene als immuntherapie und immun-gentherapie auf viraler basis
MX2022010460A (es) 2020-02-25 2022-09-19 Inovio Pharmaceuticals Inc Vacunas contra el coronavirus y metodos de uso.
JP2023516080A (ja) 2020-03-06 2023-04-17 ジーオー セラピューティクス，インコーポレイテッド 抗グリコｃｄ４４抗体およびその使用
CN111317558A (zh) * 2020-03-12 2020-06-23 北京三春晖医疗器械有限公司 一种运用超高压正负复合脉冲电场的肿瘤消融设备
CA3172447A1 (en) 2020-03-27 2021-09-30 Erik Hans MANTING In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
AU2021243864A1 (en) 2020-03-27 2022-11-03 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
AU2021271860B2 (en) 2020-05-14 2025-06-05 Inovio Pharmaceuticals, Inc. Vaccines for recurrent respiratory papillomatosis and methods of using the same
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
US20230272378A1 (en) 2020-06-12 2023-08-31 University Of Rochester ENCODING AND EXPRESSION OF ACE-tRNAs
CA3182607A1 (en) 2020-06-30 2022-01-06 Erik Hans MANTING Use of leukemia-derived cells in ovarian cancer vaccines
WO2022056490A1 (en) 2020-09-14 2022-03-17 Vor Biopharma, Inc. Chimeric antigen receptors for treatment of cancer
CA3196677A1 (en) 2020-11-05 2022-05-12 Erik Hans MANTING Use of tumor-independent antigens in immunotherapies
AU2022211682A1 (en) 2021-01-22 2023-08-03 Mendus B.V. Methods of tumor vaccination
EP4301782A1 (de) 2021-03-05 2024-01-10 Go Therapeutics, Inc. Anti-glyco-cd44-antikörper und deren verwendungen
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
EP4376877A2 (de) 2021-07-29 2024-06-05 Vor Biopharma Inc. Chimäre antigenrezeptoren zur behandlung von krebs
WO2023010118A1 (en) 2021-07-29 2023-02-02 Vor Biopharma Inc. Nfat-responsive reporter systems for assessing chimeric antigen receptor activation and methods of making and using the same
WO2023014863A1 (en) 2021-08-05 2023-02-09 Go Therapeutics, Inc. Anti-glyco-muc4 antibodies and their uses
AU2022328341A1 (en) 2021-08-13 2024-04-04 Inovio Pharmaceuticals, Inc. Combination therapy to treat brain cancer
JP2024536722A (ja) 2021-09-03 2024-10-08 ジーオー セラピューティクス，インコーポレイテッド 抗グリコｃｍｅｔ抗体およびその使用
WO2023034571A1 (en) 2021-09-03 2023-03-09 Go Therapeutics, Inc. Anti-glyco-lamp1 antibodies and their uses
US20250134919A1 (en) 2022-02-07 2025-05-01 University Of Rochester OPTIMIZED SEQUENCES FOR ENHANCED tRNA EXPRESSION OR/AND NONSENSE MUTATION SUPPRESSION
US20240002800A1 (en) 2022-05-16 2024-01-04 Mendus B.V. Use of leukemia-derived cells for enhancing natural killer (nk) cell therapy
KR102789925B1 (ko) * 2022-06-09 2025-04-04 김경수 전파를 이용한 환자 치료 정보를 제공하는 방법
EP4634373A1 (de) 2022-12-16 2025-10-22 University of Rochester Reparatur von dysfunktion der barriere in der speiseröhre
EP4461803A1 (de) * 2023-05-11 2024-11-13 Cellectis S.A. Modulares elektroporationsverfahren und system
WO2024236547A1 (en) 2023-05-18 2024-11-21 Inceptor Bio, Llc Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
WO2025046513A1 (en) 2023-08-29 2025-03-06 Inceptor Bio, Llc Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
WO2025101685A1 (en) 2023-11-09 2025-05-15 University Of Rochester Suppression of nonsense mutations using anticodon engineered (ace)-trnas

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1099062A (en) * 1913-12-10 1914-06-02 Peter P Laposkey Electric scalp appliance.
DE863111C (de) * 1951-07-03 1953-01-15 Walter Hallegger Instrument zur transkutanen und subkutanen Erwaermung und Iontophorese und Verfahrenzu seiner Anwendung
US4116238A (en) * 1976-08-18 1978-09-26 Midgard Electronics Company, Inc. High voltage constant current source for iontophoresis
US4528265A (en) * 1982-05-11 1985-07-09 Becker Robert O Processes and products involving cell modification
US4784737A (en) * 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US5128257A (en) * 1987-08-31 1992-07-07 Baer Bradford W Electroporation apparatus and process
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
WO1989006555A1 (en) 1988-01-21 1989-07-27 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
WO1989010690A1 (en) * 1988-05-02 1989-11-16 University Of South Florida Method for electrofusing biological particles to tissues
US4955378A (en) 1988-05-02 1990-09-11 University Of South Florida Apparatus and methods for performing electrofusion at specific anatomical sites
ES2012944A6 (es) * 1989-01-09 1990-04-16 Tomas Justribo Jose Ramon Procedimiento y su dispositivo para la admionistracion de farmacos mediante ionoforesis, para tratamiento loco-regionales.
CS275292B2 (en) * 1989-02-22 1992-02-19 Cvut Fakulta Elektrotechnick Private rehabilitation apparatus with ion transcutaneous acceleration
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5468223A (en) * 1992-11-30 1995-11-21 C.N.R.S. Paris Electrochemotherapy
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method
US6261281B1 (en) * 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
EA002087B1 (ru) * 1997-04-03 2001-12-24 Электрофект Ас Способ введения фармацевтических препаратов и нуклеиновых кислот в скелетную мышцу
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6009347A (en) * 1998-01-27 1999-12-28 Genetronics, Inc. Electroporation apparatus with connective electrode template

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US20030097089A1 (en) 2003-05-22
DE69604509D1 (de) 1999-11-04
US6418341B1 (en) 2002-07-09
CA2218255C (en) 2001-11-20
DE69604509T2 (de) 2000-01-13
AU5925996A (en) 1996-12-24
US6451002B1 (en) 2002-09-17
GR3031963T3 (en) 2000-03-31
CN1187145A (zh) 1998-07-08
WO1996039226A1 (en) 1996-12-12
US6567694B2 (en) 2003-05-20
KR19990021949A (ko) 1999-03-25
US6569149B2 (en) 2003-05-27
EP0874663B1 (de) 1999-09-29
ES2140096T3 (es) 2000-02-16
CA2218255A1 (en) 1996-12-12
US5993434A (en) 1999-11-30
AU702054B2 (en) 1999-02-11
JPH11506630A (ja) 1999-06-15
CN1150950C (zh) 2004-05-26
KR100260238B1 (ko) 2000-07-01
US20020198485A1 (en) 2002-12-26
EP0874663A1 (de) 1998-11-04
US20030009148A1 (en) 2003-01-09

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