ATE182892T1 - Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren - Google Patents

Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren

Info

Publication number
ATE182892T1
ATE182892T1 AT93909605T AT93909605T ATE182892T1 AT E182892 T1 ATE182892 T1 AT E182892T1 AT 93909605 T AT93909605 T AT 93909605T AT 93909605 T AT93909605 T AT 93909605T AT E182892 T1 ATE182892 T1 AT E182892T1
Authority
AT
Austria
Prior art keywords
pyridazo
eukephalinase
mercaptoacetylamide
ace inhibitors
diazepine derivatives
Prior art date
Application number
AT93909605T
Other languages
German (de)
English (en)
Inventor
Gary A Flynn
Patrick W Shum
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE182892T1 publication Critical patent/ATE182892T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT93909605T 1992-05-15 1993-04-21 Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren ATE182892T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US4000393A 1993-04-09 1993-04-09

Publications (1)

Publication Number Publication Date
ATE182892T1 true ATE182892T1 (de) 1999-08-15

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93909605T ATE182892T1 (de) 1992-05-15 1993-04-21 Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren

Country Status (19)

Country Link
US (1) US5366973A (enExample)
EP (1) EP0640086B1 (enExample)
JP (1) JP3360079B2 (enExample)
KR (1) KR100281450B1 (enExample)
AT (1) ATE182892T1 (enExample)
AU (1) AU669364B2 (enExample)
CA (1) CA2133963C (enExample)
DE (1) DE69325904T2 (enExample)
DK (1) DK0640086T3 (enExample)
ES (1) ES2138622T3 (enExample)
FI (1) FI108230B (enExample)
GR (1) GR3031287T3 (enExample)
HU (1) HU223663B1 (enExample)
IL (1) IL105680A (enExample)
MX (1) MX9302824A (enExample)
NO (1) NO302573B1 (enExample)
NZ (1) NZ251930A (enExample)
TW (1) TW270115B (enExample)
WO (1) WO1993023403A1 (enExample)

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Also Published As

Publication number Publication date
DE69325904D1 (de) 1999-09-09
CA2133963A1 (en) 1993-11-25
FI945363L (fi) 1994-11-14
TW270115B (enExample) 1996-02-11
JPH07506832A (ja) 1995-07-27
US5366973A (en) 1994-11-22
NO944335L (no) 1995-01-13
IL105680A0 (en) 1993-09-22
FI108230B (fi) 2001-12-14
HU223663B1 (hu) 2004-11-29
HUT71099A (en) 1995-11-28
JP3360079B2 (ja) 2002-12-24
GR3031287T3 (en) 1999-12-31
MX9302824A (es) 1994-05-31
ES2138622T3 (es) 2000-01-16
CA2133963C (en) 1998-07-07
FI945363A0 (fi) 1994-11-14
KR950701634A (ko) 1995-04-28
EP0640086A1 (en) 1995-03-01
NO302573B1 (no) 1998-03-23
DK0640086T3 (da) 1999-12-06
AU669364B2 (en) 1996-06-06
DE69325904T2 (de) 1999-12-09
WO1993023403A1 (en) 1993-11-25
NZ251930A (en) 1996-02-27
NO944335D0 (no) 1994-11-14
KR100281450B1 (ko) 2001-02-01
EP0640086B1 (en) 1999-08-04
AU4033293A (en) 1993-12-13
IL105680A (en) 1998-01-04

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