FI108230B - Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä - Google Patents
Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä Download PDFInfo
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- FI108230B FI108230B FI945363A FI945363A FI108230B FI 108230 B FI108230 B FI 108230B FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A FI 108230 B FI108230 B FI 108230B
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- oxo
- compound
- pyridazo
- amino
- diazepine
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Neurosurgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88496392A | 1992-05-15 | 1992-05-15 | |
| US88496392 | 1992-05-15 | ||
| US4000393A | 1993-04-09 | 1993-04-09 | |
| US4000393 | 1993-04-09 | ||
| PCT/US1993/003721 WO1993023403A1 (en) | 1992-05-15 | 1993-04-21 | NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE |
| US9303721 | 1993-04-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI945363L FI945363L (fi) | 1994-11-14 |
| FI945363A0 FI945363A0 (fi) | 1994-11-14 |
| FI108230B true FI108230B (fi) | 2001-12-14 |
Family
ID=26716641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI945363A FI108230B (fi) | 1992-05-15 | 1994-11-14 | Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä |
Country Status (19)
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|---|---|
| US (1) | US5366973A (enExample) |
| EP (1) | EP0640086B1 (enExample) |
| JP (1) | JP3360079B2 (enExample) |
| KR (1) | KR100281450B1 (enExample) |
| AT (1) | ATE182892T1 (enExample) |
| AU (1) | AU669364B2 (enExample) |
| CA (1) | CA2133963C (enExample) |
| DE (1) | DE69325904T2 (enExample) |
| DK (1) | DK0640086T3 (enExample) |
| ES (1) | ES2138622T3 (enExample) |
| FI (1) | FI108230B (enExample) |
| GR (1) | GR3031287T3 (enExample) |
| HU (1) | HU223663B1 (enExample) |
| IL (1) | IL105680A (enExample) |
| MX (1) | MX9302824A (enExample) |
| NO (1) | NO302573B1 (enExample) |
| NZ (1) | NZ251930A (enExample) |
| TW (1) | TW270115B (enExample) |
| WO (1) | WO1993023403A1 (enExample) |
Families Citing this family (58)
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| US5552397A (en) * | 1992-05-18 | 1996-09-03 | E. R. Squibb & Sons, Inc. | Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase |
| US5504080A (en) * | 1992-10-28 | 1996-04-02 | Bristol-Myers Squibb Co. | Benzo-fused lactams |
| US5654294A (en) * | 1993-05-13 | 1997-08-05 | Bristol-Myers Squibb | Spiro lactam dual action inhibitors |
| JP3563738B2 (ja) * | 1993-06-11 | 2004-09-08 | エーザイ株式会社 | アミノ酸誘導体 |
| US5525723A (en) * | 1993-11-18 | 1996-06-11 | Bristol-Myers Squibb Co. | Compounds containing a fused multiple ring lactam |
| CA2183314C (en) * | 1994-02-14 | 1999-08-31 | Gary A. Flynn | Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace |
| JPH09508906A (ja) * | 1994-02-14 | 1997-09-09 | メレル ファーマスーティカルズ インコーポレーテッド | エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類 |
| CA2183313C (en) * | 1994-02-14 | 2001-01-02 | Gary A. Flynn | Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase |
| NZ282568A (en) * | 1994-03-24 | 1997-07-27 | Merrell Pharma Inc | Use of condensed aminoacetylmercaptobenzazepines in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia |
| US5552400A (en) * | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
| US5587375A (en) * | 1995-02-17 | 1996-12-24 | Bristol-Myers Squibb Company | Azepinone compounds useful in the inhibition of ACE and NEP |
| US6699869B1 (en) | 1995-03-24 | 2004-03-02 | Myriad Genetics Inc. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
| US6245764B1 (en) | 1995-03-24 | 2001-06-12 | Molecumetics Ltd. | β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins |
| US6020331A (en) * | 1995-03-24 | 2000-02-01 | Molecumetics, Ltd. | β-sheet mimetics and use thereof as protease inhibitors |
| US5877313A (en) | 1995-05-17 | 1999-03-02 | Bristol-Myers Squibb | Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP |
| US5635504A (en) * | 1995-06-07 | 1997-06-03 | Bristol-Myers Squibb Co. | Diazepine containing dual action inhibitors |
| US5650408A (en) * | 1995-06-07 | 1997-07-22 | Karanewsky; Donald S. | Thiazolo benzazepine containing dual action inhibitors |
| US6117896A (en) * | 1997-02-10 | 2000-09-12 | Molecumetics Ltd. | Methods for regulating transcription factors |
| US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
| EP1053246B1 (en) * | 1998-02-12 | 2003-01-02 | Molecumetics, Ltd. | Beta-sheet mimetics and methods relating to the use thereof |
| IT1298268B1 (it) * | 1998-02-18 | 1999-12-20 | Zambon Spa | Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico |
| FR2777889B1 (fr) * | 1998-04-27 | 2004-07-09 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs |
| WO1999065500A1 (en) | 1998-06-17 | 1999-12-23 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination |
| US6177565B1 (en) | 1998-08-19 | 2001-01-23 | Vertex Pharmaceuticals Inc. | Process for synthesizing piperazic acid |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| DK1216038T3 (da) * | 1999-08-30 | 2005-12-27 | Sanofi Aventis Deutschland | Anvendelse af inhibitorer af reninangiotensinsystemet ved forebyggelsen af cardiovaskulære hændelser |
| GB0119305D0 (en) | 2001-04-12 | 2001-10-03 | Aventis Pharma Gmbh | Mercaptoacetylamide derivatives,a process for their preparation and their use |
| US6821971B2 (en) * | 2001-09-20 | 2004-11-23 | The Procter & Gamble Company | Fused pyrazolone compounds which inhibit the release of inflammatory cytokines |
| EP1443919A4 (en) * | 2001-11-16 | 2006-03-22 | Bristol Myers Squibb Co | DOUBLE INHIBITORS OF THE FATTY ACID BINDING PROTEIN OF THE ADIPOCYTES AND THE FATTY ACID BINDING PROTEIN OF KERATINOCYTES |
| AU2003219809A1 (en) | 2002-02-14 | 2003-09-04 | Myriad Genetics, Inc. | Beta-sheet mimetics and composition and methods relating thereto |
| US7459474B2 (en) * | 2003-06-11 | 2008-12-02 | Bristol-Myers Squibb Company | Modulators of the glucocorticoid receptor and method |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| US7420059B2 (en) * | 2003-11-20 | 2008-09-02 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
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-
1993
- 1993-04-21 DK DK93909605T patent/DK0640086T3/da active
- 1993-04-21 ES ES93909605T patent/ES2138622T3/es not_active Expired - Lifetime
- 1993-04-21 JP JP52023593A patent/JP3360079B2/ja not_active Expired - Fee Related
- 1993-04-21 CA CA002133963A patent/CA2133963C/en not_active Expired - Fee Related
- 1993-04-21 KR KR1019940704065A patent/KR100281450B1/ko not_active Expired - Fee Related
- 1993-04-21 EP EP93909605A patent/EP0640086B1/en not_active Expired - Lifetime
- 1993-04-21 HU HU9403266A patent/HU223663B1/hu not_active IP Right Cessation
- 1993-04-21 DE DE69325904T patent/DE69325904T2/de not_active Expired - Fee Related
- 1993-04-21 WO PCT/US1993/003721 patent/WO1993023403A1/en not_active Ceased
- 1993-04-21 NZ NZ251930A patent/NZ251930A/en unknown
- 1993-04-21 AU AU40332/93A patent/AU669364B2/en not_active Ceased
- 1993-04-21 AT AT93909605T patent/ATE182892T1/de not_active IP Right Cessation
- 1993-05-11 TW TW082103682A patent/TW270115B/zh active
- 1993-05-12 IL IL105680A patent/IL105680A/en not_active IP Right Cessation
- 1993-05-14 MX MX9302824A patent/MX9302824A/es not_active IP Right Cessation
- 1993-11-03 US US08/146,857 patent/US5366973A/en not_active Expired - Fee Related
-
1994
- 1994-11-14 FI FI945363A patent/FI108230B/fi not_active IP Right Cessation
- 1994-11-14 NO NO944335A patent/NO302573B1/no not_active IP Right Cessation
-
1999
- 1999-09-22 GR GR990402385T patent/GR3031287T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO944335L (no) | 1995-01-13 |
| JP3360079B2 (ja) | 2002-12-24 |
| FI945363L (fi) | 1994-11-14 |
| NO302573B1 (no) | 1998-03-23 |
| TW270115B (enExample) | 1996-02-11 |
| WO1993023403A1 (en) | 1993-11-25 |
| ES2138622T3 (es) | 2000-01-16 |
| DE69325904D1 (de) | 1999-09-09 |
| AU4033293A (en) | 1993-12-13 |
| US5366973A (en) | 1994-11-22 |
| JPH07506832A (ja) | 1995-07-27 |
| AU669364B2 (en) | 1996-06-06 |
| KR950701634A (ko) | 1995-04-28 |
| DE69325904T2 (de) | 1999-12-09 |
| NZ251930A (en) | 1996-02-27 |
| MX9302824A (es) | 1994-05-31 |
| KR100281450B1 (ko) | 2001-02-01 |
| EP0640086A1 (en) | 1995-03-01 |
| DK0640086T3 (da) | 1999-12-06 |
| NO944335D0 (no) | 1994-11-14 |
| FI945363A0 (fi) | 1994-11-14 |
| HU223663B1 (hu) | 2004-11-29 |
| IL105680A (en) | 1998-01-04 |
| HUT71099A (en) | 1995-11-28 |
| EP0640086B1 (en) | 1999-08-04 |
| CA2133963A1 (en) | 1993-11-25 |
| GR3031287T3 (en) | 1999-12-31 |
| ATE182892T1 (de) | 1999-08-15 |
| IL105680A0 (en) | 1993-09-22 |
| CA2133963C (en) | 1998-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |