GR3031287T3 - NOVEL MERCAPTOACETYLAMIDO PYRIDAZO 1,2]PYRIDAZINE, PYRAZOLO 1,2]PYRIDAZINE, PYRIDAZO 1,2-a] 1,2]DIAZEPINE AND PYRAZOLO 1,2-a] 1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE. - Google Patents

NOVEL MERCAPTOACETYLAMIDO PYRIDAZO 1,2]PYRIDAZINE, PYRAZOLO 1,2]PYRIDAZINE, PYRIDAZO 1,2-a] 1,2]DIAZEPINE AND PYRAZOLO 1,2-a] 1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE.

Info

Publication number
GR3031287T3
GR3031287T3 GR990402385T GR990402385T GR3031287T3 GR 3031287 T3 GR3031287 T3 GR 3031287T3 GR 990402385 T GR990402385 T GR 990402385T GR 990402385 T GR990402385 T GR 990402385T GR 3031287 T3 GR3031287 T3 GR 3031287T3
Authority
GR
Greece
Prior art keywords
pyridazo
pyrazolo
pyridazine
diazepine
enkephalinase
Prior art date
Application number
GR990402385T
Other languages
Greek (el)
English (en)
Inventor
Gary A Flynn
Patrick W Shum
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of GR3031287T3 publication Critical patent/GR3031287T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
GR990402385T 1992-05-15 1999-09-22 NOVEL MERCAPTOACETYLAMIDO PYRIDAZO 1,2]PYRIDAZINE, PYRAZOLO 1,2]PYRIDAZINE, PYRIDAZO 1,2-a] 1,2]DIAZEPINE AND PYRAZOLO 1,2-a] 1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE. GR3031287T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US4000393A 1993-04-09 1993-04-09
PCT/US1993/003721 WO1993023403A1 (en) 1992-05-15 1993-04-21 NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

Publications (1)

Publication Number Publication Date
GR3031287T3 true GR3031287T3 (en) 1999-12-31

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990402385T GR3031287T3 (en) 1992-05-15 1999-09-22 NOVEL MERCAPTOACETYLAMIDO PYRIDAZO 1,2]PYRIDAZINE, PYRAZOLO 1,2]PYRIDAZINE, PYRIDAZO 1,2-a] 1,2]DIAZEPINE AND PYRAZOLO 1,2-a] 1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE.

Country Status (19)

Country Link
US (1) US5366973A (enExample)
EP (1) EP0640086B1 (enExample)
JP (1) JP3360079B2 (enExample)
KR (1) KR100281450B1 (enExample)
AT (1) ATE182892T1 (enExample)
AU (1) AU669364B2 (enExample)
CA (1) CA2133963C (enExample)
DE (1) DE69325904T2 (enExample)
DK (1) DK0640086T3 (enExample)
ES (1) ES2138622T3 (enExample)
FI (1) FI108230B (enExample)
GR (1) GR3031287T3 (enExample)
HU (1) HU223663B1 (enExample)
IL (1) IL105680A (enExample)
MX (1) MX9302824A (enExample)
NO (1) NO302573B1 (enExample)
NZ (1) NZ251930A (enExample)
TW (1) TW270115B (enExample)
WO (1) WO1993023403A1 (enExample)

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Also Published As

Publication number Publication date
IL105680A (en) 1998-01-04
HU223663B1 (hu) 2004-11-29
KR100281450B1 (ko) 2001-02-01
NO944335L (no) 1995-01-13
EP0640086B1 (en) 1999-08-04
AU669364B2 (en) 1996-06-06
FI945363L (fi) 1994-11-14
HUT71099A (en) 1995-11-28
FI945363A0 (fi) 1994-11-14
JPH07506832A (ja) 1995-07-27
ES2138622T3 (es) 2000-01-16
IL105680A0 (en) 1993-09-22
EP0640086A1 (en) 1995-03-01
DK0640086T3 (da) 1999-12-06
NO302573B1 (no) 1998-03-23
TW270115B (enExample) 1996-02-11
CA2133963C (en) 1998-07-07
US5366973A (en) 1994-11-22
JP3360079B2 (ja) 2002-12-24
WO1993023403A1 (en) 1993-11-25
DE69325904D1 (de) 1999-09-09
KR950701634A (ko) 1995-04-28
CA2133963A1 (en) 1993-11-25
AU4033293A (en) 1993-12-13
DE69325904T2 (de) 1999-12-09
FI108230B (fi) 2001-12-14
ATE182892T1 (de) 1999-08-15
MX9302824A (es) 1994-05-31
NO944335D0 (no) 1994-11-14
NZ251930A (en) 1996-02-27

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