ATE161289T1 - Repamycinbestimmung - Google Patents
RepamycinbestimmungInfo
- Publication number
- ATE161289T1 ATE161289T1 AT94913093T AT94913093T ATE161289T1 AT E161289 T1 ATE161289 T1 AT E161289T1 AT 94913093 T AT94913093 T AT 94913093T AT 94913093 T AT94913093 T AT 94913093T AT E161289 T1 ATE161289 T1 AT E161289T1
- Authority
- AT
- Austria
- Prior art keywords
- repamycin
- determination
- rapamycin
- processes
- making
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 2
- 238000003149 assay kit Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1292—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Actinomyces; from Streptomyces (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939307491A GB9307491D0 (en) | 1993-04-08 | 1993-04-08 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE161289T1 true ATE161289T1 (de) | 1998-01-15 |
Family
ID=10733650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94913093T ATE161289T1 (de) | 1993-04-08 | 1994-03-30 | Repamycinbestimmung |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8039599B1 (de) |
| EP (1) | EP0693132B1 (de) |
| JP (4) | JP3397325B2 (de) |
| KR (2) | KR100404162B1 (de) |
| CN (1) | CN1080312C (de) |
| AT (1) | ATE161289T1 (de) |
| AU (1) | AU677321B2 (de) |
| BR (1) | BR9406210A (de) |
| CZ (1) | CZ284431B6 (de) |
| DE (1) | DE69407402T2 (de) |
| DK (1) | DK0693132T3 (de) |
| ES (1) | ES2110230T3 (de) |
| FI (1) | FI110670B (de) |
| GB (1) | GB9307491D0 (de) |
| GR (1) | GR3025753T3 (de) |
| HU (1) | HU221606B (de) |
| NO (1) | NO320470B1 (de) |
| NZ (1) | NZ265051A (de) |
| PL (1) | PL185855B1 (de) |
| RU (1) | RU2175672C2 (de) |
| SK (1) | SK280048B6 (de) |
| WO (1) | WO1994024304A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| AU686629B2 (en) | 1993-04-23 | 1998-02-12 | Wyeth | Rapamycin Conjugates and Antibodies |
| US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
| GB9318612D0 (en) * | 1993-09-08 | 1993-10-27 | Sandoz Ltd | An assay |
| US5635406A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies |
| WO1998009970A2 (en) * | 1996-09-09 | 1998-03-12 | American Home Products Corporation | Alkylated rapamycin derivatives |
| US6709873B1 (en) | 1997-04-09 | 2004-03-23 | Isodiagnostika Inc. | Method for production of antibodies to specific sites of rapamycin |
| AU740304B2 (en) * | 1997-04-09 | 2001-11-01 | Isotechnika Inc. | Method for production of antibodies to specific sites of rapamycin |
| DE19951684A1 (de) * | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Neuer immunologischer Assay zur Bestimmung von C-peptidhaltigen Kontaminanten in Proben von Humanisulin und dessen Derivaten |
| US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
| US7157561B2 (en) * | 2001-07-13 | 2007-01-02 | Roche Diagnostics Operations, Inc. | Methods of inhibiting transmission of a costimulatory signal of lymphocytes |
| US20040243224A1 (en) * | 2003-04-03 | 2004-12-02 | Medtronic Vascular, Inc. | Methods and compositions for inhibiting narrowing in mammalian vascular pathways |
| US20050176080A1 (en) * | 2004-02-10 | 2005-08-11 | Vani Bodepudi | Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays |
| WO2005085290A1 (en) * | 2004-03-05 | 2005-09-15 | Astellas Pharma Inc. | Anti fk778antibodies and high sensitive immunoassay methods |
| EP1730525B1 (de) * | 2004-03-10 | 2013-06-19 | Seradyn, Inc. | Immuntests für everolimus |
| ATE410431T1 (de) * | 2004-04-14 | 2008-10-15 | Wyeth Corp | Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| AU2005292647A1 (en) * | 2004-08-10 | 2006-04-13 | Wyeth | CCI-779 derivatives and methods of making same |
| US8021849B2 (en) | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
| BRPI0609476B1 (pt) | 2005-03-21 | 2015-12-08 | Cytacoat Ab | agente antimicrobial compreendendo um composto de cisteína covalentemente ligado a um substrato, em particular pela ligação através de uma ponte s-s via uma molécula espaçadora |
| US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| US20080081379A1 (en) * | 2006-07-13 | 2008-04-03 | Sigler Gerald F | Homogeneous double receptor agglutination assay for immunosuppressant drugs |
| US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
| FR2908658B1 (fr) * | 2006-11-20 | 2011-11-11 | Centre Nat Rech Scient | Composition pour la prevention et/ou le traitement des maladies associees a la surexpression du tnf et/ou de l'il-12 |
| ES2405364T3 (es) | 2006-12-29 | 2013-05-30 | Abbott Laboratories | Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera |
| WO2008082984A2 (en) | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
| ES2393135T3 (es) | 2006-12-29 | 2012-12-18 | Abbott Laboratories | Ensayo mejorado para fármacos inmunosupresores |
| US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
| US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| US20110097733A1 (en) | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
| LT2560645T (lt) | 2010-04-21 | 2016-10-10 | Syntarga B.V. | Cc-1065 analogų ir bifunkcinių linkerių konjugatai |
| BR112014032916A2 (pt) * | 2012-06-28 | 2017-08-01 | Pfizer | anticorpos anti-fármacos e usos destes para o monitoramento de fármaco |
| RU2769700C2 (ru) | 2014-01-10 | 2022-04-05 | Байондис Б.В. | Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo |
| KR20160099725A (ko) | 2014-01-10 | 2016-08-22 | 신톤 바이오파머슈티칼즈 비.브이. | 자궁내막암의 치료에서 사용하기 위한 듀오카르마이신 adc |
| US20170320965A1 (en) * | 2014-09-22 | 2017-11-09 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
| JP7319362B2 (ja) | 2018-11-02 | 2023-08-01 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | マクロフィリン結合医薬アッセイに使用するための結合競合剤およびその使用方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE92501T1 (de) | 1984-10-04 | 1993-08-15 | Sandoz Ag | Monoklonale antikoerper gegen zyklosporine. |
| US5169773A (en) * | 1984-10-04 | 1992-12-08 | Sandoz Ltd. | Monoclonal antibodies to cyclosporins |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| ATE98700T1 (de) | 1987-06-05 | 1994-01-15 | Fujisawa Pharmaceutical Co | Anti-fr-900506-stoffe-antikoerper und hoechstempfindliches enzym-immunoassay-verfahren. |
| JPH02495A (ja) * | 1987-12-25 | 1990-01-05 | Tosoh Corp | モノクローナル抗体、その製法及びそれを用いた測定法 |
| CA2039541A1 (en) * | 1990-04-05 | 1991-10-06 | Ethel B. Jacobson | Monoclonal antibodies to avermectins |
| EP0473961B1 (de) * | 1990-08-15 | 1996-01-03 | Abbott Laboratories | Immunotestreagenzien und Verfahren zur Bestimmung von Cyclosporin |
| PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5322772A (en) | 1991-04-09 | 1994-06-21 | Children's Research Institute | Rapamycin assay |
| FI921595A (fi) * | 1991-04-17 | 1992-10-18 | American Home Prod | Rapamycinkarbamater |
| US5194447A (en) | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5514544A (en) * | 1991-07-26 | 1996-05-07 | Eli Lilly And Company | Activator gene for macrolide biosynthesis |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| AU686629B2 (en) | 1993-04-23 | 1998-02-12 | Wyeth | Rapamycin Conjugates and Antibodies |
| US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
| WO1994025072A1 (en) | 1993-04-23 | 1994-11-10 | American Home Products Corporation | Rapamycin conjugates and antibodies |
| US6187547B1 (en) * | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
-
1993
- 1993-04-08 GB GB939307491A patent/GB9307491D0/en active Pending
-
1994
- 1994-03-30 DK DK94913093.4T patent/DK0693132T3/da active
- 1994-03-30 HU HU9501975A patent/HU221606B/hu unknown
- 1994-03-30 SK SK1257-95A patent/SK280048B6/sk not_active IP Right Cessation
- 1994-03-30 NZ NZ265051A patent/NZ265051A/en not_active IP Right Cessation
- 1994-03-30 CN CN94191718A patent/CN1080312C/zh not_active Expired - Lifetime
- 1994-03-30 RU RU95119595/13A patent/RU2175672C2/ru active
- 1994-03-30 PL PL94310967A patent/PL185855B1/pl unknown
- 1994-03-30 CZ CZ952583A patent/CZ284431B6/cs not_active IP Right Cessation
- 1994-03-30 KR KR10-2002-7004572A patent/KR100404162B1/ko not_active IP Right Cessation
- 1994-03-30 EP EP94913093A patent/EP0693132B1/de not_active Expired - Lifetime
- 1994-03-30 JP JP52268294A patent/JP3397325B2/ja not_active Expired - Lifetime
- 1994-03-30 KR KR1019950704410A patent/KR100347166B1/ko not_active IP Right Cessation
- 1994-03-30 AU AU65377/94A patent/AU677321B2/en not_active Expired
- 1994-03-30 WO PCT/EP1994/001006 patent/WO1994024304A1/en active IP Right Grant
- 1994-03-30 ES ES94913093T patent/ES2110230T3/es not_active Expired - Lifetime
- 1994-03-30 DE DE69407402T patent/DE69407402T2/de not_active Expired - Lifetime
- 1994-03-30 AT AT94913093T patent/ATE161289T1/de active
- 1994-03-30 BR BR9406210A patent/BR9406210A/pt not_active Application Discontinuation
-
1995
- 1995-09-14 FI FI954319A patent/FI110670B/fi not_active IP Right Cessation
- 1995-10-06 NO NO19953975A patent/NO320470B1/no not_active IP Right Cessation
-
1997
- 1997-12-23 GR GR970403403T patent/GR3025753T3/el unknown
-
2000
- 2000-06-02 US US09/585,743 patent/US8039599B1/en not_active Expired - Fee Related
-
2001
- 2001-01-09 US US09/757,212 patent/US6635745B2/en not_active Ceased
- 2001-03-19 JP JP2001078335A patent/JP2001302698A/ja active Pending
- 2001-08-20 US US09/933,104 patent/US8039600B2/en not_active Expired - Fee Related
-
2002
- 2002-05-02 JP JP2002130451A patent/JP4287619B2/ja not_active Expired - Lifetime
-
2006
- 2006-03-22 JP JP2006079344A patent/JP2006249090A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |