BR9406210A - Ensaio de rapamicina - Google Patents
Ensaio de rapamicinaInfo
- Publication number
- BR9406210A BR9406210A BR9406210A BR9406210A BR9406210A BR 9406210 A BR9406210 A BR 9406210A BR 9406210 A BR9406210 A BR 9406210A BR 9406210 A BR9406210 A BR 9406210A BR 9406210 A BR9406210 A BR 9406210A
- Authority
- BR
- Brazil
- Prior art keywords
- rapamycin
- assay
- rapamycin assay
- processes
- making
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 3
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002930 sirolimus Drugs 0.000 title abstract 2
- 238000003556 assay Methods 0.000 title 1
- 238000003149 assay kit Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1292—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939307491A GB9307491D0 (en) | 1993-04-08 | 1993-04-08 | Organic compounds |
| PCT/EP1994/001006 WO1994024304A1 (en) | 1993-04-08 | 1994-03-30 | Rapamycin assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9406210A true BR9406210A (pt) | 1996-02-06 |
Family
ID=10733650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9406210A BR9406210A (pt) | 1993-04-08 | 1994-03-30 | Ensaio de rapamicina |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8039599B1 (pt) |
| EP (1) | EP0693132B1 (pt) |
| JP (4) | JP3397325B2 (pt) |
| KR (2) | KR100404162B1 (pt) |
| CN (1) | CN1080312C (pt) |
| AT (1) | ATE161289T1 (pt) |
| AU (1) | AU677321B2 (pt) |
| BR (1) | BR9406210A (pt) |
| CZ (1) | CZ284431B6 (pt) |
| DE (1) | DE69407402T2 (pt) |
| DK (1) | DK0693132T3 (pt) |
| ES (1) | ES2110230T3 (pt) |
| FI (1) | FI110670B (pt) |
| GB (1) | GB9307491D0 (pt) |
| GR (1) | GR3025753T3 (pt) |
| HU (1) | HU221606B (pt) |
| NO (1) | NO320470B1 (pt) |
| NZ (1) | NZ265051A (pt) |
| PL (1) | PL185855B1 (pt) |
| RU (1) | RU2175672C2 (pt) |
| SK (1) | SK280048B6 (pt) |
| WO (1) | WO1994024304A1 (pt) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| WO1994025022A1 (en) | 1993-04-23 | 1994-11-10 | Abbott Laboratories | Rapamycin conjugates and antibodies |
| US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
| GB9318612D0 (en) * | 1993-09-08 | 1993-10-27 | Sandoz Ltd | An assay |
| US5635406A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies |
| JP2001500126A (ja) * | 1996-09-09 | 2001-01-09 | アメリカン・ホーム・プロダクツ・コーポレイション | アルキル化ラパマイシン誘導体 |
| US6709873B1 (en) | 1997-04-09 | 2004-03-23 | Isodiagnostika Inc. | Method for production of antibodies to specific sites of rapamycin |
| CA2286311A1 (en) * | 1997-04-09 | 1998-10-15 | Isotechnika, Inc. | Method for production of antibodies to specific sites of rapamycin |
| DE19951684A1 (de) * | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Neuer immunologischer Assay zur Bestimmung von C-peptidhaltigen Kontaminanten in Proben von Humanisulin und dessen Derivaten |
| US7157561B2 (en) * | 2001-07-13 | 2007-01-02 | Roche Diagnostics Operations, Inc. | Methods of inhibiting transmission of a costimulatory signal of lymphocytes |
| US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
| US20040243224A1 (en) * | 2003-04-03 | 2004-12-02 | Medtronic Vascular, Inc. | Methods and compositions for inhibiting narrowing in mammalian vascular pathways |
| US20050176080A1 (en) * | 2004-02-10 | 2005-08-11 | Vani Bodepudi | Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays |
| US20070178544A1 (en) * | 2004-03-05 | 2007-08-02 | Kouichi Tamura | Anti fk778antibodies and high sensitive immunoassay methods |
| JP4540704B2 (ja) * | 2004-03-10 | 2010-09-08 | セラディン インコーポレイテッド | エベロリムスの測定方法および測定キット |
| AU2005238432A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| WO2006038972A1 (en) * | 2004-08-10 | 2006-04-13 | Wyeth | Cci-779 derivatives and methods of making same |
| US8021849B2 (en) | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
| KR101365712B1 (ko) * | 2005-03-21 | 2014-02-24 | 시타코트 에이비 | 스페이서 분자를 경유하는 ｓ―ｓ 가교를 통한 결합에 의하여 기질에 공유 결합된 시스테인 성분을 포함하는 항미생물제 |
| US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| US20080081379A1 (en) * | 2006-07-13 | 2008-04-03 | Sigler Gerald F | Homogeneous double receptor agglutination assay for immunosuppressant drugs |
| US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
| FR2908658B1 (fr) * | 2006-11-20 | 2011-11-11 | Centre Nat Rech Scient | Composition pour la prevention et/ou le traitement des maladies associees a la surexpression du tnf et/ou de l'il-12 |
| ES2393135T3 (es) | 2006-12-29 | 2012-12-18 | Abbott Laboratories | Ensayo mejorado para fármacos inmunosupresores |
| EP2118654B1 (en) | 2006-12-29 | 2013-03-27 | Abbott Laboratories | Diagnostic test for the detection of a molecule or drug in whole blood |
| US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
| EP2118657B1 (en) | 2006-12-29 | 2014-05-21 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
| US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| US20110097733A1 (en) | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
| HUE030846T2 (en) | 2010-04-21 | 2017-06-28 | Syntarga Bv | Conjugates of CC-1065 analogues and bifunctional linkers |
| BR112014032916A2 (pt) * | 2012-06-28 | 2017-08-01 | Pfizer | anticorpos anti-fármacos e usos destes para o monitoramento de fármaco |
| CA2935433C (en) | 2014-01-10 | 2019-04-02 | Synthon Biopharmaceuticals B.V. | Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies |
| CA2935430C (en) | 2014-01-10 | 2018-09-18 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs for use in treatment of endometrial cancer |
| WO2016046173A1 (en) * | 2014-09-22 | 2016-03-31 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
| WO2020092153A1 (en) | 2018-11-02 | 2020-05-07 | Siemens Healthcare Diagnostics Inc. | Binding competitors for use in macrophilin-binding pharmaceutical assays and methods of use thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169773A (en) * | 1984-10-04 | 1992-12-08 | Sandoz Ltd. | Monoclonal antibodies to cyclosporins |
| JPH074269B2 (ja) | 1984-10-04 | 1995-01-25 | サンド・アクチエンゲゼルシャフト | シクロスポリン類に対するモノクロ−ナル抗体 |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| EP0293892B1 (en) | 1987-06-05 | 1993-12-15 | Fujisawa Pharmaceutical Co., Ltd. | Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method |
| JPH02495A (ja) * | 1987-12-25 | 1990-01-05 | Tosoh Corp | モノクローナル抗体、その製法及びそれを用いた測定法 |
| CA2039541A1 (en) * | 1990-04-05 | 1991-10-06 | Ethel B. Jacobson | Monoclonal antibodies to avermectins |
| EP0473961B1 (en) * | 1990-08-15 | 1996-01-03 | Abbott Laboratories | Immunoassay reagents and method for determining cyclosporine |
| PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5322772A (en) | 1991-04-09 | 1994-06-21 | Children's Research Institute | Rapamycin assay |
| US5194447A (en) | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| NO921449L (no) * | 1991-04-17 | 1992-10-19 | American Home Prod | Karbamater av rapamycin |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5514544A (en) * | 1991-07-26 | 1996-05-07 | Eli Lilly And Company | Activator gene for macrolide biosynthesis |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| WO1994025022A1 (en) | 1993-04-23 | 1994-11-10 | Abbott Laboratories | Rapamycin conjugates and antibodies |
| AU6711994A (en) | 1993-04-23 | 1994-11-21 | American Home Products Corporation | Rapamycin conjugates and antibodies |
| US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
| US6187547B1 (en) * | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
-
1993
- 1993-04-08 GB GB939307491A patent/GB9307491D0/en active Pending
-
1994
- 1994-03-30 EP EP94913093A patent/EP0693132B1/en not_active Expired - Lifetime
- 1994-03-30 KR KR10-2002-7004572A patent/KR100404162B1/ko not_active IP Right Cessation
- 1994-03-30 JP JP52268294A patent/JP3397325B2/ja not_active Expired - Lifetime
- 1994-03-30 BR BR9406210A patent/BR9406210A/pt not_active Application Discontinuation
- 1994-03-30 DK DK94913093.4T patent/DK0693132T3/da active
- 1994-03-30 KR KR1019950704410A patent/KR100347166B1/ko not_active IP Right Cessation
- 1994-03-30 SK SK1257-95A patent/SK280048B6/sk not_active IP Right Cessation
- 1994-03-30 RU RU95119595/13A patent/RU2175672C2/ru active
- 1994-03-30 HU HU9501975A patent/HU221606B/hu unknown
- 1994-03-30 ES ES94913093T patent/ES2110230T3/es not_active Expired - Lifetime
- 1994-03-30 CZ CZ952583A patent/CZ284431B6/cs not_active IP Right Cessation
- 1994-03-30 AU AU65377/94A patent/AU677321B2/en not_active Expired
- 1994-03-30 AT AT94913093T patent/ATE161289T1/de active
- 1994-03-30 PL PL94310967A patent/PL185855B1/pl unknown
- 1994-03-30 WO PCT/EP1994/001006 patent/WO1994024304A1/en active IP Right Grant
- 1994-03-30 CN CN94191718A patent/CN1080312C/zh not_active Expired - Lifetime
- 1994-03-30 DE DE69407402T patent/DE69407402T2/de not_active Expired - Lifetime
- 1994-03-30 NZ NZ265051A patent/NZ265051A/en not_active IP Right Cessation
-
1995
- 1995-09-14 FI FI954319A patent/FI110670B/fi not_active IP Right Cessation
- 1995-10-06 NO NO19953975A patent/NO320470B1/no not_active IP Right Cessation
-
1997
- 1997-12-23 GR GR970403403T patent/GR3025753T3/el unknown
-
2000
- 2000-06-02 US US09/585,743 patent/US8039599B1/en not_active Expired - Fee Related
-
2001
- 2001-01-09 US US09/757,212 patent/US6635745B2/en not_active Ceased
- 2001-03-19 JP JP2001078335A patent/JP2001302698A/ja active Pending
- 2001-08-20 US US09/933,104 patent/US8039600B2/en not_active Expired - Fee Related
-
2002
- 2002-05-02 JP JP2002130451A patent/JP4287619B2/ja not_active Expired - Lifetime
-
2006
- 2006-03-22 JP JP2006079344A patent/JP2006249090A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9406210A (pt) | Ensaio de rapamicina | |
| MY104946A (en) | Antigen antibody conjugate. | |
| EP1181938A3 (en) | Rapamycin conjugates and antibodies | |
| AU5055593A (en) | Antibodies specific for HIV | |
| IS2508B (is) | Mótefni gegn ED-B hneppinu í fíbrónektíni, smíði þeirra og notkanir | |
| DK261386A (da) | Monoklonale antistoffer | |
| ATE160575T1 (de) | Für toxin b von clostridium difficile spezifische monoklonale antikörper | |
| GB8504104D0 (en) | Hcmv monoclonal antibodies | |
| NO163920C (no) | Fremgangsmaate for bestemmelse av pivka-ii i fysiologiske proever. | |
| AU4032095A (en) | Immunoassays for haptens and hapten tracer-antibody complex which can be used therefor, and process for the preparation thereof | |
| ATE193534T1 (de) | Benzodiazepin-derivate sowie deren konjugate mit proteinen und polypeptiden | |
| EP0194158A3 (en) | Anti-nicotine and anti-cotinine antibodies (monoclonal and other), and their uses in nicotine and cotinine assays | |
| ATE116004T1 (de) | Antikörper gegen menschliches sperma, ihre herstellung und anwendung. | |
| DE3850993D1 (de) | Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2. | |
| ES2088464T3 (es) | Uso y administracion de enzimas. | |
| CA2095735A1 (en) | Monoclonal antibodies to hepatitis c virus and method for using same | |
| CA2156397A1 (en) | Rapamycin assay | |
| IE882250L (en) | Monoclonal antibodies and methods for diagnosis of Phytophthora infection | |
| AR002242A1 (es) | Haptenos de imidazolinona y antigenos y conjugados enzimáticos preparados a partir de los mismos, compuestos intermediarios para preparar los haptenos, anticuerpos, hibridomas, y ,usos de los haptenos e hibridomas | |
| HU9701386D0 (en) | Immunoassay method | |
| PT98106A (pt) | Anticorpos monoclonais contra especies de mycosphaerella e linhas celulares de hibridoma que os produzem | |
| CA2559998A1 (en) | Rapamycin conjugates and antibodies |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer |
Free format text: NOVARTIS AG (NOVARTIS SA) (NOVARTIS INC.) (CH) |
|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| CKFC | Appeal: appeal against refusal | ||
| B15K | Others concerning applications: alteration of classification |
Ipc: C07K 16/12 (2006.01) |