DK0693132T3 - Rapamycinassay - Google Patents
RapamycinassayInfo
- Publication number
- DK0693132T3 DK0693132T3 DK94913093.4T DK94913093T DK0693132T3 DK 0693132 T3 DK0693132 T3 DK 0693132T3 DK 94913093 T DK94913093 T DK 94913093T DK 0693132 T3 DK0693132 T3 DK 0693132T3
- Authority
- DK
- Denmark
- Prior art keywords
- rapamycin
- rapamycinassay
- processes
- making
- monoclonal antibodies
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 abstract 2
- 238000003149 assay kit Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1292—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Actinomyces; from Streptomyces (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939307491A GB9307491D0 (en) | 1993-04-08 | 1993-04-08 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0693132T3 true DK0693132T3 (da) | 1998-03-02 |
Family
ID=10733650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94913093.4T DK0693132T3 (da) | 1993-04-08 | 1994-03-30 | Rapamycinassay |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US8039599B1 (da) |
| EP (1) | EP0693132B1 (da) |
| JP (4) | JP3397325B2 (da) |
| KR (2) | KR100347166B1 (da) |
| CN (1) | CN1080312C (da) |
| AT (1) | ATE161289T1 (da) |
| AU (1) | AU677321B2 (da) |
| BR (1) | BR9406210A (da) |
| CZ (1) | CZ284431B6 (da) |
| DE (1) | DE69407402T2 (da) |
| DK (1) | DK0693132T3 (da) |
| ES (1) | ES2110230T3 (da) |
| FI (1) | FI110670B (da) |
| GB (1) | GB9307491D0 (da) |
| GR (1) | GR3025753T3 (da) |
| HU (1) | HU221606B (da) |
| NO (1) | NO320470B1 (da) |
| NZ (1) | NZ265051A (da) |
| PL (1) | PL185855B1 (da) |
| RU (1) | RU2175672C2 (da) |
| SK (1) | SK280048B6 (da) |
| WO (1) | WO1994024304A1 (da) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
| US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
| AU686629B2 (en) * | 1993-04-23 | 1998-02-12 | Wyeth | Rapamycin Conjugates and Antibodies |
| GB9318612D0 (en) * | 1993-09-08 | 1993-10-27 | Sandoz Ltd | An assay |
| US5635406A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Stabilized standards and calibrators containing rapamycin and tacrolimus bound to anti-rapamycin and anti-tacrolimus antibodies |
| CN1235608A (zh) * | 1996-09-09 | 1999-11-17 | 美国家用产品公司 | 烷基化的雷帕霉素衍生物 |
| US6709873B1 (en) | 1997-04-09 | 2004-03-23 | Isodiagnostika Inc. | Method for production of antibodies to specific sites of rapamycin |
| CA2286311A1 (en) * | 1997-04-09 | 1998-10-15 | Isotechnika, Inc. | Method for production of antibodies to specific sites of rapamycin |
| DE19951684A1 (de) * | 1999-10-27 | 2001-05-03 | Aventis Pharma Gmbh | Neuer immunologischer Assay zur Bestimmung von C-peptidhaltigen Kontaminanten in Proben von Humanisulin und dessen Derivaten |
| US7193065B2 (en) * | 2001-07-13 | 2007-03-20 | Roche Diagnostics Operations, Inc. | Protease inhibitor conjugates and antibodies useful in immunoassay |
| US7157561B2 (en) * | 2001-07-13 | 2007-01-02 | Roche Diagnostics Operations, Inc. | Methods of inhibiting transmission of a costimulatory signal of lymphocytes |
| US20040243224A1 (en) * | 2003-04-03 | 2004-12-02 | Medtronic Vascular, Inc. | Methods and compositions for inhibiting narrowing in mammalian vascular pathways |
| US20050176080A1 (en) * | 2004-02-10 | 2005-08-11 | Vani Bodepudi | Hapten, immunogens and derivatives of ascomycin useful for preparation of antibodies and immunoassays |
| US20070178544A1 (en) * | 2004-03-05 | 2007-08-02 | Kouichi Tamura | Anti fk778antibodies and high sensitive immunoassay methods |
| ES2425167T3 (es) * | 2004-03-10 | 2013-10-11 | Seradyn, Inc. | Inmunoensayos para everolimús |
| BRPI0509810A (pt) | 2004-04-14 | 2007-09-18 | Wyeth Corp | método para a sìntese regioespecìfica de um 42-hemiéster de rapamicina ou um 32-hemiéster de fk-506 com um ácido dicarboxìlico, 42-hemiéster de rapamicina regioespecìfica, anticorpo de rapamicina, produto, e, 32-hemiéster de fk506 regioespecìfico |
| EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
| EP1776370A1 (en) * | 2004-08-10 | 2007-04-25 | Wyeth a Corporation of the State of Delaware | Cci-779 derivatives and methods of making same |
| US8021849B2 (en) | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
| JP5222129B2 (ja) | 2005-03-21 | 2013-06-26 | シタコート アーベー | 特にスペーサー分子を介してｓ−ｓ架橋により結合することによって基材に共有結合したシステイン化合物を含む抗菌剤 |
| US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| US20080081379A1 (en) * | 2006-07-13 | 2008-04-03 | Sigler Gerald F | Homogeneous double receptor agglutination assay for immunosuppressant drugs |
| US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
| FR2908658B1 (fr) * | 2006-11-20 | 2011-11-11 | Centre Nat Rech Scient | Composition pour la prevention et/ou le traitement des maladies associees a la surexpression du tnf et/ou de l'il-12 |
| US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
| ES2393135T3 (es) | 2006-12-29 | 2012-12-18 | Abbott Laboratories | Ensayo mejorado para fármacos inmunosupresores |
| WO2008082984A2 (en) | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
| ES2405364T3 (es) | 2006-12-29 | 2013-05-30 | Abbott Laboratories | Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera |
| US20080287675A1 (en) * | 2007-05-18 | 2008-11-20 | Abbott Laboratories | Cascade system |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| US20110097733A1 (en) | 2009-10-27 | 2011-04-28 | Michel Anciaux | Process for the production of a hybridoma and antibody obtained therefrom, able to recognize more than one vitamin d metabolite |
| CA2796712C (en) | 2010-04-21 | 2017-02-28 | Syntarga B.V. | Novel conjugates of cc-1065 analogs and bifunctional linkers |
| BR112014032916A2 (pt) * | 2012-06-28 | 2017-08-01 | Pfizer | anticorpos anti-fármacos e usos destes para o monitoramento de fármaco |
| MX368396B (es) | 2014-01-10 | 2019-10-01 | Synthon Biopharmaceuticals Bv | Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada. |
| JP6224268B2 (ja) | 2014-01-10 | 2017-11-01 | シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． | 子宮内膜癌の治療において使用するためのデュオカルマイシンａｄｃ |
| EP3197919A1 (en) * | 2014-09-22 | 2017-08-02 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
| EP3873509B1 (en) | 2018-11-02 | 2024-06-12 | Siemens Healthcare Diagnostics, Inc. | Binding competitors for use in macrophilin-binding pharmaceutical assays and methods of use thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169773A (en) * | 1984-10-04 | 1992-12-08 | Sandoz Ltd. | Monoclonal antibodies to cyclosporins |
| EP0198026B1 (en) | 1984-10-04 | 1993-08-04 | Sandoz Ag | Monoclonal antibodies to cyclosporings |
| US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| EP0293892B1 (en) | 1987-06-05 | 1993-12-15 | Fujisawa Pharmaceutical Co., Ltd. | Anti-FR-900506 substance antibodies and highly-sensitive enzyme immunoassay method |
| JPH02495A (ja) * | 1987-12-25 | 1990-01-05 | Tosoh Corp | モノクローナル抗体、その製法及びそれを用いた測定法 |
| CA2039541A1 (en) * | 1990-04-05 | 1991-10-06 | Ethel B. Jacobson | Monoclonal antibodies to avermectins |
| ATE132504T1 (de) * | 1990-08-15 | 1996-01-15 | Abbott Lab | Immunotestreagenzien und verfahren zur bestimmung von cyclosporin |
| PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
| US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5322772A (en) | 1991-04-09 | 1994-06-21 | Children's Research Institute | Rapamycin assay |
| JPH05112573A (ja) * | 1991-04-17 | 1993-05-07 | American Home Prod Corp | ラパマイシンのカルバミン酸エステル類 |
| US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5194447A (en) | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5514544A (en) * | 1991-07-26 | 1996-05-07 | Eli Lilly And Company | Activator gene for macrolide biosynthesis |
| US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
| AU686629B2 (en) | 1993-04-23 | 1998-02-12 | Wyeth | Rapamycin Conjugates and Antibodies |
| US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
| WO1994025072A1 (en) | 1993-04-23 | 1994-11-10 | American Home Products Corporation | Rapamycin conjugates and antibodies |
| US6187547B1 (en) * | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
-
1993
- 1993-04-08 GB GB939307491A patent/GB9307491D0/en active Pending
-
1994
- 1994-03-30 JP JP52268294A patent/JP3397325B2/ja not_active Expired - Lifetime
- 1994-03-30 SK SK1257-95A patent/SK280048B6/sk not_active IP Right Cessation
- 1994-03-30 DK DK94913093.4T patent/DK0693132T3/da active
- 1994-03-30 ES ES94913093T patent/ES2110230T3/es not_active Expired - Lifetime
- 1994-03-30 CN CN94191718A patent/CN1080312C/zh not_active Expired - Lifetime
- 1994-03-30 EP EP94913093A patent/EP0693132B1/en not_active Expired - Lifetime
- 1994-03-30 AU AU65377/94A patent/AU677321B2/en not_active Expired
- 1994-03-30 WO PCT/EP1994/001006 patent/WO1994024304A1/en active IP Right Grant
- 1994-03-30 BR BR9406210A patent/BR9406210A/pt not_active Application Discontinuation
- 1994-03-30 DE DE69407402T patent/DE69407402T2/de not_active Expired - Lifetime
- 1994-03-30 KR KR1019950704410A patent/KR100347166B1/ko not_active IP Right Cessation
- 1994-03-30 AT AT94913093T patent/ATE161289T1/de active
- 1994-03-30 CZ CZ952583A patent/CZ284431B6/cs not_active IP Right Cessation
- 1994-03-30 PL PL94310967A patent/PL185855B1/pl unknown
- 1994-03-30 HU HU9501975A patent/HU221606B/hu unknown
- 1994-03-30 RU RU95119595/13A patent/RU2175672C2/ru active
- 1994-03-30 KR KR10-2002-7004572A patent/KR100404162B1/ko not_active IP Right Cessation
- 1994-03-30 NZ NZ265051A patent/NZ265051A/en not_active IP Right Cessation
-
1995
- 1995-09-14 FI FI954319A patent/FI110670B/fi not_active IP Right Cessation
- 1995-10-06 NO NO19953975A patent/NO320470B1/no not_active IP Right Cessation
-
1997
- 1997-12-23 GR GR970403403T patent/GR3025753T3/el unknown
-
2000
- 2000-06-02 US US09/585,743 patent/US8039599B1/en not_active Expired - Fee Related
-
2001
- 2001-01-09 US US09/757,212 patent/US6635745B2/en not_active Ceased
- 2001-03-19 JP JP2001078335A patent/JP2001302698A/ja active Pending
- 2001-08-20 US US09/933,104 patent/US8039600B2/en not_active Expired - Fee Related
-
2002
- 2002-05-02 JP JP2002130451A patent/JP4287619B2/ja not_active Expired - Lifetime
-
2006
- 2006-03-22 JP JP2006079344A patent/JP2006249090A/ja active Pending
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