CA2559998A1 - Rapamycin conjugates and antibodies - Google Patents
Rapamycin conjugates and antibodies Download PDFInfo
- Publication number
- CA2559998A1 CA2559998A1 CA002559998A CA2559998A CA2559998A1 CA 2559998 A1 CA2559998 A1 CA 2559998A1 CA 002559998 A CA002559998 A CA 002559998A CA 2559998 A CA2559998 A CA 2559998A CA 2559998 A1 CA2559998 A1 CA 2559998A1
- Authority
- CA
- Canada
- Prior art keywords
- rapamycin
- antibodies specific
- antibodies
- conjugates
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 7
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 6
- 229960002930 sirolimus Drugs 0.000 title abstract 6
- 102000018679 Tacrolimus Binding Proteins Human genes 0.000 abstract 1
- 108010027179 Tacrolimus Binding Proteins Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin or a derivative thereof, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides monoclonal antibodies specific for rapamycin or a ring opened derivative of rapamycin.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5303093A | 1993-04-23 | 1993-04-23 | |
| US08/053,030 | 1993-04-23 | ||
| US22420594A | 1994-04-14 | 1994-04-14 | |
| US08/224,205 | 1994-04-14 | ||
| CA002161101A CA2161101A1 (en) | 1993-04-23 | 1994-04-22 | Rapamycin conjugates and antibodies |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002161101A Division CA2161101A1 (en) | 1993-04-23 | 1994-04-22 | Rapamycin conjugates and antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2559998A1 true CA2559998A1 (en) | 1994-11-10 |
| CA2559998C CA2559998C (en) | 2009-04-14 |
Family
ID=37480453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002559998A Expired - Lifetime CA2559998C (en) | 1993-04-23 | 1994-04-22 | Rapamycin conjugates and antibodies |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2559998C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022272154A3 (en) * | 2021-06-25 | 2023-02-02 | Apertor Pharmaceuticals, Inc. | Small molecule compounds |
-
1994
- 1994-04-22 CA CA002559998A patent/CA2559998C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022272154A3 (en) * | 2021-06-25 | 2023-02-02 | Apertor Pharmaceuticals, Inc. | Small molecule compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2559998C (en) | 2009-04-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1181938A3 (en) | Rapamycin conjugates and antibodies | |
| PL310967A1 (en) | Rapamycine test | |
| AU4992997A (en) | Humanized anti-cd11a antibodies | |
| IL118565A0 (en) | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates | |
| AU735411C (en) | Stable lyophilized pharmaceutical preparations of monoclonal or polyclonal antibodies | |
| AU1701001A (en) | Antibodies against signal regulator proteins | |
| AU6016699A (en) | Microcantilever detector for explosives | |
| AU5869596A (en) | Anti-gp130 monoclonal antibodies | |
| AU1743201A (en) | Receptor binding conjugates | |
| CA2220447A1 (en) | Novel fusion protein recovery and purification methods | |
| AU5686698A (en) | Methods for the production of chicken monoclonal antibodies | |
| WO1999020747A3 (en) | HUMAN CHECKPOINT KINASE, hCDS1, COMPOSITIONS AND METHODS | |
| AU7117296A (en) | Lithology-independent gradient nmr gas detection | |
| WO1999065947A3 (en) | Monoclonal antibodies directed against the g3bp protein, and uses | |
| AU4583397A (en) | Assay for the detection of antibodies against p53 | |
| AU7714294A (en) | Reagents and methods for the detection and quantification of testosterone in fluid samples | |
| AU5999199A (en) | Novel antibodies, drugs containing these antibodies and methods for screening compounds by using these antibodies | |
| CA2559998A1 (en) | Rapamycin conjugates and antibodies | |
| WO2001029220A3 (en) | Mage-a12 antigenic peptides and uses thereof | |
| AU8448591A (en) | Process for testing gene-disease associations | |
| AU2547995A (en) | Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1, the antigen itself, and uses thereof | |
| AU6358996A (en) | Condensed thiazole derivatives, having 5-ht receptor affinity | |
| AU6764196A (en) | Methods and antibodies for detecting creatine kinase | |
| CA2188835A1 (en) | Novel compounds and methods for synthesis and therapy | |
| WO1996040763A3 (en) | Peptides for hiv-1 detection |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20140422 |