ATE410431T1 - Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper - Google Patents
Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörperInfo
- Publication number
- ATE410431T1 ATE410431T1 AT05735488T AT05735488T ATE410431T1 AT E410431 T1 ATE410431 T1 AT E410431T1 AT 05735488 T AT05735488 T AT 05735488T AT 05735488 T AT05735488 T AT 05735488T AT E410431 T1 ATE410431 T1 AT E410431T1
- Authority
- AT
- Austria
- Prior art keywords
- esters
- rapamycin
- precursors
- antibodies
- conjugates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56196604P | 2004-04-14 | 2004-04-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE410431T1 true ATE410431T1 (de) | 2008-10-15 |
Family
ID=34965703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05735488T ATE410431T1 (de) | 2004-04-14 | 2005-04-12 | Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper |
Country Status (14)
Country | Link |
---|---|
US (2) | US7445916B2 (de) |
EP (1) | EP1735321B1 (de) |
JP (1) | JP2007532655A (de) |
CN (1) | CN1942478A (de) |
AT (1) | ATE410431T1 (de) |
AU (1) | AU2005238432A1 (de) |
BR (1) | BRPI0509810A (de) |
CA (1) | CA2562962A1 (de) |
DE (1) | DE602005010228D1 (de) |
DK (1) | DK1735321T3 (de) |
ES (1) | ES2313328T3 (de) |
MX (1) | MXPA06011882A (de) |
PL (1) | PL1735321T3 (de) |
WO (1) | WO2005105812A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA82328C2 (uk) | 2002-07-30 | 2008-04-10 | Уайт | Парентеральна композиція на основі гідроксіестеру рапаміцину (варіанти) та спосіб її приготування |
WO2005105812A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
CN1946852A (zh) * | 2004-04-27 | 2007-04-11 | 惠氏公司 | 利用雷帕霉素特异性甲基化酶标记雷帕霉素 |
PE20060642A1 (es) * | 2004-08-10 | 2006-08-01 | Wyeth Corp | Derivados de 42-ester de rapamicina con acido 2,2-bis(hidoximetil)propionico (cci-779) y metodos para su preparacion |
EP1957501A2 (de) * | 2005-12-07 | 2008-08-20 | Wyeth a Corporation of the State of Delaware | Skalierbares verfahren zur herstellung eines rapamycin-42-esters aus einem rapamycin-42-ester-boronat |
CN101351702A (zh) * | 2005-12-07 | 2009-01-21 | 惠氏公司 | 结晶雷帕霉素的制备方法以及使用差示扫描量热法测量雷帕霉素化合物结晶度的方法 |
CN101321769A (zh) * | 2005-12-07 | 2008-12-10 | 惠氏公司 | 制备纯化的晶体cci-779的方法 |
US7605257B2 (en) * | 2006-03-07 | 2009-10-20 | Wyeth | Processes for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants |
US8022188B2 (en) * | 2006-04-24 | 2011-09-20 | Abbott Laboratories | Immunosuppressant binding antibodies and methods of obtaining and using same |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
DK2365802T3 (da) | 2008-11-11 | 2017-11-13 | Univ Texas | Mikrokapsler af rapamycin og anvendelse til behandling af cancer |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
ES2700824T3 (es) | 2012-08-16 | 2019-02-19 | Pfizer | Procedimientos y composiciones de glucoconjugación |
EP2968281B1 (de) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor-hemmer zur vorbeugung von darmpolypenwachstum |
CA3206208A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
EP3848065B1 (de) | 2017-05-15 | 2023-07-26 | C. R. Bard, Inc. | Medizinische vorrichtung mit wirkstofffreisetzender beschichtung und zwischenschicht |
JP7262581B2 (ja) | 2018-11-14 | 2023-04-21 | ルトニックス,インコーポレーテッド | 改質されたデバイス表面に薬物溶出コーティングを有する医療用デバイス |
CN113939324A (zh) | 2019-04-08 | 2022-01-14 | 巴德外周血管股份有限公司 | 在经改性装置表面上具有药物洗脱涂层的医疗装置 |
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ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
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US5210030A (en) * | 1990-06-25 | 1993-05-11 | Merck & Co., Inc. | Process for selectively acylating immunomycin |
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US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
US5078999A (en) | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
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US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
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US5489680A (en) | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
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US7153983B2 (en) * | 2002-03-25 | 2006-12-26 | Council Of Scientific And Industrial Research | Chemo-enzymatic process for the preparation of opticaly enriched β-benzyl-γ-butyrolactones |
US6745478B2 (en) | 2002-07-18 | 2004-06-08 | Delillo Dominick D. | Multi-purpose work knife |
WO2005016935A2 (en) | 2003-08-07 | 2005-02-24 | Wyeth | Regioselective synthesis of cci-779 |
EP1737869A1 (de) * | 2004-04-14 | 2007-01-03 | Wyeth a Corporation of the State of Delaware | Regiospezifische synthese von rapamycin-42-esterderivaten |
JP2007532650A (ja) * | 2004-04-14 | 2007-11-15 | ワイス | プロリンcci−779(2,2−ビス(ヒドロキシメチル)プロピオン酸とのプロリン−ラパマイシン42−エステル)ならびに細菌リパーゼを使用するプロリンcci−779およびcci−779の二段階酵素的合成 |
WO2005105812A1 (en) * | 2004-04-14 | 2005-11-10 | Wyeth | Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
BRPI0512856A (pt) * | 2004-06-30 | 2008-04-08 | Combinatorx Inc | métodos e reagentes para o tratamento de distúrbios metabólicos |
-
2005
- 2005-04-12 WO PCT/US2005/012268 patent/WO2005105812A1/en not_active Application Discontinuation
- 2005-04-12 DE DE602005010228T patent/DE602005010228D1/de not_active Expired - Fee Related
- 2005-04-12 AT AT05735488T patent/ATE410431T1/de not_active IP Right Cessation
- 2005-04-12 US US11/104,349 patent/US7445916B2/en active Active
- 2005-04-12 MX MXPA06011882A patent/MXPA06011882A/es active IP Right Grant
- 2005-04-12 PL PL05735488T patent/PL1735321T3/pl unknown
- 2005-04-12 JP JP2007508443A patent/JP2007532655A/ja not_active Withdrawn
- 2005-04-12 CN CNA200580011299XA patent/CN1942478A/zh not_active Withdrawn
- 2005-04-12 AU AU2005238432A patent/AU2005238432A1/en not_active Withdrawn
- 2005-04-12 EP EP05735488A patent/EP1735321B1/de not_active Not-in-force
- 2005-04-12 DK DK05735488T patent/DK1735321T3/da active
- 2005-04-12 CA CA002562962A patent/CA2562962A1/en not_active Abandoned
- 2005-04-12 ES ES05735488T patent/ES2313328T3/es active Active
- 2005-04-12 BR BRPI0509810-6A patent/BRPI0509810A/pt not_active IP Right Cessation
-
2008
- 2008-09-29 US US12/240,230 patent/US7625726B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2562962A1 (en) | 2005-11-10 |
CN1942478A (zh) | 2007-04-04 |
ES2313328T3 (es) | 2009-03-01 |
MXPA06011882A (es) | 2006-12-14 |
EP1735321A1 (de) | 2006-12-27 |
JP2007532655A (ja) | 2007-11-15 |
AU2005238432A1 (en) | 2005-11-10 |
US7625726B2 (en) | 2009-12-01 |
BRPI0509810A (pt) | 2007-09-18 |
US20050234087A1 (en) | 2005-10-20 |
WO2005105812A1 (en) | 2005-11-10 |
US20090029426A1 (en) | 2009-01-29 |
EP1735321B1 (de) | 2008-10-08 |
PL1735321T3 (pl) | 2009-04-30 |
DE602005010228D1 (de) | 2008-11-20 |
US7445916B2 (en) | 2008-11-04 |
DK1735321T3 (da) | 2009-01-12 |
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Legal Events
Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |