DK1735321T3 - Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer - Google Patents
Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistofferInfo
- Publication number
- DK1735321T3 DK1735321T3 DK05735488T DK05735488T DK1735321T3 DK 1735321 T3 DK1735321 T3 DK 1735321T3 DK 05735488 T DK05735488 T DK 05735488T DK 05735488 T DK05735488 T DK 05735488T DK 1735321 T3 DK1735321 T3 DK 1735321T3
- Authority
- DK
- Denmark
- Prior art keywords
- rapamycin
- esters
- dicarboxylic acid
- precursors
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56196604P | 2004-04-14 | 2004-04-14 | |
PCT/US2005/012268 WO2005105812A1 (en) | 2004-04-14 | 2005-04-12 | Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1735321T3 true DK1735321T3 (da) | 2009-01-12 |
Family
ID=34965703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05735488T DK1735321T3 (da) | 2004-04-14 | 2005-04-12 | Fremgangsmåde til fremstilling af rapamycin 42-estere og FK-506 32-estere med dicarboxylsyre, precursors for rapamycinkonjugater og antistoffer |
Country Status (14)
Country | Link |
---|---|
US (2) | US7445916B2 (de) |
EP (1) | EP1735321B1 (de) |
JP (1) | JP2007532655A (de) |
CN (1) | CN1942478A (de) |
AT (1) | ATE410431T1 (de) |
AU (1) | AU2005238432A1 (de) |
BR (1) | BRPI0509810A (de) |
CA (1) | CA2562962A1 (de) |
DE (1) | DE602005010228D1 (de) |
DK (1) | DK1735321T3 (de) |
ES (1) | ES2313328T3 (de) |
MX (1) | MXPA06011882A (de) |
PL (1) | PL1735321T3 (de) |
WO (1) | WO2005105812A1 (de) |
Families Citing this family (29)
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NZ537829A (en) * | 2002-07-30 | 2006-09-29 | Wyeth Corp | Parenteral formulations containing a rapamycin hydroxyester |
US7445916B2 (en) * | 2004-04-14 | 2008-11-04 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
JP2007534337A (ja) * | 2004-04-27 | 2007-11-29 | ワイス | ラパマイシン特異的メチラーゼを用いるラパマイシンの標識 |
PA8641501A1 (es) * | 2004-08-10 | 2006-09-08 | Wyeth Corp | Derivados de cci-779 y metodo para su preparacion |
KR20080077147A (ko) * | 2005-12-07 | 2008-08-21 | 와이어쓰 | 결정성 라파마이신의 제조 방법 및 시차 주사 열량계를사용하는 라파마이신 화합물의 결정화도의 측정 방법 |
US7622578B2 (en) * | 2005-12-07 | 2009-11-24 | Wyeth | Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate |
RU2008121240A (ru) * | 2005-12-07 | 2010-01-20 | Вайет (Us) | Способ получения очищенного кристаллического cci-779 |
AU2007223963A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Process for preparing water-soluble polyethylene glycol conjugates of macrolide immunosuppressants |
US8022188B2 (en) * | 2006-04-24 | 2011-09-20 | Abbott Laboratories | Immunosuppressant binding antibodies and methods of obtaining and using same |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
WO2010024898A2 (en) | 2008-08-29 | 2010-03-04 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
EP2365802B1 (de) | 2008-11-11 | 2017-08-02 | The Board of Regents,The University of Texas System | Mikrokapseln von rapamycin und deren verwendung zur behandlung von krebs |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
IN2015DN00694A (de) * | 2012-08-16 | 2015-06-26 | Pfizer | |
EP2968281B1 (de) | 2013-03-13 | 2020-08-05 | The Board of Regents of The University of Texas System | Mtor-hemmer zur vorbeugung von darmpolypenwachstum |
CA3206208A1 (en) | 2013-12-31 | 2015-07-09 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
EP3624863B1 (de) | 2017-05-15 | 2021-04-14 | C.R. Bard, Inc. | Medizinische vorrichtung mit wirkstofffreisetzender beschichtung und zwischenschicht |
EP3880266A1 (de) | 2018-11-14 | 2021-09-22 | Lutonix, Inc. | Medizinische vorrichtung mit wirkstofffreisetzender beschichtung auf modifizierter vorrichtungsoberfläche |
EP3952937A1 (de) | 2019-04-08 | 2022-02-16 | Bard Peripheral Vascular, Inc. | Medizinische vorrichtung mit wirkstofffreisetzender beschichtung auf modifizierter vorrichtungsoberfläche |
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ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5210030A (en) * | 1990-06-25 | 1993-05-11 | Merck & Co., Inc. | Process for selectively acylating immunomycin |
US5023264A (en) | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
PT98990A (pt) | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
US5221670A (en) | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
US5378696A (en) | 1990-09-19 | 1995-01-03 | American Home Products Corporation | Rapamycin esters |
US5233036A (en) | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
US5078999A (en) | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
US5130507A (en) * | 1991-05-23 | 1992-07-14 | Eaton Corporation | Capacitive switch assembly |
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US5162333A (en) | 1991-09-11 | 1992-11-10 | American Home Products Corporation | Aminodiesters of rapamycin |
US5177203A (en) | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
US5256790A (en) | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5411967A (en) | 1992-10-13 | 1995-05-02 | American Home Products Corporation | Carbamates of rapamycin |
US5302584A (en) | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
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US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US5260300A (en) | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
US5252579A (en) | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
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ES2295093T3 (es) | 1993-04-23 | 2008-04-16 | Wyeth | Conjugados y anticuerpos de rapamicina. |
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GB2281294A (en) * | 1993-08-23 | 1995-03-01 | Fujisawa Pharmaceutical Co | Process for producing half esters of the macrolide FK506 |
US5373014A (en) | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
US5391730A (en) | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
US5378836A (en) | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5385910A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
US5385909A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
US5385908A (en) | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
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US5463048A (en) | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
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US5563145A (en) | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
US6261813B1 (en) | 1995-09-11 | 2001-07-17 | Albany Molecular Research, Inc. | Two step enzymatic acylation |
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US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
US7153983B2 (en) * | 2002-03-25 | 2006-12-26 | Council Of Scientific And Industrial Research | Chemo-enzymatic process for the preparation of opticaly enriched β-benzyl-γ-butyrolactones |
US6745478B2 (en) | 2002-07-18 | 2004-06-08 | Delillo Dominick D. | Multi-purpose work knife |
RU2339639C2 (ru) | 2003-08-07 | 2008-11-27 | Уайт | Региоселективный синтез cci-779 |
US7445916B2 (en) * | 2004-04-14 | 2008-11-04 | Wyeth | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies |
KR20070015544A (ko) * | 2004-04-14 | 2007-02-05 | 와이어쓰 | 라파마이신 42-에스테르 유도체의 위치특이성 합성 |
EP1751168A1 (de) * | 2004-04-14 | 2007-02-14 | Wyeth | Prolin cci-779 (prolin-rapamycin 42-ester mit 2,2-bis(hydroxymethyl)propionsäure) und zweistufige enzymatische synthese von prolin cci-779 und cci-779 mit mikrobieller lipase |
RU2007103178A (ru) * | 2004-06-30 | 2008-08-10 | Комбинаторкс, Инкорпорейтед (Us) | Способы и реагенты для лечения метаболических нарушений |
-
2005
- 2005-04-12 US US11/104,349 patent/US7445916B2/en active Active
- 2005-04-12 DK DK05735488T patent/DK1735321T3/da active
- 2005-04-12 EP EP05735488A patent/EP1735321B1/de not_active Not-in-force
- 2005-04-12 AU AU2005238432A patent/AU2005238432A1/en not_active Withdrawn
- 2005-04-12 CA CA002562962A patent/CA2562962A1/en not_active Abandoned
- 2005-04-12 JP JP2007508443A patent/JP2007532655A/ja not_active Withdrawn
- 2005-04-12 WO PCT/US2005/012268 patent/WO2005105812A1/en not_active Application Discontinuation
- 2005-04-12 ES ES05735488T patent/ES2313328T3/es active Active
- 2005-04-12 DE DE602005010228T patent/DE602005010228D1/de not_active Expired - Fee Related
- 2005-04-12 CN CNA200580011299XA patent/CN1942478A/zh not_active Withdrawn
- 2005-04-12 MX MXPA06011882A patent/MXPA06011882A/es active IP Right Grant
- 2005-04-12 AT AT05735488T patent/ATE410431T1/de not_active IP Right Cessation
- 2005-04-12 PL PL05735488T patent/PL1735321T3/pl unknown
- 2005-04-12 BR BRPI0509810-6A patent/BRPI0509810A/pt not_active IP Right Cessation
-
2008
- 2008-09-29 US US12/240,230 patent/US7625726B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7445916B2 (en) | 2008-11-04 |
US7625726B2 (en) | 2009-12-01 |
CN1942478A (zh) | 2007-04-04 |
PL1735321T3 (pl) | 2009-04-30 |
MXPA06011882A (es) | 2006-12-14 |
US20050234087A1 (en) | 2005-10-20 |
US20090029426A1 (en) | 2009-01-29 |
WO2005105812A1 (en) | 2005-11-10 |
ES2313328T3 (es) | 2009-03-01 |
CA2562962A1 (en) | 2005-11-10 |
ATE410431T1 (de) | 2008-10-15 |
AU2005238432A1 (en) | 2005-11-10 |
EP1735321B1 (de) | 2008-10-08 |
JP2007532655A (ja) | 2007-11-15 |
BRPI0509810A (pt) | 2007-09-18 |
DE602005010228D1 (de) | 2008-11-20 |
EP1735321A1 (de) | 2006-12-27 |
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