ATE157975T1 - Oxazolidinedione-derivate, ihre herstellung und ihre verwendung zur hemmung zucker und lipid in blut - Google Patents
Oxazolidinedione-derivate, ihre herstellung und ihre verwendung zur hemmung zucker und lipid in blutInfo
- Publication number
- ATE157975T1 ATE157975T1 AT94301341T AT94301341T ATE157975T1 AT E157975 T1 ATE157975 T1 AT E157975T1 AT 94301341 T AT94301341 T AT 94301341T AT 94301341 T AT94301341 T AT 94301341T AT E157975 T1 ATE157975 T1 AT E157975T1
- Authority
- AT
- Austria
- Prior art keywords
- lipid
- blood
- preparation
- combine
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3823693 | 1993-02-26 | ||
| JP19730493 | 1993-08-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE157975T1 true ATE157975T1 (de) | 1997-09-15 |
Family
ID=26377445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94301341T ATE157975T1 (de) | 1993-02-26 | 1994-02-25 | Oxazolidinedione-derivate, ihre herstellung und ihre verwendung zur hemmung zucker und lipid in blut |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US5665748A (enEXAMPLES) |
| EP (1) | EP0612743B1 (enEXAMPLES) |
| JP (2) | JP3328720B2 (enEXAMPLES) |
| KR (1) | KR940019699A (enEXAMPLES) |
| CN (1) | CN1098411A (enEXAMPLES) |
| AT (1) | ATE157975T1 (enEXAMPLES) |
| AU (1) | AU673034B2 (enEXAMPLES) |
| CA (1) | CA2116387C (enEXAMPLES) |
| DE (1) | DE69405425T2 (enEXAMPLES) |
| DK (1) | DK0612743T3 (enEXAMPLES) |
| ES (1) | ES2108375T3 (enEXAMPLES) |
| FI (1) | FI940904A7 (enEXAMPLES) |
| GR (1) | GR3025342T3 (enEXAMPLES) |
| HU (1) | HUT70159A (enEXAMPLES) |
| NO (1) | NO305079B1 (enEXAMPLES) |
| PH (1) | PH31468A (enEXAMPLES) |
| RU (1) | RU2126797C1 (enEXAMPLES) |
| TW (1) | TW268952B (enEXAMPLES) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5468762A (en) * | 1994-05-18 | 1995-11-21 | American Home Products Corporation | Azolidinediones as antihyperglycemic agents |
| US5641796A (en) * | 1994-11-01 | 1997-06-24 | Eli Lilly And Company | Oral hypoglycemic agents |
| TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
| CA2171702A1 (en) * | 1995-03-14 | 1996-09-15 | Takashi Sohda | Benzofuran compounds and their use |
| JPH09136877A (ja) * | 1995-06-16 | 1997-05-27 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及び用途 |
| AU2177797A (en) | 1996-04-03 | 1997-10-22 | Takeda Chemical Industries Ltd. | Oxazole derivatives, their production and use |
| JPH09323930A (ja) * | 1996-04-04 | 1997-12-16 | Takeda Chem Ind Ltd | 悪液質の予防・治療剤 |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| FR2749583B1 (fr) | 1996-06-07 | 1998-08-21 | Lipha | Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| KR100579765B1 (ko) * | 1996-07-01 | 2006-12-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도 |
| US6372750B2 (en) | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| AU740444B2 (en) | 1996-08-19 | 2001-11-01 | Japan Tobacco Inc. | Propionic acid derivatives and use thereof |
| US6313113B1 (en) * | 1997-04-15 | 2001-11-06 | Reddy-Cheminor, Inc. | Heterocyclic compounds having antidiabetic, hypolipidemic and antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| EP1087963B1 (en) | 1998-06-19 | 2004-08-25 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| CN1053186C (zh) * | 1998-07-09 | 2000-06-07 | 华东理工大学 | 喹啉噁唑啉化合物 |
| JP2000044551A (ja) * | 1998-07-27 | 2000-02-15 | Konica Corp | ３−置換−３−オキソ−２−（２，４−オキサゾリジンジオン−３−イル）プロピオン酸アミド化合物の製造方法 |
| AU6331199A (en) * | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders |
| US6121300A (en) * | 1998-11-10 | 2000-09-19 | Wagle; Dilip R. | Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium salts |
| CZ300543B6 (cs) * | 1998-12-01 | 2009-06-10 | Dr. Reddy's Laboratories Limited | Farmaceutický prípravek a zpusob jeho prípravy |
| WO2000061581A1 (en) | 1999-04-07 | 2000-10-19 | Sankyo Company, Limited | Amine derivatives |
| US6380191B1 (en) | 1999-06-18 | 2002-04-30 | Merck & Co. Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| WO2000078312A1 (en) | 1999-06-18 | 2000-12-28 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| JP4316787B2 (ja) * | 2000-01-11 | 2009-08-19 | 壽製薬株式会社 | エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、 |
| US7105551B2 (en) | 2000-12-20 | 2006-09-12 | Smithkline Beecham Corporation | Thiazole derivatives for treating PPAR related disorders |
| WO2002076959A1 (fr) * | 2001-03-23 | 2002-10-03 | Takeda Chemical Industries, Ltd. | Derive heterocyclique a cinq membres d'acide alcanoique |
| TW200300681A (en) * | 2001-11-12 | 2003-06-16 | Ono Pharmaceutical Co | Carboxylic acid derivative compound and medicament containing same as active ingredient |
| AU2003203170A1 (en) * | 2002-01-17 | 2003-07-30 | Takeda Chemical Industries, Ltd. | Nitrogenous heterocyclic compounds, process for preparation of the same and use thereof |
| TWI327462B (en) * | 2002-01-18 | 2010-07-21 | Sumitomo Chemical Co | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same |
| US7232828B2 (en) | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US7781464B2 (en) * | 2003-01-17 | 2010-08-24 | Bexel Pharmaceuticals, Inc. | Heterocyclic diphenyl ethers |
| EA200501710A1 (ru) | 2003-04-30 | 2006-06-30 | ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи | Замещённые карбоновые кислоты |
| US7087576B2 (en) * | 2003-10-07 | 2006-08-08 | Bexel Pharmaceuticals, Inc. | Dipeptide phenyl ethers |
| US20070173434A1 (en) * | 2004-01-20 | 2007-07-26 | Shi Guo Q | Antidiabetic oxazolidinediones and thiazolidinediones |
| JP2008518926A (ja) * | 2004-10-28 | 2008-06-05 | ジ インスティチューツ フォー ファーマシューティカル ディスカバリー、エルエルシー | 置換フェニルアルカン酸 |
| TW200932219A (en) * | 2007-10-24 | 2009-08-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430337A (en) * | 1982-06-23 | 1984-02-07 | Pfizer Inc. | Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity |
| US5232925A (en) * | 1987-09-04 | 1993-08-03 | Beecham Group P.L.C. | Compounds |
| WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
| JP2991801B2 (ja) * | 1990-04-27 | 1999-12-20 | 三共株式会社 | ベンジリデンチアゾリジン化合物 |
| US5037842A (en) * | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
| GB9017218D0 (en) * | 1990-08-06 | 1990-09-19 | Beecham Group Plc | Novel compounds |
| HUT68370A (en) * | 1991-04-11 | 1995-06-28 | Takeda Chemical Industries Ltd | Thiazolidine derivatives, pharmaceutical compositions containing them and process for their production |
| DE69228122T2 (de) * | 1991-07-30 | 1999-06-24 | Yamanouchi Pharmaceutical Co., Ltd., Tokio/Tokyo | Neues bisheterocyclisches derivat und salz und hypoglykämische zusammensetzung |
| JPH05202042A (ja) * | 1992-01-24 | 1993-08-10 | Sankyo Co Ltd | 糖尿病性合併症治療剤 |
| FI935920L (fi) * | 1992-04-30 | 1993-12-29 | Taiho Pharmaceutical Co Ltd | Oxazolinderivat och deras farmaceutiskt godtagbara salter |
| US5928152A (en) * | 1994-08-05 | 1999-07-27 | Acuson Corporation | Method and apparatus for a baseband processor of a receive beamformer system |
-
1994
- 1994-02-10 TW TW083101207A patent/TW268952B/zh active
- 1994-02-15 AU AU55158/94A patent/AU673034B2/en not_active Ceased
- 1994-02-23 NO NO940610A patent/NO305079B1/no not_active IP Right Cessation
- 1994-02-24 PH PH47836A patent/PH31468A/en unknown
- 1994-02-24 CA CA002116387A patent/CA2116387C/en not_active Expired - Fee Related
- 1994-02-25 RU RU94006013A patent/RU2126797C1/ru active
- 1994-02-25 DK DK94301341.7T patent/DK0612743T3/da active
- 1994-02-25 DE DE69405425T patent/DE69405425T2/de not_active Expired - Fee Related
- 1994-02-25 JP JP02841794A patent/JP3328720B2/ja not_active Expired - Fee Related
- 1994-02-25 ES ES94301341T patent/ES2108375T3/es not_active Expired - Lifetime
- 1994-02-25 FI FI940904A patent/FI940904A7/fi unknown
- 1994-02-25 AT AT94301341T patent/ATE157975T1/de not_active IP Right Cessation
- 1994-02-25 EP EP94301341A patent/EP0612743B1/en not_active Expired - Lifetime
- 1994-02-25 HU HU9400578A patent/HUT70159A/hu unknown
- 1994-02-26 CN CN94103283A patent/CN1098411A/zh active Pending
- 1994-02-26 KR KR1019940003595A patent/KR940019699A/ko not_active Abandoned
-
1995
- 1995-11-06 US US08/554,107 patent/US5665748A/en not_active Expired - Fee Related
-
1997
- 1997-04-04 US US08/832,916 patent/US5972970A/en not_active Expired - Fee Related
- 1997-11-11 GR GR970402984T patent/GR3025342T3/el unknown
-
1999
- 1999-04-16 US US09/292,748 patent/US6147099A/en not_active Expired - Fee Related
-
2000
- 2000-03-01 JP JP2000060384A patent/JP2000191651A/ja not_active Abandoned
- 2000-09-22 US US09/667,247 patent/US6552058B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO305079B1 (no) | 1999-03-29 |
| EP0612743B1 (en) | 1997-09-10 |
| HUT70159A (en) | 1995-09-28 |
| JP2000191651A (ja) | 2000-07-11 |
| US5972970A (en) | 1999-10-26 |
| FI940904L (fi) | 1994-11-29 |
| FI940904A0 (fi) | 1994-02-25 |
| CA2116387A1 (en) | 1994-08-27 |
| KR940019699A (ko) | 1994-09-14 |
| RU2126797C1 (ru) | 1999-02-27 |
| CN1098411A (zh) | 1995-02-08 |
| NO940610L (no) | 1994-08-29 |
| US6552058B1 (en) | 2003-04-22 |
| DK0612743T3 (da) | 1998-04-20 |
| PH31468A (en) | 1998-11-03 |
| EP0612743A1 (en) | 1994-08-31 |
| US5665748A (en) | 1997-09-09 |
| FI940904A7 (fi) | 1994-11-29 |
| JP3328720B2 (ja) | 2002-09-30 |
| NO940610D0 (no) | 1994-02-23 |
| HU9400578D0 (en) | 1994-05-30 |
| DE69405425T2 (de) | 1998-03-19 |
| CA2116387C (en) | 2003-12-23 |
| AU5515894A (en) | 1994-09-01 |
| US6147099A (en) | 2000-11-14 |
| TW268952B (enEXAMPLES) | 1996-01-21 |
| GR3025342T3 (en) | 1998-02-27 |
| ES2108375T3 (es) | 1997-12-16 |
| JPH07165735A (ja) | 1995-06-27 |
| DE69405425D1 (de) | 1997-10-16 |
| AU673034B2 (en) | 1996-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |