ATE156375T1 - Wirkstoffabgabevorrichtungen - Google Patents

Wirkstoffabgabevorrichtungen

Info

Publication number
ATE156375T1
ATE156375T1 AT93905344T AT93905344T ATE156375T1 AT E156375 T1 ATE156375 T1 AT E156375T1 AT 93905344 T AT93905344 T AT 93905344T AT 93905344 T AT93905344 T AT 93905344T AT E156375 T1 ATE156375 T1 AT E156375T1
Authority
AT
Austria
Prior art keywords
drug delivery
delivery devices
liquid
skin
subject
Prior art date
Application number
AT93905344T
Other languages
German (de)
English (en)
Inventor
Joseph Gross
Shlomo Zucker
Original Assignee
Elan Med Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Med Tech filed Critical Elan Med Tech
Application granted granted Critical
Publication of ATE156375T1 publication Critical patent/ATE156375T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
AT93905344T 1992-03-13 1993-03-11 Wirkstoffabgabevorrichtungen ATE156375T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85059592A 1992-03-13 1992-03-13
US07/981,652 US5279544A (en) 1990-12-13 1992-11-25 Transdermal or interdermal drug delivery devices

Publications (1)

Publication Number Publication Date
ATE156375T1 true ATE156375T1 (de) 1997-08-15

Family

ID=27126940

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93905344T ATE156375T1 (de) 1992-03-13 1993-03-11 Wirkstoffabgabevorrichtungen

Country Status (9)

Country Link
US (1) US5279544A (Direct)
EP (1) EP0630276B1 (Direct)
JP (1) JPH07508427A (Direct)
AT (1) ATE156375T1 (Direct)
AU (1) AU3632593A (Direct)
CA (1) CA2131794A1 (Direct)
DE (1) DE69312916T2 (Direct)
TW (1) TW286286B (Direct)
WO (1) WO1993017754A1 (Direct)

Families Citing this family (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
EP0796128B1 (de) * 1994-12-09 1999-03-10 Novartis AG Transdermales system
EP1131131A1 (en) 1995-04-23 2001-09-12 Electromagnetic Bracing Systems, Inc. Transdermal active drug delivery system and method
AU5869796A (en) * 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
US5858001A (en) * 1995-12-11 1999-01-12 Elan Medical Technologies Limited Cartridge-based drug delivery device
ZA975326B (en) * 1996-06-18 1998-01-14 Alza Corp Device and method for enhancing transdermal flux of agents being delivered or sampled.
CA2259437C (en) * 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
CA2265906C (en) * 1996-09-17 2003-11-11 Deka Products Limited Partnership System for delivery of drugs by transport
US20060002959A1 (en) * 1996-11-14 2006-01-05 Government Of The United States Skin-sctive adjuvants for transcutaneous immuization
US20060002949A1 (en) * 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
WO1998028037A1 (en) 1996-12-20 1998-07-02 Alza Corporation Device and method for enhancing transdermal agent flux
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US5848966A (en) * 1997-03-04 1998-12-15 Graphic Controls Corporation Medical device easily removed from skin and a method of removal therefrom
US20040258703A1 (en) * 1997-11-14 2004-12-23 The Government Of The Us, As Represented By The Secretary Of The Army Skin-active adjuvants for transcutaneous immunization
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
WO1999029298A2 (en) 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
EP1911488A3 (en) 1997-12-11 2008-12-03 Alza Corporation Device for enhancing transdermal agent flux
ATE221400T1 (de) 1997-12-11 2002-08-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
EP1037686B1 (en) 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
US6208893B1 (en) * 1998-01-27 2001-03-27 Genetronics, Inc. Electroporation apparatus with connective electrode template
US5957895A (en) 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
US6091975A (en) * 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
CA2330207C (en) * 1998-06-10 2005-08-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
EP1100579B1 (en) * 1998-07-13 2015-09-02 Inovio Pharmaceuticals, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US7922709B2 (en) 1998-07-13 2011-04-12 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
US6678556B1 (en) * 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
WO2000002620A1 (en) * 1998-07-13 2000-01-20 Genetronics, Inc. Method and apparatus for electrically assisted topical delivery of agents for cosmetic applications
DE69921489T2 (de) * 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US7048723B1 (en) * 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
JP4180244B2 (ja) 1999-04-16 2008-11-12 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 内部センサを有する電気的な移動による送出装置系
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
WO2000074763A2 (en) 1999-06-04 2000-12-14 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US6179804B1 (en) 1999-08-18 2001-01-30 Oxypatch, Llc Treatment apparatus for wounds
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20020198509A1 (en) * 1999-10-14 2002-12-26 Mikszta John A. Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
CN101238998A (zh) * 1999-11-15 2008-08-13 维尔克工业有限公司 皮肤附着件
DE60024312T2 (de) 1999-12-10 2006-08-17 Alza Corp., Mountain View Transdermale Wirkstoffabgabe von makromolekularen Wirkstoffen und Vorrichtung hierfür
AU782610B2 (en) 1999-12-10 2005-08-11 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
AU2088301A (en) 1999-12-16 2001-06-25 Alza Corporation Device for enhancing transdermal flux of sampled agents
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6659982B2 (en) * 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6629949B1 (en) * 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
AU2001265056A1 (en) * 2000-05-26 2001-12-11 The Procter And Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US7473244B2 (en) * 2000-06-02 2009-01-06 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6607513B1 (en) * 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6656147B1 (en) * 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US6952605B1 (en) * 2000-08-10 2005-10-04 Respironics, Inc. Pneumatic release mechanism for a patient contacting article
CA2424520C (en) * 2000-08-21 2007-01-02 The Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
KR20030068127A (ko) 2000-08-24 2003-08-19 알자 코포레이션 경피적 핵산 샘플링 방법
US6749575B2 (en) * 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
US6690959B2 (en) 2000-09-01 2004-02-10 Medtronic, Inc. Skin-mounted electrodes with nano spikes
JP5507030B2 (ja) 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
WO2002030506A2 (en) 2000-10-12 2002-04-18 Ink Jet Technology Ltd. Transdermal method
US7419481B2 (en) * 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
ATE416692T1 (de) 2000-10-13 2008-12-15 Alza Corp Mikronadelelementhalter für schlagapplikator
ATE428357T1 (de) * 2000-10-13 2009-05-15 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
AU9682701A (en) 2000-10-13 2002-04-22 Alza Corp Microblade array impact applicator
US7131987B2 (en) * 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
ATE428466T1 (de) * 2000-10-26 2009-05-15 Alza Corp Transdermales arzneistoffverabreichungssytem mit beschichteten mikrovorsprüngen
EP1345646A2 (en) * 2000-12-14 2003-09-24 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2002050584A2 (en) * 2000-12-21 2002-06-27 Biovalve Technologies, Inc. Microneedle array systems
EP1372708B1 (en) * 2001-02-13 2008-06-18 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE ARMY Vaccine for transcutaneous immunization against travellers' diarrhoea
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6855372B2 (en) * 2001-03-16 2005-02-15 Alza Corporation Method and apparatus for coating skin piercing microprojections
EP1381423A1 (en) * 2001-04-13 2004-01-21 Becton, Dickinson and Company Methods and devices for administration of substances into the intradermal layer of skin for systemic absorption
DE60233939D1 (de) * 2001-04-20 2009-11-19 Alza Corp Mikroprojektionsanordnung mit einem überzug, der ein vorteilhaftes mittel enthält
EP1752189A3 (en) 2001-04-20 2007-02-21 Alza Corporation Microprojection array having a beneficial agent containing coating
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
CN100349629C (zh) 2001-09-12 2007-11-21 贝克顿迪肯森公司 用于药物传送的微针为基础的笔装置和使用该装置的方法
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US8361037B2 (en) * 2001-09-19 2013-01-29 Valeritas, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) * 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US20030135201A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US6689100B2 (en) 2001-10-05 2004-02-10 Becton, Dickinson And Company Microdevice and method of delivering or withdrawing a substance through the skin of an animal
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
WO2003048031A2 (en) * 2001-11-30 2003-06-12 Alza Corporation Methods and apparatuses for forming microprojection arrays
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
AU2003220143A1 (en) * 2002-03-11 2003-09-29 Altea Therapeutics Corporation Transdermal integrated actuator device, methods of making and using same
AU2003218371B2 (en) 2002-03-26 2008-06-12 Becton, Dickinson And Company Multi-stage fluid delivery device and method
US7115108B2 (en) * 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7047070B2 (en) * 2002-04-02 2006-05-16 Becton, Dickinson And Company Valved intradermal delivery device and method of intradermally delivering a substance to a patient
WO2003094995A1 (en) * 2002-05-06 2003-11-20 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
GB2389793A (en) * 2002-06-18 2003-12-24 Euro Celtique Sa Transdermal delivery system
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
KR20050054483A (ko) * 2002-06-28 2005-06-10 알자 코포레이션 코팅된 미세돌출부를 갖는 경피용 약물 전달 장치
CA2492867C (en) * 2002-07-19 2011-07-05 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
EP1523355B1 (en) * 2002-07-22 2019-01-23 Becton, Dickinson and Company Patch-like infusion device
CA2497086A1 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
WO2004024211A2 (en) * 2002-09-12 2004-03-25 Children's Hospital Medical Center Method and device for painless injection of medication
US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US20040115167A1 (en) * 2002-09-30 2004-06-17 Michel Cormier Drug delivery device and method having coated microprojections incorporating vasoconstrictors
US20040106904A1 (en) * 2002-10-07 2004-06-03 Gonnelli Robert R. Microneedle array patch
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
KR100562498B1 (ko) * 2003-02-12 2006-03-21 삼성전자주식회사 씨엠피 설비의 패드 컨디셔너
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
AU2004264839B2 (en) * 2003-06-13 2009-06-04 Becton, Dickinson And Company Improved intra-dermal delivery of biologically active agents
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
US20040265365A1 (en) * 2003-06-30 2004-12-30 Daddona Peter E. Method for coating skin piercing microprojections
BRPI0412029A (pt) 2003-06-30 2006-09-05 Alza Corp formulações para microprojeções revestidas contendo contra-ìons não-voláteis
WO2005018705A2 (en) 2003-08-12 2005-03-03 Becton, Dickinson And Company Patch-like infusion device
US20050180952A1 (en) * 2003-08-26 2005-08-18 Pettis Ronald J. Methods for intradermal delivery of therapeutics agents
US7320676B2 (en) * 2003-10-02 2008-01-22 Medtronic, Inc. Pressure sensing in implantable medical devices
US9033920B2 (en) * 2003-10-02 2015-05-19 Medtronic, Inc. Determining catheter status
US8323244B2 (en) * 2007-03-30 2012-12-04 Medtronic, Inc. Catheter malfunction determinations using physiologic pressure
US9138537B2 (en) * 2003-10-02 2015-09-22 Medtronic, Inc. Determining catheter status
US8317770B2 (en) * 2006-04-06 2012-11-27 Medtronic, Inc. Systems and methods of identifying catheter malfunctions using pressure sensing
CA2542874A1 (en) * 2003-10-23 2005-05-12 Alza Corporation Compositions of stabilized dna for coating microprojections
US7022116B2 (en) * 2003-10-23 2006-04-04 Medtronic, Inc. Method for monitoring bolus delivery
CN1897898A (zh) * 2003-10-24 2007-01-17 阿尔扎公司 用于增强透皮药物传递的预处理方法和系统
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
AU2004287412A1 (en) 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
US7097631B2 (en) 2003-10-31 2006-08-29 Alza Corporation Self-actuating applicator for microprojection array
CN100548228C (zh) * 2003-11-13 2009-10-14 阿尔扎公司 用于透皮递送的组合物和装置
JP2007512052A (ja) * 2003-11-28 2007-05-17 アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド 迅速な経皮投与系および方法
US8017145B2 (en) * 2003-12-22 2011-09-13 Conopco, Inc. Exfoliating personal care wipe article containing an array of projections
WO2005079440A2 (en) * 2004-02-17 2005-09-01 Children's Hospital Medical Center Improved injection devicew for administering a vaccine
US20050256499A1 (en) * 2004-03-03 2005-11-17 Pettis Ronald J Methods and devices for improving delivery of a substance to skin
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
CA2562642A1 (en) * 2004-04-13 2005-11-03 Alza Corporation Apparatus and method for transdermal delivery of multiple vaccines
US7217251B2 (en) * 2004-04-22 2007-05-15 Medtronic, Inc. Pressure relief methods in a medical catheter system
WO2005105199A1 (en) * 2004-04-22 2005-11-10 Medtronic, Inc. Diagnostic methods for branching catheter systems
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
AU2005244734A1 (en) 2004-05-13 2005-12-01 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
US20060030811A1 (en) * 2004-08-03 2006-02-09 Wong Patrick S Method and device for enhancing transdermal agent flux
US7846488B2 (en) * 2004-11-18 2010-12-07 3M Innovative Properties Company Masking method for coating a microneedle array
JP5015787B2 (ja) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの接触コーティング法
DE602005027397D1 (de) * 2004-11-18 2011-05-19 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
JP4793806B2 (ja) 2005-03-22 2011-10-12 Ｔｔｉ・エルビュー株式会社 イオントフォレーシス装置
US20060253079A1 (en) * 2005-04-25 2006-11-09 Mcdonough Justin Stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
DE102005024151A1 (de) * 2005-05-23 2006-11-30 Thomas Nicola Vorrichtung zur Peritonealdialyse
JP5161776B2 (ja) * 2005-09-06 2013-03-13 セラジェクト， インコーポレイテッド 薬物粒子および／または薬物を吸着した粒子を含む、固溶体穿孔器
JP2009507576A (ja) * 2005-09-12 2009-02-26 アルザ コーポレイション 被膜可能な経皮送達微小突起アセンブリ
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
US20080033338A1 (en) * 2005-12-28 2008-02-07 Smith Gregory A Electroosmotic pump apparatus and method to deliver active agents to biological interfaces
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US20070299388A1 (en) * 2006-04-25 2007-12-27 Alza Corporation Microprojection array application with multilayered microprojection member for high drug loading
WO2007127811A2 (en) * 2006-04-25 2007-11-08 Alza Corporation Microprojection array application with grouped microprojections for high drug loading
CA2657435A1 (en) 2006-07-10 2008-07-03 Medipacs, Inc. Super elastic epoxy hydrogel
US8007493B2 (en) 2006-10-16 2011-08-30 Syneron Medical Ltd. Methods and devices for treating tissue
US8273080B2 (en) * 2006-10-16 2012-09-25 Syneron Medical Ltd. Methods and devices for treating tissue
US8133216B2 (en) * 2006-10-16 2012-03-13 Syneron Medical Ltd. Methods and devices for treating tissue
US20080281389A1 (en) * 2006-10-16 2008-11-13 Primaeva Medical Inc. Methods and devices for treating tissue
US8142426B2 (en) 2006-10-16 2012-03-27 Syneron Medical Ltd. Methods and devices for treating tissue
EP2121111B1 (en) * 2007-01-22 2018-03-14 Corium International, Inc. Applicators for microneedle arrays
CN101678166B (zh) * 2007-03-02 2012-08-22 特克法马许可公司 模块化的给药系统
US9044537B2 (en) 2007-03-30 2015-06-02 Medtronic, Inc. Devices and methods for detecting catheter complications
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US20080312647A1 (en) * 2007-06-15 2008-12-18 Primaeva Medical, Inc. Methods and devices for treating tissue
US8845630B2 (en) * 2007-06-15 2014-09-30 Syneron Medical Ltd Devices and methods for percutaneous energy delivery
US20090036958A1 (en) * 2007-08-01 2009-02-05 Primaeva Medical, Inc. Methods and devices for treating tissue
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US20090112205A1 (en) * 2007-10-31 2009-04-30 Primaeva Medical, Inc. Cartridge electrode device
WO2009057173A1 (en) * 2007-11-02 2009-05-07 M & T S.R.L. Device for localized transfer of a filler
JP2011505520A (ja) 2007-12-03 2011-02-24 メディパックス インコーポレイテッド 流体計量供給装置
US20090156958A1 (en) * 2007-12-12 2009-06-18 Mehta Bankim H Devices and methods for percutaneous energy delivery
USD610690S1 (en) * 2008-04-16 2010-02-23 Hisamitsu Pharmaceutical Co., Inc. Combined medical patch and package
USD617463S1 (en) * 2008-04-16 2010-06-08 Hisamitsu Pharmaceutical Co., Inc. Combined medical patch and package
CN102105108B (zh) * 2008-05-21 2013-12-04 谢拉杰克特股份有限公司 制作固体溶液穿孔器贴剂的方法及其使用
CA2727015A1 (en) * 2008-06-04 2009-12-10 Coda Therapeutics, Inc. Treatment of pain with gap junction modulation compounds
CN102231995B (zh) 2008-12-02 2014-10-22 阿勒根公司 注射装置
WO2010090858A2 (en) * 2009-01-21 2010-08-12 Medtronic, Inc. Catheter systems having flow restrictors
US20100217254A1 (en) * 2009-02-25 2010-08-26 Primaeva Medical, Inc. Methods for applying energy to tissue using isolated energy sources
AU2010238605B2 (en) * 2009-04-24 2015-10-29 Corium Pharma Solutions, Inc. Methods for manufacturing microprojection arrays
US20100286600A1 (en) * 2009-05-08 2010-11-11 Bommannan D Bommi Transdermal patch device
US9238102B2 (en) 2009-09-10 2016-01-19 Medipacs, Inc. Low profile actuator and improved method of caregiver controlled administration of therapeutics
ES2929490T3 (es) 2009-12-16 2022-11-29 Becton Dickinson Co Dispositivo de autoinyección
DK2512560T3 (en) 2009-12-16 2018-07-16 Becton Dickinson Co Even injector device
ES2714698T3 (es) 2009-12-16 2019-05-29 Becton Dickinson Co Dispositivo de autoinyección
US9717850B2 (en) 2009-12-16 2017-08-01 Becton, Dickinson And Company Self-injection device
CN102753213B (zh) 2009-12-16 2015-04-29 贝克顿·迪金森公司 自注射装置
JP5827237B2 (ja) 2009-12-16 2015-12-02 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 自己注射デバイス
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US9500186B2 (en) 2010-02-01 2016-11-22 Medipacs, Inc. High surface area polymer actuator with gas mitigating components
EP2547328B1 (en) * 2010-02-11 2017-06-07 Ecole Polytechnique Fédérale de Lausanne (EPFL) Ccr7 ligand delivery and co-delivery in immunotherapy
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US8926568B2 (en) * 2010-05-20 2015-01-06 Shl Group Ab Medicament delivery device comprising a manual activation member with improved gripping and activation abilities
CN103153360B (zh) 2010-09-02 2016-04-06 贝克顿·迪金森公司 具有带激活阻止器的针盖的自注射装置
US8668675B2 (en) 2010-11-03 2014-03-11 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
CA2906274A1 (en) 2012-03-14 2013-09-19 Medipacs, Inc. Smart polymer materials with excess reactive molecules
CA2868534A1 (en) 2012-03-27 2013-10-03 Coda Therapeutics, Inc. Compositions and treatments based on cadherin modulation
CN104768567B (zh) 2012-05-18 2017-07-11 奥塔哥创业有限公司 用于伤口愈合的联合治疗和组合物
EP2934660B1 (en) 2012-12-21 2019-07-17 Corium, Inc. Microarray for delivery of therapeutic agent and method of making same
KR102571835B1 (ko) 2013-02-28 2023-08-30 소렌토 쎄라퓨틱스, 인코포레이티드 경피 약물 전달 장치
US9861801B2 (en) 2013-02-28 2018-01-09 Kimberly-Clark Worldwide, Inc. Drug delivery device
US9539382B2 (en) 2013-03-12 2017-01-10 Medtronic, Inc. Stepped catheters with flow restrictors and infusion systems using the same
JP6487899B2 (ja) 2013-03-12 2019-03-20 コリウム インターナショナル， インコーポレイテッド 微小突起アプリケータ
BR112015022625B1 (pt) 2013-03-15 2023-01-31 Corium, Inc Aparelho de microestrutura para entrega de agente terapêutico
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
AU2014237357B2 (en) 2013-03-15 2019-11-28 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators and methods of use
JP2016512754A (ja) 2013-03-15 2016-05-09 コリウム インターナショナル， インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
WO2015017561A1 (en) 2013-07-30 2015-02-05 Zosano Pharma, Inc. Low-profile microneedle patch applicator
AU2015253253B2 (en) 2014-04-30 2019-09-12 Sorrento Therapeutics, Inc. Transdermal drug delivery apparatus and methods
WO2015168219A1 (en) 2014-04-30 2015-11-05 Kimberly-Clark World Wide, Inc. Controller portion of transdermal drug delivery apparatus and methods
EP3137150B1 (en) 2014-04-30 2019-09-04 Sorrento Therapeutics, Inc. Receptacle portion of transdermal drug delivery apparatus
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
RU2715685C2 (ru) 2015-03-10 2020-03-02 Аллерган Фармасьютикалз Холдингз (Айрленд) Анлимитед Кампани Многоигольное инъекционное устройство
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
RU2725968C2 (ru) 2016-04-08 2020-07-07 Аллерган, Инк. Аспирационно-инъекционное устройство
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
JP6608336B2 (ja) * 2016-06-06 2019-11-20 三島光産株式会社 マイクロニードルアレイ
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
JP2019013524A (ja) * 2017-07-07 2019-01-31 凸版印刷株式会社 マイクロニードル
BR112020025315A2 (pt) * 2018-07-02 2021-03-09 Nitto Denko Corporation Estrutura
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
CN114028718B (zh) * 2021-12-06 2022-05-17 湖南省万卓医疗器械有限公司 一种基于数据分析的磁透复合治疗装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921475A (en) * 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
FR2562800A1 (fr) * 1984-04-11 1985-10-18 Fournier Laboratoires Dispositif pour l'administration percutanee de medicaments
US4886514A (en) * 1985-05-02 1989-12-12 Ivac Corporation Electrochemically driven drug dispenser
SU1296174A1 (ru) * 1985-06-20 1987-03-15 Устиновский Государственный Медицинский Институт Устройство дл электрофореза лекарственных веществ
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5090963A (en) * 1990-10-19 1992-02-25 Product Development (Z.G.S.) Ltd. Electrochemically driven metering medicament dispenser

Also Published As

Publication number Publication date
DE69312916T2 (de) 1998-01-08
EP0630276B1 (en) 1997-08-06
WO1993017754A1 (en) 1993-09-16
JPH07508427A (ja) 1995-09-21
AU3632593A (en) 1993-10-05
EP0630276A1 (en) 1994-12-28
DE69312916D1 (de) 1997-09-11
CA2131794A1 (en) 1993-09-16
TW286286B (Direct) 1996-09-21
US5279544A (en) 1994-01-18

Similar Documents

Publication Publication Date Title
ATE156375T1 (de) Wirkstoffabgabevorrichtungen
DE60029784D1 (de) Kostengüstige infusionsvorrichtung
DE60132909D1 (de) Implantierbare medizinische vorrichtung zum abgeben einer flüssigkeit
SE9704769D0 (sv) Medical device
BR9407238A (pt) Dispositivo implantável de fornecimento de droga
FI903925A7 (fi) Painettu annostelulaite lääkkeen annostelemiseksi ihon läpi
DE69520492D1 (de) Flüssige arzneizubereitungen enthaltend schilddrüsenhormone
FI941569A7 (fi) Laite lääkeaineen antamiseksi ihon läpi säädetyllä ajan mukana muuttuv alla virtauksella
ATE343969T1 (de) Beschichtete medizinische geräte
ATE209051T1 (de) Vorrichtung zum aufbringen von medikamentenflüssigkeit auf schleimhäute in körperhöhlungen
DE50103873D1 (de) Infusionseinrichtung für die Verabreichung eines Therapeutikums
DE69121881D1 (de) Hautelektrodenaufbau und dazugehöriges gerät zur transdermalen verabreichung von heilmitteln
DE60131156D1 (de) Gerät zum einbringen eines medikamentes in das respiratorische system
PT885620E (pt) Dispositivo para a injeccao de um medicamento liquido
ATE63059T1 (de) Vorrichtung mit zwei schichten zur freisetzung von arzneimitteln.
ATE77601T1 (de) Dosierungsvorrichtung.
DK0936894T3 (da) Indretning til afgivelse af aktivt middel
DE69705319D1 (de) Vorrichtung mit mehreren strömungspfaden zur oralen verabreichung von boluseinheiten
BR8802589A (pt) Sistema de administracao de drogas transdermico eletrosforetico/eletro-osmotico
ES2170776T3 (es) Sistema de administracion de vacuna.
EP1199084A3 (en) High current density iontophoretic device
FR2668926B1 (fr) Reservoir pour douche autonome portable, sterile, et douche qui en est equipee.
ES2136605T3 (es) Dispositivo electrico de aplicacion transdermica de farmacos con un agente de contrarresto.
ES2008822A6 (es) Dispositivo y metodo para el tratamiento de enfermedades de las encias.
FR2592585B3 (fr) Dispositif facilitant l'injection d'une substance liquide dans le reservoir, implante sous la peau, d'alimentation d'un catheter.