ATE128704T1 - Substituierte azetidinone als entzündungshemmende und antidegenerative wirkstoffe. - Google Patents
Substituierte azetidinone als entzündungshemmende und antidegenerative wirkstoffe.Info
- Publication number
- ATE128704T1 ATE128704T1 AT89200864T AT89200864T ATE128704T1 AT E128704 T1 ATE128704 T1 AT E128704T1 AT 89200864 T AT89200864 T AT 89200864T AT 89200864 T AT89200864 T AT 89200864T AT E128704 T1 ATE128704 T1 AT E128704T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammatory
- antidegenerative
- active ingredients
- substituted azetidinones
- azetidinones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Reinforced Plastic Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17968888A | 1988-04-11 | 1988-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE128704T1 true ATE128704T1 (de) | 1995-10-15 |
Family
ID=22657566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89200864T ATE128704T1 (de) | 1988-04-11 | 1989-04-06 | Substituierte azetidinone als entzündungshemmende und antidegenerative wirkstoffe. |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0337549B1 (de) |
| JP (1) | JP2736113B2 (de) |
| KR (1) | KR930008223B1 (de) |
| CN (1) | CN1037144A (de) |
| AT (1) | ATE128704T1 (de) |
| AU (1) | AU621865B2 (de) |
| CA (1) | CA1337990C (de) |
| DE (1) | DE68924439T2 (de) |
| DK (1) | DK169329B1 (de) |
| ES (1) | ES2079373T3 (de) |
| FI (1) | FI891689A (de) |
| GR (1) | GR3017656T3 (de) |
| HU (1) | HUT50761A (de) |
| IE (1) | IE891140L (de) |
| IL (1) | IL89835A0 (de) |
| LV (1) | LV11459B (de) |
| NO (1) | NO891470L (de) |
| NZ (1) | NZ228600A (de) |
| PT (1) | PT90222B (de) |
| YU (1) | YU71489A (de) |
| ZA (1) | ZA892549B (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229510A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | β-lactams useful in determining the amount of elastase in a clinical sample |
| US5229381A (en) * | 1983-12-01 | 1993-07-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| WO1992018488A1 (fr) * | 1991-04-10 | 1992-10-29 | Japan Tobacco Inc. | Nouveau derive d'oxazinone |
| IL99658A0 (en) * | 1990-10-15 | 1992-08-18 | Merck & Co Inc | Substituted azetidinones and pharmaceutical compositions containing them |
| GB9103654D0 (en) * | 1991-02-21 | 1991-04-10 | Merck Sharp & Dohme | Chemical process |
| US5104862A (en) * | 1991-03-20 | 1992-04-14 | Merck & Co., Inc. | Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5100880A (en) * | 1991-03-20 | 1992-03-31 | Merck & Co., Inc. | Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone |
| US5348953A (en) * | 1991-06-25 | 1994-09-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| WO1993000332A1 (en) * | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5688787A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof |
| MY131273A (en) * | 1991-07-23 | 2007-07-31 | Schering Corp | Substituted beta-lactam compounds useful as hypocholesterolemic agents and processes for the preparation thereof |
| US5688785A (en) * | 1991-07-23 | 1997-11-18 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| EP0529719A1 (de) * | 1991-08-26 | 1993-03-03 | Merck & Co. Inc. | Test zur Bestimmung der Hemmung der PMN-Elastase durch N-substituierte Azetidinone |
| US5274080A (en) * | 1991-08-26 | 1993-12-28 | Merck & Co., Inc. | Monospecific antibodies useful in evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| US5276139A (en) * | 1991-08-26 | 1994-01-04 | Merck & Co., Inc. | Haptens useful in evaluating inhibition of PNN elastase by N-substituted azetidinones |
| US5229267A (en) * | 1991-08-26 | 1993-07-20 | Merck & Co., Inc. | Assay for evaluating inhibition of PMN elastase by N-substituted azetidinones |
| US5149838A (en) * | 1991-09-20 | 1992-09-22 | Merck & Co., Inc. | Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents |
| GB2266527A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted azetidinones useful in the treatment of leukemia |
| US5250676A (en) * | 1992-03-23 | 1993-10-05 | University Of Notre Dame Du Lac | Process for the preparation of 3-substituted-2-azetidinones |
| CA2147129A1 (en) * | 1992-10-27 | 1994-05-11 | James B. Doherty | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
| MY128261A (en) * | 1992-10-27 | 2007-01-31 | Merck Sharp & Dohme | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
| US5591737A (en) * | 1992-12-17 | 1997-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| WO1994013636A1 (en) * | 1992-12-17 | 1994-06-23 | Merck & Co., Inc. | New substituted azetidinones as anti-inflammatory and antidegenerative agents |
| LT3595B (en) | 1993-01-21 | 1995-12-27 | Schering Corp | Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents |
| GB9314350D0 (en) * | 1993-07-12 | 1993-08-25 | Zeneca Ltd | Armide derivatives |
| US5420010A (en) * | 1993-07-30 | 1995-05-30 | Merck & Co., Inc. | Assay for evaluating inhibition of polymorphonuclear leukocyte elastase by N-substituted azetidinones |
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| CA2184385A1 (en) * | 1994-03-11 | 1995-09-14 | Philip Davies | Composition for the treatment of lung disease |
| US5627176A (en) * | 1994-03-25 | 1997-05-06 | Schering Corporation | Substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5624920A (en) * | 1994-11-18 | 1997-04-29 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5633246A (en) * | 1994-11-18 | 1997-05-27 | Schering Corporation | Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents |
| US5656624A (en) * | 1994-12-21 | 1997-08-12 | Schering Corporation | 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents |
| WO1996029307A1 (fr) * | 1995-03-23 | 1996-09-26 | Japan Tobacco Inc. | Composes de diphenylmethyle-azetidinone et inhibiteur d'elastase |
| US5747485A (en) * | 1995-04-13 | 1998-05-05 | Merck & Co., Inc. | Substituted azetidiones as anti-inflammatory and antidegenerative agents |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| CZ422197A3 (cs) * | 1995-07-01 | 1998-06-17 | Smithkline Beecham Plc | Azetidinonové deriváty, způsob jejich přípravy, meziprodukty tohoto postupu, farmaceutický prostředek obsahující tyto sloučeniny a použití těchto sloučenin jako léčiv |
| WO1997013750A1 (en) * | 1995-10-09 | 1997-04-17 | Chiroscience Limited | Azetidinones and their therapeutic use as cytokine inhibitors |
| EP0869943A1 (de) * | 1995-12-08 | 1998-10-14 | Smithkline Beecham Plc | Monocyclische beta-lactame zur behandlung von atherosklerose |
| CZ341098A3 (cs) * | 1996-04-26 | 1999-03-17 | Smithkline Beecham Plc | Azetidinonové deriváty pro ošetřování aterosklerózy |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| US6242439B1 (en) * | 1997-10-07 | 2001-06-05 | Boehringer Ingelheim (Canada) Ltd. | Azetidinone derivatives for the treatment of HCMV infections |
| DE69810800T2 (de) * | 1997-10-07 | 2003-09-18 | Boehringer Ingelheim (Canada) Ltd., Laval | Azetidinonderivate zur behandlung von hcmv entzündungen |
| AU9425998A (en) * | 1997-10-07 | 1999-04-27 | Boehringer Ingelheim (Canada) Ltd. | Azetidinone derivatives for the treatment of hcmv infections |
| WO1999064395A1 (en) * | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
| US6335324B1 (en) | 1998-06-25 | 2002-01-01 | Bristol-Myers Squibb Co. | Beta lactam compounds and their use as inhibitors of tryptase |
| EP1099690A4 (de) * | 1998-07-23 | 2001-10-17 | Shionogi & Co | Monozyklische beta-lactamverbindungen und chymase inhibitoren, die diese enthalten |
| AU4343500A (en) | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
| CA2442219C (en) | 2001-03-28 | 2007-09-11 | Schering Corporation | Enantioselective synthesis of azetidinone intermediate compounds |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| US7235543B2 (en) | 2003-03-07 | 2007-06-26 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| US8440819B2 (en) | 2008-02-22 | 2013-05-14 | Allergan, Inc. | Therapeutic substituted beta-lactams |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680391A (en) * | 1983-12-01 | 1987-07-14 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
-
1989
- 1989-04-04 NZ NZ228600A patent/NZ228600A/en unknown
- 1989-04-04 IL IL89835A patent/IL89835A0/xx unknown
- 1989-04-06 ES ES89200864T patent/ES2079373T3/es not_active Expired - Lifetime
- 1989-04-06 EP EP89200864A patent/EP0337549B1/de not_active Expired - Lifetime
- 1989-04-06 AT AT89200864T patent/ATE128704T1/de not_active IP Right Cessation
- 1989-04-06 DE DE68924439T patent/DE68924439T2/de not_active Expired - Fee Related
- 1989-04-07 CA CA000595997A patent/CA1337990C/en not_active Expired - Fee Related
- 1989-04-07 ZA ZA892549A patent/ZA892549B/xx unknown
- 1989-04-07 PT PT90222A patent/PT90222B/pt not_active IP Right Cessation
- 1989-04-10 HU HU891708A patent/HUT50761A/hu unknown
- 1989-04-10 YU YU00714/89A patent/YU71489A/xx unknown
- 1989-04-10 FI FI891689A patent/FI891689A/fi not_active Application Discontinuation
- 1989-04-10 IE IE891140A patent/IE891140L/xx not_active IP Right Cessation
- 1989-04-10 AU AU32630/89A patent/AU621865B2/en not_active Ceased
- 1989-04-10 NO NO89891470A patent/NO891470L/no unknown
- 1989-04-10 CN CN89103271A patent/CN1037144A/zh active Pending
- 1989-04-10 KR KR1019890004702A patent/KR930008223B1/ko active IP Right Grant
- 1989-04-10 DK DK170589A patent/DK169329B1/da not_active IP Right Cessation
- 1989-04-11 JP JP1091723A patent/JP2736113B2/ja not_active Expired - Fee Related
-
1995
- 1995-10-05 GR GR950402512T patent/GR3017656T3/el unknown
-
1996
- 1996-02-01 LV LVP-96-24A patent/LV11459B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL89835A0 (en) | 1989-12-15 |
| LV11459A (lv) | 1996-08-20 |
| NO891470L (no) | 1989-10-12 |
| EP0337549A1 (de) | 1989-10-18 |
| CN1037144A (zh) | 1989-11-15 |
| DK170589A (da) | 1989-10-12 |
| FI891689A (fi) | 1989-10-12 |
| IE891140L (en) | 1989-10-11 |
| JPH026471A (ja) | 1990-01-10 |
| FI891689A0 (fi) | 1989-04-10 |
| AU621865B2 (en) | 1992-03-26 |
| ZA892549B (en) | 1989-11-29 |
| KR900016121A (ko) | 1990-11-12 |
| DE68924439D1 (de) | 1995-11-09 |
| GR3017656T3 (en) | 1996-01-31 |
| NO891470D0 (no) | 1989-04-10 |
| DE68924439T2 (de) | 1996-05-09 |
| EP0337549B1 (de) | 1995-10-04 |
| ES2079373T3 (es) | 1996-01-16 |
| DK169329B1 (da) | 1994-10-10 |
| NZ228600A (en) | 1992-02-25 |
| PT90222B (pt) | 1994-07-29 |
| PT90222A (pt) | 1989-11-10 |
| HUT50761A (en) | 1990-03-28 |
| DK170589D0 (da) | 1989-04-10 |
| JP2736113B2 (ja) | 1998-04-02 |
| CA1337990C (en) | 1996-01-23 |
| YU71489A (en) | 1991-10-31 |
| LV11459B (en) | 1996-12-20 |
| AU3263089A (en) | 1989-10-12 |
| KR930008223B1 (ko) | 1993-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |