DE3751700D1 - Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel - Google Patents

Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel

Info

Publication number
DE3751700D1
DE3751700D1 DE3751700T DE3751700T DE3751700D1 DE 3751700 D1 DE3751700 D1 DE 3751700D1 DE 3751700 T DE3751700 T DE 3751700T DE 3751700 T DE3751700 T DE 3751700T DE 3751700 D1 DE3751700 D1 DE 3751700D1
Authority
DE
Germany
Prior art keywords
inflammatory
substituted cephalosporin
cephalosporin sulfones
degenerative agents
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3751700T
Other languages
English (en)
Inventor
James B Doherty
Paul E Finke
Raymond A Firestone
William K Hagmann
Kevan R Thompson
Shrenik K Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3751700D1 publication Critical patent/DE3751700D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
DE3751700T 1986-11-12 1987-11-02 Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel Expired - Lifetime DE3751700D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93019386A 1986-11-12 1986-11-12

Publications (1)

Publication Number Publication Date
DE3751700D1 true DE3751700D1 (de) 1996-03-21

Family

ID=25459038

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3751700T Expired - Lifetime DE3751700D1 (de) 1986-11-12 1987-11-02 Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel

Country Status (16)

Country Link
EP (1) EP0267723B1 (de)
JP (1) JPS63198688A (de)
KR (1) KR880006249A (de)
CN (1) CN87107753A (de)
AT (1) ATE133954T1 (de)
AU (1) AU611104B2 (de)
CA (1) CA1339275C (de)
DE (1) DE3751700D1 (de)
DK (1) DK590787A (de)
FI (1) FI874839A (de)
HU (1) HUT52511A (de)
IL (1) IL84359A0 (de)
NO (1) NO874699L (de)
NZ (1) NZ222399A (de)
PT (1) PT86074B (de)
ZA (1) ZA878467B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
US4992541A (en) * 1989-08-01 1991-02-12 Merck & Co., Inc. Process for the preparation of 1,1-dioxo-7-substituted cephems
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
AU661453B2 (en) * 1989-10-06 1995-07-27 Synphar Laboratories, Inc. Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
ATE208374T1 (de) * 1992-02-18 2001-11-15 Otsuka Kagaku Kk Beta-laktam und cepham verbindungen und ihre herstellung
GB2266526A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted cephalosporin sulfones useful in the treatment of leukemia
GB2266525A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted cephalosporin sulfone compositions useful in the treatment of leukemia
WO1993024493A1 (fr) * 1992-05-27 1993-12-09 Teijin Limited Derive de cephalosporine
WO1994010143A1 (en) * 1992-10-27 1994-05-11 Merck & Co., Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
WO1997008174A1 (en) * 1995-08-31 1997-03-06 Smithkline Beecham Corporation Interleukin converting enzyme and apoptosis
WO1997007805A1 (en) * 1995-08-31 1997-03-06 Smithkline Beecham Corporation Interleukin converting enzyme and apoptosis
GB9525697D0 (en) * 1995-12-15 1996-02-14 Pharmacia Spa Cephem derivatives
CN106543206B (zh) * 2016-09-22 2018-08-31 济南康和医药科技有限公司 一种头孢类二聚体化合物的制备方法
CN113372368B (zh) * 2020-03-09 2022-04-12 苏州爱科百发生物医药技术有限公司 一种弹性蛋白酶抑制剂前药及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
US4699904A (en) * 1985-07-01 1987-10-13 Merck & Co., Inc. Tetrazolyl derivatives of β-lactams useful as elastase inhibitors

Also Published As

Publication number Publication date
CA1339275C (en) 1997-08-12
CN87107753A (zh) 1988-06-29
IL84359A0 (en) 1988-04-29
DK590787D0 (da) 1987-11-11
EP0267723A2 (de) 1988-05-18
NO874699L (no) 1988-05-13
KR880006249A (ko) 1988-07-22
FI874839A0 (fi) 1987-11-03
DK590787A (da) 1988-05-13
NO874699D0 (no) 1987-11-11
HUT52511A (en) 1990-07-28
PT86074A (en) 1987-12-01
ATE133954T1 (de) 1996-02-15
AU8062487A (en) 1988-05-19
EP0267723A3 (en) 1989-12-06
NZ222399A (en) 1991-07-26
ZA878467B (en) 1988-09-28
AU611104B2 (en) 1991-06-06
JPS63198688A (ja) 1988-08-17
FI874839A (fi) 1988-05-13
PT86074B (pt) 1990-11-07
EP0267723B1 (de) 1996-02-07

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Legal Events

Date Code Title Description
8332 No legal effect for de