ZA878467B - New substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents - Google Patents

New substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents

Info

Publication number
ZA878467B
ZA878467B ZA878467A ZA878467A ZA878467B ZA 878467 B ZA878467 B ZA 878467B ZA 878467 A ZA878467 A ZA 878467A ZA 878467 A ZA878467 A ZA 878467A ZA 878467 B ZA878467 B ZA 878467B
Authority
ZA
South Africa
Prior art keywords
inflammatory
new substituted
substituted cephalosporin
antidegenerative agents
cephalosporin sulfones
Prior art date
Application number
ZA878467A
Other languages
English (en)
Inventor
James B Doherty
B Doherty James
William K Hagmann
K Hagmann William
Paul E Finke
E Finke Paul
Shrenik K Shah
K Shah Shrenik
Raymond A Firestone
A Firestone Raymond
Kevan R Thompson
R Thompson Kevan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA878467B publication Critical patent/ZA878467B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA878467A 1986-11-12 1987-11-11 New substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents ZA878467B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93019386A 1986-11-12 1986-11-12

Publications (1)

Publication Number Publication Date
ZA878467B true ZA878467B (en) 1988-09-28

Family

ID=25459038

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878467A ZA878467B (en) 1986-11-12 1987-11-11 New substituted cephalosporin sulfones as anti-inflammatory and antidegenerative agents

Country Status (16)

Country Link
EP (1) EP0267723B1 (de)
JP (1) JPS63198688A (de)
KR (1) KR880006249A (de)
CN (1) CN87107753A (de)
AT (1) ATE133954T1 (de)
AU (1) AU611104B2 (de)
CA (1) CA1339275C (de)
DE (1) DE3751700D1 (de)
DK (1) DK590787A (de)
FI (1) FI874839A (de)
HU (1) HUT52511A (de)
IL (1) IL84359A0 (de)
NO (1) NO874699L (de)
NZ (1) NZ222399A (de)
PT (1) PT86074B (de)
ZA (1) ZA878467B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
US4992541A (en) * 1989-08-01 1991-02-12 Merck & Co., Inc. Process for the preparation of 1,1-dioxo-7-substituted cephems
ZA907976B (en) * 1989-10-06 1991-09-25 Synphar Lab Inc Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
ATE208374T1 (de) * 1992-02-18 2001-11-15 Otsuka Kagaku Kk Beta-laktam und cepham verbindungen und ihre herstellung
GB2266526A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted cephalosporin sulfones useful in the treatment of leukemia
GB2266525A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted cephalosporin sulfone compositions useful in the treatment of leukemia
WO1993024493A1 (fr) * 1992-05-27 1993-12-09 Teijin Limited Derive de cephalosporine
CA2147129A1 (en) * 1992-10-27 1994-05-11 James B. Doherty New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
WO1997007805A1 (en) * 1995-08-31 1997-03-06 Smithkline Beecham Corporation Interleukin converting enzyme and apoptosis
EP0859779A4 (de) * 1995-08-31 2000-04-12 Smithkline Beecham Corp Interleukin-konvertierendes enzym und apoptosis
GB9525697D0 (en) * 1995-12-15 1996-02-14 Pharmacia Spa Cephem derivatives
CN106543206B (zh) * 2016-09-22 2018-08-31 济南康和医药科技有限公司 一种头孢类二聚体化合物的制备方法
CN113372368B (zh) * 2020-03-09 2022-04-12 苏州爱科百发生物医药技术有限公司 一种弹性蛋白酶抑制剂前药及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
US4699904A (en) * 1985-07-01 1987-10-13 Merck & Co., Inc. Tetrazolyl derivatives of β-lactams useful as elastase inhibitors

Also Published As

Publication number Publication date
FI874839A (fi) 1988-05-13
DK590787D0 (da) 1987-11-11
FI874839A0 (fi) 1987-11-03
NZ222399A (en) 1991-07-26
EP0267723A2 (de) 1988-05-18
ATE133954T1 (de) 1996-02-15
KR880006249A (ko) 1988-07-22
DE3751700D1 (de) 1996-03-21
AU611104B2 (en) 1991-06-06
NO874699D0 (no) 1987-11-11
IL84359A0 (en) 1988-04-29
CA1339275C (en) 1997-08-12
EP0267723B1 (de) 1996-02-07
PT86074B (pt) 1990-11-07
HUT52511A (en) 1990-07-28
JPS63198688A (ja) 1988-08-17
NO874699L (no) 1988-05-13
AU8062487A (en) 1988-05-19
DK590787A (da) 1988-05-13
EP0267723A3 (en) 1989-12-06
CN87107753A (zh) 1988-06-29
PT86074A (en) 1987-12-01

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