EP0859779A4 - Interleukin-konvertierendes enzym und apoptosis - Google Patents
Interleukin-konvertierendes enzym und apoptosisInfo
- Publication number
- EP0859779A4 EP0859779A4 EP96932941A EP96932941A EP0859779A4 EP 0859779 A4 EP0859779 A4 EP 0859779A4 EP 96932941 A EP96932941 A EP 96932941A EP 96932941 A EP96932941 A EP 96932941A EP 0859779 A4 EP0859779 A4 EP 0859779A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- apoptosis
- converting enzyme
- interleukin converting
- interleukin
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US308295P | 1995-08-31 | 1995-08-31 | |
US3082P | 1995-08-31 | ||
PCT/US1996/013967 WO1997008174A1 (en) | 1995-08-31 | 1996-08-29 | Interleukin converting enzyme and apoptosis |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0859779A1 EP0859779A1 (de) | 1998-08-26 |
EP0859779A4 true EP0859779A4 (de) | 2000-04-12 |
Family
ID=21704039
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP96932941A Withdrawn EP0859779A4 (de) | 1995-08-31 | 1996-08-29 | Interleukin-konvertierendes enzym und apoptosis |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0859779A4 (de) |
JP (1) | JPH11511463A (de) |
WO (1) | WO1997008174A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1479385B1 (de) | 1996-10-15 | 2008-07-02 | G.D. Searle LLC | Verwendung von Cyclooxygenase-2 Inhibitoren zur Behandlung und Vorbeugung von Neoplasia |
US6270980B1 (en) * | 1997-06-05 | 2001-08-07 | Idun Pharmaceuticals, Inc. | Rapid methods for identifying modifiers of cellular apoptosis activity |
WO1999046248A1 (en) | 1998-03-09 | 1999-09-16 | Vertex Pharmaceuticals Incorporated | 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors |
PT1064298E (pt) | 1998-03-19 | 2009-01-02 | Vertex Pharma | Inibidores de caspasas |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
JP2002322068A (ja) * | 2001-02-26 | 2002-11-08 | Japan Science & Technology Corp | 血管再生促進剤 |
NZ530765A (en) | 2001-06-26 | 2006-11-30 | Amgen Fremont Inc | Antibodies that bind OPGL and compositions and methods for the treatment of bone diseases |
MXPA05002514A (es) | 2002-09-06 | 2005-05-27 | Amgen Inc | Anticuerpo monoclonal anti-il-1r1 humano terapeutico. |
CN1980658A (zh) | 2004-05-27 | 2007-06-13 | 沃泰克斯药物股份有限公司 | 治疗自身炎性疾病的ice抑制剂 |
US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0124081A2 (de) * | 1983-05-02 | 1984-11-07 | Merck & Co. Inc. | Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung |
EP0267723A2 (de) * | 1986-11-12 | 1988-05-18 | Merck & Co. Inc. | Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel |
WO1989010926A1 (en) * | 1988-05-13 | 1989-11-16 | Farmitalia Carlo Erba S.R.L. | 1,1-dioxo-cephem-4-carbothiolic acid derivatives |
EP0411929A1 (de) * | 1989-08-01 | 1991-02-06 | Merck & Co. Inc. | Verfahren zur Herstellung von 1,1-dioxo-7-substituierter Cepheme |
WO1991004977A1 (en) * | 1989-10-06 | 1991-04-18 | Synphar Laboratories, Inc. | Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof |
GB2266525A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted cephalosporin sulfone compositions useful in the treatment of leukemia |
GB2266526A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted cephalosporin sulfones useful in the treatment of leukemia |
DE4341332A1 (de) * | 1992-12-04 | 1994-06-09 | Erba Carlo Spa | 4-Alkyl- und 4-Alkenyl-Delta-3-Cephemsulfone |
WO1994028003A1 (en) * | 1993-05-20 | 1994-12-08 | Pharmacia S.P.A. | Tricyclic defem sulphones as elastase inhibitors |
WO1995002603A2 (en) * | 1993-07-14 | 1995-01-26 | Pharmacia S.P.A. | Use of cephem derivatives as anti-metastatic agents |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5446037A (en) * | 1991-12-05 | 1995-08-29 | Synphar Laboratories, Inc. | 2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents |
-
1996
- 1996-08-29 WO PCT/US1996/013967 patent/WO1997008174A1/en not_active Application Discontinuation
- 1996-08-29 EP EP96932941A patent/EP0859779A4/de not_active Withdrawn
- 1996-08-29 JP JP9510590A patent/JPH11511463A/ja active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0124081A2 (de) * | 1983-05-02 | 1984-11-07 | Merck & Co. Inc. | Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung |
EP0267723A2 (de) * | 1986-11-12 | 1988-05-18 | Merck & Co. Inc. | Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel |
WO1989010926A1 (en) * | 1988-05-13 | 1989-11-16 | Farmitalia Carlo Erba S.R.L. | 1,1-dioxo-cephem-4-carbothiolic acid derivatives |
EP0411929A1 (de) * | 1989-08-01 | 1991-02-06 | Merck & Co. Inc. | Verfahren zur Herstellung von 1,1-dioxo-7-substituierter Cepheme |
WO1991004977A1 (en) * | 1989-10-06 | 1991-04-18 | Synphar Laboratories, Inc. | Novel 2-spirocyclopropyl cephalosporin sulfone derivatives and processes for the preparation thereof |
GB2266525A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted cephalosporin sulfone compositions useful in the treatment of leukemia |
GB2266526A (en) * | 1992-03-17 | 1993-11-03 | Merck & Co Inc | Substituted cephalosporin sulfones useful in the treatment of leukemia |
DE4341332A1 (de) * | 1992-12-04 | 1994-06-09 | Erba Carlo Spa | 4-Alkyl- und 4-Alkenyl-Delta-3-Cephemsulfone |
WO1994028003A1 (en) * | 1993-05-20 | 1994-12-08 | Pharmacia S.P.A. | Tricyclic defem sulphones as elastase inhibitors |
WO1995002603A2 (en) * | 1993-07-14 | 1995-01-26 | Pharmacia S.P.A. | Use of cephem derivatives as anti-metastatic agents |
Non-Patent Citations (16)
Also Published As
Publication number | Publication date |
---|---|
JPH11511463A (ja) | 1999-10-05 |
WO1997008174A1 (en) | 1997-03-06 |
EP0859779A1 (de) | 1998-08-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19980223 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20000225 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): BE CH DE ES FR GB IT LI NL |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000524 |