EP0851760A4 - Interleukin umwandelndes enzym und apoptose - Google Patents

Interleukin umwandelndes enzym und apoptose

Info

Publication number
EP0851760A4
EP0851760A4 EP96930620A EP96930620A EP0851760A4 EP 0851760 A4 EP0851760 A4 EP 0851760A4 EP 96930620 A EP96930620 A EP 96930620A EP 96930620 A EP96930620 A EP 96930620A EP 0851760 A4 EP0851760 A4 EP 0851760A4
Authority
EP
European Patent Office
Prior art keywords
apoptosis
converting enzyme
interleukin converting
interleukin
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96930620A
Other languages
English (en)
French (fr)
Other versions
EP0851760A1 (de
Inventor
Mark Alan Levy
John Gerald Gleason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0851760A1 publication Critical patent/EP0851760A1/de
Publication of EP0851760A4 publication Critical patent/EP0851760A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96930620A 1995-08-31 1996-08-29 Interleukin umwandelndes enzym und apoptose Withdrawn EP0851760A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US308395P 1995-08-31 1995-08-31
US3083 1995-08-31
PCT/US1996/013867 WO1997007805A1 (en) 1995-08-31 1996-08-29 Interleukin converting enzyme and apoptosis

Publications (2)

Publication Number Publication Date
EP0851760A1 EP0851760A1 (de) 1998-07-08
EP0851760A4 true EP0851760A4 (de) 1998-11-25

Family

ID=21704047

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96930620A Withdrawn EP0851760A4 (de) 1995-08-31 1996-08-29 Interleukin umwandelndes enzym und apoptose

Country Status (3)

Country Link
EP (1) EP0851760A4 (de)
JP (1) JPH11514345A (de)
WO (1) WO1997007805A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2901899A (en) 1998-03-09 1999-09-27 Vertex Pharmaceuticals Incorporated 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors
KR100928878B1 (ko) 1998-03-19 2009-11-30 버텍스 파마슈티칼스 인코포레이티드 카스파제의 억제제
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AU2005249503B2 (en) 2003-11-10 2011-08-25 Vertex Pharmaceuticals Incorporated ICE inhibitors for the treatment of autoinflammatory diseases
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124081A2 (de) * 1983-05-02 1984-11-07 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
EP0267723A2 (de) * 1986-11-12 1988-05-18 Merck & Co. Inc. Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel
WO1995002603A2 (en) * 1993-07-14 1995-01-26 Pharmacia S.P.A. Use of cephem derivatives as anti-metastatic agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2266525A (en) * 1992-03-17 1993-11-03 Merck & Co Inc Substituted cephalosporin sulfone compositions useful in the treatment of leukemia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124081A2 (de) * 1983-05-02 1984-11-07 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
EP0267723A2 (de) * 1986-11-12 1988-05-18 Merck & Co. Inc. Substituierte Cephalosporinsulfone als anti-entzündliche und anti-degenerative Mittel
WO1995002603A2 (en) * 1993-07-14 1995-01-26 Pharmacia S.P.A. Use of cephem derivatives as anti-metastatic agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M. ALPEGIANI ET AL.: "Cephem Sulfones as Inactivators of Human Leukocyte Elastase. 5. 7-alpha-Methoxy- and 7-alpha-Chloro-1,1-dioxocephem 4-Ketones", J. MED. CHEM., vol. 37, no. 23, 1994, pages 4003 - 4019, XP002077984 *
P. E. FINKE ET AL.: "Inhibition of Human Leukocyte Elastase. 4. Selection of a Substituted Cephalosporin (L-658,758) as a Topical Aerosol", J. MED. CHEM., vol. 35, no. 21, 1992, pages 3731 - 3744, XP002077983 *
See also references of WO9707805A1 *

Also Published As

Publication number Publication date
WO1997007805A1 (en) 1997-03-06
JPH11514345A (ja) 1999-12-07
EP0851760A1 (de) 1998-07-08

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Legal Events

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