ATE121089T1 - Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten. - Google Patents

Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten.

Info

Publication number
ATE121089T1
ATE121089T1 AT92903994T AT92903994T ATE121089T1 AT E121089 T1 ATE121089 T1 AT E121089T1 AT 92903994 T AT92903994 T AT 92903994T AT 92903994 T AT92903994 T AT 92903994T AT E121089 T1 ATE121089 T1 AT E121089T1
Authority
AT
Austria
Prior art keywords
pyrrolo
production
optically active
pharmaceutical preparations
preparations containing
Prior art date
Application number
AT92903994T
Other languages
English (en)
Inventor
Claude Cotrel
Gerard Roussel
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9408772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE121089(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of ATE121089T1 publication Critical patent/ATE121089T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT92903994T 1991-01-17 1992-01-16 Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten. ATE121089T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9100490A FR2671800B1 (fr) 1991-01-17 1991-01-17 Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.

Publications (1)

Publication Number Publication Date
ATE121089T1 true ATE121089T1 (de) 1995-04-15

Family

ID=9408772

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92903994T ATE121089T1 (de) 1991-01-17 1992-01-16 Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten.

Country Status (29)

Country Link
US (5) US6319926B1 (de)
EP (2) EP0495717A1 (de)
JP (1) JPH06504548A (de)
AR (1) AR248024A1 (de)
AT (1) ATE121089T1 (de)
AU (2) AU671797B2 (de)
CA (1) CA2099782C (de)
CZ (1) CZ281011B6 (de)
DE (1) DE69202060T2 (de)
DK (1) DK0609210T3 (de)
ES (1) ES2071486T3 (de)
FI (1) FI100331B (de)
FR (1) FR2671800B1 (de)
HU (1) HU218928B (de)
IE (1) IE66110B1 (de)
IL (1) IL100677A (de)
MA (1) MA22392A1 (de)
MX (1) MX9200180A (de)
NO (1) NO179911C (de)
NZ (1) NZ241313A (de)
OA (1) OA09807A (de)
PH (1) PH30982A (de)
PL (1) PL166976B1 (de)
RU (1) RU2110519C1 (de)
SK (1) SK279060B6 (de)
TN (1) TNSN92004A1 (de)
WO (1) WO1992012980A1 (de)
YU (1) YU48878B (de)
ZA (1) ZA92302B (de)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
US5786357A (en) * 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
ES2101653B1 (es) * 1995-07-10 1998-04-01 Asturpharma S A (+)-6-(5-cloropirid-2-il)-7-oxo-viniloxicarboniloxi-5,6-dihidropirrolo(3,4b)pirazina y su uso para un procedimiento de preparacion de (+)-6-(5-cloropirid-2-il)-5-(4-metilpiperazin-1-il)-carboniloxi-7-oxo-5,6-dihidropirrolo(3,4b)pirazina.
US6339086B1 (en) * 1999-05-14 2002-01-15 Swpracor, Inc. Methods of making and using N-desmethylzopiclone
TW200734459A (en) 1999-10-04 2007-09-16 Ajinomoto Kk Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria
WO2005060968A1 (en) 2003-12-11 2005-07-07 Sepracor Inc. Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
WO2005063248A1 (en) * 2003-12-22 2005-07-14 Sepracor Inc. Modafinil combination therapy for improving sleep quality
JP2007517040A (ja) * 2003-12-24 2007-06-28 セプレイコー インコーポレイテッド 睡眠の質を改善するためのメラトニン併用療法
DK1742624T3 (da) * 2004-02-18 2010-03-08 Sepracor Inc Dopamin-agonist-kombinationsterapi med sedativer til forbedring af søvnkvalitet
CA2677465A1 (en) 2004-04-05 2005-10-20 Sepracor Inc. Methods of treatment using eszopiclone
AU2006260686A1 (en) * 2005-06-21 2006-12-28 Generics [Uk] Limited Process for enantiomeric separation of zopiclone
US20090111818A1 (en) * 2005-07-06 2009-04-30 Sepracor Inc. Combinations of Eszopiclone and O-Desmethylvenlafaxine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
US20070098788A1 (en) * 2005-10-28 2007-05-03 Gore Subhash P Non-benzodiazepine hypnotic compositions
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
CA2637542A1 (en) * 2006-01-17 2007-07-26 Glenmark Pharmaceuticals Limited Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b] pyrazine derivative
WO2007088073A1 (en) * 2006-02-03 2007-08-09 Synthon B.V. Zopiclone resolution using l-tartaric acid
US20080027223A1 (en) * 2006-03-23 2008-01-31 Teva Pharmaceutical Industries Ltd. Polymorphs of eszopiclone malate
WO2007124025A2 (en) * 2006-04-20 2007-11-01 Teva Pharmaceutical Industries Ltd. Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone
EP1904499A1 (de) * 2006-06-26 2008-04-02 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von zopiclon
US7786304B2 (en) * 2006-11-06 2010-08-31 Centaur Pharmaceutical Pvt. Ltd. Process for the preparation of eszopiclone
TW200846340A (en) * 2007-01-31 2008-12-01 Teva Pharma Methods for preparing eszopiclone
ATE515259T1 (de) * 2007-05-29 2011-07-15 Lek Pharmaceuticals Pharmazeutische zusammensetzung mit eszopiclon
US20080305171A1 (en) * 2007-06-07 2008-12-11 Kristin Anne Arnold Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there
TW200918534A (en) * 2007-06-25 2009-05-01 Teva Pharma Racemization process of R-zopiclone
EP2020403A1 (de) 2007-08-02 2009-02-04 Esteve Quimica, S.A. Verfahren zur Auflösung von Zopiclon und Zwischenprodukten
US20090198058A1 (en) * 2007-08-06 2009-08-06 Dhananjay Govind Sathe Process for Preparation of Dextrorotatory Isomer of 6-(5- chloro-pyrid-2-yl)-5-[(4-methyl -1-piperazinyl) carbonyloxy] -7-oxo-6,7-dihydro-5H-pyrrolo [3,4-b] pyrazine (Eszopiclone)
US8269005B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8212036B2 (en) 2007-12-19 2012-07-03 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8268832B2 (en) * 2007-12-19 2012-09-18 Sunovion Pharmaceuticals Inc. Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198277B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
US8198278B2 (en) 2007-12-19 2012-06-12 Sunovion Pharmaceuticals Inc. Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
WO2009085972A1 (en) * 2007-12-19 2009-07-09 Sepracor Inc. Maleate, besylate, and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine
US20110053945A1 (en) * 2007-12-19 2011-03-03 Sepracor Inc. Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihy-dro-5h-pyrrolo[3,4-b]pyrazine
WO2009101634A2 (en) * 2008-02-13 2009-08-20 Lupin Limited A novel process for the preparation of eszopiclone
AU2009223153A1 (en) 2008-03-12 2009-09-17 Emory University Use of GABAa receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness
US20090269409A1 (en) * 2008-04-24 2009-10-29 Mukesh Kumar Garg Pharmaceutical compositions comprising eszopiclone
CN101607961B (zh) * 2008-06-18 2011-08-10 天津天士力集团有限公司 一种右佐匹克隆结晶及其组合物
NZ592976A (en) 2008-11-07 2012-03-30 Cipla Ltd Process for resolving zopiclone
EP2370136A4 (de) * 2008-12-01 2015-12-30 Map Pharmaceuticals Inc Inhalative freisetzungsverfahren und vorrichtungen
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
AU2010208240A1 (en) 2009-01-30 2011-09-22 Sunovion Pharmaceuticals Inc Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5H-pyrrol o [3,4-b] pyrazine and methods for measuring effectiveness of coating
WO2010116385A2 (en) 2009-04-08 2010-10-14 Rubicon Research Private Limited Pharmaceutical compositions for alleviating unpleasant taste
EP2345654A1 (de) 2010-01-05 2011-07-20 LEK Pharmaceuticals d.d. Eszopiclon-Teilchen und Verfahren zu deren Herstellung
EP2345655A1 (de) 2010-01-05 2011-07-20 LEK Pharmaceuticals d.d. Verfahren zur Racemisierung von 6-(5-Chlorpyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin
CN103193779B (zh) * 2012-01-05 2016-04-20 成都弘达药业有限公司 一种右佐匹克隆的制备方法
EP2934486A2 (de) * 2012-12-20 2015-10-28 Kashiv Pharma, LLC Schmelztablettenformulierung zur erhöhten bioverfügbarkeit
US9636340B2 (en) 2013-11-12 2017-05-02 Ayyappan K. Rajasekaran Kinase inhibitors
JP2020007252A (ja) * 2018-07-05 2020-01-16 アクティブファーマ株式会社 エスゾピクロンジベンゾイル−ｄ−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−ｄ−酒石酸塩の結晶

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA04285A (fr) * 1972-01-07 1979-12-31 Rhone Poulenc Sa Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation.
AR208414A1 (es) * 1974-11-07 1976-12-27 Rhone Poulenc Ind Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2)
US4962124A (en) 1987-11-17 1990-10-09 Analgesic Associates Onset-hastened/enhanced antipyretic response
US4868214A (en) 1987-11-17 1989-09-19 Analgesic Associates Onset-hastened/enhanced analgesia
US5102890A (en) 1989-09-05 1992-04-07 Rhone-Poulenc Sante Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them
FR2671800B1 (fr) 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent.
WO1993010788A1 (en) 1991-12-02 1993-06-10 Sepracor, Inc. Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone
US5786357A (en) 1991-12-02 1998-07-28 Sepracor Inc. Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone
US5331000A (en) 1992-03-09 1994-07-19 Sepracor Inc. Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen
US6436926B1 (en) * 1999-05-10 2002-08-20 Medpointe, Inc. Compositions and methods for treating superficial fungal infections
US7476737B2 (en) * 2005-09-05 2009-01-13 Dr. Reddy's Laboratories Limited Eszopiclone process
WO2007088073A1 (en) * 2006-02-03 2007-08-09 Synthon B.V. Zopiclone resolution using l-tartaric acid

Also Published As

Publication number Publication date
HUT68915A (en) 1995-08-28
US20060194806A1 (en) 2006-08-31
YU48878B (sh) 2002-09-19
US6319926B1 (en) 2001-11-20
NO931919L (no) 1993-05-26
EP0609210B1 (de) 1995-04-12
CA2099782A1 (fr) 1992-07-18
NO179911C (no) 1997-01-08
US6444673B1 (en) 2002-09-03
FI933248A (fi) 1993-07-16
MX9200180A (es) 1992-07-01
YU5592A (sh) 1994-11-15
PL166976B1 (pl) 1995-07-31
IE920126A1 (en) 1992-07-29
AR248024A1 (es) 1995-05-31
US7381724B2 (en) 2008-06-03
AU3032195A (en) 1995-11-09
US7125874B2 (en) 2006-10-24
FI100331B (fi) 1997-11-14
US20020193378A1 (en) 2002-12-19
SK71993A3 (en) 1993-12-08
US6864257B2 (en) 2005-03-08
EP0495717A1 (de) 1992-07-22
DE69202060T2 (de) 1995-10-26
OA09807A (fr) 1994-04-15
RU2110519C1 (ru) 1998-05-10
NZ241313A (en) 1993-03-26
CZ281011B6 (cs) 1996-05-15
DK0609210T3 (da) 1995-07-03
TNSN92004A1 (fr) 1993-06-08
FR2671800B1 (fr) 1993-03-12
NO931919D0 (no) 1993-05-26
SK279060B6 (sk) 1998-06-03
CZ138093A3 (en) 1994-02-16
AU671797B2 (en) 1996-09-12
US20050043311A1 (en) 2005-02-24
IE66110B1 (en) 1995-12-13
ES2071486T3 (es) 1995-06-16
PH30982A (en) 1997-12-23
FR2671800A1 (fr) 1992-07-24
EP0609210A1 (de) 1994-08-10
EP0609210A4 (de) 1993-09-17
HU9302063D0 (en) 1993-10-28
ZA92302B (en) 1992-10-28
IL100677A0 (en) 1992-09-06
AU1226492A (en) 1992-08-27
FI933248A0 (fi) 1993-07-16
MA22392A1 (fr) 1992-10-01
CA2099782C (fr) 2002-12-03
DE69202060D1 (de) 1995-05-18
IL100677A (en) 1995-11-27
HU218928B (hu) 2000-12-28
JPH06504548A (ja) 1994-05-26
NO179911B (no) 1996-09-30
WO1992012980A1 (fr) 1992-08-06

Similar Documents

Publication Publication Date Title
ATE121089T1 (de) Optisch aktives 5h-pyrrolo(3,4-b>pyrazinderivat, seine herstellung und pharmazeutische zubereitungen die es enthalten.
ATE109145T1 (de) Heterozyklische acylaminothiazolderivate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
DE10199027I1 (de) Fluorcytidinderivate deren Herstellung und Arzneimittel die diese Derivate enthalten
DE69015842T2 (de) Nicotinsäurederivate und diese enthaltende pharmazeutische Zusammensetzungen.
DE3852145T2 (de) Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
ATE128363T1 (de) Tablette mit verbesserter bioverfügbarkeit enthaltend dichlormethylendiphosphonsäure als wirkstoff.
DK0391185T3 (da) 1,8-Naphthyridiner
DE68905171T2 (de) Benzol-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die diese enthalten.
DE68906992T2 (de) Indanylring enthaltende pyrethinester, deren herstellung und deren anwendung als pestizide.
ATE32882T1 (de) Phenylnonatetraensaeurederivate, ihre herstellung und pharmazeutische praeparate mit diesen derivaten.
DE3670638D1 (de) Indol-3-yl-chinazolin-1,4-benzodiazepin-5,13-dione, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
DE69104608T2 (de) Pharmazeutische Zubereitungen, Clavulansäure enthaltend, für die Behandlung der Periodontitis.
ATE106883T1 (de) Azelastin-embonat, verfahren zu seiner herstellung und pharmazeutische zubereitungen, die als wirkstoff azelastin-embonat enthalten.
DE3878988D1 (de) 1,2-di(4-isobutylphenyl)aethylen, dessen herstellung und verwendung als zwischenprodukt.
DE69113365T2 (de) Optisch aktives Morpholinooxobutansäure-Hydroxybinaphthalinderivat und seine Herstellung.
DE3764233D1 (de) Cyclopentylaether, deren herstellung und pharmazeutische formulierung.
DE68902789T2 (de) 4-hydroxy-isoxazol-derivate, deren herstellung und kosmetische und pharmazeutische zusammensetzungen, die sie enthalten.
DE3773128D1 (de) Cyclopentanaether, ihre herstellung und pharmazeutische formulierung.
ATA263687A (de) Neue imidazo(1,2-a)pyridinderivate und deren herstellung und diese enthaltende pharmazeutische zubereitungen
ATE77820T1 (de) Substituierte tetrahydroisochinolin-verbindungen, ihre herstellung und diese enthaltende pharmazeutische mittel.
ATE86242T1 (de) Benzol-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die diese enthalten.
ATE45956T1 (de) 11 beta-phenyl-gonane, deren herstellung und diese enthaltende pharmazeutische praeparate.
ATE31313T1 (de) 13alpha-alkylgonane, deren herstellung und diese enthaltende pharmazeutische praeparate.
ATE70840T1 (de) Benzothiepino(5,4-c>pyridazin-verbindungen und ihre pharmazeutischen wirkungen.
ATE102202T1 (de) 5-fluormethyl-1,2,4-triazolo(1,5-a)pyrimidin-2sulfonamide, verfahren zu ihrer herstellung und zubereitungen als herbizide.

Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time