AR248024A1 - Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables. - Google Patents
Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables.Info
- Publication number
- AR248024A1 AR248024A1 AR92321649A AR32164992A AR248024A1 AR 248024 A1 AR248024 A1 AR 248024A1 AR 92321649 A AR92321649 A AR 92321649A AR 32164992 A AR32164992 A AR 32164992A AR 248024 A1 AR248024 A1 AR 248024A1
- Authority
- AR
- Argentina
- Prior art keywords
- salt
- preparation
- dextrogiro
- pyrrolo
- pyrazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PREPARACION DEL ISOMERO DEXTROGIRO DE LA (CLORO-5 PIRIDIL-2)-6 (METIL-4 PIPERAZINIL-1) CARBONILOXI-5 OXO-7 DIHIDRO-6, 7 5H-PIRROLO ¡3, 4- B¿PIRAZINA, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, QUE COMPRENDE DESDOBLAR LA (CLORO-5 PIRIDIL-2)-6 (METIL-4 PIPERAZINIL-1)CARBONILOXI-5 OXO 7 DIHIDRO-6, 7 5H-PIRROLO ¡3, 4-B¿PIRAZINA RACEMICA MEDIANTE ACIDO D(+)-0, 0'-DIBENZOILTARTARICO OPERANDOSE EN UNSOLVENTE ORGANICO; AISLAR LA SAL BRUTA; RECRISTALIZARLA DESDE UN SOLVENTE ORGANICO PARA OBTENER LA SAL DEL ISOM-RO DEXTROGIRO; DESDOBLAR LA SAL EN MEDIO ALCALINO Y SEPARAR LA FASE ORGANICA; LAVAR Y SECAR LA FASE ORGANICA; Y PURIFICAR LA FASE ORGANICA POR RECRISTALIZACION EN UN SOLVENTE ORGANICO PARA OBTENER EL ISOMERO DEXTROGIRO PURO, EL CUAL EVENTUALMENTE SE TRANSFORMA EN UNA SAL FARMACEUTICAMENTE ACEPTABLE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9100490A FR2671800B1 (fr) | 1991-01-17 | 1991-01-17 | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR248024A1 true AR248024A1 (es) | 1995-05-31 |
Family
ID=9408772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR92321649A AR248024A1 (es) | 1991-01-17 | 1992-01-16 | Preparacion del isomero dextrogiro de la (cloro-5 piridil-2)-6 (metil-4 piperazinil-1) carboniloxi-5 oxo-7 hihidro-6, 7 5h-pirrolo ¡3, 4-b¿pirazina, y sus sales farmaceuticamente aceptables. |
Country Status (29)
Country | Link |
---|---|
US (5) | US6319926B1 (es) |
EP (2) | EP0609210B1 (es) |
JP (1) | JPH06504548A (es) |
AR (1) | AR248024A1 (es) |
AT (1) | ATE121089T1 (es) |
AU (2) | AU671797B2 (es) |
CA (1) | CA2099782C (es) |
CZ (1) | CZ281011B6 (es) |
DE (1) | DE69202060T2 (es) |
DK (1) | DK0609210T3 (es) |
ES (1) | ES2071486T3 (es) |
FI (1) | FI100331B (es) |
FR (1) | FR2671800B1 (es) |
HU (1) | HU218928B (es) |
IE (1) | IE66110B1 (es) |
IL (1) | IL100677A (es) |
MA (1) | MA22392A1 (es) |
MX (1) | MX9200180A (es) |
NO (1) | NO179911C (es) |
NZ (1) | NZ241313A (es) |
OA (1) | OA09807A (es) |
PH (1) | PH30982A (es) |
PL (1) | PL166976B1 (es) |
RU (1) | RU2110519C1 (es) |
SK (1) | SK279060B6 (es) |
TN (1) | TNSN92004A1 (es) |
WO (1) | WO1992012980A1 (es) |
YU (1) | YU48878B (es) |
ZA (1) | ZA92302B (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2671800B1 (fr) | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
US5786357A (en) | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
ES2101653B1 (es) * | 1995-07-10 | 1998-04-01 | Asturpharma S A | (+)-6-(5-cloropirid-2-il)-7-oxo-viniloxicarboniloxi-5,6-dihidropirrolo(3,4b)pirazina y su uso para un procedimiento de preparacion de (+)-6-(5-cloropirid-2-il)-5-(4-metilpiperazin-1-il)-carboniloxi-7-oxo-5,6-dihidropirrolo(3,4b)pirazina. |
US6339086B1 (en) * | 1999-05-14 | 2002-01-15 | Swpracor, Inc. | Methods of making and using N-desmethylzopiclone |
TW200734460A (en) | 1999-10-04 | 2007-09-16 | Ajinomoto Kk | Genes for heat resistant enzymes of amino acid biosynthetic pathway derived from thermophilic coryneform bacteria |
PT1691811E (pt) | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão |
WO2005063248A1 (en) * | 2003-12-22 | 2005-07-14 | Sepracor Inc. | Modafinil combination therapy for improving sleep quality |
EP1696959A2 (en) * | 2003-12-24 | 2006-09-06 | Sepracor, Inc. | Melatonin combination therapy for improving sleep quality |
US20050267176A1 (en) * | 2004-02-18 | 2005-12-01 | Sepracor Inc. | Dopamine-agonist combination therapy for improving sleep quality |
US7776858B2 (en) | 2004-04-05 | 2010-08-17 | Sepracor Inc. | Methods of treatment of chronic pain using eszopiclone |
AU2006260686A1 (en) * | 2005-06-21 | 2006-12-28 | Generics [Uk] Limited | Process for enantiomeric separation of zopiclone |
US20080293726A1 (en) | 2005-07-06 | 2008-11-27 | Sepracor Inc. | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders |
MX2008000249A (es) * | 2005-07-06 | 2008-03-18 | Sepracor Inc | Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos. |
US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
US20070098788A1 (en) * | 2005-10-28 | 2007-05-03 | Gore Subhash P | Non-benzodiazepine hypnotic compositions |
AU2006308889A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | GABA receptor mediated modulation of neurogenesis |
BRPI0621028A2 (pt) * | 2006-01-17 | 2011-11-29 | Glenmark Pharmaceuticals Ltd | processo para a preparação de um derivado de 5h-pirrolo[3,4-b]pirazina oticamente ativo |
AR059296A1 (es) * | 2006-02-03 | 2008-03-26 | Synthon Bv | Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona. |
US20080027223A1 (en) * | 2006-03-23 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Polymorphs of eszopiclone malate |
US20070270590A1 (en) * | 2006-04-20 | 2007-11-22 | Marioara Mendelovici | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
US20080015197A1 (en) * | 2006-06-26 | 2008-01-17 | Alex Mainfeld | Process for the preparatrion of zopiclone |
US7786304B2 (en) * | 2006-11-06 | 2010-08-31 | Centaur Pharmaceutical Pvt. Ltd. | Process for the preparation of eszopiclone |
WO2008094690A2 (en) * | 2007-01-31 | 2008-08-07 | Teva Pharmaceutical Industries Ltd. | Methods for preparing eszopiclone |
EP1997482B1 (en) * | 2007-05-29 | 2011-07-06 | LEK Pharmaceuticals d.d. | A pharmaceutical composition comprising eszopiclone |
US20080305171A1 (en) * | 2007-06-07 | 2008-12-11 | Kristin Anne Arnold | Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there |
TW200918534A (en) * | 2007-06-25 | 2009-05-01 | Teva Pharma | Racemization process of R-zopiclone |
EP2020403A1 (en) | 2007-08-02 | 2009-02-04 | Esteve Quimica, S.A. | Process for the resolution of zopiclone and intermediate compounds |
WO2009063486A2 (en) * | 2007-08-06 | 2009-05-22 | Usv Limited | Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone) |
CA2747008C (en) * | 2007-12-19 | 2017-12-12 | Richard Hsia | Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine |
CA2812705C (en) * | 2007-12-19 | 2015-08-18 | Sunovion Pharmaceuticals Inc. | Maleate, besylate and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine |
US8268832B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
US8198277B2 (en) * | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
US8212036B2 (en) | 2007-12-19 | 2012-07-03 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
US8269005B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
US8198278B2 (en) | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
WO2009101634A2 (en) * | 2008-02-13 | 2009-08-20 | Lupin Limited | A novel process for the preparation of eszopiclone |
WO2009114740A2 (en) | 2008-03-12 | 2009-09-17 | Emory University | USE OF GABAa RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EXCESSIVE SLEEPINESS AND DISORDERS ASSOCIATED WITH EXCESSIVE SLEEPINESS |
US20090269409A1 (en) * | 2008-04-24 | 2009-10-29 | Mukesh Kumar Garg | Pharmaceutical compositions comprising eszopiclone |
CN101607961B (zh) * | 2008-06-18 | 2011-08-10 | 天津天士力集团有限公司 | 一种右佐匹克隆结晶及其组合物 |
JP2012508219A (ja) | 2008-11-07 | 2012-04-05 | シプラ・リミテッド | ゾピクロンを分割するための方法 |
US20100196286A1 (en) * | 2008-12-01 | 2010-08-05 | Armer Thomas A | Inhalation delivery methods and devices |
WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
WO2010088385A1 (en) | 2009-01-30 | 2010-08-05 | Sepracor Inc. | Coated tablets of 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrol o [3,4-b] pyrazine and methods for measuring effectiveness of coating |
WO2010116385A2 (en) | 2009-04-08 | 2010-10-14 | Rubicon Research Private Limited | Pharmaceutical compositions for alleviating unpleasant taste |
EP2345655A1 (en) | 2010-01-05 | 2011-07-20 | LEK Pharmaceuticals d.d. | A process for racemisation of 6-(5-chloropyridin-2-yl)-7-(4-methyl-1-piperazinyl)carbonyloxy-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
EP2345654A1 (en) | 2010-01-05 | 2011-07-20 | LEK Pharmaceuticals d.d. | Eszopiclone particles and a process for their preparation |
CN103193779B (zh) * | 2012-01-05 | 2016-04-20 | 成都弘达药业有限公司 | 一种右佐匹克隆的制备方法 |
AU2013361307A1 (en) * | 2012-12-20 | 2015-07-09 | Kashiv Pharma, Llc | Orally disintegrating tablet formulation for enhanced bioavailability |
US9636340B2 (en) | 2013-11-12 | 2017-05-02 | Ayyappan K. Rajasekaran | Kinase inhibitors |
JP2020007252A (ja) * | 2018-07-05 | 2020-01-16 | アクティブファーマ株式会社 | エスゾピクロンジベンゾイル−d−酒石酸塩の製造方法、エスゾピクロンの製造方法、及びエスゾピクロンジベンゾイル−d−酒石酸塩の結晶 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA04285A (fr) * | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
AR208414A1 (es) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2) |
US4962124A (en) | 1987-11-17 | 1990-10-09 | Analgesic Associates | Onset-hastened/enhanced antipyretic response |
US4868214A (en) | 1987-11-17 | 1989-09-19 | Analgesic Associates | Onset-hastened/enhanced analgesia |
US5102890A (en) | 1989-09-05 | 1992-04-07 | Rhone-Poulenc Sante | Pyrrole derivatives, their preparation and pharmaceutical compositions which contain them |
FR2671800B1 (fr) | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
WO1993010788A1 (en) | 1991-12-02 | 1993-06-10 | Sepracor, Inc. | Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone |
US5786357A (en) * | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
US5331000A (en) | 1992-03-09 | 1994-07-19 | Sepracor Inc. | Antipyretic and analgesic methods and compositions containing optically pure R(-) ketoprofen |
US6436926B1 (en) * | 1999-05-10 | 2002-08-20 | Medpointe, Inc. | Compositions and methods for treating superficial fungal infections |
US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
AR059296A1 (es) * | 2006-02-03 | 2008-03-26 | Synthon Bv | Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona. |
-
1991
- 1991-01-17 FR FR9100490A patent/FR2671800B1/fr not_active Expired - Fee Related
-
1992
- 1992-01-15 MA MA22677A patent/MA22392A1/fr unknown
- 1992-01-15 ZA ZA92302A patent/ZA92302B/xx unknown
- 1992-01-15 NZ NZ241313A patent/NZ241313A/xx not_active IP Right Cessation
- 1992-01-16 IE IE920126A patent/IE66110B1/en not_active IP Right Cessation
- 1992-01-16 PL PL92299834A patent/PL166976B1/pl unknown
- 1992-01-16 ES ES92903994T patent/ES2071486T3/es not_active Expired - Lifetime
- 1992-01-16 WO PCT/FR1992/000031 patent/WO1992012980A1/fr active IP Right Grant
- 1992-01-16 SK SK719-93A patent/SK279060B6/sk not_active IP Right Cessation
- 1992-01-16 JP JP4504006A patent/JPH06504548A/ja active Pending
- 1992-01-16 AR AR92321649A patent/AR248024A1/es active
- 1992-01-16 IL IL10067792A patent/IL100677A/en not_active IP Right Cessation
- 1992-01-16 DK DK92903994.9T patent/DK0609210T3/da active
- 1992-01-16 HU HU9302063A patent/HU218928B/hu unknown
- 1992-01-16 AT AT92903994T patent/ATE121089T1/de not_active IP Right Cessation
- 1992-01-16 RU RU93051787A patent/RU2110519C1/ru active
- 1992-01-16 DE DE69202060T patent/DE69202060T2/de not_active Expired - Lifetime
- 1992-01-16 MX MX9200180A patent/MX9200180A/es unknown
- 1992-01-16 CA CA002099782A patent/CA2099782C/fr not_active Expired - Fee Related
- 1992-01-16 PH PH43784A patent/PH30982A/en unknown
- 1992-01-16 EP EP92903994A patent/EP0609210B1/fr not_active Expired - Lifetime
- 1992-01-16 AU AU12264/92A patent/AU671797B2/en not_active Expired
- 1992-01-16 CZ CS931380A patent/CZ281011B6/cs not_active IP Right Cessation
- 1992-01-16 EP EP92400111A patent/EP0495717A1/fr active Pending
- 1992-01-17 YU YU5592A patent/YU48878B/sh unknown
- 1992-01-17 TN TNTNSN92004A patent/TNSN92004A1/fr unknown
-
1993
- 1993-05-26 NO NO931919A patent/NO179911C/no not_active IP Right Cessation
- 1993-06-17 OA OA60387A patent/OA09807A/fr unknown
- 1993-07-16 FI FI933248A patent/FI100331B/fi active
-
1995
- 1995-08-30 AU AU30321/95A patent/AU3032195A/en not_active Abandoned
-
1998
- 1998-07-29 US US09/124,651 patent/US6319926B1/en not_active Expired - Fee Related
-
2000
- 2000-11-28 US US09/722,438 patent/US6444673B1/en not_active Expired - Lifetime
-
2002
- 2002-07-23 US US10/200,510 patent/US6864257B2/en not_active Expired - Fee Related
-
2004
- 2004-09-28 US US10/951,844 patent/US7125874B2/en not_active Expired - Fee Related
-
2006
- 2006-05-03 US US11/416,570 patent/US7381724B2/en not_active Expired - Fee Related
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