ATE107353T1 - Blutplättchenlysat, verfahren zu seiner herstellung sowie ein solches lysat enthaltendes zellkulturmedium. - Google Patents
Blutplättchenlysat, verfahren zu seiner herstellung sowie ein solches lysat enthaltendes zellkulturmedium.Info
- Publication number
- ATE107353T1 ATE107353T1 AT89905220T AT89905220T ATE107353T1 AT E107353 T1 ATE107353 T1 AT E107353T1 AT 89905220 T AT89905220 T AT 89905220T AT 89905220 T AT89905220 T AT 89905220T AT E107353 T1 ATE107353 T1 AT E107353T1
- Authority
- AT
- Austria
- Prior art keywords
- lysate
- pct
- platelets
- cell culture
- platelet
- Prior art date
Links
- 239000006166 lysate Substances 0.000 title abstract 5
- 239000006143 cell culture medium Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000007788 liquid Substances 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 102000008946 Fibrinogen Human genes 0.000 abstract 1
- 108010049003 Fibrinogen Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 244000309466 calf Species 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 229940012952 fibrinogen Drugs 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8801537A SE8801537D0 (sv) | 1988-04-26 | 1988-04-26 | Cellodlingsmedium samt forfarande for dess framstellning |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE107353T1 true ATE107353T1 (de) | 1994-07-15 |
Family
ID=20372119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89905220T ATE107353T1 (de) | 1988-04-26 | 1989-04-26 | Blutplättchenlysat, verfahren zu seiner herstellung sowie ein solches lysat enthaltendes zellkulturmedium. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5198357A (de) |
EP (1) | EP0413727B1 (de) |
JP (1) | JPH03505156A (de) |
AT (1) | ATE107353T1 (de) |
AU (1) | AU3539289A (de) |
DE (1) | DE68916244T2 (de) |
SE (1) | SE8801537D0 (de) |
WO (1) | WO1989010398A1 (de) |
Families Citing this family (70)
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US5723443A (en) * | 1988-02-02 | 1998-03-03 | Hankyu-Kyoei Bussan Co. Ltd. | Lipid metabolism promoting agent and its use |
JPH04198129A (ja) * | 1990-11-28 | 1992-07-17 | Sumitomo Pharmaceut Co Ltd | 活性型ビタミンd↓3類含有組成物 |
DE69809391T2 (de) * | 1997-02-06 | 2003-07-10 | Therasense, Inc. | Kleinvolumiger sensor zur in-vitro bestimmung |
JP3521382B2 (ja) * | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
DE19821060A1 (de) | 1997-09-23 | 1999-04-15 | Bundesrepublik Deutschland Let | Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung |
CA2305350C (en) * | 1997-09-23 | 2015-04-07 | Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des Robert-Koch-Instituts | Costimulating polypeptide of t cells, monoclonal antibodies, and the preparation and use thereof |
WO2005103086A1 (en) | 2004-04-23 | 2005-11-03 | Bundesrepublik Deutschland letztvertreten durch das Robert-Koch-Institut vertreten durch seinen Präsidenten | Method for the treatment of t cell mediated conditions by depletion of icos-positive cells in vivo |
US20060039991A1 (en) * | 2004-08-20 | 2006-02-23 | Alberto Gorrochategui Barrueta | Biological tissue regenerative agent and method for preparing and using same |
WO2006122002A2 (en) * | 2005-05-09 | 2006-11-16 | Panomics, Inc. | Multiplex capture of nucleic acids |
US8632970B2 (en) | 2005-05-09 | 2014-01-21 | Affymetrix, Inc. | Multiplex capture of nucleic acids |
DE602006020715D1 (de) | 2005-05-12 | 2011-04-28 | Affymetrix Inc | Multiplex-assays für verzweigtkettige dna |
WO2007001986A2 (en) * | 2005-06-20 | 2007-01-04 | Yuling Luo | Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations |
SE528214C2 (sv) * | 2005-06-23 | 2006-09-26 | Proliff Ab | Förfarande för framställning av blodplättslysat |
US7927798B2 (en) * | 2005-10-05 | 2011-04-19 | Panomics, Inc. | Detection of nucleic acids from whole blood |
EP1978977A4 (de) * | 2006-01-24 | 2010-03-17 | Christopher J Centeno | Mesenchymalstammzellenisolierung und transplantationsverfahren und system zur verwendung in einer klinischen einstellung |
EP2069479A1 (de) * | 2006-09-18 | 2009-06-17 | Medizinische Universität Graz | Plasmafreies blutplättchenlysat zur verwendung als zusatz in zellkulturen und zur herstellung von zelltherapeutika |
US9095562B2 (en) * | 2007-07-05 | 2015-08-04 | Regenerative Sciences, Inc. | Methods and compositions for optimized expansion and implantation of mesenchymal stem cells |
WO2009085969A2 (en) * | 2007-12-19 | 2009-07-09 | Regenerative Sciences, Llc | Compositions and methods to promote implantation and engrafment of stem cells |
WO2009114785A2 (en) * | 2008-03-14 | 2009-09-17 | Regenerative Sciences, Inc. | Compositions and methods for cartilage repair |
EP3266453A1 (de) | 2008-07-03 | 2018-01-10 | Mayo Foundation for Medical Education and Research | Krebsbehandlung |
FI3584310T3 (fi) | 2008-09-16 | 2024-07-02 | Mayo Found Medical Education & Res | Verihiutaleiden sisältöä sisältäviä koostumuksia |
WO2010065854A1 (en) | 2008-12-05 | 2010-06-10 | Regenerative Sciences, Llc | Methods and compositions to facilitate repair of avascular tissue |
US20100168022A1 (en) * | 2008-12-11 | 2010-07-01 | Centeno Christopher J | Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens |
US20110054929A1 (en) * | 2009-09-01 | 2011-03-03 | Cell Solutions Colorado Llc | Stem Cell Marketplace |
HUP0900603A2 (en) * | 2009-09-25 | 2012-02-28 | Biomarker Kft | Cell culture medium |
US9113950B2 (en) | 2009-11-04 | 2015-08-25 | Regenerative Sciences, Llc | Therapeutic delivery device |
EP3034625B1 (de) | 2010-10-21 | 2017-10-04 | Advanced Cell Diagnostics, Inc. | Hochsensitives verfahren für den in-situ-nachweis von nukleinsäuren |
PL2707030T3 (pl) | 2011-05-09 | 2020-08-24 | Mayo Foundation For Medical Education And Research | Metody leczenia raka |
US9788539B2 (en) | 2011-05-17 | 2017-10-17 | Velico Medical, Inc. | Platelet protection solution having beta-galactosidase and sialidase inhibitors |
JP2014515352A (ja) | 2011-05-17 | 2014-06-30 | ベリコ メディカル インコーポレイティッド | シアリダーゼ阻害剤を用いた血小板の保存の改善法 |
US9609861B2 (en) | 2011-05-17 | 2017-04-04 | Velico Medical Inc. | Platelet additive solution having a β-galactosidase inhibitor |
EP2540819A1 (de) * | 2011-06-27 | 2013-01-02 | Rheinisch-Westfälische Technische Hochschule Aachen (RWTH) | Verfahren zur Kultivierung von Zellen in einem Medium mit Plättchenlysat |
CN103702674B (zh) * | 2011-06-27 | 2018-05-29 | 爱默蕾大学 | 血小板裂解物的组合物、用途和制备 |
ES2803499T3 (es) | 2011-06-29 | 2021-01-27 | Biorestorative Therapies Inc | Composiciones y métodos de células grasas marrones |
AU2012279995C1 (en) | 2011-07-06 | 2019-10-24 | Cell Therapy Limited | Progenitor cells of mesodermal lineage |
ITRM20110500A1 (it) * | 2011-09-23 | 2013-03-24 | Futura Stem Cells Sa | Lisato piastrinico, usi di esso e metodo per la sua preparazione |
JP6184971B2 (ja) | 2011-11-23 | 2017-08-23 | セル セラピー リミテッドCell Therapy Limited | 血小板溶解物ゲル |
US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
EP2733200A1 (de) | 2012-11-15 | 2014-05-21 | Biorigen International SA | Zellkulturzusätze |
KR20150113978A (ko) * | 2013-01-28 | 2015-10-08 | 리제너러티브 사이언시즈, 엘엘씨 | 혈소판 용해 및 활성화를 위한 디바이스 및 방법 |
WO2014120886A1 (en) | 2013-01-30 | 2014-08-07 | Velico Medical, Inc. | Platelet additive solution having a self-assembling hydrogel-forming peptide |
EP2986714B1 (de) | 2013-04-19 | 2021-01-06 | Biorestorative Therapies, Inc. | Stammzellen aus menschlichem braunen fettgewebe und verwendungen |
WO2015031465A1 (en) * | 2013-08-27 | 2015-03-05 | Cook General Biotechnology Llc | Bioactive compositions derivable from platelet concentrates, and methods for preparing and using same |
AU2015259094B2 (en) | 2014-05-16 | 2021-09-02 | Mayo Foundation For Medical Education And Research | Cell culture media compositions for primary cells |
GB201410504D0 (en) | 2014-06-12 | 2014-07-30 | Cell Therapy Ltd | Immuno-modulaltory progenitor (IMP) cell |
CN106604750B (zh) | 2014-06-16 | 2021-05-07 | 梅约医学教育与研究基金会 | 治疗骨髓瘤 |
US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
GB201513996D0 (en) | 2015-08-07 | 2015-09-23 | Cell Therapy Ltd | Immuno-oncology mesodermal progenitor (IOMP) cell |
TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體-抗體組合物及其製造及使用方法 |
KR20170037379A (ko) * | 2015-09-25 | 2017-04-04 | (주)프로스테믹스 | 세포의 증식 촉진용 조성물 및 이를 포함하는 세포 배양용 배지 |
TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
CN108368543B (zh) | 2015-10-12 | 2023-06-13 | 领先细胞医疗诊断有限公司 | 高噪声样品中原位检测核苷酸变体及相关的组合物和方法 |
GB201518263D0 (en) | 2015-10-15 | 2015-12-02 | Oxford Bioelectronics Ltd | Method |
US11571469B2 (en) | 2016-01-07 | 2023-02-07 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression |
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EP3432928A4 (de) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | Verfahren zur verbesserung des therapeutischen index für ein chemotherapeutikum |
AU2017238119A1 (en) | 2016-03-21 | 2018-10-11 | Mayo Foundation For Medical Education And Research | Methods for reducing toxicity of a chemotherapeutic drug |
US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
US20200325442A1 (en) | 2016-06-02 | 2020-10-15 | Pl Bioscience Gmbh | Method for producing a platelet-lysate-containing gel |
JP2019526579A (ja) | 2016-09-01 | 2019-09-19 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチMayo Foundation For Medical Education And Research | T細胞癌を標的とする為の方法及び組成物 |
CA3035378A1 (en) | 2016-09-01 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Carrier-pd-l1 binding agent compositions for treating cancers |
CA3035655A1 (en) | 2016-09-06 | 2018-03-15 | Mayo Foundation For Medical Education And Research | Methods of treating pd-l1 expressing cancer |
KR102486055B1 (ko) | 2016-09-06 | 2023-01-09 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 파클리탁셀-알부민-결합제 조성물 및 그의 사용 및 제조 방법 |
EP3509635A1 (de) | 2016-09-06 | 2019-07-17 | Vavotar Life Sciences LLC | Verfahren zur behandlung von dreifach negativem brustkrebs unter verwendung von zusammensetzungen aus antikörpern und trägerproteinen |
CN109468262A (zh) * | 2018-10-30 | 2019-03-15 | 中国科学院苏州生物医学工程技术研究所 | 家畜血细胞制备动物细胞培养液的方法及其制得的动物细胞培养液的应用 |
GB201900554D0 (en) | 2019-01-15 | 2019-03-06 | Cell Therapy Ltd | Mesodermal killer (mk) cell |
WO2020148520A1 (en) | 2019-01-15 | 2020-07-23 | Cell Therapy Limited | Mesodermal killer (mk) cell |
CN110484497A (zh) * | 2019-09-05 | 2019-11-22 | 中国人民解放军南部战区总医院 | 一种血小板裂解液及其制备方法和应用 |
US11951134B2 (en) | 2019-09-30 | 2024-04-09 | North Carolina State University | Cationic platelet lysate compositions and related methods |
CN116926001A (zh) * | 2022-04-06 | 2023-10-24 | 上海我武干细胞科技有限公司 | 血清替代物及其制备方法与应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8000527A (nl) * | 1980-01-29 | 1981-08-17 | Stichting Vrienden Van De Stic | Werkwijze voor het bevorderen van hybridisatie van cellen in vitro en van de produktie en uitscheiding van stoffen, gevormd door dergelijke celhybriden, werkwijze voor het bevorderen van de produktie van monoclonale antilichamen in vitro door toepassing van een hybridomatechniek, alsmede endotheelcellen en/of supernatant van endotheelcellen. |
US4350687A (en) * | 1980-02-10 | 1982-09-21 | Research Corporation | Platelet derived cell growth factor |
US4473552A (en) * | 1981-03-16 | 1984-09-25 | Jost Leonora I | Anaerobic method for preserving whole blood, tissue and components containing living mammalian cells |
US4987079A (en) * | 1982-07-06 | 1991-01-22 | Wilbur D. Smith | Composition and method for in vitro cell culture |
US4520107A (en) * | 1982-09-28 | 1985-05-28 | Polydex Chemicals Ltd. | Tissue culture and cell growth-promoting material and its method of manufacture |
US5045468A (en) * | 1986-12-12 | 1991-09-03 | Cell Enterprises, Inc. | Protein-free culture medium which promotes hybridoma growth |
NO162160C (no) * | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
US4959308A (en) * | 1987-08-27 | 1990-09-25 | Board Of Regents, The University Of Texas System | Immunoassay for antibodies binding platelets |
-
1988
- 1988-04-26 SE SE8801537A patent/SE8801537D0/xx unknown
-
1989
- 1989-04-26 WO PCT/SE1989/000232 patent/WO1989010398A1/en active IP Right Grant
- 1989-04-26 EP EP89905220A patent/EP0413727B1/de not_active Expired - Lifetime
- 1989-04-26 JP JP1504957A patent/JPH03505156A/ja active Pending
- 1989-04-26 AU AU35392/89A patent/AU3539289A/en not_active Abandoned
- 1989-04-26 AT AT89905220T patent/ATE107353T1/de not_active IP Right Cessation
- 1989-04-26 US US07/634,113 patent/US5198357A/en not_active Expired - Fee Related
- 1989-04-26 DE DE68916244T patent/DE68916244T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH03505156A (ja) | 1991-11-14 |
EP0413727A1 (de) | 1991-02-27 |
DE68916244T2 (de) | 1995-02-09 |
WO1989010398A1 (en) | 1989-11-02 |
DE68916244D1 (de) | 1994-07-21 |
SE8801537D0 (sv) | 1988-04-26 |
US5198357A (en) | 1993-03-30 |
AU3539289A (en) | 1989-11-24 |
EP0413727B1 (de) | 1994-06-15 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |