ATE104310T1 - Verfahren zur herstellung von isepamicin. - Google Patents

Verfahren zur herstellung von isepamicin.

Info

Publication number
ATE104310T1
ATE104310T1 AT90306657T AT90306657T ATE104310T1 AT E104310 T1 ATE104310 T1 AT E104310T1 AT 90306657 T AT90306657 T AT 90306657T AT 90306657 T AT90306657 T AT 90306657T AT E104310 T1 ATE104310 T1 AT E104310T1
Authority
AT
Austria
Prior art keywords
isoserine
isepamicin
preparation
compounds
diformyl
Prior art date
Application number
AT90306657T
Other languages
English (en)
Inventor
Chou-Hong Tann
Tiruvettipuram K Thiruvengadam
John Sze-Hung Chiu
Cesar Colon
Michael D Green
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE104310T1 publication Critical patent/ATE104310T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT90306657T 1989-06-21 1990-06-19 Verfahren zur herstellung von isepamicin. ATE104310T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36957889A 1989-06-21 1989-06-21
EP90306657A EP0405820B1 (de) 1989-06-21 1990-06-19 Verfahren zur Herstellung von Isepamicin

Publications (1)

Publication Number Publication Date
ATE104310T1 true ATE104310T1 (de) 1994-04-15

Family

ID=23456036

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93102033T ATE152094T1 (de) 1989-06-21 1990-06-19 N-geschützte (s)-isoserin-verbindungen
AT90306657T ATE104310T1 (de) 1989-06-21 1990-06-19 Verfahren zur herstellung von isepamicin.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT93102033T ATE152094T1 (de) 1989-06-21 1990-06-19 N-geschützte (s)-isoserin-verbindungen

Country Status (16)

Country Link
EP (3) EP0478707A1 (de)
JP (2) JPH0692433B2 (de)
KR (1) KR940003496B1 (de)
AT (2) ATE152094T1 (de)
AU (1) AU629960B2 (de)
CA (2) CA2062788C (de)
DE (2) DE69030590T2 (de)
DK (2) DK0405820T3 (de)
ES (2) ES2063274T3 (de)
FI (1) FI96955C (de)
GR (1) GR3023942T3 (de)
HK (2) HK185096A (de)
HU (1) HU207338B (de)
NO (1) NO177349C (de)
RU (1) RU2120444C1 (de)
WO (1) WO1990015810A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100927626B1 (ko) * 2002-09-18 2009-11-20 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 이세파마이신의 제조 방법
CN101928310B (zh) * 2010-03-26 2012-09-05 常州方圆制药有限公司 3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法
CN102190690B (zh) * 2011-04-01 2015-01-21 福州博立医药科技有限公司 一种简便且高收率阿贝卡星合成方法
CN105524129B (zh) * 2015-12-25 2018-06-26 无锡济民可信山禾药业股份有限公司 一种硫酸依替米星的制备方法
RU2659032C1 (ru) * 2017-04-26 2018-06-27 Федеральное государственное бюджетное образовательное учреждение высшего образования "Удмуртский государственный университет" Способ модификации гентамицина сополимером винилпирролидона с диацеталем акролеина
CN108586313B (zh) * 2018-03-31 2019-12-27 海正药业南通有限公司 一种新型合成n-取代苯酐-(s)-异丝氨酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
EP0156771A3 (de) * 1984-03-29 1986-03-19 Biochemie Gesellschaft M.B.H. Cephalosporinverbindungen

Also Published As

Publication number Publication date
NO915071L (no) 1991-12-20
WO1990015810A2 (en) 1990-12-27
EP0405820A3 (en) 1991-04-10
EP0547031B1 (de) 1997-04-23
AU5946390A (en) 1991-01-08
HUT59934A (en) 1992-07-28
FI96955C (fi) 1996-09-25
AU629960B2 (en) 1992-10-15
JPH04502474A (ja) 1992-05-07
KR940003496B1 (ko) 1994-04-23
DK0405820T3 (da) 1994-05-16
WO1990015810A3 (en) 1991-04-04
DE69008052T2 (de) 1994-07-28
CA2325082A1 (en) 1990-12-22
HU906641D0 (en) 1992-03-30
JPH07133267A (ja) 1995-05-23
HK1000153A1 (en) 1998-01-02
DE69030590T2 (de) 1997-08-07
KR920701226A (ko) 1992-08-11
DK0547031T3 (da) 1997-05-20
NO177349C (no) 1995-08-30
EP0547031A1 (de) 1993-06-16
CA2062788A1 (en) 1990-12-22
NO177349B (no) 1995-05-22
NO915071D0 (no) 1991-12-20
ES2063274T3 (es) 1995-01-01
GR3023942T3 (en) 1997-09-30
ATE152094T1 (de) 1997-05-15
EP0405820B1 (de) 1994-04-13
JP2500059B2 (ja) 1996-05-29
FI915953A0 (fi) 1991-12-18
HU207338B (en) 1993-03-29
HK185096A (en) 1996-10-11
JPH0692433B2 (ja) 1994-11-16
DE69030590D1 (de) 1997-05-28
EP0405820A2 (de) 1991-01-02
DE69008052D1 (de) 1994-05-19
CA2062788C (en) 2001-10-23
RU2120444C1 (ru) 1998-10-20
FI96955B (fi) 1996-06-14
ES2100380T3 (es) 1997-06-16
EP0478707A1 (de) 1992-04-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee