ATA902490A - Rekombinantes pockenvirus-wirtsselektionssystem - Google Patents

Rekombinantes pockenvirus-wirtsselektionssystem

Info

Publication number
ATA902490A
ATA902490A AT0902490A AT902490A ATA902490A AT A902490 A ATA902490 A AT A902490A AT 0902490 A AT0902490 A AT 0902490A AT 902490 A AT902490 A AT 902490A AT A902490 A ATA902490 A AT A902490A
Authority
AT
Austria
Prior art keywords
selection system
host selection
virus host
small virus
recombinant small
Prior art date
Application number
AT0902490A
Other languages
English (en)
Other versions
AT400955B (de
Inventor
Enzo Paoletti
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/320,471 external-priority patent/US5155020A/en
Application filed by Health Research Inc filed Critical Health Research Inc
Publication of ATA902490A publication Critical patent/ATA902490A/de
Application granted granted Critical
Publication of AT400955B publication Critical patent/AT400955B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/20011—Rhabdoviridae
    • C12N2760/20111—Lyssavirus, e.g. rabies virus
    • C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT0902490A 1989-03-08 1990-03-02 Rekombinantes pockenvirus-wirtsselektionssystem AT400955B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/320,471 US5155020A (en) 1989-03-08 1989-03-08 Recombinant poxvirus host range selection system
US47817990A 1990-02-14 1990-02-14

Publications (2)

Publication Number Publication Date
ATA902490A true ATA902490A (de) 1995-09-15
AT400955B AT400955B (de) 1996-05-28

Family

ID=26982509

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0902490A AT400955B (de) 1989-03-08 1990-03-02 Rekombinantes pockenvirus-wirtsselektionssystem

Country Status (15)

Country Link
US (1) US5453364A (de)
JP (1) JP3044062B2 (de)
AT (1) AT400955B (de)
AU (1) AU625584B2 (de)
BE (1) BE1004212A5 (de)
CA (1) CA2011654C (de)
CH (1) CH682669A5 (de)
DE (1) DE4090351T1 (de)
DK (1) DK157091A (de)
GB (1) GB2245272B (de)
IE (1) IE62441B1 (de)
IT (1) IT1239987B (de)
LU (1) LU88000A1 (de)
NL (1) NL9020389A (de)
WO (1) WO1990010693A1 (de)

Families Citing this family (74)

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US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
US5364773A (en) * 1991-03-07 1994-11-15 Virogenetics Corporation Genetically engineered vaccine strain
US7767449B1 (en) 1981-12-24 2010-08-03 Health Research Incorporated Methods using modified vaccinia virus
US5505941A (en) * 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
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BR9106879A (pt) 1990-09-25 1993-07-20 Cantab Pharma Res Virus mutuante nao retroviral,uso do mesmo,vacina e processo de manufaturar umvirus mutante
US5665362A (en) * 1990-09-25 1997-09-09 Cantab Pharmaceuticals Research Limited Viral vaccines
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US5837261A (en) * 1990-09-25 1998-11-17 Cantab Pharmaceuticals Research Limited Viral vaccines
AU699903B2 (en) * 1990-11-20 1998-12-17 Virogenetics Corporation Measles virus recombinant poxvirus vaccine
US6309647B1 (en) 1999-07-15 2001-10-30 Aventis Pasteur Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
US5756102A (en) * 1990-11-20 1998-05-26 Virogenetics Corporation Poxvirus-canine distemper virus (CDV) recombinants and compositions and methods employing the recombinants
US5766598A (en) * 1991-03-07 1998-06-16 Virogenetics Corporation Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products
KR100242671B1 (ko) * 1991-03-07 2000-03-02 고돈 에릭 유전학적으로 처리한 백신 균주
AU672581B2 (en) * 1991-03-07 1996-10-10 Virogenetics Corporation Immunodeficiency virus recombinant poxvirus vaccine
DE69229390T2 (de) 1991-08-26 1999-11-11 Immuno Ag, Wien Direkt molekuläre Klonierung eines modifizierten Genoms eines Chordopocken-Virus
DK0758397T3 (da) * 1994-04-29 2005-10-10 Baxter Healthcare Sa Rekombinante poxvira med fremmede polynucleotider i essentielle regioner
ATE324435T1 (de) 1995-02-21 2006-05-15 Cantab Pharmaceuticals Res Ltd Virale zubereitungen, vektoren, immunogene und impfstoffe
EP0862449A4 (de) * 1995-09-29 1998-11-11 Immunex Corp Chemokin-inhibitor
AU2660397A (en) * 1996-04-05 1997-10-29 Board Of Regents, The University Of Texas System Methods for producing soluble, biologically-active disulfide bond-containing eukaryotic proteins in bacterial cells
US20030138454A1 (en) * 1997-06-09 2003-07-24 Oxxon Pharmaccines, Ltd. Vaccination method
US6083715A (en) * 1997-06-09 2000-07-04 Board Of Regents, The University Of Texas System Methods for producing heterologous disulfide bond-containing polypeptides in bacterial cells
GB9711957D0 (en) * 1997-06-09 1997-08-06 Isis Innovation Methods and reagents for vaccination
MXPA00008352A (es) 1998-02-27 2002-10-17 Univ Pennsylvania Vacunas, composiciones inmunoterapeuticas y metodos para usar las mismas.
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EP1301637B1 (de) * 2000-07-14 2008-06-11 The Trustees Of The University Of Pennsylvania Für akzessorische hiv proteine kodierende dna impfstoffe
CN1549730A (zh) 2000-10-04 2004-11-24 ���������Ǵ�ѧ�й��� 黄病毒和瘟病毒衣壳蛋白的组成和使用方法
US8216585B2 (en) 2001-05-25 2012-07-10 The Trustees Of The University Of Pennsylvania Targeted particles and methods of using the same
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WO2003085087A2 (en) 2002-04-09 2003-10-16 Aventis Pasteur, Limited Modified cea nucleic acid and expression vectors
CN1596126A (zh) 2001-11-30 2005-03-16 埃西斯创新有限公司 疫苗
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ES2256747T3 (es) * 2002-05-16 2006-07-16 Bavarian Nordic A/S Expresion de genes en el virus de la vacuna modificado, usando el promotor ati de la viruela de la vaca.
ATE535249T1 (de) 2003-06-13 2011-12-15 Univ Pennsylvania Vakzine, immuntherapeutika und verfahren zu ihrer verwendung
NZ570709A (en) 2003-06-13 2010-04-30 Univ Pennsylvania Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same
US20050175627A1 (en) * 2003-09-24 2005-08-11 Oxxon Therapeutics Ltd. HIV pharmaccines
JP4668919B2 (ja) * 2003-10-08 2011-04-13 サノフィ パストゥール インコーポレイテッド 修飾ｃｅａ／ｂ７ベクター
WO2007050095A2 (en) 2004-11-19 2007-05-03 The Trustees Of The University Of Pennsylvania Improved vaccines and methods for using the same
AU2007208452B2 (en) * 2006-01-13 2012-07-05 The Trustees Of The University Of Pennsylvania Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same
WO2007082105A2 (en) 2006-01-16 2007-07-19 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chlamydia vaccine
DK3037429T3 (en) 2006-07-28 2019-01-21 Univ Pennsylvania IMPROVED HIV VACCINES
US9687515B2 (en) 2007-11-19 2017-06-27 Transgene S.A. Poxviral oncolytic vectors
KR101542276B1 (ko) * 2007-11-19 2015-08-06 트랜스진 에스.에이. 폭스바이러스성 온콜리틱 벡터
CN102016023A (zh) * 2008-04-04 2011-04-13 宾夕法尼亚州立大学托管会 使用il-28和组合物的疫苗和免疫治疗及其使用方法
CN101990580A (zh) * 2008-04-04 2011-03-23 宾夕法尼亚州立大学托管会 屈曲病毒蛋白共有序列、编码该屈曲病毒蛋白共有序列的核酸分子和组合物及其使用方法
WO2010050939A1 (en) 2008-10-29 2010-05-06 The Trustees Of The University Of Pennsylvania Improved hcv vaccines and methods for using the same
US8921536B2 (en) 2008-10-29 2014-12-30 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
CA2653478A1 (en) * 2009-01-23 2010-07-23 Gregg Martin Automated wash system for industrial vehicles
US9050287B2 (en) 2009-01-23 2015-06-09 The Trustees Of The University Of Pennsylvania Vaccines for human papilloma virus and methods for using the same
EP2477659A4 (de) 2009-09-14 2014-01-15 Univ Pennsylvania Impfstoffe und immuntherapeutika mit dafür kodierenden il-15-rezeptor-alpha- und/oder nukleinsäuremolekülen sowie verfahren zu ihrer anwendung
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US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
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CN101935676A (zh) * 2010-08-20 2011-01-05 中国海洋大学 一种诱导扇贝组织细胞体外转化的方法
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KR20140007404A (ko) 2011-01-31 2014-01-17 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 신규 허피스 항원을 암호화하는 핵산 분자, 이것을 포함하는 백신 및 이것의 사용 방법
EA202092990A3 (ru) 2011-02-11 2021-07-30 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Молекула нуклеиновой кислоты, кодирующая коровый белок вируса гепатита в, и вакцина, содержащая указанную молекулу
US9238679B2 (en) 2011-02-11 2016-01-19 The Trustees Of The University Of Pennslyvania Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same
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KR101913674B1 (ko) 2011-10-24 2018-10-31 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 개선된 hcv 백신 및 이것을 사용하는 방법
JP6407028B2 (ja) 2011-12-12 2018-10-17 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア ＭＲＳＡのＰＢＰ２ａ及びその断片を含むタンパク質、それをコードする核酸、並びにＭＲＳＡ感染を予防する及び治療するための組成物及びそれらの使用
EA026926B1 (ru) 2011-12-12 2017-05-31 Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания Композиции, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения
US10040828B2 (en) 2012-04-10 2018-08-07 The Trustees Of The University Of Pennsylvania Human respiratory syncytial virus consensus antigens, nucleic acid constructs and vaccines made therefrom, and methods of using same
EP2897628A4 (de) * 2012-09-21 2016-06-22 Agency Science Tech & Res Neuartige abgeschwächte dengue-virusstämme zur anwendung in einem impfstoff
KR20150130438A (ko) 2013-03-12 2015-11-23 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 인간 파밀로마 바이러스용 개선된 백신 및 이것을 사용하는 방법
AU2014228405B2 (en) 2013-03-15 2017-05-11 The Trustees Of The University Of Pennsylvania Cancer vaccines and methods of treatment using the same
ES2817903T3 (es) 2013-03-15 2021-04-08 Univ Pennsylvania Proteínas de consenso del virus de la Fiebre Aftosa (VFA), secuencias codificantes y vacunas preparadas a partir de las mismas
EP3723812A4 (de) 2017-12-13 2022-02-16 Inovio Pharmaceuticals, Inc. Gegen muc16 gerichtete krebsvakzine und verwendungen davon
ES2938900T3 (es) 2017-12-13 2023-04-17 Inovio Pharmaceuticals Inc Vacunas contra el cáncer dirigidas al PRAME y usos de las mismas
JP7352547B2 (ja) 2017-12-13 2023-09-28 イノビオ ファーマシューティカルズ，インコーポレイティド メソセリンを標的とするがんワクチンおよびその使用
CN112779293A (zh) * 2021-01-27 2021-05-11 重庆市畜牧科学院 一种筛选LacZ基因标记山羊痘病毒的宿主细胞的方法

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Also Published As

Publication number Publication date
AU5332090A (en) 1990-10-09
DK157091A (da) 1991-09-26
WO1990010693A1 (en) 1990-09-20
IT9019623A0 (it) 1990-03-08
IT1239987B (it) 1993-11-27
US5453364A (en) 1995-09-26
IE900814L (en) 1990-09-08
DK157091D0 (da) 1991-09-06
NL9020389A (nl) 1991-12-02
JPH04503904A (ja) 1992-07-16
AU625584B2 (en) 1992-07-16
DE4090351T1 (de) 1997-07-24
IT9019623A1 (it) 1991-09-08
GB2245272A (en) 1992-01-02
AT400955B (de) 1996-05-28
CH682669A5 (fr) 1993-10-29
CA2011654C (en) 1995-12-19
GB2245272B (en) 1993-03-17
LU88000A1 (fr) 1992-03-11
CA2011654A1 (en) 1990-09-08
GB9117996D0 (en) 1991-10-09
IE62441B1 (en) 1995-02-08
BE1004212A5 (fr) 1992-10-13
JP3044062B2 (ja) 2000-05-22

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