AT394493B - Pharmazeutisches praeparat zur behandlung von lebererkrankungen - Google Patents
Pharmazeutisches praeparat zur behandlung von lebererkrankungen Download PDFInfo
- Publication number
- AT394493B AT394493B AT0113089A AT113089A AT394493B AT 394493 B AT394493 B AT 394493B AT 0113089 A AT0113089 A AT 0113089A AT 113089 A AT113089 A AT 113089A AT 394493 B AT394493 B AT 394493B
- Authority
- AT
- Austria
- Prior art keywords
- acid
- pharmaceutical preparation
- cysteine
- zinc acetate
- glutamic acid
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 8
- 208000019423 liver disease Diseases 0.000 title claims description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract description 28
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims abstract description 16
- 229960002989 glutamic acid Drugs 0.000 claims abstract description 15
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims abstract description 14
- 229960005261 aspartic acid Drugs 0.000 claims abstract description 13
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000004246 zinc acetate Substances 0.000 claims abstract description 12
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims abstract description 11
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims abstract description 11
- 239000011655 sodium selenate Substances 0.000 claims abstract description 10
- 235000018716 sodium selenate Nutrition 0.000 claims abstract description 10
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960002433 cysteine Drugs 0.000 claims abstract description 9
- 229960001881 sodium selenate Drugs 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims abstract description 8
- 239000004201 L-cysteine Substances 0.000 claims abstract description 7
- 235000013878 L-cysteine Nutrition 0.000 claims abstract description 7
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims abstract description 5
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 229910000368 zinc sulfate Inorganic materials 0.000 claims abstract description 4
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 5
- 239000003978 infusion fluid Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 3
- 229960001763 zinc sulfate Drugs 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 7
- 239000011701 zinc Substances 0.000 abstract description 4
- 239000011686 zinc sulphate Substances 0.000 abstract 2
- 235000009529 zinc sulphate Nutrition 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 7
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 7
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 7
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 6
- 108010024636 Glutathione Proteins 0.000 description 5
- 229960003180 glutathione Drugs 0.000 description 5
- 229910052711 selenium Inorganic materials 0.000 description 5
- 239000011669 selenium Substances 0.000 description 5
- 229940091258 selenium supplement Drugs 0.000 description 5
- 231100000331 toxic Toxicity 0.000 description 5
- 230000002588 toxic effect Effects 0.000 description 5
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 4
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 description 4
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 229960001456 adenosine triphosphate Drugs 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000004110 gluconeogenesis Effects 0.000 description 4
- 235000013922 glutamic acid Nutrition 0.000 description 4
- 229950006238 nadide Drugs 0.000 description 4
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 235000003704 aspartic acid Nutrition 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000004220 glutamic acid Substances 0.000 description 3
- 231100000304 hepatotoxicity Toxicity 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 230000035882 stress Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 102000006587 Glutathione peroxidase Human genes 0.000 description 2
- 108700016172 Glutathione peroxidases Proteins 0.000 description 2
- 206010067125 Liver injury Diseases 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 102100033220 Xanthine oxidase Human genes 0.000 description 2
- 108010093894 Xanthine oxidase Proteins 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- HWXBTNAVRSUOJR-UHFFFAOYSA-N alpha-hydroxyglutaric acid Natural products OC(=O)C(O)CCC(O)=O HWXBTNAVRSUOJR-UHFFFAOYSA-N 0.000 description 2
- 229940009533 alpha-ketoglutaric acid Drugs 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 231100000234 hepatic damage Toxicity 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000005229 liver cell Anatomy 0.000 description 2
- 230000008818 liver damage Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 125000003396 thiol group Chemical group [H]S* 0.000 description 2
- SGOJMJDHHYBSAA-CZIDNERZSA-N (2s)-2-aminobutanedioic acid;(2s)-2-aminopentanedioic acid;(2r)-2-amino-3-sulfanylpropanoic acid Chemical compound SC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC(O)=O.OC(=O)[C@@H](N)CCC(O)=O SGOJMJDHHYBSAA-CZIDNERZSA-N 0.000 description 1
- MNIQECRMTVGZBM-UHFFFAOYSA-N 3-(1-methylpyrrolidin-2-yl)pyridine;7h-purin-6-amine Chemical compound NC1=NC=NC2=C1NC=N2.CN1CCCC1C1=CC=CN=C1 MNIQECRMTVGZBM-UHFFFAOYSA-N 0.000 description 1
- 230000002407 ATP formation Effects 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- 208000002381 Brain Hypoxia Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 206010019728 Hepatitis alcoholic Diseases 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 206010020575 Hyperammonaemia Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 208000002353 alcoholic hepatitis Diseases 0.000 description 1
- 230000003510 anti-fibrotic effect Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 150000001510 aspartic acids Chemical class 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000007882 cirrhosis Effects 0.000 description 1
- 208000019425 cirrhosis of liver Diseases 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012059 conventional drug carrier Substances 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 150000002307 glutamic acids Chemical class 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 231100000334 hepatotoxic Toxicity 0.000 description 1
- 230000003082 hepatotoxic effect Effects 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 230000037427 ion transport Effects 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000006705 mitochondrial oxidative phosphorylation Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008014 pharmaceutical binder Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- VNOYUJKHFWYWIR-ITIYDSSPSA-N succinyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 VNOYUJKHFWYWIR-ITIYDSSPSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 230000004143 urea cycle Effects 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/315—Zinc compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0113089A AT394493B (de) | 1989-05-11 | 1989-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen |
| CH2481/89A CH674311A5 (enrdf_load_stackoverflow) | 1989-05-11 | 1989-07-04 | |
| US07/521,702 US5102910A (en) | 1989-05-11 | 1990-05-10 | Pharmaceutical preparation and method of treatment for liver dysfunction |
| CA002016470A CA2016470C (en) | 1989-05-11 | 1990-05-10 | Pharmaceutical preparation and method of treatment for liver dysfunction |
| ES90890146T ES2043351T3 (es) | 1989-05-11 | 1990-05-11 | Preparado farmaceutico para el tratamiento de enfermedades hepaticas. |
| AT90890146T ATE77954T1 (de) | 1989-05-11 | 1990-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen. |
| DE9090890146T DE59000195D1 (de) | 1989-05-11 | 1990-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen. |
| EP90890146A EP0397646B1 (de) | 1989-05-11 | 1990-05-11 | Pharmazeutisches Präparat zur Behandlung von Lebererkrankungen |
| DK90890146.5T DK0397646T3 (da) | 1989-05-11 | 1990-05-11 | Farmaceutisk præparat til behandling af leversygdomme |
| GR920401612T GR3005282T3 (enrdf_load_stackoverflow) | 1989-05-11 | 1992-07-29 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0113089A AT394493B (de) | 1989-05-11 | 1989-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA113089A ATA113089A (de) | 1991-10-15 |
| AT394493B true AT394493B (de) | 1992-04-10 |
Family
ID=3507244
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0113089A AT394493B (de) | 1989-05-11 | 1989-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen |
| AT90890146T ATE77954T1 (de) | 1989-05-11 | 1990-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90890146T ATE77954T1 (de) | 1989-05-11 | 1990-05-11 | Pharmazeutisches praeparat zur behandlung von lebererkrankungen. |
Country Status (9)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9305932A (pt) * | 1992-02-19 | 1997-08-26 | Colby Corp Ltd | Processo para enfrentar e proporcionar resistência a eczema à intoxicação por micotoxina e à sindrome de definharnento de alces em animais processo para tratamento de eczerna de intoxicação por micotoxina e de doença de definnarnento de alces em animais composição de consistência fluida ou pastosa bolo para emprego no tratamento de eczema intoxicação por micotoxina e de sindrome de definhamento de alces composição e processo para tratamento de disturbios que reagem à administração de zinco e composição |
| US5276018A (en) * | 1992-07-17 | 1994-01-04 | Brigham And Women's Hospital | Composition comprising amino acids and methods for decreasing muscle breakdown |
| KR970008105B1 (ko) * | 1993-06-28 | 1997-05-21 | 주식회사 미원 | L-아스파테이트 또는 아스파라긴을 유효성분으로 함유하는 알콜성 장해 보호제 및 그의 제조방법 |
| EP1574211A1 (en) * | 2004-03-09 | 2005-09-14 | Inserm | Use of antagonists of the CB1 receptor for the manufacture of a composition useful for the treatment of hepatic diseases |
| WO2006061992A1 (ja) * | 2004-12-10 | 2006-06-15 | Ajinomoto Co., Inc. | 肝疾患予防・治療用組成物 |
| WO2009043106A1 (en) * | 2007-10-03 | 2009-04-09 | Velacor Therapeutics Pty Ltd | Inorganic selenium and angiogenesis |
| US20090269796A1 (en) * | 2007-12-05 | 2009-10-29 | The General Hospital Corporation | Methods of detecting and treating myocardial ischemia and myocardial infarction |
| DE102011001768A1 (de) * | 2011-04-04 | 2012-10-04 | Gunnar Frank | Präparat oder Nahrungsergänzungsmittel |
| JP6535322B2 (ja) | 2013-05-08 | 2019-06-26 | ガンブロ・ルンディア・エービーＧａｍｂｒｏ Ｌｕｎｄｉａ Ａｂ | 透析製剤 |
| US20190336523A1 (en) * | 2017-11-30 | 2019-11-07 | Medico Consl Co., Ltd | Combination drug suitable for treatment and prevention of non-alcoholic fatty liver disease (NAFLD) and/or non-alcoholic steatohepatitis (NASH), and/or hepatic fatty degeneration |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2090133A (en) * | 1980-11-12 | 1982-07-07 | Patterson Janice Anne | Veterinary Composition containing Vitamin E and Selenium Compounds |
| US4599234A (en) * | 1983-10-07 | 1986-07-08 | Amer M Samir | Synergistic diet comprising selenium based compounds |
| DE3542309A1 (de) * | 1985-11-29 | 1987-06-04 | Cardona Federico Dr | Medizinisches antioxidativum |
| DE3628010A1 (de) * | 1986-08-19 | 1988-02-25 | Astra Chem Gmbh | Arzneimittel fuer die verwendung bei der behandlung von hypertonie |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1792034A1 (de) * | 1964-09-28 | 1971-10-07 | Yamanouchi Pharma Co Ltd | Verwendung von Glutathion-Aminosaeure-Gemischen als Leberschutzmittel fuer Mensch und Tier |
| US4124718A (en) * | 1977-01-21 | 1978-11-07 | Merrell Toraude Et Compagnie | Enhancing zinc serum and tissue levels |
| JPS6058908B2 (ja) * | 1978-10-11 | 1985-12-23 | 参天製薬株式会社 | システイン誘導体 |
| US4758431A (en) * | 1980-04-14 | 1988-07-19 | Thomas Jefferson University | Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
| US4440788A (en) * | 1980-05-13 | 1984-04-03 | Mitsubishi Chemical Industries, Limited | Cysteine derivatives |
| IL61080A0 (en) * | 1980-09-19 | 1980-11-30 | Garfinkel D | Pharmaceutical composition containing zinc ions |
| JPS5832850A (ja) * | 1981-08-22 | 1983-02-25 | Santen Pharmaceut Co Ltd | スルホシステイン誘導体 |
| JPS58126767A (ja) * | 1982-01-22 | 1983-07-28 | Ajinomoto Co Inc | 肝臓病患者用栄養組成物 |
| US4446154A (en) * | 1982-03-03 | 1984-05-01 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
| JPS5916817A (ja) * | 1982-07-16 | 1984-01-28 | Eisai Co Ltd | アミノ酸輸液 |
| JPS62258321A (ja) * | 1986-05-01 | 1987-11-10 | Senjiyu Seiyaku Kk | 肝障害抑制剤 |
-
1989
- 1989-05-11 AT AT0113089A patent/AT394493B/de not_active IP Right Cessation
- 1989-07-04 CH CH2481/89A patent/CH674311A5/de not_active IP Right Cessation
-
1990
- 1990-05-10 CA CA002016470A patent/CA2016470C/en not_active Expired - Lifetime
- 1990-05-10 US US07/521,702 patent/US5102910A/en not_active Expired - Lifetime
- 1990-05-11 EP EP90890146A patent/EP0397646B1/de not_active Expired - Lifetime
- 1990-05-11 DK DK90890146.5T patent/DK0397646T3/da not_active Application Discontinuation
- 1990-05-11 ES ES90890146T patent/ES2043351T3/es not_active Expired - Lifetime
- 1990-05-11 DE DE9090890146T patent/DE59000195D1/de not_active Expired - Lifetime
- 1990-05-11 AT AT90890146T patent/ATE77954T1/de not_active IP Right Cessation
-
1992
- 1992-07-29 GR GR920401612T patent/GR3005282T3/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2090133A (en) * | 1980-11-12 | 1982-07-07 | Patterson Janice Anne | Veterinary Composition containing Vitamin E and Selenium Compounds |
| US4599234A (en) * | 1983-10-07 | 1986-07-08 | Amer M Samir | Synergistic diet comprising selenium based compounds |
| DE3542309A1 (de) * | 1985-11-29 | 1987-06-04 | Cardona Federico Dr | Medizinisches antioxidativum |
| DE3628010A1 (de) * | 1986-08-19 | 1988-02-25 | Astra Chem Gmbh | Arzneimittel fuer die verwendung bei der behandlung von hypertonie |
Non-Patent Citations (3)
| Title |
|---|
| B. HELWIG, H. HELWIG, MODERNE ARZNEMITTEL, 5. AUFLAGE, WISSENSCHAFTLICHE VERLAGSGESELLSCHAFT MBH STUTTGART, 1980, SEITEN 616-634, 384, 389, 802 * |
| RÖMPPS CHEMIE-LEXIKON, 8. AUFLAGE, FRANCK'SCHE VERLAGSBUCHHANDLUNG STUTTGART, 1987, SEITEN 3795-3798 * |
| W. KRAUSE, P. OEHME, DAS DEUTSCHE GESUNDHEITSWESEN, 34. JG, 1979, SEITEN 1713-1718, 1769-1774 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2016470A1 (en) | 1990-11-11 |
| DE59000195D1 (de) | 1992-08-13 |
| ATE77954T1 (de) | 1992-07-15 |
| US5102910A (en) | 1992-04-07 |
| EP0397646A1 (de) | 1990-11-14 |
| ES2043351T3 (es) | 1993-12-16 |
| GR3005282T3 (enrdf_load_stackoverflow) | 1993-05-24 |
| DK0397646T3 (da) | 1992-08-24 |
| ATA113089A (de) | 1991-10-15 |
| CH674311A5 (enrdf_load_stackoverflow) | 1990-05-31 |
| CA2016470C (en) | 1995-11-07 |
| EP0397646B1 (de) | 1992-07-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee | ||
| EIH | Change in the person of patent owner | ||
| ELA | Expired due to lapse of time |