DE69621756T2 - Betahydroxybuttersäure oder Acetoessigsäure oder deren Salze oder Ester zur Verwendung zur Verbesserung der Gehirnfunktion - Google Patents

Betahydroxybuttersäure oder Acetoessigsäure oder deren Salze oder Ester zur Verwendung zur Verbesserung der Gehirnfunktion

Info

Publication number
DE69621756T2
DE69621756T2 DE69621756T DE69621756T DE69621756T2 DE 69621756 T2 DE69621756 T2 DE 69621756T2 DE 69621756 T DE69621756 T DE 69621756T DE 69621756 T DE69621756 T DE 69621756T DE 69621756 T2 DE69621756 T2 DE 69621756T2
Authority
DE
Germany
Prior art keywords
acid
beta
esters
salts
brain function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69621756T
Other languages
English (en)
Other versions
DE69621756D1 (de
Inventor
M D Hiraide
Dohi, Ph D
Motohisa Suzuki
Yoshihiro Shiba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Publication of DE69621756D1 publication Critical patent/DE69621756D1/de
Application granted granted Critical
Publication of DE69621756T2 publication Critical patent/DE69621756T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69621756T 1995-12-01 1996-11-22 Betahydroxybuttersäure oder Acetoessigsäure oder deren Salze oder Ester zur Verwendung zur Verbesserung der Gehirnfunktion Expired - Lifetime DE69621756T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP33775095 1995-12-01
JP20267196 1996-07-31
JP20267696 1996-08-01
JP29924796A JP4598203B2 (ja) 1995-12-01 1996-10-24 脳機能改善剤

Publications (2)

Publication Number Publication Date
DE69621756D1 DE69621756D1 (de) 2002-07-18
DE69621756T2 true DE69621756T2 (de) 2002-10-24

Family

ID=27476120

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69621756T Expired - Lifetime DE69621756T2 (de) 1995-12-01 1996-11-22 Betahydroxybuttersäure oder Acetoessigsäure oder deren Salze oder Ester zur Verwendung zur Verbesserung der Gehirnfunktion

Country Status (7)

Country Link
US (2) US6136862A (de)
EP (2) EP1188437A3 (de)
JP (1) JP4598203B2 (de)
CA (1) CA2191677C (de)
DE (1) DE69621756T2 (de)
HK (1) HK1043055A1 (de)
TW (1) TW577736B (de)

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US6323237B1 (en) 1997-03-17 2001-11-27 Btg International Limited Therapeutic compositions
US20090253781A1 (en) * 2002-05-24 2009-10-08 Btg International Limited Therapeutic compositions
ATE283056T1 (de) * 1998-07-22 2004-12-15 Metabolix Inc Nahrungs- und therapeutische verwendung von hydroxyalkanoat oligomere
WO2000015216A1 (en) 1998-09-15 2000-03-23 Btg International Limited Therapeutic compositions (ii)
US20020119191A1 (en) * 2000-04-24 2002-08-29 Hitoo Nishino Pharmaceutical or food composition for treatment or prevention of brain edema
US20020006959A1 (en) 2000-05-01 2002-01-17 Henderson Samuel T. Use of medium chain triglycerides for the treatment and prevention of Alzheimer's Disease and other diseases resulting from reduced Neuronal Metabolism
US20070179197A1 (en) * 2000-05-01 2007-08-02 Accera, Inc. Compositions and methods for improving or preserving brain function
US6835750B1 (en) 2000-05-01 2004-12-28 Accera, Inc. Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
CN1135983C (zh) * 2001-06-28 2004-01-28 中山大学 二酸（5－雄甾烯－17－酮－3β－羟基）二酯用于制备药物
US9597395B2 (en) 2001-12-07 2017-03-21 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of cardiovascular conditions
US7771716B2 (en) 2001-12-07 2010-08-10 Cytori Therapeutics, Inc. Methods of using regenerative cells in the treatment of musculoskeletal disorders
US20050048035A1 (en) 2001-12-07 2005-03-03 Fraser John K. Methods of using regenerative cells in the treatment of stroke and related diseases and disorders
US20050095228A1 (en) 2001-12-07 2005-05-05 Fraser John K. Methods of using regenerative cells in the treatment of peripheral vascular disease and related disorders
WO2004077938A2 (en) * 2003-03-06 2004-09-16 Accera Inc. Novel chemical entities and methods for their use in treatment of metabolic disorders
AU2004245567B2 (en) * 2003-06-03 2011-06-23 Oxford University Innovation Limited Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives
US7132221B2 (en) * 2003-09-12 2006-11-07 Headway Technologies, Inc. Method to print photoresist lines with negative sidewalls
GB0410266D0 (en) * 2004-05-07 2004-06-09 Ketocytonyx Inc Treatment of apoptosis
GB0420856D0 (en) * 2004-09-20 2004-10-20 Ketocytonyx Inc Cns modulators
EP1778213B1 (de) 2004-07-16 2017-04-05 BTG International Limited Verfahren zur herstellung oligomerer verbindungen
WO2006020179A2 (en) * 2004-07-20 2006-02-23 Ketocytonyx Inc. Oligomeric ketone compounds
US20070225252A1 (en) * 2004-07-23 2007-09-27 Gross Richard A Ketogenic Saccharides
EP1793813A4 (de) * 2004-09-21 2011-05-18 Btg Int Ltd Behandlung von adhd
EP1796658B1 (de) * 2004-09-21 2016-03-30 BTG International Limited Dopaminerge mimetika
KR20060094421A (ko) * 2005-02-24 2006-08-29 고재영 신규한 뇌졸중 치료제 조성물
US20060252775A1 (en) * 2005-05-03 2006-11-09 Henderson Samuel T Methods for reducing levels of disease associated proteins
WO2007001883A2 (en) * 2005-06-20 2007-01-04 Accera, Inc. Method to reduce oxidative damage and improve mitochondrial efficiency
HUE035852T2 (en) 2006-04-03 2018-05-28 Accera Inc Use of ketogen compounds to treat memory decline
US20100056631A1 (en) 2006-10-30 2010-03-04 Ophtecs Corporation Antiallergenic composition
WO2008110034A1 (fr) * 2007-03-14 2008-09-18 Shantou University Acide gras 3-hydroxy et ses dérivés pour améliorer l'apprentissage et/ou la mémoire chez des individus
US8758740B2 (en) 2007-03-30 2014-06-24 Earthus, Inc Composition for promoting ketone body production
MX2009011002A (es) 2007-04-12 2010-03-15 Univ Minnesota Composiciones de proteccion de isquemia/reperfusion y metodos de uso.
KR101335021B1 (ko) 2007-07-31 2013-12-12 액세라인크 게놈 테스트의 용도 및 인지 기능 저하 치료용 케톤성 화합물
EP2240017B1 (de) 2008-01-04 2019-03-13 Oxford University Innovation Limited Ketonkörper und ketonkörperester als blutfettsenkende mittel
KR101734152B1 (ko) * 2008-07-03 2017-05-11 액세라인크 신경계 장애의 치료를 위한 아세토아세테이트의 모노글리세리드 및 유도체
US8105809B2 (en) * 2008-07-03 2012-01-31 Accera, Inc. Enzymatic synthesis of acetoacetate esters and derivatives
WO2010021993A1 (en) 2008-08-19 2010-02-25 Cytori Therapeutics, Inc. Methods of using adipose tissue-derived cells in the treatment of the lymphatic system and malignant disease
US8642654B2 (en) * 2009-04-16 2014-02-04 Isis Innovation Limited Hydroxybutyrate ester and medical use thereof
ES2655367T3 (es) * 2008-08-21 2018-02-19 Oxford University Innovation Limited Bebida que comprende éster de hidroxibutirato y uso médico de la misma
US20120065179A1 (en) * 2009-04-14 2012-03-15 YKI, Ytemiska Institutet AB Prodrug comprising beta-keto carboxylic acid, beta-keto carboxylic acid salt or beta-keto carboxylic acid ester for drug delivery
GB201002983D0 (en) 2010-02-22 2010-04-07 Tdeltas Ltd Nutritinal composition
GB201206192D0 (en) 2012-04-05 2012-05-23 Tdeltas Ltd Ketone bodies and ketone body esters and for maintaining or improving muscle power output
AU2013337308B2 (en) 2012-11-05 2018-06-21 Tdeltas Ketone bodies to protect tissues from damage by ionizing radiation
GB201304467D0 (en) 2013-03-12 2013-04-24 Tdeltas Ltd Compound for use in protecting skin
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US20170065638A1 (en) * 2014-02-10 2017-03-09 Cytori Therapeutics, Inc. Regenerative cell therapy for central nervous system (cns) disorders and ptsd
US10137102B2 (en) 2014-07-21 2018-11-27 Oulun Yliopisto Oligomeric forms of 3-hydroxybutyrate
US11241403B2 (en) 2016-03-11 2022-02-08 Axcess Global Sciences, Llc Beta-hydroxybutyrate mixed salt compositions and methods of use
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CA3036688A1 (en) * 2016-09-12 2018-03-15 University Of South Florida Neuroregeneration improved by ketone
US10307398B2 (en) 2016-09-20 2019-06-04 Regents Of The University Of Minnesota Resuscitation composition and methods of making and using
US9925164B1 (en) * 2017-01-12 2018-03-27 Neuroenergy Ventures, Inc. Glyceryl 3-hydroxybutyrates for traumatic brain injury
US11065217B2 (en) 2017-01-27 2021-07-20 Temple University—Of the Commonwealth System of Higher Education Use of short chain fatty acids for the treatment and prevention of diseases and disorders
US10376528B2 (en) 2017-03-10 2019-08-13 Tecton Group, Llc Composition comprising ketone body and nicotinamide adenine dinucleotide modulator and methyl donor
US20190231742A1 (en) * 2017-04-20 2019-08-01 Theodore B. VANITALLIE Nutritional agents used to prevent and treat hypersensitivity and other allergic-type disorders
US11202769B2 (en) 2017-11-22 2021-12-21 Axcess Global Sciences, Llc Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function
US10925843B2 (en) 2018-04-18 2021-02-23 Axcess Global Sciences, Llc Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate
US11944598B2 (en) 2017-12-19 2024-04-02 Axcess Global Sciences, Llc Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer
CA3088213A1 (en) * 2018-02-01 2019-08-08 Wellstat Therapeutics Corporation Compositions and devices for systemic delivery of uridine
JP6979918B2 (ja) * 2018-03-30 2021-12-15 大阪瓦斯株式会社 ヒト老化細胞賦活剤
US11806324B2 (en) 2018-04-18 2023-11-07 Axcess Global Sciences, Llc Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies
CN110151744A (zh) * 2019-05-28 2019-08-23 南方医科大学 丁酸类化合物在制备治疗缺血性脑卒中的药物或功能食品中的应用
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US11969430B1 (en) 2023-03-10 2024-04-30 Axcess Global Sciences, Llc Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance

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Also Published As

Publication number Publication date
TW577736B (en) 2004-03-01
EP1188437A3 (de) 2002-03-27
EP0780123B1 (de) 2002-06-12
DE69621756D1 (de) 2002-07-18
US6136862A (en) 2000-10-24
HK1043055A1 (zh) 2002-09-06
CA2191677C (en) 2007-03-06
JP4598203B2 (ja) 2010-12-15
US6232345B1 (en) 2001-05-15
CA2191677A1 (en) 1997-06-02
JPH1095730A (ja) 1998-04-14
EP0780123A1 (de) 1997-06-25
EP1188437A2 (de) 2002-03-20

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