AT374684B - Verfahren zur herstellung von waessrigen loesungen von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen - Google Patents

Verfahren zur herstellung von waessrigen loesungen von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen

Info

Publication number
AT374684B
AT374684B AT0204781A AT204781A AT374684B AT 374684 B AT374684 B AT 374684B AT 0204781 A AT0204781 A AT 0204781A AT 204781 A AT204781 A AT 204781A AT 374684 B AT374684 B AT 374684B
Authority
AT
Austria
Prior art keywords
organically
water
organic compounds
aqueous solutions
producing aqueous
Prior art date
Application number
AT0204781A
Other languages
German (de)
English (en)
Other versions
ATA204781A (de
Inventor
Jozsef Dipl Ing Chem D Szejtli
Eva Dipl Ing Chem Dr Bolla
Agnes Dipl Ing Chem Dr Stadler
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of ATA204781A publication Critical patent/ATA204781A/de
Application granted granted Critical
Publication of AT374684B publication Critical patent/AT374684B/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT0204781A 1980-05-09 1981-05-08 Verfahren zur herstellung von waessrigen loesungen von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen AT374684B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU801141A HU181703B (en) 1980-05-09 1980-05-09 Process for producing aqueus solutuins of water insoluble or hardly soluble vitamines, steroides, localanesthetics, prostanoides and non-steroid and antiphlogistic agents

Publications (2)

Publication Number Publication Date
ATA204781A ATA204781A (de) 1983-10-15
AT374684B true AT374684B (de) 1984-05-25

Family

ID=10953012

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0204781A AT374684B (de) 1980-05-09 1981-05-08 Verfahren zur herstellung von waessrigen loesungen von in wasser nicht oder nur begrenzt loeslichen biologisch aktiven organischen verbindungen

Country Status (7)

Country Link
JP (1) JPS574914A (cs)
AT (1) AT374684B (cs)
BE (1) BE888736A (cs)
CH (1) CH661517A5 (cs)
DE (1) DE3118218A1 (cs)
FR (1) FR2484252A1 (cs)
HU (1) HU181703B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187653A3 (en) * 1985-01-10 1987-08-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Pharmaceutical compositions replacing the bile and aidinpharmaceutical compositions replacing the bile and aiding the digestion of fats, and process for their preparatig the digestion of fats, and process for their preparation on

Families Citing this family (50)

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JPS5936656A (ja) * 1982-08-23 1984-02-28 Teijin Ltd 新規包接化合物及びそれを活性成分とする薬剤
HU194858B (en) * 1982-12-03 1988-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
SE8305864D0 (sv) * 1983-10-25 1983-10-25 L E Medical Ogondroppar
EP0146841A3 (de) * 1983-12-17 1986-11-20 Consortium für elektrochemische Industrie GmbH Wasserlösliche Mischether des beta-Cyclodextrins und ein Verfahren zu ihrer Herstellung
EP0147685B1 (de) * 1983-12-17 1989-04-26 Hoechst Aktiengesellschaft Ether des beta-Cyclodextrins und ein Verfahren zu ihrer Herstellung
DE3346123A1 (de) * 1983-12-21 1985-06-27 Janssen Pharmaceutica, N.V., Beerse Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung
JPH0651725B2 (ja) * 1985-02-28 1994-07-06 メルシャン株式会社 部分メチル化シクロデキストリン及びその製造方法
US6407079B1 (en) * 1985-07-03 2002-06-18 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
JPS62123196A (ja) * 1985-11-22 1987-06-04 Nisshin Flour Milling Co Ltd プレドニゾロン包接化合物
JPH0637388B2 (ja) * 1986-02-17 1994-05-18 千寿製薬株式会社 水性液剤
DE3609116A1 (de) * 1986-03-14 1987-09-17 Herbe Wirkstoffe Gmbh Zubereitungen von gewuerzen oder drogen
CA1328078C (en) * 1987-12-22 1994-03-29 Harry Finch Aqueous formulations containing a piperidinylcyclopentylheptenoic acid derivative
ES2037385T3 (es) * 1988-01-14 1993-06-16 Akzo N.V. Un procedimiento de manufactura de una preparacion farmaceutica para administracion local.
GR1000597B (el) * 1988-01-19 1992-08-26 Judah Moses Folkman Παραγοντας αναστολης αναπτυξης και χρηση του.
DE3815902A1 (de) * 1988-05-10 1989-11-23 Schwarz Pharma Gmbh Einschlussverbindungen des 1-(4-(2-(5-chloro-2-methoxybenzamido)ethyl) -phenylsulfonyl)-3-cyclohexylharnstoffs mit (alpha)-,ss-,(gamma)-cyclodextrinen, jeweils diese enthaltendes pharmazeutisches praeparat und verfahren zu deren herstellung
JP2735122B2 (ja) * 1988-06-13 1998-04-02 旭化成工業株式会社 メキタジンの液状シロップ製剤
NL8801670A (nl) 1988-07-01 1990-02-01 Walter Adrianus Josephus Johan Farmaceutisch preparaat.
FR2640137A1 (fr) * 1988-12-08 1990-06-15 Texinfine Sa Systemes transporteurs de principes actifs lipophiles et leur procede d'obtention
US5093127A (en) * 1989-06-02 1992-03-03 Fujisawa Pharmaceutical Co., Ltd. Preparation of fr115224 substrate for parenteral administration
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes
USRE34578E (en) * 1990-05-07 1994-04-05 Lubkin; Virginia Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
DE4207922A1 (de) * 1992-03-13 1993-09-23 Pharmatech Gmbh Wasserloesliche einschlussverbindungen und verfahren zu deren herstellung
DE4227569C1 (de) * 1992-08-20 1994-06-09 Inst Chemo Biosensorik Verfahren zum empfindlichen enzymatischen Nachweis von anorganischem Phosphat
JPH0753396A (ja) * 1993-08-19 1995-02-28 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法および用途
JPH06157330A (ja) * 1992-11-27 1994-06-03 Ensuiko Sugar Refining Co Ltd タキソールのサイクロデキストリン包接物，その製造法と用途
US5684169A (en) * 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
JP2715240B2 (ja) * 1993-05-18 1998-02-18 株式会社第一ラジオアイソトープ研究所 放射性ヨウ素標識脂肪酸−シクロデキストリン複合体およびこれを含有するイメージング剤
DE4338508A1 (de) * 1993-11-11 1995-05-18 Asta Medica Ag Arzneimittelzubereitungen enthaltend Thioctsäure oder Dihydroliponsäure in Form von Einschlußverbindungen mit Cyclodextrinen oder Cyclodextrinderivaten und in Form von Granulaten, Kau- oder Brausetabletten
RU2135176C1 (ru) * 1993-12-14 1999-08-27 Эли Лилли Энд Компани Водорастворенный комплекс включения соединений бензотиофена с водорастворимым циклодекстрином, способ его получения и фармацевтическая композиция
DE4405545A1 (de) * 1994-02-22 1995-08-31 Dietl Hans Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation
JP3934705B2 (ja) * 1995-05-26 2007-06-20 ノバルティス ファーマ株式会社 サイクロデキストリン組成物
JP2006328090A (ja) * 1995-05-26 2006-12-07 Nobaruteisu Fuaama Kk サイクロデキストリン組成物
ES2243994T5 (es) 1996-04-19 2009-10-29 Grifols Inc. Procedimiento para la inactivacion virica de proteinas de la sangre liofilizadas.
KR19980033113A (ko) * 1996-10-25 1998-07-25 야스다케 히지 국소 마취제 수용액, 국소 마취제의 용해도를 개선시키는 방법, 신경독성이 감소된 국소 마취제 및 국소 마취제의 신경 독성을 감소시키는 방법
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
US7074824B2 (en) 2001-07-31 2006-07-11 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
US6962944B2 (en) 2001-07-31 2005-11-08 Arqule, Inc. Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same
DE10200657B4 (de) * 2002-01-10 2010-12-09 Wacker Chemie Ag 2:1-Komplex aus β- oder γ-Cyclodextrin und α-Tocopherol
FR2835434B1 (fr) * 2002-02-01 2006-03-03 Lvmh Rech Utilisation cosmetique ou dermatologique de la vitamine a ou de ses esters, en association avec une beta-cyclodextrine partiellement methylee
MXPA05010330A (es) 2003-03-28 2006-05-31 Ivax Corp Formulaciones de cladribina para el mejor suministro oral y a traves de la mucosa.
SG175450A1 (en) 2003-03-28 2011-11-28 Ares Trading Sa Oral formulations of cladribine
UA81305C2 (en) 2003-07-02 2007-12-25 Ares Trading Sa Formulation of cladribine (variants), cladribine-cyclodextrin complex, use of cladribine-cyclodextrin complex, mixture
US6960300B2 (en) * 2003-09-08 2005-11-01 Sami Labs Limited Process for preparing water soluble diterpenes and their applications
DE102005017775A1 (de) * 2005-04-13 2006-10-19 Schering Ag Komplexe aus Vitamin D-Verbindungen oder deren Analoga mit einem 5Z,7E,10(19)-Trien-System und methlierten Derivaten des ß-Cyclodextrins
US9382490B2 (en) 2012-12-27 2016-07-05 Shell Oil Company Compositions
EP2938710A1 (en) 2012-12-27 2015-11-04 Shell Internationale Research Maatschappij B.V. Compositions
ES2860526T3 (es) 2013-07-19 2021-10-05 Boehringer Ingelheim Vetmedica Gmbh Derivados de ciclodextrina eterificada conservados que contienen una composición farmacéutica acuosa líquida

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5835968B2 (ja) * 1974-02-25 1983-08-05 帝人株式会社 サイクロデキストリン包接化合物の製造法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187653A3 (en) * 1985-01-10 1987-08-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Pharmaceutical compositions replacing the bile and aidinpharmaceutical compositions replacing the bile and aiding the digestion of fats, and process for their preparatig the digestion of fats, and process for their preparation on

Also Published As

Publication number Publication date
JPS574914A (en) 1982-01-11
FR2484252B1 (cs) 1984-06-29
HU181703B (en) 1983-11-28
BE888736A (fr) 1981-08-28
FR2484252A1 (fr) 1981-12-18
DE3118218A1 (de) 1982-04-22
ATA204781A (de) 1983-10-15
CH661517A5 (de) 1987-07-31

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Legal Events

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ELJ Ceased due to non-payment of the annual fee