AT298374B

AT298374B - Verfahren zur Abtrennung eines nicht unterhalb 200°C siedenden Fermentationsproduktes

Verfahren zur Abtrennung eines nicht unterhalb 200°C siedenden Fermentationsproduktes

Info

Publication number: AT298374B
Authority: AT; Austria
Prior art keywords: solvent; water; product; fermentation; liquid
Prior art date: 1969-11-03

Application number

AT988070A

Other languages

German (de)

English (en)

Original Assignee

Lilly Co Eli

Priority date

1969-11-03

Filing date

1970-11-03

Publication date

1972-05-10

1970-11-03 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1972-05-10 Application granted granted Critical

1972-05-10 Publication of AT298374B publication Critical patent/AT298374B/de

Links

238000000855 fermentation Methods 0.000 title claims description 47
230000004151 fermentation Effects 0.000 title claims description 47
238000000034 method Methods 0.000 title claims description 27
238000000926 separation method Methods 0.000 title description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
239000007788 liquid Substances 0.000 claims description 31
239000003960 organic solvent Substances 0.000 claims description 17
238000004821 distillation Methods 0.000 claims description 16
238000010533 azeotropic distillation Methods 0.000 claims description 10
239000007791 liquid phase Substances 0.000 claims description 7
239000000047 product Substances 0.000 description 55
239000002904 solvent Substances 0.000 description 40
ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 28
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 18
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
239000000203 mixture Substances 0.000 description 15
239000000243 solution Substances 0.000 description 15
229930191564 Monensin Natural products 0.000 description 14
GAOZTHIDHYLHMS-UHFFFAOYSA-N Monensin A Natural products O1C(CC)(C2C(CC(O2)C2C(CC(C)C(O)(CO)O2)C)C)CCC1C(O1)(C)CCC21CC(O)C(C)C(C(C)C(OC)C(C)C(O)=O)O2 GAOZTHIDHYLHMS-UHFFFAOYSA-N 0.000 description 14
230000000694 effects Effects 0.000 description 14
229960005358 monensin Drugs 0.000 description 14
GAOZTHIDHYLHMS-KEOBGNEYSA-N monensin A Chemical compound C([C@@](O1)(C)[C@H]2CC[C@@](O2)(CC)[C@H]2[C@H](C[C@@H](O2)[C@@H]2[C@H](C[C@@H](C)[C@](O)(CO)O2)C)C)C[C@@]21C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O2 GAOZTHIDHYLHMS-KEOBGNEYSA-N 0.000 description 14
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
239000007787 solid Substances 0.000 description 12
239000012071 phase Substances 0.000 description 10
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 10
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HOKIDJSKDBPKTQ-GLXFQSAKSA-M cephalosporin C(1-) Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H]([NH3+])C([O-])=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-M 0.000 description 7
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ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 4
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