AR227636A1 - Procedimiento para producir acido treo-3-amino-2-hidroxibutanoil aminoacetico intermediarios para prepararlo y procedimiento para preparar los intermediarios - Google Patents
Procedimiento para producir acido treo-3-amino-2-hidroxibutanoil aminoacetico intermediarios para prepararlo y procedimiento para preparar los intermediariosInfo
- Publication number
- AR227636A1 AR227636A1 AR278992A AR27899279A AR227636A1 AR 227636 A1 AR227636 A1 AR 227636A1 AR 278992 A AR278992 A AR 278992A AR 27899279 A AR27899279 A AR 27899279A AR 227636 A1 AR227636 A1 AR 227636A1
- Authority
- AR
- Argentina
- Prior art keywords
- intermediaries
- prepare
- procedure
- hydroxibutanoyl
- treo
- Prior art date
Links
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title 2
- 229960002449 glycine Drugs 0.000 title 1
- 235000013905 glycine and its sodium salt Nutrition 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/48—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14550978A JPS5572151A (en) | 1978-11-25 | 1978-11-25 | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation |
| JP15315778A JPS5579353A (en) | 1978-12-13 | 1978-12-13 | Preparation of (2s,3r)-3-amino-2-hydroxy-4- phenylbutanoylaminoacetic acid and its intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR227636A1 true AR227636A1 (es) | 1982-11-30 |
Family
ID=26476602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR278992A AR227636A1 (es) | 1978-11-25 | 1979-11-22 | Procedimiento para producir acido treo-3-amino-2-hidroxibutanoil aminoacetico intermediarios para prepararlo y procedimiento para preparar los intermediarios |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US4281180A (es) |
| AR (1) | AR227636A1 (es) |
| AU (1) | AU530362B2 (es) |
| CA (3) | CA1182125A (es) |
| CH (3) | CH650265A5 (es) |
| DE (2) | DE2954076C2 (es) |
| DK (1) | DK162288C (es) |
| ES (1) | ES486572A1 (es) |
| FR (3) | FR2442227A1 (es) |
| GB (2) | GB2090595B (es) |
| IT (2) | IT1194593B (es) |
| NL (2) | NL188162C (es) |
| SE (3) | SE452888B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4370318A (en) * | 1980-07-07 | 1983-01-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin-related compounds as immunopotentiator |
| JPS5767516A (en) * | 1980-09-24 | 1982-04-24 | Microbial Chem Res Found | Novel analgesic agent |
| DE3276110D1 (en) * | 1981-03-04 | 1987-05-27 | Ici Plc | Amide derivatives, processes for preparing them, their use as fungicides and pesticidal compositions containing them |
| JPS58110553A (ja) * | 1981-12-24 | 1983-07-01 | Microbial Chem Res Found | ベスタチンのγ型結晶及びその製造法 |
| JPS606647A (ja) * | 1983-06-17 | 1985-01-14 | Microbial Chem Res Found | アルフアメニン及びその関連化合物と合成法 |
| JPS62205095A (ja) * | 1986-03-04 | 1987-09-09 | Toyo Jozo Co Ltd | 新生理活性物質アルドスタチンおよびその製造法 |
| US4681972A (en) * | 1986-09-16 | 1987-07-21 | Warner-Lambert Company | Separation of diastereomers |
| US4871870A (en) * | 1987-03-16 | 1989-10-03 | Biomeasure, Inc. | Immunomodulators and method of making same |
| IT1216104B (it) * | 1988-03-16 | 1990-02-22 | Zambon Spa | Peptidi ad attivita' farmaceutica. |
| IT1217567B (it) * | 1988-05-11 | 1990-03-30 | Zambon Spa | Processo diastereoselettivo per la preparazione di intermedi utili per la sintesi di derivati peptidici |
| JPH0759507B2 (ja) * | 1989-02-23 | 1995-06-28 | 日本化薬株式会社 | 骨髄異形成症候群治療剤 |
| NL9101380A (nl) * | 1991-08-13 | 1993-03-01 | Dsm Nv | Werkwijze voor de bereiding van een alfa-aminozuur, de overeenkomstige ester en amide. |
| US5455353A (en) * | 1993-03-24 | 1995-10-03 | Hoffmann-La Roche Inc. | 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides |
| US5656603A (en) * | 1995-05-31 | 1997-08-12 | Loyola University Of Chicago | Aminopeptidase P inhibitors and uses thereof |
| CA2312385A1 (en) * | 1999-06-22 | 2000-12-22 | Daiso Co., Ltd. | Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives |
| JP2005029470A (ja) * | 2001-06-21 | 2005-02-03 | Japan Energy Electronic Materials Inc | 新規ノルスタチン誘導体 |
| NZ596304A (en) * | 2009-05-28 | 2014-01-31 | Novartis Ag | Substituted aminopropionic derivatives as neprilysin inhibitors |
| EP2435402B1 (en) | 2009-05-28 | 2016-04-13 | Novartis AG | Substituted aminobutyric derivatives as neprilysin inhibitors |
| JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
| CN101891647B (zh) * | 2010-03-15 | 2012-12-19 | 浙江普洛康裕制药有限公司 | 一种乌苯美司的制备方法 |
| CA2817368C (en) * | 2010-12-15 | 2019-12-31 | Theravance, Inc. | Neprilysin inhibitors |
| CN102391145B (zh) * | 2011-08-31 | 2014-07-02 | 深圳万乐药业有限公司 | 一种乌苯美司中间体的光学异构体的拆分方法 |
| EP2956445A1 (en) | 2013-02-14 | 2015-12-23 | Novartis AG | Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy |
| LT2956464T (lt) | 2013-02-14 | 2018-07-10 | Novartis Ag | Pakeisti bisfenilbutanoinės fosfonrūgšties dariniai, kaip nep (neutralios endopeptidazės) inhibitoriai |
| CN103360277A (zh) * | 2013-04-01 | 2013-10-23 | 上海信谊万象药业股份有限公司 | 一种乌苯美司重结晶的方法 |
| CN103333089A (zh) * | 2013-06-20 | 2013-10-02 | 深圳万乐药业有限公司 | N-[(2s,3r)-4-苯基-3-苄基-3-苄氧甲酰氨基-2-羟基丁酰]-l-亮氨酸苄酯的晶型及其制备方法 |
| CN106117075B (zh) * | 2016-01-14 | 2020-06-12 | 上海信谊万象药业股份有限公司 | 一种新型乌苯美司重结晶方法 |
| US20190256454A1 (en) * | 2016-07-05 | 2019-08-22 | Novartis Ag | New process for early sacubitril intermediates |
| CN106631880B (zh) * | 2016-08-01 | 2018-06-01 | 四川青木制药有限公司 | 一种乌苯美司δ晶型及其制备方法 |
| CN106831473B (zh) * | 2017-02-22 | 2019-07-16 | 江西瑞雅药业有限公司 | 3-酰胺基-4-(2’-烷氧基-4-联苯基)丁酸衍生物及其制备方法、药物组合物 |
| CA3221177A1 (en) | 2021-11-01 | 2023-05-04 | Meghan Kerrisk Campbell | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
| CN115784918A (zh) * | 2022-11-24 | 2023-03-14 | 四川青木制药有限公司 | 一种高纯度乌苯美司中间体的制备方法 |
| CN115594606A (zh) * | 2022-12-16 | 2023-01-13 | 成都傲科新技术有限责任公司（Cn） | 苏式-2-羟基-3-乙酰氨基-4-苯基羰基丁酸不对称合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2242086A1 (en) * | 1973-09-03 | 1975-03-28 | Aries Robert | Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli |
| US4052449A (en) * | 1974-07-01 | 1977-10-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Biologically active substance, bestatin, and production thereof |
| US4179573A (en) * | 1974-07-01 | 1979-12-18 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid |
| US4029547A (en) * | 1974-07-01 | 1977-06-14 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Biologically active substance, bestatin, and production thereof |
| US4189604A (en) * | 1975-07-22 | 1980-02-19 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Bestatin |
| GB1510477A (en) * | 1975-07-22 | 1978-05-10 | Microbial Chem Res Found | Peptides and to amino acid intermediates thereof |
| FR2351952A1 (fr) * | 1975-09-12 | 1977-12-16 | Nobel Hoechst Chimie | Procede de fabrication de derives n-acyles de glycines a substituees par des radicaux aromatiques |
| CH614928A5 (es) * | 1975-09-12 | 1979-12-28 | Nobel Hoechst Chimie | |
| JPS609487B2 (ja) * | 1976-03-26 | 1985-03-11 | 財団法人微生物化学研究会 | 免疫制癌剤 |
| US4105789A (en) * | 1976-05-10 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Carboxyalkylacylamino acids |
| GB1540019A (en) * | 1977-06-01 | 1979-02-07 | Microbial Chem Res Found | Bestatin derivatives |
| FR2393788A2 (fr) * | 1977-06-10 | 1979-01-05 | Microbial Chem Res Found | Derives de bestatine |
| JPS6026099B2 (ja) * | 1977-09-21 | 1985-06-21 | 財団法人微生物化学研究会 | ペプチド、その酸附加塩およびその製造法 |
| US4243678A (en) * | 1977-12-30 | 1981-01-06 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Acylhydrocarbylaminoalkanoic acids, compositions and uses |
-
1979
- 1979-11-22 DK DK496379A patent/DK162288C/da active
- 1979-11-22 CA CA000340428A patent/CA1182125A/en not_active Expired
- 1979-11-22 AR AR278992A patent/AR227636A1/es active
- 1979-11-22 IT IT27487/79A patent/IT1194593B/it active
- 1979-11-22 DE DE2954076A patent/DE2954076C2/de not_active Expired
- 1979-11-22 FR FR7928830A patent/FR2442227A1/fr active Granted
- 1979-11-22 DE DE19792947140 patent/DE2947140A1/de active Granted
- 1979-11-22 CH CH10433/79A patent/CH650265A5/de not_active IP Right Cessation
- 1979-11-22 GB GB8200496A patent/GB2090595B/en not_active Expired
- 1979-11-22 AU AU53115/79A patent/AU530362B2/en not_active Ceased
- 1979-11-22 CH CH5649/81A patent/CH653687A5/de not_active IP Right Cessation
- 1979-11-22 ES ES486572A patent/ES486572A1/es not_active Expired
- 1979-11-22 SE SE7909655A patent/SE452888B/sv not_active IP Right Cessation
- 1979-11-22 GB GB7940413A patent/GB2037754B/en not_active Expired
- 1979-11-22 NL NLAANVRAGE7908510,A patent/NL188162C/xx not_active IP Right Cessation
- 1979-11-22 CH CH6192/83A patent/CH653669A5/de not_active IP Right Cessation
- 1979-11-23 US US06/096,693 patent/US4281180A/en not_active Expired - Lifetime
-
1980
- 1980-05-12 FR FR8010563A patent/FR2449078A1/fr active Granted
- 1980-11-28 US US06/211,035 patent/US4391986A/en not_active Expired - Lifetime
-
1981
- 1981-07-10 FR FR8113611A patent/FR2483409B1/fr not_active Expired
- 1981-10-06 NL NL8104545A patent/NL8104545A/nl not_active Application Discontinuation
- 1981-10-14 SE SE8106084A patent/SE453748B/sv not_active IP Right Cessation
- 1981-12-15 IT IT8125614A patent/IT1211147B/it active
- 1981-12-31 US US06/336,492 patent/US4453003A/en not_active Expired - Lifetime
-
1982
- 1982-06-14 CA CA000405157A patent/CA1170667A/en not_active Expired
- 1982-08-24 CA CA000410051A patent/CA1167464A/en not_active Expired
-
1984
- 1984-07-31 SE SE8403931A patent/SE466200B/sv not_active IP Right Cessation
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