FR2242086A1 - Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli - Google Patents

Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli

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Publication number
FR2242086A1
FR2242086A1 FR7331680A FR7331680A FR2242086A1 FR 2242086 A1 FR2242086 A1 FR 2242086A1 FR 7331680 A FR7331680 A FR 7331680A FR 7331680 A FR7331680 A FR 7331680A FR 2242086 A1 FR2242086 A1 FR 2242086A1
Authority
FR
France
Prior art keywords
active against
bacilli
antiviral
antibacterial
positive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7331680A
Other languages
French (fr)
Other versions
FR2242086B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to FR7331680A priority Critical patent/FR2242086A1/en
Publication of FR2242086A1 publication Critical patent/FR2242086A1/en
Application granted granted Critical
Publication of FR2242086B1 publication Critical patent/FR2242086B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula (I) and their mineral and organic salts are nw (where R is NO2, methylsulphonyl, methylmercapto or acetyl). (I) have antibacterial and antiviral props. and are water-soluble. (I) have broad spectrum activity, and are active against Gram-positive and -negative cocci and bacilli, including pneumococci and meningococci (very active) and hemolytic streptococci (moderately active). They are also active against Miyagawanella spp., including tradroma virus, M. lymphogranulomatosis, M. ornithosis and M. psittaci. Absorption is rapid for oral doses (800 mg/day), max. serum levels being attained within 2-4 hrs. (3-8 mu g/ml,) with a plasma half life of ca 13 hrs. Tissue levels (lung, kidney) are higher (up to x100) than serum levels; levels in spinal fluid are ca 50% of serum levels. Excretion in the urine is slow, 40-50% of the dose being excreted in the urine over 1 week.
FR7331680A 1973-09-03 1973-09-03 Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli Granted FR2242086A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7331680A FR2242086A1 (en) 1973-09-03 1973-09-03 Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7331680A FR2242086A1 (en) 1973-09-03 1973-09-03 Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli

Publications (2)

Publication Number Publication Date
FR2242086A1 true FR2242086A1 (en) 1975-03-28
FR2242086B1 FR2242086B1 (en) 1977-01-28

Family

ID=9124540

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7331680A Granted FR2242086A1 (en) 1973-09-03 1973-09-03 Antibacterial, antiviral dihydroxy butyric acid derivs - active against Gram-positive and -negative cocci and bacilli

Country Status (1)

Country Link
FR (1) FR2242086A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2449078A1 (en) * 1978-11-25 1980-09-12 Nippon Kayaku Kk PROCESS FOR THE PRODUCTION OF PROTECTED THREO-3-AMINO ACID 2-HYDROXY-4-OXOBUTANOIC OR ITS ESTERS AND APPLICATION TO THE PRODUCTION OF THREO-3-AMINO-2-HYDROXYBUTANOIC ACID

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2449078A1 (en) * 1978-11-25 1980-09-12 Nippon Kayaku Kk PROCESS FOR THE PRODUCTION OF PROTECTED THREO-3-AMINO ACID 2-HYDROXY-4-OXOBUTANOIC OR ITS ESTERS AND APPLICATION TO THE PRODUCTION OF THREO-3-AMINO-2-HYDROXYBUTANOIC ACID
US4281180A (en) * 1978-11-25 1981-07-28 Nippon Kayaku Kabushiki Kaisha Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them

Also Published As

Publication number Publication date
FR2242086B1 (en) 1977-01-28

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