AR112040A1 - Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen - Google Patents

Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen

Info

Publication number
AR112040A1
AR112040A1 ARP180101781A ARP180101781A AR112040A1 AR 112040 A1 AR112040 A1 AR 112040A1 AR P180101781 A ARP180101781 A AR P180101781A AR P180101781 A ARP180101781 A AR P180101781A AR 112040 A1 AR112040 A1 AR 112040A1
Authority
AR
Argentina
Prior art keywords
diethylphenyl
quinazoline
piperidin
carboxamide
dimethylamino
Prior art date
Application number
ARP180101781A
Other languages
English (en)
Spanish (es)
Inventor
Germano Darasmo
Matteo Danello
Ilaria Candiani
Marina Caldarelli
Massimo Zampieri
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR112040A1 publication Critical patent/AR112040A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/42Phosphorus; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP180101781A 2017-06-29 2018-06-28 Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen AR112040A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17305826 2017-06-29

Publications (1)

Publication Number Publication Date
AR112040A1 true AR112040A1 (es) 2019-09-11

Family

ID=59313166

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101781A AR112040A1 (es) 2017-06-29 2018-06-28 Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen

Country Status (18)

Country Link
US (3) US11160806B2 (enExample)
EP (1) EP3645535B1 (enExample)
JP (1) JP7141416B2 (enExample)
KR (1) KR102609333B1 (enExample)
CN (1) CN110896636B (enExample)
AR (1) AR112040A1 (enExample)
AU (1) AU2018293729B9 (enExample)
CA (1) CA3068357C (enExample)
CL (1) CL2019003848A1 (enExample)
EA (1) EA039764B1 (enExample)
ES (1) ES2900048T3 (enExample)
IL (1) IL271628B2 (enExample)
MA (1) MA49498A (enExample)
PL (1) PL3645535T3 (enExample)
SG (1) SG11201912651WA (enExample)
TW (1) TWI750393B (enExample)
UY (1) UY37778A (enExample)
WO (1) WO2019002454A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025002962A1 (en) 2023-06-30 2025-01-02 Nerviano Medical Sciences S.R.L. Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma
WO2025021587A1 (en) 2023-07-21 2025-01-30 Nerviano Medical Sciences S.R.L. Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2303891B1 (en) * 2008-06-26 2016-02-17 Les Laboratoires Servier Pyrazolo-quinazolines as protein kinase activity modulators

Also Published As

Publication number Publication date
TW201904971A (zh) 2019-02-01
CL2019003848A1 (es) 2020-07-10
CA3068357C (en) 2022-04-19
US11160806B2 (en) 2021-11-02
UY37778A (es) 2019-01-31
AU2018293729A1 (en) 2020-01-23
CA3068357A1 (en) 2019-01-03
US20220016122A1 (en) 2022-01-20
US20240350501A1 (en) 2024-10-24
PL3645535T3 (pl) 2022-03-21
BR112019027924A2 (pt) 2020-08-18
TWI750393B (zh) 2021-12-21
IL271628A (en) 2020-02-27
IL271628B2 (en) 2023-07-01
EP3645535A1 (en) 2020-05-06
KR102609333B1 (ko) 2023-12-01
JP2020525477A (ja) 2020-08-27
MA49498A (fr) 2021-05-26
EP3645535B1 (en) 2021-09-08
EA039764B1 (ru) 2022-03-11
IL271628B1 (en) 2023-03-01
CN110896636B (zh) 2022-07-19
AU2018293729B2 (en) 2022-03-10
AU2018293729B9 (en) 2022-07-14
US20200246339A1 (en) 2020-08-06
SG11201912651WA (en) 2020-01-30
JP7141416B2 (ja) 2022-09-22
KR20200020905A (ko) 2020-02-26
WO2019002454A1 (en) 2019-01-03
EA202090115A1 (ru) 2020-05-25
CN110896636A (zh) 2020-03-20
ES2900048T3 (es) 2022-03-15

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