UY37778A - NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN - Google Patents

NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN

Info

Publication number
UY37778A
UY37778A UY0001037778A UY37778A UY37778A UY 37778 A UY37778 A UY 37778A UY 0001037778 A UY0001037778 A UY 0001037778A UY 37778 A UY37778 A UY 37778A UY 37778 A UY37778 A UY 37778A
Authority
UY
Uruguay
Prior art keywords
piperidin
carboxamide
amino
dietilfenil
quinazolina
Prior art date
Application number
UY0001037778A
Other languages
English (en)
Spanish (es)
Inventor
Marina Caldarelli
Ilaria Candiani
Matteo D’ANELLO
Germano D’Arasmo
Massimo Zampieri
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of UY37778A publication Critical patent/UY37778A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/42Phosphorus; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
UY0001037778A 2017-06-29 2018-06-21 NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN UY37778A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17305826 2017-06-29

Publications (1)

Publication Number Publication Date
UY37778A true UY37778A (es) 2019-01-31

Family

ID=59313166

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037778A UY37778A (es) 2017-06-29 2018-06-21 NUEVA SAL DE N-(2,6-DIETILFENIL)-8-({4-[4-(DIMETILAMINO)PIPERIDIN-1-IL]-2- METOXIFENIL}AMINO)-1-METIL-4,5-DIHIDRO- 1H-PIRAZOLO[4,3-h]QUINAZOLINA-3- CARBOXAMIDA, SU PREPARACIÓN, Y LAS FORMULACIONES QUE LA CONTIENEN

Country Status (18)

Country Link
US (3) US11160806B2 (enExample)
EP (1) EP3645535B1 (enExample)
JP (1) JP7141416B2 (enExample)
KR (1) KR102609333B1 (enExample)
CN (1) CN110896636B (enExample)
AR (1) AR112040A1 (enExample)
AU (1) AU2018293729B9 (enExample)
CA (1) CA3068357C (enExample)
CL (1) CL2019003848A1 (enExample)
EA (1) EA039764B1 (enExample)
ES (1) ES2900048T3 (enExample)
IL (1) IL271628B2 (enExample)
MA (1) MA49498A (enExample)
PL (1) PL3645535T3 (enExample)
SG (1) SG11201912651WA (enExample)
TW (1) TWI750393B (enExample)
UY (1) UY37778A (enExample)
WO (1) WO2019002454A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025002962A1 (en) 2023-06-30 2025-01-02 Nerviano Medical Sciences S.R.L. Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma
WO2025021587A1 (en) 2023-07-21 2025-01-30 Nerviano Medical Sciences S.R.L. Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2303891B1 (en) * 2008-06-26 2016-02-17 Les Laboratoires Servier Pyrazolo-quinazolines as protein kinase activity modulators

Also Published As

Publication number Publication date
TW201904971A (zh) 2019-02-01
CL2019003848A1 (es) 2020-07-10
CA3068357C (en) 2022-04-19
US11160806B2 (en) 2021-11-02
AU2018293729A1 (en) 2020-01-23
CA3068357A1 (en) 2019-01-03
US20220016122A1 (en) 2022-01-20
US20240350501A1 (en) 2024-10-24
AR112040A1 (es) 2019-09-11
PL3645535T3 (pl) 2022-03-21
BR112019027924A2 (pt) 2020-08-18
TWI750393B (zh) 2021-12-21
IL271628A (en) 2020-02-27
IL271628B2 (en) 2023-07-01
EP3645535A1 (en) 2020-05-06
KR102609333B1 (ko) 2023-12-01
JP2020525477A (ja) 2020-08-27
MA49498A (fr) 2021-05-26
EP3645535B1 (en) 2021-09-08
EA039764B1 (ru) 2022-03-11
IL271628B1 (en) 2023-03-01
CN110896636B (zh) 2022-07-19
AU2018293729B2 (en) 2022-03-10
AU2018293729B9 (en) 2022-07-14
US20200246339A1 (en) 2020-08-06
SG11201912651WA (en) 2020-01-30
JP7141416B2 (ja) 2022-09-22
KR20200020905A (ko) 2020-02-26
WO2019002454A1 (en) 2019-01-03
EA202090115A1 (ru) 2020-05-25
CN110896636A (zh) 2020-03-20
ES2900048T3 (es) 2022-03-15

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Effective date: 20250612