IL271628B2 - A new salt of n-(6,2-diethylphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}amino)-1-methyl-5,4-dihydro-1h -pyrazolo[3,4-h]quinazoline-3-carboxamide, its preparation and formulations containing it - Google Patents
A new salt of n-(6,2-diethylphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}amino)-1-methyl-5,4-dihydro-1h -pyrazolo[3,4-h]quinazoline-3-carboxamide, its preparation and formulations containing itInfo
- Publication number
- IL271628B2 IL271628B2 IL271628A IL27162819A IL271628B2 IL 271628 B2 IL271628 B2 IL 271628B2 IL 271628 A IL271628 A IL 271628A IL 27162819 A IL27162819 A IL 27162819A IL 271628 B2 IL271628 B2 IL 271628B2
- Authority
- IL
- Israel
- Prior art keywords
- tumors
- lymphoma
- compound
- methyl
- diethylphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305826 | 2017-06-29 | ||
| PCT/EP2018/067394 WO2019002454A1 (en) | 2017-06-29 | 2018-06-28 | NOVEL N- (2,6-DIETHYLPHENYL) -8 - ({4- [4- (DIMETHYLAMINO) PIPERIDIN-1-YL] -2-METHOXYPHENYL} AMINO) -1-METHYL-4,5-DIHYDRO-1H SALT -PYRAZOLO [4,3-H] QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING THE SAME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL271628A IL271628A (en) | 2020-02-27 |
| IL271628B1 IL271628B1 (en) | 2023-03-01 |
| IL271628B2 true IL271628B2 (en) | 2023-07-01 |
Family
ID=59313166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL271628A IL271628B2 (en) | 2017-06-29 | 2019-12-22 | A new salt of n-(6,2-diethylphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}amino)-1-methyl-5,4-dihydro-1h -pyrazolo[3,4-h]quinazoline-3-carboxamide, its preparation and formulations containing it |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US11160806B2 (enExample) |
| EP (1) | EP3645535B1 (enExample) |
| JP (1) | JP7141416B2 (enExample) |
| KR (1) | KR102609333B1 (enExample) |
| CN (1) | CN110896636B (enExample) |
| AR (1) | AR112040A1 (enExample) |
| AU (1) | AU2018293729B9 (enExample) |
| CA (1) | CA3068357C (enExample) |
| CL (1) | CL2019003848A1 (enExample) |
| EA (1) | EA039764B1 (enExample) |
| ES (1) | ES2900048T3 (enExample) |
| IL (1) | IL271628B2 (enExample) |
| MA (1) | MA49498A (enExample) |
| PL (1) | PL3645535T3 (enExample) |
| PY (1) | PY1850855A (enExample) |
| SG (1) | SG11201912651WA (enExample) |
| TW (1) | TWI750393B (enExample) |
| UY (1) | UY37778A (enExample) |
| WO (1) | WO2019002454A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025002962A1 (en) | 2023-06-30 | 2025-01-02 | Nerviano Medical Sciences S.R.L. | Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma |
| WO2025021587A1 (en) | 2023-07-21 | 2025-01-30 | Nerviano Medical Sciences S.R.L. | Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156315A1 (en) * | 2008-06-26 | 2009-12-30 | Nerviano Medical Sciences S.R.L. | Pyrazolo-quinazolines |
-
2018
- 2018-06-21 UY UY0001037778A patent/UY37778A/es not_active Application Discontinuation
- 2018-06-28 JP JP2019572116A patent/JP7141416B2/ja active Active
- 2018-06-28 ES ES18732820T patent/ES2900048T3/es active Active
- 2018-06-28 WO PCT/EP2018/067394 patent/WO2019002454A1/en not_active Ceased
- 2018-06-28 CA CA3068357A patent/CA3068357C/en active Active
- 2018-06-28 EP EP18732820.8A patent/EP3645535B1/en active Active
- 2018-06-28 AU AU2018293729A patent/AU2018293729B9/en active Active
- 2018-06-28 EA EA202090115A patent/EA039764B1/ru unknown
- 2018-06-28 TW TW107122235A patent/TWI750393B/zh active
- 2018-06-28 CN CN201880043442.0A patent/CN110896636B/zh active Active
- 2018-06-28 SG SG11201912651WA patent/SG11201912651WA/en unknown
- 2018-06-28 AR ARP180101781A patent/AR112040A1/es unknown
- 2018-06-28 PL PL18732820T patent/PL3645535T3/pl unknown
- 2018-06-28 PY PY201801850855A patent/PY1850855A/es unknown
- 2018-06-28 MA MA049498A patent/MA49498A/fr unknown
- 2018-06-28 US US16/624,488 patent/US11160806B2/en active Active
- 2018-06-28 KR KR1020207002339A patent/KR102609333B1/ko active Active
-
2019
- 2019-12-22 IL IL271628A patent/IL271628B2/en unknown
- 2019-12-26 CL CL2019003848A patent/CL2019003848A1/es unknown
-
2021
- 2021-09-30 US US17/490,318 patent/US20220016122A1/en not_active Abandoned
-
2024
- 2024-07-01 US US18/760,494 patent/US20240350501A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009156315A1 (en) * | 2008-06-26 | 2009-12-30 | Nerviano Medical Sciences S.R.L. | Pyrazolo-quinazolines |
Non-Patent Citations (2)
| Title |
|---|
| BOWKER, MICHAEL J., AND P. HEINRICH STAHL., PREPARATION OF WATER-SOLUBLE COMPOUNDS THROUGH SALT FORMATION., 31 January 2008 (2008-01-31) * |
| SAAL, C., AND A. BECKER., PHARMACEUTICAL SALTS: A SUMMARY ON DOSES OF SALT FORMERS FROM THE ORANGE BOOK., 16 July 2013 (2013-07-16) * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2900048T3 (es) | 2022-03-15 |
| MA49498A (fr) | 2021-05-26 |
| US11160806B2 (en) | 2021-11-02 |
| KR20200020905A (ko) | 2020-02-26 |
| IL271628B1 (en) | 2023-03-01 |
| AU2018293729B9 (en) | 2022-07-14 |
| UY37778A (es) | 2019-01-31 |
| US20220016122A1 (en) | 2022-01-20 |
| CN110896636A (zh) | 2020-03-20 |
| SG11201912651WA (en) | 2020-01-30 |
| EA202090115A1 (ru) | 2020-05-25 |
| KR102609333B1 (ko) | 2023-12-01 |
| EP3645535B1 (en) | 2021-09-08 |
| PY1850855A (es) | 2019-04-01 |
| TW201904971A (zh) | 2019-02-01 |
| US20240350501A1 (en) | 2024-10-24 |
| JP2020525477A (ja) | 2020-08-27 |
| CN110896636B (zh) | 2022-07-19 |
| EA039764B1 (ru) | 2022-03-11 |
| CL2019003848A1 (es) | 2020-07-10 |
| US20200246339A1 (en) | 2020-08-06 |
| EP3645535A1 (en) | 2020-05-06 |
| AU2018293729B2 (en) | 2022-03-10 |
| CA3068357A1 (en) | 2019-01-03 |
| WO2019002454A1 (en) | 2019-01-03 |
| PL3645535T3 (pl) | 2022-03-21 |
| TWI750393B (zh) | 2021-12-21 |
| AR112040A1 (es) | 2019-09-11 |
| CA3068357C (en) | 2022-04-19 |
| JP7141416B2 (ja) | 2022-09-22 |
| AU2018293729A1 (en) | 2020-01-23 |
| BR112019027924A2 (pt) | 2020-08-18 |
| IL271628A (en) | 2020-02-27 |
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