AR112040A1 - Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen - Google Patents

Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen

Info

Publication number
AR112040A1
AR112040A1 ARP180101781A ARP180101781A AR112040A1 AR 112040 A1 AR112040 A1 AR 112040A1 AR P180101781 A ARP180101781 A AR P180101781A AR P180101781 A ARP180101781 A AR P180101781A AR 112040 A1 AR112040 A1 AR 112040A1
Authority
AR
Argentina
Prior art keywords
diethylphenyl
quinazoline
piperidin
carboxamide
dimethylamino
Prior art date
Application number
ARP180101781A
Other languages
English (en)
Inventor
Germano Darasmo
Matteo Danello
Ilaria Candiani
Marina Caldarelli
Massimo Zampieri
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of AR112040A1 publication Critical patent/AR112040A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Fosfato de N-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1H-pirazolo[4,3-h]quinazolina-3-carboxamida de fórmula (1).
ARP180101781A 2017-06-29 2018-06-28 Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen AR112040A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17305826 2017-06-29

Publications (1)

Publication Number Publication Date
AR112040A1 true AR112040A1 (es) 2019-09-11

Family

ID=59313166

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101781A AR112040A1 (es) 2017-06-29 2018-06-28 Sal de n-(2,6-dietilfenil)-8-({4-[4-(dimetilamino)piperidin-1-il]-2-metoxifenil}amino)-1-metil-4,5-dihidro-1h-pirazolo[4,3-h]quinazolina-3-carboxamida, su preparación, y las formulaciones que la contienen

Country Status (19)

Country Link
US (2) US11160806B2 (es)
EP (1) EP3645535B1 (es)
JP (1) JP7141416B2 (es)
KR (1) KR102609333B1 (es)
CN (1) CN110896636B (es)
AR (1) AR112040A1 (es)
AU (1) AU2018293729B9 (es)
BR (1) BR112019027924A2 (es)
CA (1) CA3068357C (es)
CL (1) CL2019003848A1 (es)
EA (1) EA039764B1 (es)
ES (1) ES2900048T3 (es)
IL (1) IL271628B2 (es)
MA (1) MA49498A (es)
PL (1) PL3645535T3 (es)
SG (1) SG11201912651WA (es)
TW (1) TWI750393B (es)
UY (1) UY37778A (es)
WO (1) WO2019002454A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102076689B (zh) 2008-06-26 2014-10-15 内尔维阿诺医学科学有限公司 吡唑并-喹唑啉类

Also Published As

Publication number Publication date
UY37778A (es) 2019-01-31
PL3645535T3 (pl) 2022-03-21
CN110896636B (zh) 2022-07-19
US20220016122A1 (en) 2022-01-20
TWI750393B (zh) 2021-12-21
SG11201912651WA (en) 2020-01-30
MA49498A (fr) 2021-05-26
CL2019003848A1 (es) 2020-07-10
CN110896636A (zh) 2020-03-20
EP3645535A1 (en) 2020-05-06
US11160806B2 (en) 2021-11-02
AU2018293729B2 (en) 2022-03-10
CA3068357A1 (en) 2019-01-03
WO2019002454A1 (en) 2019-01-03
ES2900048T3 (es) 2022-03-15
JP7141416B2 (ja) 2022-09-22
KR102609333B1 (ko) 2023-12-01
EA202090115A1 (ru) 2020-05-25
IL271628A (en) 2020-02-27
EP3645535B1 (en) 2021-09-08
US20200246339A1 (en) 2020-08-06
JP2020525477A (ja) 2020-08-27
KR20200020905A (ko) 2020-02-26
EA039764B1 (ru) 2022-03-11
IL271628B1 (en) 2023-03-01
AU2018293729A1 (en) 2020-01-23
BR112019027924A2 (pt) 2020-08-18
IL271628B2 (en) 2023-07-01
CA3068357C (en) 2022-04-19
AU2018293729B9 (en) 2022-07-14
TW201904971A (zh) 2019-02-01

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