PL3645535T3 - Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierające - Google Patents
Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierająceInfo
- Publication number
- PL3645535T3 PL3645535T3 PL18732820T PL18732820T PL3645535T3 PL 3645535 T3 PL3645535 T3 PL 3645535T3 PL 18732820 T PL18732820 T PL 18732820T PL 18732820 T PL18732820 T PL 18732820T PL 3645535 T3 PL3645535 T3 PL 3645535T3
- Authority
- PL
- Poland
- Prior art keywords
- diethylphenyl
- pyrazolo
- quinazoline
- piperidin
- carboxamide
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17305826 | 2017-06-29 | ||
| PCT/EP2018/067394 WO2019002454A1 (en) | 2017-06-29 | 2018-06-28 | NOVEL N- (2,6-DIETHYLPHENYL) -8 - ({4- [4- (DIMETHYLAMINO) PIPERIDIN-1-YL] -2-METHOXYPHENYL} AMINO) -1-METHYL-4,5-DIHYDRO-1H SALT -PYRAZOLO [4,3-H] QUINAZOLINE-3-CARBOXAMIDE, ITS PREPARATION AND FORMULATIONS CONTAINING THE SAME |
| EP18732820.8A EP3645535B1 (en) | 2017-06-29 | 2018-06-28 | New salt of n-(2,6-diethylphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}amino)-1-methyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide, its preparation and formulations containing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3645535T3 true PL3645535T3 (pl) | 2022-03-21 |
Family
ID=59313166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18732820T PL3645535T3 (pl) | 2017-06-29 | 2018-06-28 | Nowa sól N-(2,6-dietylofenylo)-8-({4-[4-(dimetyloamino)piperydyn-1-ylo]-2-metoksyfenylo}amino)-1-metylo-4,5-dihydro-1H-pirazolo[4,3-h]chinazolino-3-karboksyamidu, jej wytwarzanie oraz kompozycje ją zawierające |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11160806B2 (enExample) |
| EP (1) | EP3645535B1 (enExample) |
| JP (1) | JP7141416B2 (enExample) |
| KR (1) | KR102609333B1 (enExample) |
| CN (1) | CN110896636B (enExample) |
| AR (1) | AR112040A1 (enExample) |
| AU (1) | AU2018293729B9 (enExample) |
| CA (1) | CA3068357C (enExample) |
| CL (1) | CL2019003848A1 (enExample) |
| EA (1) | EA039764B1 (enExample) |
| ES (1) | ES2900048T3 (enExample) |
| IL (1) | IL271628B2 (enExample) |
| MA (1) | MA49498A (enExample) |
| PL (1) | PL3645535T3 (enExample) |
| SG (1) | SG11201912651WA (enExample) |
| TW (1) | TWI750393B (enExample) |
| UY (1) | UY37778A (enExample) |
| WO (1) | WO2019002454A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025002962A1 (en) | 2023-06-30 | 2025-01-02 | Nerviano Medical Sciences S.R.L. | Use of a mps1 inhibitor for the treatment of hepatocellular carcinoma |
| WO2025021587A1 (en) | 2023-07-21 | 2025-01-30 | Nerviano Medical Sciences S.R.L. | Combination of a mps1 inhibitor and immune checkpoint inhibitors, uses and pharmaceutical compositions thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2303891B1 (en) * | 2008-06-26 | 2016-02-17 | Les Laboratoires Servier | Pyrazolo-quinazolines as protein kinase activity modulators |
-
2018
- 2018-06-21 UY UY0001037778A patent/UY37778A/es not_active Application Discontinuation
- 2018-06-28 EP EP18732820.8A patent/EP3645535B1/en active Active
- 2018-06-28 CA CA3068357A patent/CA3068357C/en active Active
- 2018-06-28 TW TW107122235A patent/TWI750393B/zh active
- 2018-06-28 KR KR1020207002339A patent/KR102609333B1/ko active Active
- 2018-06-28 ES ES18732820T patent/ES2900048T3/es active Active
- 2018-06-28 JP JP2019572116A patent/JP7141416B2/ja active Active
- 2018-06-28 AU AU2018293729A patent/AU2018293729B9/en active Active
- 2018-06-28 AR ARP180101781A patent/AR112040A1/es unknown
- 2018-06-28 MA MA049498A patent/MA49498A/fr unknown
- 2018-06-28 US US16/624,488 patent/US11160806B2/en active Active
- 2018-06-28 EA EA202090115A patent/EA039764B1/ru unknown
- 2018-06-28 CN CN201880043442.0A patent/CN110896636B/zh active Active
- 2018-06-28 WO PCT/EP2018/067394 patent/WO2019002454A1/en not_active Ceased
- 2018-06-28 PL PL18732820T patent/PL3645535T3/pl unknown
- 2018-06-28 SG SG11201912651WA patent/SG11201912651WA/en unknown
-
2019
- 2019-12-22 IL IL271628A patent/IL271628B2/en unknown
- 2019-12-26 CL CL2019003848A patent/CL2019003848A1/es unknown
-
2021
- 2021-09-30 US US17/490,318 patent/US20220016122A1/en not_active Abandoned
-
2024
- 2024-07-01 US US18/760,494 patent/US20240350501A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW201904971A (zh) | 2019-02-01 |
| CL2019003848A1 (es) | 2020-07-10 |
| CA3068357C (en) | 2022-04-19 |
| US11160806B2 (en) | 2021-11-02 |
| UY37778A (es) | 2019-01-31 |
| AU2018293729A1 (en) | 2020-01-23 |
| CA3068357A1 (en) | 2019-01-03 |
| US20220016122A1 (en) | 2022-01-20 |
| US20240350501A1 (en) | 2024-10-24 |
| AR112040A1 (es) | 2019-09-11 |
| BR112019027924A2 (pt) | 2020-08-18 |
| TWI750393B (zh) | 2021-12-21 |
| IL271628A (en) | 2020-02-27 |
| IL271628B2 (en) | 2023-07-01 |
| EP3645535A1 (en) | 2020-05-06 |
| KR102609333B1 (ko) | 2023-12-01 |
| JP2020525477A (ja) | 2020-08-27 |
| MA49498A (fr) | 2021-05-26 |
| EP3645535B1 (en) | 2021-09-08 |
| EA039764B1 (ru) | 2022-03-11 |
| IL271628B1 (en) | 2023-03-01 |
| CN110896636B (zh) | 2022-07-19 |
| AU2018293729B2 (en) | 2022-03-10 |
| AU2018293729B9 (en) | 2022-07-14 |
| US20200246339A1 (en) | 2020-08-06 |
| SG11201912651WA (en) | 2020-01-30 |
| JP7141416B2 (ja) | 2022-09-22 |
| KR20200020905A (ko) | 2020-02-26 |
| WO2019002454A1 (en) | 2019-01-03 |
| EA202090115A1 (ru) | 2020-05-25 |
| CN110896636A (zh) | 2020-03-20 |
| ES2900048T3 (es) | 2022-03-15 |
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