AR103653A1 - Complejos de acetato de abiraterona, proceso para prepararlos y composiciones farmacéuticas que los contienen - Google Patents
Complejos de acetato de abiraterona, proceso para prepararlos y composiciones farmacéuticas que los contienenInfo
- Publication number
- AR103653A1 AR103653A1 ARP160100363A ARP160100363A AR103653A1 AR 103653 A1 AR103653 A1 AR 103653A1 AR P160100363 A ARP160100363 A AR P160100363A AR P160100363 A ARP160100363 A AR P160100363A AR 103653 A1 AR103653 A1 AR 103653A1
- Authority
- AR
- Argentina
- Prior art keywords
- polyethylene glycol
- copolymers based
- abiraterone acetate
- complex
- pharmaceutically acceptable
- Prior art date
Links
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical class C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 5
- 229920001223 polyethylene glycol Polymers 0.000 abstract 5
- 229960004103 abiraterone acetate Drugs 0.000 abstract 2
- 229920001400 block copolymer Polymers 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 210000002784 stomach Anatomy 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 abstract 1
- 229920002675 Polyoxyl Polymers 0.000 abstract 1
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 abstract 1
- 229920006187 aquazol Polymers 0.000 abstract 1
- 239000012861 aquazol Substances 0.000 abstract 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 abstract 1
- 238000001246 colloidal dispersion Methods 0.000 abstract 1
- 239000008139 complexing agent Substances 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 150000005690 diesters Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 abstract 1
- FYUWIEKAVLOHSE-UHFFFAOYSA-N ethenyl acetate;1-ethenylpyrrolidin-2-one Chemical compound CC(=O)OC=C.C=CN1CCCC1=O FYUWIEKAVLOHSE-UHFFFAOYSA-N 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 229920000578 graft copolymer Polymers 0.000 abstract 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 1
- 229940072106 hydroxystearate Drugs 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 abstract 1
- 238000013149 parallel artificial membrane permeability assay Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 230000008092 positive effect Effects 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- 229940051084 zytiga Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Fórmulas complejas farmacéuticamente aceptables que comprenden complejos de acetato de abiraterona y excipientes farmacéuticamente aceptables, proceso para prepararlas y composiciones farmacéuticas que las contienen. La fórmula compleja de la presente presenta propiedades fisicoquímicas superiores que tienen como consecuencia un menor efecto con los alimentos, por lo cual puede empleársela en una dosis significativamente menor y no es necesario tomarla con el estómago vacío. Reivindicación 1: Un complejo estable caracterizado porque presenta características fisicoquímicas y un rendimiento biológico superiores, que comprende (a) acetato de abiraterona como compuesto activo, o una combinación de compuestos activos que incluye acetato de abiraterona; (b) al menos un agente formador de complejos que se selecciona entre los glicéridos de polietilenglicol que están compuestos por monoglicéridos, diglicéridos o triglicéridos y monoésteres o diésteres de polietilenglicol, la hidroxipropilcelulosa, los poloxámeros, la vinilpirrolidona / el acetato de vinilo, el polietilenglicol, la poli(2-etil-2-oxazolina), la polivinilpirrolidona, los copolímeros de bloques a base de óxido de etileno y óxido de propileno, el poli(ácido maleico / éter de metil vinilo), los copolímeros injertados a base de polivinilcaprolactama-acetato de polivinilo-polietilenglicol, el hidroxiestearato de polioxilo 15, los copolímeros de bloques a base de óxido de etileno / propileno, los copolimeros injertados a base de alcohol polivinílico y polietilenglicol y el succinato de d-a tocoferil polietilenglicol 1000; y (c) de resultar deseable, diversos excipientes farmacéuticamente aceptables; donde el complejo comprende partículas cuyo tamaño es inferior a 600 nm y presenta una o más de las siguientes características: puede ser redispersado de manera instantánea en medios relevantes desde el punto de vista fisiológico; presenta una velocidad de disolución superior; es estable en una forma sólida o en una en solución o una dispersión coloidal; presenta una solubilidad aparente en el agua de al menos 0,6 mg/ml; en un análisis con rayos X, presenta una forma sólida con un carácter amorfo; presente una permeabilidad PAMPA de el menos 0,5 × 10⁻⁶ cm/s cuando se lo dispersa en agua destilada, la cual no se reduce con el tiempo durante un período de al menos 3 meses; no presenta un efecto positivo con los alimentos (se caracteriza por una proporción entre el estado alimentado y el ayuno que es inferior a 1,25), por lo cual es posible administrarlo en una dosis significativamente menor y no es necesario tomarlo con el estómago vacío; la variabilidad de su exposición es significativamente menor que la que puede obtenerse con Zytiga.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1500055A HUP1500055A1 (hu) | 2015-02-09 | 2015-02-09 | Abirateron acetát komplexei, eljárás elõállításukra, és az azokat tartalmazó gyógyászati készítmények |
Publications (1)
Publication Number | Publication Date |
---|---|
AR103653A1 true AR103653A1 (es) | 2017-05-24 |
Family
ID=89991732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160100363A AR103653A1 (es) | 2015-02-09 | 2016-02-10 | Complejos de acetato de abiraterona, proceso para prepararlos y composiciones farmacéuticas que los contienen |
Country Status (18)
Country | Link |
---|---|
US (4) | US9623034B2 (es) |
EP (1) | EP3256108B1 (es) |
JP (1) | JP6697473B2 (es) |
CN (1) | CN107278152A (es) |
AR (1) | AR103653A1 (es) |
AU (1) | AU2016217534A1 (es) |
BR (1) | BR112017017089A2 (es) |
CA (1) | CA2976053A1 (es) |
ES (1) | ES2737955T3 (es) |
HK (1) | HK1246189B (es) |
HU (2) | HUP1500055A1 (es) |
IL (1) | IL253793B (es) |
MX (1) | MX2017010280A (es) |
PL (1) | PL3256108T3 (es) |
RU (1) | RU2017129740A (es) |
SG (1) | SG11201706273QA (es) |
TW (1) | TWI696463B (es) |
WO (1) | WO2016128891A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP1500055A1 (hu) | 2015-02-09 | 2016-08-29 | Druggability Technologies Ip Holdco Ltd | Abirateron acetát komplexei, eljárás elõállításukra, és az azokat tartalmazó gyógyászati készítmények |
US10722527B2 (en) | 2015-04-10 | 2020-07-28 | Capsugel Belgium Nv | Abiraterone acetate lipid formulations |
CN110022901A (zh) | 2016-12-14 | 2019-07-16 | 成药技术Ip控股有限公司 | 含有塞来昔布的药物组合物 |
JP2020502144A (ja) * | 2016-12-19 | 2020-01-23 | ドラッガビリティー テクノロジーズ アイピー ホールディング カンパニー リミテッドDruggability Technologies Ip Holdco Limited | スボレキサントの医薬製剤 |
AU2018316248A1 (en) * | 2017-08-09 | 2020-01-30 | Nangenex Nanotechnology Incorporated | Pharmaceutical composition comprising Abiraterone acetate and Darulotamide |
CN111617258A (zh) * | 2019-02-28 | 2020-09-04 | 江苏恒瑞医药股份有限公司 | 一种制备阿比特龙或其衍生物药物组合物的方法及其应用 |
CZ2019168A3 (cs) | 2019-03-20 | 2020-09-30 | Zentiva, K.S. | Farmaceutická kompozice obsahující abirateron acetát |
CN110170058B (zh) * | 2019-06-24 | 2022-02-11 | 李建恒 | 一种阿比特龙包合物及其制备方法 |
CN110538150A (zh) | 2019-09-26 | 2019-12-06 | 湖南瑞林医药科技有限公司 | 一种含有醋酸阿比特龙的药物组合物及其制备方法和应用 |
CN117881411A (zh) * | 2021-06-01 | 2024-04-12 | 艾迪雅生物有限责任公司 | 用于眼部药物的延长释放药物递送系统和使用方法 |
JP7320903B2 (ja) | 2021-12-15 | 2023-08-04 | 湖南慧▲澤▼生物医▲薬▼科技有限公司 | アビラテロン酢酸エステルを含む組成物及び使用 |
WO2024080308A1 (ja) * | 2022-10-12 | 2024-04-18 | 中外製薬株式会社 | ペプチド、界面活性剤及びポリマーを含む組成物 |
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US9592244B2 (en) | 2017-03-14 |
US10130582B2 (en) | 2018-11-20 |
RU2017129740A (ru) | 2019-03-11 |
HK1246189B (zh) | 2020-03-27 |
EP3256108A1 (en) | 2017-12-20 |
WO2016128891A1 (en) | 2016-08-18 |
HUP1500055A1 (hu) | 2016-08-29 |
TW201639580A (zh) | 2016-11-16 |
PL3256108T3 (pl) | 2019-12-31 |
TWI696463B (zh) | 2020-06-21 |
US20170182172A1 (en) | 2017-06-29 |
JP2018504443A (ja) | 2018-02-15 |
US20160228455A1 (en) | 2016-08-11 |
US10668016B2 (en) | 2020-06-02 |
MX2017010280A (es) | 2017-12-04 |
ES2737955T3 (es) | 2020-01-17 |
SG11201706273QA (en) | 2017-08-30 |
CN107278152A (zh) | 2017-10-20 |
IL253793A0 (en) | 2017-09-28 |
US20160331763A1 (en) | 2016-11-17 |
JP6697473B2 (ja) | 2020-05-20 |
RU2017129740A3 (es) | 2019-08-06 |
HUE045398T2 (hu) | 2019-12-30 |
US9623034B2 (en) | 2017-04-18 |
US20190046437A1 (en) | 2019-02-14 |
AU2016217534A1 (en) | 2017-09-07 |
IL253793B (en) | 2021-02-28 |
EP3256108B1 (en) | 2019-05-01 |
BR112017017089A2 (pt) | 2018-06-26 |
CA2976053A1 (en) | 2016-08-18 |
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