AR100530A1 - Compuestos antihelmínticos - Google Patents
Compuestos antihelmínticosInfo
- Publication number
- AR100530A1 AR100530A1 ARP150101560A ARP150101560A AR100530A1 AR 100530 A1 AR100530 A1 AR 100530A1 AR P150101560 A ARP150101560 A AR P150101560A AR P150101560 A ARP150101560 A AR P150101560A AR 100530 A1 AR100530 A1 AR 100530A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- aryl
- halogen
- haloalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 46
- -1 cyano, hydroxy Chemical group 0.000 abstract 42
- 125000003118 aryl group Chemical group 0.000 abstract 38
- 229910052736 halogen Inorganic materials 0.000 abstract 38
- 150000002367 halogens Chemical class 0.000 abstract 38
- 125000001188 haloalkyl group Chemical group 0.000 abstract 37
- 125000003282 alkyl amino group Chemical group 0.000 abstract 34
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 34
- 125000000623 heterocyclic group Chemical group 0.000 abstract 34
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 26
- 125000003342 alkenyl group Chemical group 0.000 abstract 25
- 125000000304 alkynyl group Chemical group 0.000 abstract 25
- 125000001072 heteroaryl group Chemical group 0.000 abstract 25
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 23
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 21
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 20
- 125000001424 substituent group Chemical group 0.000 abstract 18
- 125000003545 alkoxy group Chemical group 0.000 abstract 15
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 15
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 15
- 125000004414 alkyl thio group Chemical group 0.000 abstract 15
- 125000005140 aralkylsulfonyl group Chemical group 0.000 abstract 15
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 15
- 125000002837 carbocyclic group Chemical group 0.000 abstract 15
- 125000000262 haloalkenyl group Chemical group 0.000 abstract 15
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 15
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 abstract 15
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 15
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 15
- 125000000232 haloalkynyl group Chemical group 0.000 abstract 15
- 125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 15
- 125000005367 heteroarylalkylthio group Chemical group 0.000 abstract 15
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 15
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 abstract 15
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 abstract 15
- 125000005368 heteroarylthio group Chemical group 0.000 abstract 15
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 15
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 14
- 125000005135 aryl sulfinyl group Chemical group 0.000 abstract 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 12
- 125000004659 aryl alkyl thio group Chemical group 0.000 abstract 11
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 11
- 125000005110 aryl thio group Chemical group 0.000 abstract 11
- 125000004104 aryloxy group Chemical group 0.000 abstract 11
- 125000005884 carbocyclylalkyl group Chemical group 0.000 abstract 11
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 11
- 125000005090 alkenylcarbonyl group Chemical group 0.000 abstract 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 10
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 10
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 10
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 10
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 9
- 239000001257 hydrogen Substances 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 8
- 229910052760 oxygen Inorganic materials 0.000 abstract 8
- 229910052717 sulfur Inorganic materials 0.000 abstract 8
- 230000000507 anthelmentic effect Effects 0.000 abstract 7
- 125000005087 alkynylcarbonyl group Chemical group 0.000 abstract 6
- 125000004122 cyclic group Chemical group 0.000 abstract 6
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 5
- 125000002619 bicyclic group Chemical group 0.000 abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000005647 linker group Chemical group 0.000 abstract 4
- 125000004043 oxo group Chemical group O=* 0.000 abstract 4
- 125000006413 ring segment Chemical group 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002393 azetidinyl group Chemical group 0.000 abstract 2
- 125000002527 bicyclic carbocyclic group Chemical group 0.000 abstract 2
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000003566 oxetanyl group Chemical group 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B41/00—Circuit arrangements or apparatus for igniting or operating discharge lamps
- H05B41/02—Details
- H05B41/04—Starting switches
- H05B41/06—Starting switches thermal only
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000256P | 2014-05-19 | 2014-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100530A1 true AR100530A1 (es) | 2016-10-12 |
Family
ID=54554638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101560A AR100530A1 (es) | 2014-05-19 | 2015-05-19 | Compuestos antihelmínticos |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10045979B2 (enExample) |
| EP (1) | EP3145925B1 (enExample) |
| JP (1) | JP6616786B2 (enExample) |
| CN (1) | CN106536518B (enExample) |
| AR (1) | AR100530A1 (enExample) |
| AU (2) | AU2015264336B2 (enExample) |
| CA (1) | CA2949511A1 (enExample) |
| ES (1) | ES2842592T3 (enExample) |
| MX (2) | MX375153B (enExample) |
| NZ (1) | NZ726874A (enExample) |
| WO (1) | WO2015179414A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN105130948A (zh) | 2010-04-22 | 2015-12-09 | 弗特克斯药品有限公司 | 制备环烷基甲酰胺基-吲哚化合物的方法 |
| JP6543268B2 (ja) | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| MX375153B (es) * | 2014-05-19 | 2025-03-06 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelminticos. |
| EP3247701B1 (en) | 2015-01-20 | 2021-09-22 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic compounds, compositions and method of using thereof |
| JOP20190072A1 (ar) | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| US11517568B2 (en) | 2018-09-12 | 2022-12-06 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| US11364234B2 (en) | 2018-09-12 | 2022-06-21 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| WO2020061103A1 (en) | 2018-09-18 | 2020-03-26 | Nikang Therapeutics, Inc. | Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors |
| EP3643711A1 (en) | 2018-10-24 | 2020-04-29 | Bayer Animal Health GmbH | New anthelmintic compounds |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| CR20230325A (es) | 2020-12-30 | 2023-12-11 | Tyra Biosciences Inc | Compuestos de indazol como inhibidores de cinasas |
| WO2022165513A1 (en) | 2021-01-29 | 2022-08-04 | Cedilla Therapeutics, Inc. | Cdk2 inhibitors and methods of using the same |
| CA3225439A1 (en) | 2021-06-26 | 2022-12-29 | Cedilla Therapeutics, Inc. | Cdk2 inhibitors and methods of using the same |
Family Cites Families (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6426333B1 (en) | 1996-09-19 | 2002-07-30 | Merial | Spot-on formulations for combating parasites |
| FR2753377B1 (fr) | 1996-09-19 | 1999-09-24 | Rhone Merieux | Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides |
| NL160809C (nl) | 1970-05-15 | 1979-12-17 | Duphar Int Res | Werkwijze ter bereiding van benzoylureumverbindingen, alsmede werkwijze ter bereiding van insekticide prepara- ten op basis van benzoylureumverbindingen. |
| US3985763A (en) | 1970-06-20 | 1976-10-12 | Bayer Aktiengesellschaft | Oxazolyl-acetic acid derivatives and oxazolyl-coumarines |
| DE2030507C3 (de) * | 1970-06-20 | 1975-05-22 | Bayer Ag, 5090 Leverkusen | Oxazolyl-cumarine, deren Herstellung und Verwendung |
| US3950360A (en) | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| JPS4914624A (enExample) | 1972-06-08 | 1974-02-08 | ||
| US3818047A (en) | 1972-08-07 | 1974-06-18 | C Henrick | Substituted pyrones |
| SE434277B (sv) | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| CH604517A5 (enExample) | 1976-08-19 | 1978-09-15 | Ciba Geigy Ag | |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4134973A (en) | 1977-04-11 | 1979-01-16 | Merck & Co., Inc. | Carbohydrate derivatives of milbemycin and processes therefor |
| US4199569A (en) | 1977-10-03 | 1980-04-22 | Merck & Co., Inc. | Selective hydrogenation products of C-076 compounds and derivatives thereof |
| US4144352A (en) | 1977-12-19 | 1979-03-13 | Merck & Co., Inc. | Milbemycin compounds as anthelmintic agents |
| DE2961415D1 (en) | 1978-05-20 | 1982-01-28 | Bayer Ag | Heteroaryloxy-acetamides, process for their preparation and their use as herbicides |
| DE2822155A1 (de) * | 1978-05-20 | 1979-11-22 | Bayer Ag | Substituierte carbonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| US4203976A (en) | 1978-08-02 | 1980-05-20 | Merck & Co., Inc. | Sugar derivatives of C-076 compounds |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| JPS57139012A (en) | 1981-02-23 | 1982-08-27 | Sankyo Co Ltd | Anthelmintic composition |
| US4427663A (en) | 1982-03-16 | 1984-01-24 | Merck & Co., Inc. | 4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof |
| DE3235931A1 (de) | 1982-09-29 | 1984-03-29 | Bayer Ag, 5090 Leverkusen | Koeder zur bekaempfung von ungeziefer |
| JPS59199673A (ja) | 1983-04-25 | 1984-11-12 | Sumitomo Chem Co Ltd | 含窒素複素環化合物、その製造法およびそれを有効成分とする有害生物防除剤 |
| EP0179022B1 (de) | 1984-10-18 | 1990-11-07 | Ciba-Geigy Ag | Benzoylphenylharnstoffe |
| EP0192060B1 (de) | 1985-02-04 | 1991-09-18 | Nihon Bayer Agrochem K.K. | Heterocyclische Verbindungen |
| EP0237482A1 (de) | 1986-03-06 | 1987-09-16 | Ciba-Geigy Ag | C(29)-Carbonyloxi-milbemycin-Derivate zur Bekämpfung von tier- und pflanzenparasitären Schädlingen |
| ES2019932B3 (es) | 1986-03-25 | 1991-07-16 | Sankyo Co | Compuestos macrolidos. |
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| EP0319142B1 (en) | 1987-11-03 | 1994-04-06 | Beecham Group Plc | Intermediates for the preparation of anthelmintic macrolide antibiotics |
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-
2015
- 2015-05-19 MX MX2018015206A patent/MX375153B/es unknown
- 2015-05-19 NZ NZ726874A patent/NZ726874A/en not_active IP Right Cessation
- 2015-05-19 AU AU2015264336A patent/AU2015264336B2/en not_active Ceased
- 2015-05-19 CA CA2949511A patent/CA2949511A1/en not_active Abandoned
- 2015-05-19 JP JP2016568820A patent/JP6616786B2/ja not_active Expired - Fee Related
- 2015-05-19 EP EP15726481.3A patent/EP3145925B1/en not_active Not-in-force
- 2015-05-19 AR ARP150101560A patent/AR100530A1/es active IP Right Grant
- 2015-05-19 ES ES15726481T patent/ES2842592T3/es active Active
- 2015-05-19 CN CN201580034873.7A patent/CN106536518B/zh not_active Expired - Fee Related
- 2015-05-19 WO PCT/US2015/031599 patent/WO2015179414A1/en not_active Ceased
- 2015-05-19 MX MX2016015090A patent/MX361606B/es active IP Right Grant
- 2015-05-19 US US15/311,848 patent/US10045979B2/en active Active
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2018
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- 2018-11-30 AU AU2018271390A patent/AU2018271390B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2949511A1 (en) | 2015-11-26 |
| MX375153B (es) | 2025-03-06 |
| MX361606B (es) | 2018-12-11 |
| US10463661B2 (en) | 2019-11-05 |
| EP3145925B1 (en) | 2020-11-04 |
| NZ726874A (en) | 2018-03-23 |
| EP3145925A1 (en) | 2017-03-29 |
| CN106536518A (zh) | 2017-03-22 |
| WO2015179414A1 (en) | 2015-11-26 |
| JP2017520530A (ja) | 2017-07-27 |
| MX2016015090A (es) | 2017-03-27 |
| US10045979B2 (en) | 2018-08-14 |
| CN106536518B (zh) | 2020-05-12 |
| US20170100394A1 (en) | 2017-04-13 |
| AU2018271390A1 (en) | 2018-12-20 |
| JP6616786B2 (ja) | 2019-12-04 |
| US20180338972A1 (en) | 2018-11-29 |
| AU2015264336B2 (en) | 2018-08-30 |
| AU2018271390B2 (en) | 2020-10-22 |
| ES2842592T3 (es) | 2021-07-14 |
| AU2015264336A1 (en) | 2016-12-15 |
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