AR083026A1 - Derivados de ciclohexenona y composiciones para el tratamiento del cancer de pulmon - Google Patents
Derivados de ciclohexenona y composiciones para el tratamiento del cancer de pulmonInfo
- Publication number
- AR083026A1 AR083026A1 ARP110103399A ARP110103399A AR083026A1 AR 083026 A1 AR083026 A1 AR 083026A1 AR P110103399 A ARP110103399 A AR P110103399A AR P110103399 A ARP110103399 A AR P110103399A AR 083026 A1 AR083026 A1 AR 083026A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nr5r6
- compositions
- treatment
- alkynyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 2
- 150000002596 lactones Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000006648 (C1-C8) haloalkyl group Chemical group 0.000 abstract 1
- BGCPLWWYPZAURQ-UHFFFAOYSA-N 5-[[5-chloro-2-(2,2,6,6-tetramethylmorpholin-4-yl)pyrimidin-4-yl]amino]-3-(3-hydroxy-3-methylbutyl)-1-methylbenzimidazol-2-one Chemical compound ClC=1C(=NC(=NC=1)N1CC(OC(C1)(C)C)(C)C)NC1=CC2=C(N(C(N2CCC(C)(C)O)=O)C)C=C1 BGCPLWWYPZAURQ-UHFFFAOYSA-N 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical class O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW99131844 | 2010-09-20 | ||
| TW99145853 | 2010-12-24 | ||
| US13/070,308 US8309611B2 (en) | 2010-09-20 | 2011-03-23 | Methods and compositions for treating lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR083026A1 true AR083026A1 (es) | 2013-01-23 |
Family
ID=45818282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103399A AR083026A1 (es) | 2010-09-20 | 2011-09-16 | Derivados de ciclohexenona y composiciones para el tratamiento del cancer de pulmon |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8309611B2 (OSRAM) |
| EP (1) | EP2655309A4 (OSRAM) |
| JP (1) | JP2014504256A (OSRAM) |
| KR (2) | KR20150014534A (OSRAM) |
| CN (1) | CN103221373A (OSRAM) |
| AR (1) | AR083026A1 (OSRAM) |
| AU (1) | AU2011306068B2 (OSRAM) |
| BR (1) | BR112013006567A2 (OSRAM) |
| CA (1) | CA2809762C (OSRAM) |
| CO (1) | CO6700836A2 (OSRAM) |
| EA (1) | EA201370071A1 (OSRAM) |
| IL (1) | IL225262A0 (OSRAM) |
| MA (1) | MA34598B1 (OSRAM) |
| MX (1) | MX2011007763A (OSRAM) |
| MY (1) | MY157341A (OSRAM) |
| PH (1) | PH12013500529A1 (OSRAM) |
| SG (1) | SG188610A1 (OSRAM) |
| TW (1) | TWI483718B (OSRAM) |
| WO (1) | WO2012039793A1 (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8309611B2 (en) | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
| CN103570531A (zh) * | 2012-07-25 | 2014-02-12 | 丽丰实业股份有限公司 | 樟芝菌丝体的化合物及其用途 |
| MX2015006337A (es) * | 2012-11-21 | 2015-09-07 | Golden Biotechnology Corp | Metodos y composiciones para tratar enfermedades neurodegenerativas. |
| TWI612026B (zh) * | 2013-02-20 | 2018-01-21 | 國鼎生物科技股份有限公司 | 環己烯酮組成物及其製造方法 |
| TWI597061B (zh) * | 2013-02-20 | 2017-09-01 | 國鼎生物科技股份有限公司 | 治療白血病之方法及組成物 |
| US20140274979A1 (en) * | 2013-03-13 | 2014-09-18 | Golden Biotechnology Corporation | Method for the treatment of fatty liver disease |
| TWI583376B (zh) * | 2013-03-20 | 2017-05-21 | 曾卉菱 | Compounds isolated from Antelroxicus and their use |
| JP5908002B2 (ja) * | 2013-03-20 | 2016-04-26 | 卉菱 曽 | ベニクスノキタケに含まれる化合物及びその用途 |
| US9480723B2 (en) * | 2013-05-02 | 2016-11-01 | Kingland Property Corporation, Ltd. | Method of preparing an extract of Antrodia cinnamomea having an elevated antcin C and zhankuic C content |
| CN104211627A (zh) * | 2013-05-29 | 2014-12-17 | 曾卉菱 | 牛樟芝化合物、萃取物及其用途 |
| CN104706682B (zh) * | 2013-12-12 | 2018-01-30 | 富裔实业股份有限公司 | 一种中草药萃取物及其用于制备肺癌药物的用途 |
| CN105237365B (zh) * | 2014-07-09 | 2017-09-08 | 台湾利得生物科技股份有限公司 | 樟芝固态培养菌丝体的萃取物及其应用 |
| WO2016011130A1 (en) * | 2014-07-17 | 2016-01-21 | National Taiwan University | Compositions and methods for the preparation of 4-oxy-2-cyclohexenone and 6-oxy-2-cyclohexenone compounds |
| JP6593856B2 (ja) * | 2014-09-03 | 2019-10-23 | 台灣利得生物科技股▲ふん▼有限公司 | 抗肺癌細胞転移用組成物およびその製造方法 |
| ES2869904T3 (es) * | 2014-12-30 | 2021-10-26 | Oneness Biotech Co Ltd | Compuestos de Antrodia camphorata, método para prepararlos y uso de los mismos |
| CN109195606A (zh) * | 2016-05-13 | 2019-01-11 | 国鼎生物科技股份有限公司 | 用于治疗晚期非小细胞肺癌的方法和组合物 |
| US11406605B2 (en) * | 2017-12-20 | 2022-08-09 | Golden Biotechnology Corporation | Therapeutic compositions for treating pancreatic cancer |
| MX2023006514A (es) * | 2020-12-03 | 2023-08-30 | Zymeworks Bc Inc | Construcciones heterodimericas de fc de iga y metodos de uso de estas. |
| US20240207348A1 (en) * | 2024-03-06 | 2024-06-27 | Samaara Bhardwaj | Herbal composition for cancer |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4861560B2 (ja) * | 2001-02-19 | 2012-01-25 | 株式会社明治 | 糖尿病合併症治療剤 |
| US20070116787A1 (en) * | 2005-11-21 | 2007-05-24 | Chih-Jung Yao | Cancer treatment |
| TW200829234A (en) | 2007-01-08 | 2008-07-16 | Golden Biotechnology Corp | Antrodia camphorata isophorone extract |
| CN101225066B (zh) | 2007-01-18 | 2010-09-22 | 国鼎生物科技股份有限公司 | 牛樟芝的环己烯酮萃取物 |
| TW200918498A (en) * | 2007-10-19 | 2009-05-01 | Golden Biotechnology Corp | Novel compound isolated from Antrodia camphorate extracts |
| CN101417934B (zh) * | 2007-10-24 | 2012-04-18 | 国鼎生物科技股份有限公司 | 分离自牛樟芝萃取物的化合物 |
| TW201102075A (en) * | 2009-07-09 | 2011-01-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of pancreatic cancer |
| TWI383791B (zh) * | 2009-09-09 | 2013-02-01 | 國鼎生物科技股份有限公司 | Used to inhibit the growth of gastric cancer tumor cells of the male antler ketone compounds |
| TW201109023A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of colorectal cancer |
| TW201109014A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of skin cancer |
| TW201109013A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone chemical compounds of Antrodia cinnamomea for suppressing the growth of the Lymphoma tumor cell |
| TWI394566B (zh) * | 2009-09-09 | 2013-05-01 | 國鼎生物科技股份有限公司 | Used to inhibit the growth of ovarian cancer tumor cells of the cattle camphor cyclohexene ketone compounds |
| TWI383790B (zh) * | 2009-09-09 | 2013-02-01 | 國鼎生物科技股份有限公司 | Used to inhibit the growth of oral cancer cells of the cattle Antrodylcyclohexenone compounds |
| EP2329816B1 (en) * | 2009-11-26 | 2016-04-13 | National Taiwan University | An anti-cancer active substance from antrodia camphorata, method for preparing the same and use thereof |
| US8309611B2 (en) | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
-
2011
- 2011-03-23 US US13/070,308 patent/US8309611B2/en active Active
- 2011-04-15 WO PCT/US2011/032785 patent/WO2012039793A1/en not_active Ceased
- 2011-04-15 SG SG2013020417A patent/SG188610A1/en unknown
- 2011-04-15 JP JP2013529140A patent/JP2014504256A/ja active Pending
- 2011-04-15 PH PH1/2013/500529A patent/PH12013500529A1/en unknown
- 2011-04-15 EP EP11827110.5A patent/EP2655309A4/en not_active Withdrawn
- 2011-04-15 EA EA201370071A patent/EA201370071A1/ru unknown
- 2011-04-15 MA MA35800A patent/MA34598B1/fr unknown
- 2011-04-15 MX MX2011007763A patent/MX2011007763A/es not_active Application Discontinuation
- 2011-04-15 KR KR1020157001206A patent/KR20150014534A/ko not_active Ceased
- 2011-04-15 KR KR1020137009889A patent/KR20130061746A/ko not_active Ceased
- 2011-04-15 BR BR112013006567A patent/BR112013006567A2/pt not_active IP Right Cessation
- 2011-04-15 AU AU2011306068A patent/AU2011306068B2/en active Active
- 2011-04-15 MY MYPI2013000945A patent/MY157341A/en unknown
- 2011-04-15 CA CA2809762A patent/CA2809762C/en active Active
- 2011-04-15 CN CN2011800557128A patent/CN103221373A/zh active Pending
- 2011-07-28 TW TW100126789A patent/TWI483718B/zh active
- 2011-09-16 AR ARP110103399A patent/AR083026A1/es unknown
-
2013
- 2013-03-17 IL IL225262A patent/IL225262A0/en unknown
- 2013-03-21 CO CO13056449A patent/CO6700836A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120071426A1 (en) | 2012-03-22 |
| EP2655309A1 (en) | 2013-10-30 |
| MX2011007763A (es) | 2012-07-04 |
| AU2011306068A1 (en) | 2013-05-02 |
| CO6700836A2 (es) | 2013-06-28 |
| TW201212906A (en) | 2012-04-01 |
| KR20150014534A (ko) | 2015-02-06 |
| AU2011306068B2 (en) | 2014-08-07 |
| EP2655309A4 (en) | 2014-09-03 |
| MA34598B1 (fr) | 2013-10-02 |
| PH12013500529A1 (en) | 2017-08-09 |
| IL225262A0 (en) | 2013-06-27 |
| BR112013006567A2 (pt) | 2017-10-24 |
| WO2012039793A1 (en) | 2012-03-29 |
| CA2809762C (en) | 2016-02-02 |
| CA2809762A1 (en) | 2012-03-29 |
| TWI483718B (zh) | 2015-05-11 |
| SG188610A1 (en) | 2013-04-30 |
| KR20130061746A (ko) | 2013-06-11 |
| MY157341A (en) | 2016-05-31 |
| EA201370071A1 (ru) | 2013-10-30 |
| JP2014504256A (ja) | 2014-02-20 |
| CN103221373A (zh) | 2013-07-24 |
| US8309611B2 (en) | 2012-11-13 |
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