CU20110190A7 - Análogos de isoxazol-3(2h)-ona como agentes terapéuticos - Google Patents

Análogos de isoxazol-3(2h)-ona como agentes terapéuticos

Info

Publication number
CU20110190A7
CU20110190A7 CU20110190A CU20110190A CU20110190A7 CU 20110190 A7 CU20110190 A7 CU 20110190A7 CU 20110190 A CU20110190 A CU 20110190A CU 20110190 A CU20110190 A CU 20110190A CU 20110190 A7 CU20110190 A7 CU 20110190A7
Authority
CU
Cuba
Prior art keywords
alkyl
optionally substituted
aryl
heteroaryl
atoms
Prior art date
Application number
CU20110190A
Other languages
English (en)
Inventor
Peter Schell
Daniel Pettersen
Michael Karle
Tomas Fex
Leifeng Cheng
Jonas Bostroem
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CU20110190A7 publication Critical patent/CU20110190A7/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Un compuesto de fórmula I ESPACIO PARA LA FÓRMULA o una sal farmacéuticamente aceptable de este, donde R1 y R2 son independientemente hidrógeno, deuterio, arilo, heteroarilo, alquilo C1-C8, y están opcionalmente sustituidos con uno o más sustituyentes que son independientemente R3, R3 es un arilo, heteroarilo, uno o más átomos de flúor, un alquilo C1-C6 que contiene uno o más átomos de flúor, un alquilo C1-C6 que contiene uno o más átomos de deuterio, un alquilo C1-C6 que contiene hidroxi, estando el arilo y el heteroarilo opcionalmente sustituidos con uno o más halógenos, un alcoxi fluorado, un alquilo fluorado, un sulfonilo, uno o más átomos de deuterio, un alquilo C1-C6, un alcoxi C1-C6, un nitrilo, o R3 es un alquilo C1-C6 opcionalmente sustituido con uno o más de los siguientes grupos: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; donde R4 es un alquilo C1-C10 opcionalmente sustituido con uno o más átomos de flúor, deuterio, alcoxi, carboxilato de arilo, carboxilato de alquilo; R5 y R6 se seleccionan independientemente entre hidrógeno, alquilo o pueden formar conjuntamente un anillo de carbono de 4-8 miembros; o R1 y R2 forman un anillo de carbono de 3-10 miembros que comprende opcionalmente O ó N y está opcionalmente sustituido con un alquilo o arilo C1-C10, heteroarilo opcionalmente sustituido con R3.
CU20110190A 2009-04-07 2011-10-07 Análogos de isoxazol-3(2h)-ona como agentes terapéuticos CU20110190A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16722409P 2009-04-07 2009-04-07
US17195609P 2009-04-23 2009-04-23

Publications (1)

Publication Number Publication Date
CU20110190A7 true CU20110190A7 (es) 2012-02-15

Family

ID=42934883

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20110190A CU20110190A7 (es) 2009-04-07 2011-10-07 Análogos de isoxazol-3(2h)-ona como agentes terapéuticos

Country Status (21)

Country Link
US (1) US8415378B2 (es)
EP (1) EP2417131A4 (es)
JP (1) JP5711723B2 (es)
KR (1) KR101675607B1 (es)
CN (1) CN102459246B (es)
AR (1) AR076219A1 (es)
AU (1) AU2010235236B2 (es)
BR (1) BRPI1013984A2 (es)
CA (1) CA2757879C (es)
CO (1) CO6440580A2 (es)
CU (1) CU20110190A7 (es)
EA (1) EA020825B1 (es)
EC (1) ECSP11011385A (es)
IL (1) IL215336A0 (es)
MX (1) MX2011010647A (es)
NI (1) NI201100181A (es)
SG (1) SG174463A1 (es)
TW (1) TW201040166A (es)
UY (1) UY32543A (es)
WO (1) WO2010117323A1 (es)
ZA (1) ZA201108119B (es)

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KR20140072037A (ko) 2011-08-30 2014-06-12 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
US9073881B2 (en) 2011-09-23 2015-07-07 Hoffmann-La Roche Inc. Benzoic acid derivatives
EP3822273B1 (en) 2012-06-13 2024-04-10 Incyte Holdings Corporation Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
CN102977050B (zh) * 2012-11-20 2015-04-22 浙江工业大学 一种2-苯并噻唑二甲缩醛和2-苯并噻唑甲醛的合成方法
CN102977040B (zh) * 2012-11-20 2015-06-03 浙江工业大学 一种2-喹喔啉基二甲缩醛和2-喹喔啉基甲醛的合成方法
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MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN104725300A (zh) * 2015-02-28 2015-06-24 宁波九胜创新医药科技有限公司 一种1-(6-甲基吡啶-3-基)-2-(4-甲磺酰基苯基)乙酮的制备方法
WO2016173948A1 (en) 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Indazolopyrimidinones as fibrinolysis inhibitors
CN107459514B (zh) * 2016-06-06 2020-10-23 南开大学 一类手性哌啶衍生物及其制备方法和用途
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CN107857725A (zh) * 2017-12-19 2018-03-30 苏州艾缇克药物化学有限公司 一种2‑氨基吡啶‑4‑甲醇的合成方法
CN112867716A (zh) 2018-05-04 2021-05-28 因赛特公司 Fgfr抑制剂的固体形式和其制备方法
CN112566912A (zh) 2018-05-04 2021-03-26 因赛特公司 Fgfr抑制剂的盐
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
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Also Published As

Publication number Publication date
NI201100181A (es) 2012-06-14
KR20120034611A (ko) 2012-04-12
EP2417131A4 (en) 2014-08-27
CA2757879C (en) 2017-06-06
EA201190237A1 (ru) 2012-04-30
MX2011010647A (es) 2012-02-21
SG174463A1 (en) 2011-10-28
AU2010235236A1 (en) 2011-10-20
CA2757879A1 (en) 2010-10-14
WO2010117323A1 (en) 2010-10-14
EP2417131A1 (en) 2012-02-15
EA020825B1 (ru) 2015-02-27
BRPI1013984A2 (pt) 2018-06-19
KR101675607B1 (ko) 2016-11-11
US8415378B2 (en) 2013-04-09
ECSP11011385A (es) 2011-11-30
JP2012522836A (ja) 2012-09-27
CO6440580A2 (es) 2012-05-15
ZA201108119B (en) 2012-07-25
AR076219A1 (es) 2011-05-26
TW201040166A (en) 2010-11-16
CN102459246A (zh) 2012-05-16
IL215336A0 (en) 2011-12-29
AU2010235236B2 (en) 2013-10-24
JP5711723B2 (ja) 2015-05-07
US20100261755A1 (en) 2010-10-14
CN102459246B (zh) 2014-05-07
UY32543A (es) 2010-11-30
WO2010117323A8 (en) 2010-11-18

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