UY35809A - (aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos - Google Patents

(aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos

Info

Publication number
UY35809A
UY35809A UY0001035809A UY35809A UY35809A UY 35809 A UY35809 A UY 35809A UY 0001035809 A UY0001035809 A UY 0001035809A UY 35809 A UY35809 A UY 35809A UY 35809 A UY35809 A UY 35809A
Authority
UY
Uruguay
Prior art keywords
bleeding
aza
prophylaxis
substituted
treatment
Prior art date
Application number
UY0001035809A
Other languages
English (en)
Inventor
Köbberling Dr Johannes
Beyer Dr Kristin
Röhrig Dr Susanne
Köllnberger Dr Maria
Sperzel Dr Michael
Burkhardt Dr Nils
Stegmann Dr Christian
Werner Dr Matthias
Ellermann Dr Manuel
Cancho Grande Dr Yolanda
Schlemmer Dr Karl-Heinz
Schuhmacher Dr Joachim
Hassfeld Dr Jorma
Kinzel Dr Tom
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of UY35809A publication Critical patent/UY35809A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente solicitud se refiere nuevas (aza)piridopirazolopirimidinonas e indazolopirimidinonas sustituidas, a los procesos para su preparación, los compuestos para usar solo o en combinaciones en un procedimiento para el tratamiento y/o la profilaxis de las enfermedades, en particular para el tratamiento y/o la profilaxis del sangrado agudo y recurrente en pacientes con o sin trastornos de sangrado hereditarios o adquiridos subyacentes, en el que el sangrado se asocia con una enfermedad o una intervención médica seleccionadas del grupo que consiste de la menorragia, hemorragia postparto, shock hemorrágico, traumatismo, cirugía, trasplante, accidente cerebrovascular, enfermedades del hígado, angioedema hereditario, sangrado nasal y sinovi tis y el daño del cartílago después de la hemartrosis.
UY0001035809A 2013-11-05 2014-10-31 (aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos UY35809A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13191642 2013-11-05

Publications (1)

Publication Number Publication Date
UY35809A true UY35809A (es) 2015-05-29

Family

ID=49517406

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035809A UY35809A (es) 2013-11-05 2014-10-31 (aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos

Country Status (29)

Country Link
US (3) US9598417B2 (es)
EP (1) EP3066100B1 (es)
JP (1) JP6431061B2 (es)
KR (1) KR102312780B1 (es)
CN (1) CN105683194B (es)
AP (1) AP2016009175A0 (es)
AR (1) AR098292A1 (es)
AU (1) AU2014345771B2 (es)
CA (1) CA2929378C (es)
CL (1) CL2016001076A1 (es)
CR (1) CR20160332A (es)
CU (1) CU24361B1 (es)
DO (1) DOP2016000102A (es)
EA (1) EA029373B1 (es)
ES (1) ES2732305T3 (es)
GT (1) GT201600084A (es)
HK (1) HK1223940A1 (es)
IL (1) IL244645B (es)
MA (1) MA39018A1 (es)
MX (1) MX370419B (es)
PE (1) PE20160934A1 (es)
PH (1) PH12016500828A1 (es)
SG (1) SG11201602133RA (es)
TN (1) TN2016000161A1 (es)
TW (1) TWI657089B (es)
UA (1) UA117504C2 (es)
UY (1) UY35809A (es)
WO (1) WO2015067549A1 (es)
ZA (1) ZA201602311B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY35809A (es) 2013-11-05 2015-05-29 Bayer Pharma AG (aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos
US10118930B2 (en) * 2014-11-03 2018-11-06 Bayer Pharma Aktiengesellschaft Piperidinylpyrazolopyrimidinones and their use
WO2016173948A1 (en) * 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Indazolopyrimidinones as fibrinolysis inhibitors
WO2017007917A1 (en) * 2015-07-07 2017-01-12 Mast Therapeutics, Inc. Polyoxyethylene/polyoxypropylene copolymers and fibrinolytic inhibitors, uses thereof and compositions
EP3318563A1 (en) 2016-11-07 2018-05-09 Sanofi Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders
CN110590673A (zh) * 2019-09-02 2019-12-20 南通大学 一种4-氯-7-甲基-1h-吲唑及其化学合成方法
US11618751B1 (en) 2022-03-25 2023-04-04 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
US11654057B2 (en) 2020-04-09 2023-05-23 Bio 54, Llc Devices for bleeding reduction and methods of making and using the same
WO2022166845A1 (zh) * 2021-02-05 2022-08-11 赛诺哈勃药业（成都）有限公司 一种纤溶酶抑制剂、其制备方法及应用
US20240228511A1 (en) 2021-06-09 2024-07-11 Eli Lilly And Company Substituted fused azines as kras g12d inhibitors
US11642324B1 (en) 2022-03-01 2023-05-09 Bio 54, Llc Topical tranexamic acid compositions and methods of use thereof
TW202404601A (zh) 2022-04-05 2024-02-01 加拿大商索科普拉健康與人類科學兩合公司 用於選擇性消退血栓性或血栓栓塞性疾病中血栓的凝乳酶抑制劑

Family Cites Families (12)

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FR2192559A5 (en) * 1972-07-17 1974-02-08 Ugine Kuhlmann Pyrimidino (1,2-b) indazole derivs - inters for dyes and pharmaceuticals, from 3-aminoindazoles and beta-ketone derivs
WO2006023000A1 (en) 2004-07-30 2006-03-02 Xanodyne Pharmaceuticals, Inc. Tranexamic acid formulations
AR059224A1 (es) * 2006-01-31 2008-03-19 Jerini Ag Compuestos para la inhibicion de integrinas y uso de estas
JP5531011B2 (ja) * 2008-06-06 2014-06-25 サノフイ ＴＡＦＩａの阻害剤としての大環状尿素およびスルファミド誘導体
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
JP5711723B2 (ja) 2009-04-07 2015-05-07 エメリティ・ファーマ・アクチボラグ 治療剤としてのイソオキサゾール−３（２ｈ）−オン類似体
WO2012047156A1 (en) * 2010-10-04 2012-04-12 Astrazeneca Ab Isoxazol-3(2h)-one analogs as plasminogen inhibitors and their use in the treatment of fibrinolysis related diseases
EP2640705A2 (en) * 2010-11-15 2013-09-25 Katholieke Universiteit Leuven Novel antiviral compounds
WO2012082947A1 (en) * 2010-12-16 2012-06-21 Irm Llc Compounds and compositions as tgr5 agonists
CN103370321B (zh) * 2010-12-16 2015-07-29 拜耳知识产权有限责任公司 取代的嘧啶并[1,2-b]吲唑及其作为PI3K/AKT途径的调节剂的用途
UY35809A (es) * 2013-11-05 2015-05-29 Bayer Pharma AG (aza)piridopirazolopirimidinonas e indazolopirimidinonas y sus usos
WO2016173948A1 (en) * 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Indazolopyrimidinones as fibrinolysis inhibitors

Also Published As

Publication number Publication date
HK1223940A1 (zh) 2017-08-11
CA2929378A1 (en) 2015-05-14
US10098883B2 (en) 2018-10-16
US9598417B2 (en) 2017-03-21
ZA201602311B (en) 2017-08-30
US20150126449A1 (en) 2015-05-07
MX370419B (es) 2019-12-11
TWI657089B (zh) 2019-04-21
IL244645B (en) 2019-06-30
CR20160332A (es) 2016-11-10
US20180344739A1 (en) 2018-12-06
CN105683194A (zh) 2016-06-15
EA201690935A1 (ru) 2016-10-31
JP6431061B2 (ja) 2018-11-28
EP3066100A1 (en) 2016-09-14
EP3066100B1 (en) 2019-04-17
AU2014345771A1 (en) 2016-04-14
PH12016500828A1 (en) 2016-06-13
SG11201602133RA (en) 2016-05-30
AR098292A1 (es) 2016-05-26
AU2014345771B2 (en) 2018-09-13
MA39018A1 (fr) 2017-06-30
PE20160934A1 (es) 2016-10-08
DOP2016000102A (es) 2016-06-30
UA117504C2 (uk) 2018-08-10
EA029373B1 (ru) 2018-03-30
CA2929378C (en) 2021-12-07
KR102312780B1 (ko) 2021-10-15
US20170239251A1 (en) 2017-08-24
US10668071B2 (en) 2020-06-02
NZ718100A (en) 2021-06-25
IL244645A0 (en) 2016-04-21
TN2016000161A1 (en) 2017-10-06
MX2016005969A (es) 2016-08-11
WO2015067549A1 (en) 2015-05-14
CL2016001076A1 (es) 2016-12-09
CU24361B1 (es) 2018-10-04
KR20160079093A (ko) 2016-07-05
ES2732305T3 (es) 2019-11-21
JP2016535052A (ja) 2016-11-10
TW201609728A (zh) 2016-03-16
CN105683194B (zh) 2018-09-14
AP2016009175A0 (en) 2016-04-30
GT201600084A (es) 2017-07-12

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Legal Events

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Effective date: 20211215