CO6700836A2 - Métodos y composiciones para tratamiento de cancer en pulmon - Google Patents
Métodos y composiciones para tratamiento de cancer en pulmonInfo
- Publication number
- CO6700836A2 CO6700836A2 CO13056449A CO13056449A CO6700836A2 CO 6700836 A2 CO6700836 A2 CO 6700836A2 CO 13056449 A CO13056449 A CO 13056449A CO 13056449 A CO13056449 A CO 13056449A CO 6700836 A2 CO6700836 A2 CO 6700836A2
- Authority
- CO
- Colombia
- Prior art keywords
- calkyl
- nrr
- calquinyl
- calkenyl
- lung cancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/10—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente solicitud proporcionas composiciones para el tratamiento de cáncer de pulmón que comprende un compuesto de ciclohexenona que tiene la estructura:en donde cada uno de X e Y es independientemente oxígeno, NR5 o azufre; R es hidrógeno o C(=O)C-Calquilo; cada uno de R, Ry Res independientemente un hidrógeno, metilo o (CH)m - CH; Res NRR, OR, OC(=O)R, C(=O)OR, C(=O)R, C(=O)NRR, halógeno, lactona de 5 o 6 miembros, C-Calquilo, C-Calquenilo, C-Calquinilo, arilo, glucosilo, en donde la lactona de 5 o 6 miembros, C-Calquilo, C-Calquenilo, C-Calquinilo, arilo, y glucosilo están opcionalmente substituidos con uno o más sustituyentes seleccionados de NRR, OR, OC(=O)R, C(=O)OR, C(=O)R, C(=O)NRR, C-Calquilo, C-Calquenilo, C-Calquinilo, C-Ccicloalquilo, y C-Chaloalquilo; cada uno Ry Res independientemente un hidrógeno o C-Calquilo; es un C-Calquilo, ORo NRR;m = 1-12 yn = 1-12 y o una sal metabolito, solvato o pro fármaco aceptable farmacéuticamente del mismo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW99131844 | 2010-09-20 | ||
TW99145853 | 2010-12-24 | ||
US13/070,308 US8309611B2 (en) | 2010-09-20 | 2011-03-23 | Methods and compositions for treating lung cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6700836A2 true CO6700836A2 (es) | 2013-06-28 |
Family
ID=45818282
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13056449A CO6700836A2 (es) | 2010-09-20 | 2013-03-21 | Métodos y composiciones para tratamiento de cancer en pulmon |
Country Status (18)
Country | Link |
---|---|
US (1) | US8309611B2 (es) |
EP (1) | EP2655309A4 (es) |
JP (1) | JP2014504256A (es) |
KR (2) | KR20130061746A (es) |
CN (1) | CN103221373A (es) |
AR (1) | AR083026A1 (es) |
AU (1) | AU2011306068B2 (es) |
BR (1) | BR112013006567A2 (es) |
CA (1) | CA2809762C (es) |
CO (1) | CO6700836A2 (es) |
EA (1) | EA201370071A1 (es) |
IL (1) | IL225262A0 (es) |
MA (1) | MA34598B1 (es) |
MX (1) | MX2011007763A (es) |
MY (1) | MY157341A (es) |
SG (1) | SG188610A1 (es) |
TW (1) | TWI483718B (es) |
WO (1) | WO2012039793A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8309611B2 (en) | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
CN103570531A (zh) * | 2012-07-25 | 2014-02-12 | 丽丰实业股份有限公司 | 樟芝菌丝体的化合物及其用途 |
ES2788598T3 (es) | 2012-11-21 | 2020-10-22 | Golden Biotechnology Corp | Métodos y composiciones para tratar enfermedades neurodegenerativas |
TWI597061B (zh) * | 2013-02-20 | 2017-09-01 | 國鼎生物科技股份有限公司 | 治療白血病之方法及組成物 |
US20140274979A1 (en) * | 2013-03-13 | 2014-09-18 | Golden Biotechnology Corporation | Method for the treatment of fatty liver disease |
TWI583376B (zh) * | 2013-03-20 | 2017-05-21 | Hui-Ling Zeng | Compounds isolated from Antelroxicus and their use |
JP5908002B2 (ja) * | 2013-03-20 | 2016-04-26 | 卉菱 曽 | ベニクスノキタケに含まれる化合物及びその用途 |
US9480723B2 (en) * | 2013-05-02 | 2016-11-01 | Kingland Property Corporation, Ltd. | Method of preparing an extract of Antrodia cinnamomea having an elevated antcin C and zhankuic C content |
CN104211627A (zh) * | 2013-05-29 | 2014-12-17 | 曾卉菱 | 牛樟芝化合物、萃取物及其用途 |
CN104706682B (zh) * | 2013-12-12 | 2018-01-30 | 富裔实业股份有限公司 | 一种中草药萃取物及其用于制备肺癌药物的用途 |
CN105237365B (zh) * | 2014-07-09 | 2017-09-08 | 台湾利得生物科技股份有限公司 | 樟芝固态培养菌丝体的萃取物及其应用 |
WO2016011130A1 (en) * | 2014-07-17 | 2016-01-21 | National Taiwan University | Compositions and methods for the preparation of 4-oxy-2-cyclohexenone and 6-oxy-2-cyclohexenone compounds |
JP6593856B2 (ja) * | 2014-09-03 | 2019-10-23 | 台灣利得生物科技股▲ふん▼有限公司 | 抗肺癌細胞転移用組成物およびその製造方法 |
US9884801B2 (en) * | 2014-12-30 | 2018-02-06 | Oneness Biotech Co., Ltd. | Compounds from antrodia camphorata, method for preparing the same and use thereof |
JP2019514986A (ja) * | 2016-05-13 | 2019-06-06 | ゴールデン バイオテクノロジー コーポレーション | 進行期の非小細胞肺癌を処置するための方法および組成物 |
US11406605B2 (en) * | 2017-12-20 | 2022-08-09 | Golden Biotechnology Corporation | Therapeutic compositions for treating pancreatic cancer |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4861560B2 (ja) * | 2001-02-19 | 2012-01-25 | 株式会社明治 | 糖尿病合併症治療剤 |
US20070116787A1 (en) * | 2005-11-21 | 2007-05-24 | Chih-Jung Yao | Cancer treatment |
TW200829234A (en) * | 2007-01-08 | 2008-07-16 | Golden Biotechnology Corp | Antrodia camphorata isophorone extract |
CN101225066B (zh) | 2007-01-18 | 2010-09-22 | 国鼎生物科技股份有限公司 | 牛樟芝的环己烯酮萃取物 |
TW200918498A (en) * | 2007-10-19 | 2009-05-01 | Golden Biotechnology Corp | Novel compound isolated from Antrodia camphorate extracts |
CN101417934B (zh) * | 2007-10-24 | 2012-04-18 | 国鼎生物科技股份有限公司 | 分离自牛樟芝萃取物的化合物 |
TW201102075A (en) * | 2009-07-09 | 2011-01-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of pancreatic cancer |
TW201109014A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of skin cancer |
TWI383790B (zh) * | 2009-09-09 | 2013-02-01 | Golden Biotechnology Corp | Used to inhibit the growth of oral cancer cells of the cattle Antrodylcyclohexenone compounds |
TW201109023A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone compound of Antrodia cinnomomea that suppresses growth of tumor cell of colorectal cancer |
TW201109013A (en) * | 2009-09-09 | 2011-03-16 | Golden Biotechnology Corp | Cyclohexenone chemical compounds of Antrodia cinnamomea for suppressing the growth of the Lymphoma tumor cell |
TWI383791B (zh) * | 2009-09-09 | 2013-02-01 | Golden Biotechnology Corp | Used to inhibit the growth of gastric cancer tumor cells of the male antler ketone compounds |
TWI394566B (zh) * | 2009-09-09 | 2013-05-01 | Golden Biotechnology Corp | Used to inhibit the growth of ovarian cancer tumor cells of the cattle camphor cyclohexene ketone compounds |
ES2574606T3 (es) * | 2009-11-26 | 2016-06-21 | National Taiwan University | Una sustancia activa contra el cáncer de Antrodia camphorata, método de preparación de la misma y uso de la misma |
US8309611B2 (en) | 2010-09-20 | 2012-11-13 | Golden Biotechnology Corporation | Methods and compositions for treating lung cancer |
-
2011
- 2011-03-23 US US13/070,308 patent/US8309611B2/en active Active
- 2011-04-15 EP EP11827110.5A patent/EP2655309A4/en not_active Withdrawn
- 2011-04-15 KR KR1020137009889A patent/KR20130061746A/ko active Application Filing
- 2011-04-15 CN CN2011800557128A patent/CN103221373A/zh active Pending
- 2011-04-15 MA MA35800A patent/MA34598B1/fr unknown
- 2011-04-15 MY MYPI2013000945A patent/MY157341A/en unknown
- 2011-04-15 MX MX2011007763A patent/MX2011007763A/es not_active Application Discontinuation
- 2011-04-15 JP JP2013529140A patent/JP2014504256A/ja active Pending
- 2011-04-15 AU AU2011306068A patent/AU2011306068B2/en active Active
- 2011-04-15 WO PCT/US2011/032785 patent/WO2012039793A1/en active Application Filing
- 2011-04-15 KR KR1020157001206A patent/KR20150014534A/ko not_active Application Discontinuation
- 2011-04-15 BR BR112013006567A patent/BR112013006567A2/pt not_active IP Right Cessation
- 2011-04-15 CA CA2809762A patent/CA2809762C/en active Active
- 2011-04-15 EA EA201370071A patent/EA201370071A1/ru unknown
- 2011-04-15 SG SG2013020417A patent/SG188610A1/en unknown
- 2011-07-28 TW TW100126789A patent/TWI483718B/zh active
- 2011-09-16 AR ARP110103399A patent/AR083026A1/es unknown
-
2013
- 2013-03-17 IL IL225262A patent/IL225262A0/en unknown
- 2013-03-21 CO CO13056449A patent/CO6700836A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
EA201370071A1 (ru) | 2013-10-30 |
BR112013006567A2 (pt) | 2017-10-24 |
AU2011306068B2 (en) | 2014-08-07 |
WO2012039793A1 (en) | 2012-03-29 |
KR20130061746A (ko) | 2013-06-11 |
IL225262A0 (en) | 2013-06-27 |
EP2655309A1 (en) | 2013-10-30 |
JP2014504256A (ja) | 2014-02-20 |
CN103221373A (zh) | 2013-07-24 |
MY157341A (en) | 2016-05-31 |
CA2809762A1 (en) | 2012-03-29 |
MA34598B1 (fr) | 2013-10-02 |
US20120071426A1 (en) | 2012-03-22 |
CA2809762C (en) | 2016-02-02 |
US8309611B2 (en) | 2012-11-13 |
KR20150014534A (ko) | 2015-02-06 |
TW201212906A (en) | 2012-04-01 |
AU2011306068A1 (en) | 2013-05-02 |
AR083026A1 (es) | 2013-01-23 |
SG188610A1 (en) | 2013-04-30 |
TWI483718B (zh) | 2015-05-11 |
EP2655309A4 (en) | 2014-09-03 |
MX2011007763A (es) | 2012-07-04 |
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